المؤلفون: Oladayo Amed Idris, Olubunmi Abosede Wintola, Anthony Jide Afolayan

المصدر: Saudi Journal of Biological Sciences, Vol 29, Iss 1, Pp 541-549 (2022)

مصطلحات موضوعية: Caenorhabditis elegans, Gastrointestinal infections, Anthelmintic drug, Bioactive compounds, Phytochemical, Ethnoveterinary therapists, Biology (General), QH301-705.5

الوصف: Traditional healers and ethnoveterinary therapists use several medicinal plants, such as Rumex crispus L., to treat endoparasite infections. R. crispus has been established by researchers to be effective agasint a few parasitic worms. In this study, we evaluated the potency of R. crispus extracts on the model organism, Caenorhabditis elegans and the bioactive compounds of the extracts were also identified. The solvent extracts of R. crispus were tested against C. elegans for up to 72 h. The effect of the extracts on C. elegans was examined using light microscopy (LM) and scanning electron microscopy (SEM). LM and SEM analysis showed damage on the body wall, reduced body and slight modifications of the nematode organs. The lethality test reveals a significant reduction in the viability of the nematode with the water extract of leaf (LF-WAE), among others, having the strongest potency against the nematode, with 83% lethality. Anlysis done with Fourier-transform infrared spectroscopy (FTIR) spectra reveals various characteristic vibration bands and fingerprint bands at 3400–600 cm−1, identifying phenols, organic acids, aromatics, amines, among others in the plant. The compounds were identified with liquid chromatography-mass spectrometry (LC-MS), under the categories of flavonoids, steroidal alkaloids and proanthocyanidin. In conclusion, this study confirmed that R. crispus has anthelmintic potential, using standardised C. elegans models as a tool and suggests that there could be novel compounds yet to be explored in the studied plant that could be of great benefit to livestock and humans.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1319562X21008275; https://doaj.org/toc/1319-562X

URL الوصول: https://doaj.org/article/f064ca15a8b7401fa83fb32dc32e3bad

المؤلفون: Hein Hendrik Smith, Oladayo Amed Idris, Mark Steve Maboeta

المصدر: Journal of Toxicology, Vol 2021 (2021)

مصطلحات موضوعية: Toxicology. Poisons, RA1190-1270

الوصف: The fast-growing world population places food production under enormous pressure to ensure food security. One of the most common methods to increase food production is the use of pesticides, but the continuous use thereof has numerous detrimental effects on the environment. The interest in biopesticides for a possible substitute has grown over the past two decades. To determine the research evolution of biopesticides (green pesticides), a bibliometric analysis from 1994 to 2019 was carried out. A total of 580 documents were found eligible in the Scopus database for this analysis. Parameters such as the number of articles, article citations, keywords, source impact, and countries of publication were used to analyse the documents and rank countries based on authors, productivity, article citations, and co-authorship. The analysis reveals production increased significantly from 2009 and has the most published documents in 2019 with a total of 74 articles. Asia’s most populous countries, India and China, were ranked first and second, respectively, and the USA third in terms of the most productive countries in the field of plant biopesticides. Countries in Europe and Africa however have fewer publications than expected in this field, given the fact that they are high consumers of pesticides. India, China, and the USA have 4.08%, 2.94%, and 12.5% multiple country publications (MCPs), respectively, with the USA having a stronger collaboration. Finally, there is a clear indication in this study that India and China are taking the lead in substituting synthetic pesticides with the alternative natural plant biopesticide.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1687-8191; https://doaj.org/toc/1687-8205

URL الوصول: https://doaj.org/article/78614b9e87574ea98aba83cf1c3a6b3e

المؤلفون: Tomi Lois Olatunji, Ademola Emmanuel Adetunji, Chijioke Olisah, Oladayo Amed Idris, Oluwaseyi Damilare Saliu, Frances Siebert

المصدر: Plants, Vol 10, Iss 10, p 2070 (2021)

مصطلحات موضوعية: bibliometric, Convolvulaceae, fodder, Merremia, merremins, resin glycosides, Botany, QK1-989

الوصف: The genus Merremia Dennst. ex Endl. (Convolvulaceae) is a rich source of structurally diverse phytochemicals with therapeutic relevance. This review presents the first comprehensive, up-to-date information and research progression on the nutritional value, ethnomedicinal uses, phytochemistry, pharmacological activities, and toxicity of the genus Merremia. Using the key search term “Merremia”, relevant documents and information were retrieved from electronic databases. Relevant documents were uploaded in RStudio with installed bibliometric software packages and used for data retrieval, tabulation, and network visualization. Bibliometric analysis revealed that ca. 55% of the studies related to Merremia were published in the last decade, which can be grouped into four thematic areas: (i) drug formulation, (ii) taxonomy, (iii) chemical analysis, and (iv) treatment of diseases. Ethnomedicinal uses, phytochemistry, and biological activities studies showed that species in the genus are promising medicinal plants with various pharmaceutical potentials. However, clinical studies to validate the efficacy of the reported bioactivities and the mechanisms underlying the various activities are lacking and should constitute a future research focus. Additionally, reports on the nutritional and antinutritional constituents of Merremia species revealed that the species meet high nutritional quality criteria for animals and are therefore suitable for inclusion in livestock diets. The few available investigations on toxicity indicated that most Merremia species are safe for human and animal use but not with prolonged chronic administration.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2223-7747/10/10/2070; https://doaj.org/toc/2223-7747

URL الوصول: https://doaj.org/article/a3976283f75e407397b85a48ddea1508

المؤلفون: Oladayo Amed Idris, Olubunmi Abosede Wintola, Anthony Jide Afolayan

المصدر: Asian Pacific Journal of Tropical Biomedicine, Vol 7, Iss 12, Pp 1071-1078 (2017)

مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Biology (General), QH301-705.5

الوصف: Objective: To evaluate the antioxidant activities and phytochemical content of the leaf and root extracts of Rumex crispus using the solvents extraction; methanol extract, ethanol extract, acetone extract (ACE), and water extract. Methods: Total flavonoids content, total phenolic content, and total proanthocyanidin were evaluated using spectrophotometric equivalents of the standards, quercetin, gallic acid and catechin respectively. The antioxidant activities of the plant extracts were determined using ABTS, DPPH, ferric reducing antioxidant power, total antioxidant capacity and nitric oxide scavenging assays. Results: The flavonoids and phenols contents of the extracts were in the range of (19.39 ± 4.08) to (526.23 ± 17.52) mg QE/g and (16.95 ± 12.03) to (240.68 ± 3.50) mg GAE/g, respectively. ACE of the leaf has the highest value of total flavonoids content (526.23 ± 17.52) mg QE/g while ACE of the root has the highest value of total phenolic content (240.68 ± 3.50) mg GAE/g. The highest content of total proanthocyanidin (645.38 ± 1.33) mg CE/g was in ACE of the root. Significant amounts of saponin and alkaloid were also present in the root and leaf extracts. All solvent fractions showed significant antioxidant activities (P

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2221169117309917; https://doaj.org/toc/2221-1691

URL الوصول: https://doaj.org/article/d12434a227bd4e4ebfff3e266dee85a4

المؤلفون: Oladayo Amed Idris, Olubunmi Abosede Wintola, Anthony Jide Afolayan

المصدر: Heliyon, Vol 5, Iss 1, Pp e01161- (2019)

مصطلحات موضوعية: Pharmaceutical science, Plant biology, Veterinary science, Food science, Science (General), Q1-390, Social sciences (General), H1-99

الوصف: The morbidity caused by parasite worms on susceptible hosts is of great concern and studies were carried out to explain the mechanism of infection, prevalence, host-parasite interaction and resistance of the parasite to treatment. This review elucidates the prevalence of parasitic worm infections; which is on the increases with the increase in the world population, global warming, poor standard of living particularly in troubled regions and developing nations. The neglect of the disease coupled with the resistance of these parasites to the few available drugs becomes a huge challenge that influences global disease burden. Helminths infections pose a life threat and increase the disability-adjusted life year (DALYs) of the poor and vulnerable people. On the other hand, exploration of medicinal plants as an alternative source of treatment against drugs resistance helminths, attract insufficient attention. This review focused on providing a general overview of the prevalence of helminths, host-parasite interactions, the resistance of helminths and the medicinal plants used to treat helminthic infections.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844018329876; https://doaj.org/toc/2405-8440

URL الوصول: https://doaj.org/article/b2cb01bf058b4d04bd29fd09d53493e5

المؤلفون: Mahboob Adekilekun Jimoh, Oladayo Amed Idris, Muhali Olaide Jimoh

المصدر: Plants, Vol 9, Iss 9, p 1249 (2020)

مصطلحات موضوعية: antiparasitic, human cervix adenocarcinoma, Mucuna pruriens, pharmaceutical precursors, phenolic acids, Botany, QK1-989

الوصف: This study aimed at assessing the biological activities of Mucuna pruriens seeds using cytotoxicity, phytochemical, antiparasitic screening, and antioxidant assays. Mature fruits of M. pruriens were harvested from Fort Hare University’s Research Farm located in Alice, South Africa. The collected seeds were pulverized in a standard process and taken to the laboratory for crude extraction and further treatments. Cytotoxic, antimalarial, and trypanocidal effects of crude extracts obtained from ethanol and water were tested, while the total phenolic, proanthocyanidin, and flavonoid contents of the aqueous extracts as well as their pharmacological activities were determined in vitro using 2,2-diphenyl-1-picrylhydrazyl ethanol (DPPH), ferric reducing antioxidant power (FRAP), and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays. Although the extracts showed mild antiparasitic (antiplasmodial and trypanocidal) effects, results from the cytotoxic experiment revealed that M. pruriens is not toxic to human cervix adenocarcinoma (HeLa) cells when tested using 50 µg/mL of extracts. It was observed that the seeds were remarkably rich in phenol (3730.1 ± 15.52 mg gallic acid equivalent (GAE)/g) compared to flavonoids (63.03 ± 1.95 mg quercetin equivalent (QE)/g) and proanthocyanidin (18.92 ± 1.09 mg catechin equivalent (CE)/g). Also, the antioxidant activities of the extracts were comparable to those of the standard antioxidant drugs (rutin and gallic acid) used, in a concentration-dependent manner. There was a direct relationship between phenolic acid content and antioxidant effects. It is therefore suggested that M. pruriens seeds be incorporated into human diets as a supplement to promote healthy living. Pharmaceutical industries with a particular interest in natural phenolic acids should consider using seeds of M. pruriens as pharmaceutical precursors.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2223-7747/9/9/1249; https://doaj.org/toc/2223-7747

URL الوصول: https://doaj.org/article/dae7f02a01ef426caa16cd621525e6a5

المؤلفون: Oladayo Amed Idris, Olubunmi Abosede Wintola, Anthony Jide Afolayan

المصدر: Plants, Vol 8, Iss 3, p 51 (2019)

مصطلحات موضوعية: proximate composition, mineral content, vitamins, anti-nutrient, essential oil composition, Botany, QK1-989

الوصف: Medicinal plants are a pertinent and effective remedy, employed in indigenous healthcare systems by traditional healers. This study focused on proximate parameters, minerals, vitamins, anti-nutrients and essential oil of the root and leaf of the medicinal plant; R. crispus, using the standard food analysis techniques. The result reveals that the moisture content of the leaf (7.57 ± 0.40%) and root (7.59 ± 0.08%) was not significantly different. The leaf has a higher ash, crude fat, fibre and mineral content than the root, except the carbohydrate (57.74 ± 3.06%) and Ca (1190.0 ± 0 mg/100g) values which are quite higher in the root. Traces of phytate was found in the leaf (1.15 ± 0.74%) and root (1.38 ± 0.27%) of R. crispus. The highest value of retinol, ascorbic acid and α-tocopherol was found in dried leaf (1.29 ± 0.014 mg retinol/100g), fresh leaf (159.73 ± 26.77 mg ascorbic acid/100g) and fresh root (54.90 ± 0.39 mg α-tocopherol/100g) respectively. The principal compound in the essential oil of the leaf are; 5-Eicosene, (E)-, docos-1-ene, trans-5-Octadecene, tetradecane while those found in the root are; 1-Heptacosanol, 4-Methyloctane, ethylcyclohexane, eucalyptol, m-Xylene, octadecane, phytol, and tetradecane. The research reveals that R. crispus may not only be used for medicinal purposes but could also be suitable for a complementary diet.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2223-7747/8/3/51; https://doaj.org/toc/2223-7747

URL الوصول: https://doaj.org/article/51c0630338684846b063fe11e80f2205

المؤلفون: Alade A; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, IA, USA. Azeez-alade@uiowa.edu.; Department of Epidemiology, College of Public Health, University of Iowa, Butali Laboratory, ML2198, 500 Newton Road, Iowa City, IA, 52242, USA. Azeez-alade@uiowa.edu., Mossey P; Department of Orthodontics, University of Dundee, Dundee, UK., Awotoye W; Department of Orthodontics, College of Dentistry, University of Iowa, Iowa City, IA, USA., Busch T; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, IA, USA., Oladayo AM; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, IA, USA., Aladenika E; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, IA, USA., Olujitan M; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, IA, USA., Wentworth E; Department of Genetics and Genome Sciences, University of Connecticut, Farmington, CT, USA.; Graduate Program in Genetics and Developmental Biology, University of Connecticut School of Medicine, Farmington, CT, USA., Anand D; Department of Biological Sciences, University of Delaware, Newark, DE, USA., Naicker T; Department of Paediatrics, Clinical Genetics, University of KwaZulu-Natal and Inkosi Albert Luthuli Central Hospital, Durban, South Africa., Gowans LJJ; Komfo Anokye Teaching Hospital and Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Eshete MA; Department of Surgery, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia., Adeyemo WL; Department of Oral and Maxillofacial Surgery, College of Medicine, University of Lagos, Idi-araba, Lagos, Nigeria., Zeng E; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, IA, USA., Van Otterloo E; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, IA, USA.; Department of Periodontics, College of Dentistry, University of Iowa, Iowa City, IA, USA., O'Rorke M; Department of Epidemiology, College of Public Health, University of Iowa, Butali Laboratory, ML2198, 500 Newton Road, Iowa City, IA, 52242, USA., Adeyemo A; National Human Genomic Research Institute, Bethesda, MD, USA., Murray JC; Department of Pediatrics, University of Iowa, Iowa City, IA, USA., Cotney J; Department of Genetics and Genome Sciences, University of Connecticut, Farmington, CT, USA., Lachke SA; Department of Biological Sciences, University of Delaware, Newark, DE, USA.; Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA., Romitti P; Department of Epidemiology, College of Public Health, University of Iowa, Butali Laboratory, ML2198, 500 Newton Road, Iowa City, IA, 52242, USA., Butali A; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, IA, USA. azeez-butali@uiowa.edu.; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Butali Laboratory, ML2198, 500 Newton Road, Iowa City, IA, 52242, USA. azeez-butali@uiowa.edu.

المصدر: Scientific reports [Sci Rep] 2024 Jun 20; Vol. 14 (1), pp. 14279. Date of Electronic Publication: 2024 Jun 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Cleft Palate*/genetics , Cleft Lip*/genetics, Humans ; Female ; Ghana ; Male ; Mice ; Genetic Predisposition to Disease ; Animals ; Nigeria ; Ethiopia ; Black People/genetics ; Child

مستخلص: Non-syndromic orofacial clefts (NSOFCs) are common birth defects with a complex etiology. While over 60 common risk loci have been identified, they explain only a small proportion of the heritability for NSOFCs. Rare variants have been implicated in the missing heritability. Thus, our study aimed to identify genes enriched with nonsynonymous rare coding variants associated with NSOFCs. Our sample included 814 non-syndromic cleft lip with or without palate (NSCL/P), 205 non-syndromic cleft palate only (NSCPO), and 2150 unrelated control children from Nigeria, Ghana, and Ethiopia. We conducted a gene-based analysis separately for each phenotype using three rare-variants collapsing models: (1) protein-altering (PA), (2) missense variants only (MO); and (3) loss of function variants only (LOFO). Subsequently, we utilized relevant transcriptomics data to evaluate associated gene expression and examined their mutation constraint using the gnomeAD database. In total, 13 genes showed suggestive associations (p = E-04). Among them, eight genes (ABCB1, ALKBH8, CENPF, CSAD, EXPH5, PDZD8, SLC16A9, and TTC28) were consistently expressed in relevant mouse and human craniofacial tissues during the formation of the face, and three genes (ABCB1, TTC28, and PDZD8) showed statistically significant mutation constraint. These findings underscore the role of rare variants in identifying candidate genes for NSOFCs.
(© 2024. The Author(s).)

المؤلفون: Oladayo AM; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, United States.; Iowa Institute for Oral Health Research, University of Iowa, Iowa City, IA, United States., Lawal FB; Department of Periodontology and Community Dentistry, Faculty of Dentistry, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.; University College Hospital (UCH), Ibadan, Oyo, Nigeria., Sofola OO; Department of Preventive Dentistry, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria., Uti OG; Department of Preventive Dentistry, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria., Oyapero A; Department of Preventive Dentistry, Faculty of Dentistry, Lagos State University College of Medicine, Lagos, Nigeria., Aborisade A; Department of Oral Diagnostic Sciences, Faculty of Dentistry, Bayero University Kano, Kano, Nigeria.; Department of Oral Diagnostic Sciences, Aminu Kano Teaching Hospital, Kano, Nigeria., Stewart B; Colgate-Palmolive Company, Piscataway, NJ, United States., Daep CA; Colgate-Palmolive Company, Piscataway, NJ, United States., Hines D; Colgate-Palmolive Company, Piscataway, NJ, United States., Beard J; National Dental Association Foundation, Washington, DC, United States., Dedeke A; Department of Periodontology and Community Dentistry, Faculty of Dentistry, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.; University College Hospital (UCH), Ibadan, Oyo, Nigeria., Fagbule OF; Department of Periodontology and Community Dentistry, Faculty of Dentistry, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.; University College Hospital (UCH), Ibadan, Oyo, Nigeria., Williams AT; University College Hospital (UCH), Ibadan, Oyo, Nigeria.; Department of Child Oral Health, Faculty of Dentistry, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria., Uchendu OC; Department of Community Medicine, University of Ibadan, Ibadan, Oyo, Nigeria., Ohiare K; College of Dentistry, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria., Adedire AO; College of Dentistry, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria., Yahya-Imam AA; Department of Oral and Maxillofacial Surgery, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria., Adeniji OI; Department of Restorative Dentistry, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria., Mele AB; Department of Oral Diagnostic Sciences, Faculty of Dentistry, Bayero University Kano, Kano, Nigeria.; Department of Oral Diagnostic Sciences, Aminu Kano Teaching Hospital, Kano, Nigeria., Baffa AS; Department of Oral Diagnostic Sciences, Aminu Kano Teaching Hospital, Kano, Nigeria., Adetula I; Department of Preventive Dentistry, Aminu Kano Teaching Hospital, Kano, Nigeria., Lawal TA; Division of Pediatric Surgery, Department of Surgery, University of Ibadan and University College Hospital, Ibadan, Oyo, Nigeria., Oke GA; Department of Periodontology and Community Dentistry, Faculty of Dentistry, College of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.; University College Hospital (UCH), Ibadan, Oyo, Nigeria., Butali A; Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, IA, United States.; Iowa Institute for Oral Health Research, University of Iowa, Iowa City, IA, United States.

المصدر: Frontiers in public health [Front Public Health] 2024 Jun 07; Vol. 12, pp. 1398869. Date of Electronic Publication: 2024 Jun 07 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Editorial Office Country of Publication: Switzerland NLM ID: 101616579 Publication Model: eCollection Cited Medium: Internet ISSN: 2296-2565 (Electronic) Linking ISSN: 22962565 NLM ISO Abbreviation: Front Public Health Subsets: MEDLINE

مواضيع طبية MeSH: Community Health Workers*/education , Oral Health*/education, Humans ; Nigeria ; Pilot Projects ; Nurses ; Primary Health Care ; Female ; Health Knowledge, Attitudes, Practice ; Adult ; Male

مستخلص: Introduction: The primary health care system provides an ideal setting for the integration of oral health into general health care as well as equitable access to oral health care. However, the limited oral health knowledge of primary health care workers necessitates appropriate training before they can participate in health promotion efforts. This pilot training was designed to examine the impact of the Oral Health Education module for Nurses and Community Health Care Workers on their oral health awareness and referral practices.
Methods: This study will utilize a quasi-experimental design (pre-and post with a non-equivalent control group) to assess the impact of a five-day pilot oral health education program on the knowledge and referral practices of Nurses and Community Health Workers in primary health care centers in three states in Nigeria-(Lagos, Oyo, and Kano). The training modules were developed based on the six iterative steps described in the intervention mapping framework - needs assessment, highlighting program objectives and outcomes, selection of theory and mode of intervention, designing program based on theory, designing implementation plans, and developing an evaluation plan. Only the intervention group will participate in the full educational training sessions but both groups will complete the pre-and post-intervention questionnaires.
Discussion: This pilot training combined the standardized training modules from the recently launched " Oral Health Training Course for Community Health Workers in Africa" and a newly developed maternal and child oral health module by our group using an evidence-based approach. To the best of our knowledge, this is the first program to examine the impact of the standardized OpenWHO modules. The success of this training will lay the foundation for developing a sustained channel for providing oral health education at the primary health care level in Nigeria, West Africa, and Africa.
Competing Interests: BS, CD and DH were employed by Colgate-Palmolive Company. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author, AB, declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
(Copyright © 2024 Oladayo, Lawal, Sofola, Uti, Oyapero, Aborisade, Stewart, Daep, Hines, Beard, Dedeke, Fagbule, Williams, Uchendu, Ohiare, Adedire, Yahya-Imam, Adeniji, Mele, Baffa, Adetula, Lawal, Oke and Butali.)

المؤلفون: Oladayo AM; Department Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, Iowa, USA.; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, Iowa, USA., Prochaska S; Department of Global Health, College of Public Health, University of Iowa, Iowa City, Iowa, USA., Busch T; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, Iowa, USA., Adeyemo WL; Department of Oral and Maxillofacial Surgery, University of Lagos, Lagos, Nigeria., Gowans LJJ; Department of Biochemistry and Biotechnology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana., Eshete M; Department of Surgery, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia., Awotoye W; Department Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, Iowa, USA.; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, Iowa, USA., Sule V; Department of Operative Dentistry, College of Dentistry, University of Iowa, Iowa City, Iowa, USA., Alade A; Department Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, Iowa, USA.; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, Iowa, USA., Adeyemo AA; National Human Genomic Research Institute, Bethesda, MD, USA., Mossey PA; Department of Orthodontics, University of Dundee, Dundee, UK., Prince A; College of Law, University of Iowa, Iowa City, Iowa, USA., Murray JC; Department of Pediatrics, University of Iowa, Iowa City, Iowa, USA., Butali A; Department Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa City, Iowa, USA.; Iowa Institute of Oral Health Research, University of Iowa, Iowa City, Iowa, USA.

المصدر: AJOB empirical bioethics [AJOB Empir Bioeth] 2024 Apr-Jun; Vol. 15 (2), pp. 133-146. Date of Electronic Publication: 2024 Jan 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Group, 2014- Country of Publication: United States NLM ID: 101631047 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2329-4523 (Electronic) Linking ISSN: 23294515 NLM ISO Abbreviation: AJOB Empir Bioeth Subsets: MEDLINE

مواضيع طبية MeSH: Cleft Palate*/genetics , Genetic Testing* , Parents* , Genomics* , Health Personnel* , Cleft Lip*/genetics, Humans ; Male ; Female ; Nigeria ; Adult ; Ghana ; Health Knowledge, Attitudes, Practice ; Surveys and Questionnaires ; Child ; Middle Aged ; Attitude of Health Personnel

مستخلص: Background: Inadequate knowledge among health care providers (HCPs) and parents of affected children limits the understanding and utility of secondary genetic findings (SFs) in under-represented populations in genomics research. SFs arise from deep DNA sequencing done for research or diagnostic purposes and may burden patients and their families despite their potential health importance. This study aims to evaluate the perspective of both groups regarding SFs and their choices in the return of results from genetic testing in the context of orofacial clefts.
Methods: Using an online survey, we evaluated the experiences of 252 HCPs and 197 parents across participating cleft clinics in Ghana and Nigeria toward the return of SFs across several domains.
Results: Only 1.6% of the HCPs felt they had an expert understanding of when and how to incorporate genomic medicine into practice, while 50.0% agreed that all SFs should be returned to patients. About 95.4% of parents were willing to receive all the information from genetic testing (including SFs), while the majority cited physicians as their primary information source (64%).
Conclusions: Overall, parents and providers were aware that genetic testing could help in the clinical management of diseases. However, they cited a lack of knowledge about genomic medicine, uncertain clinical utility, and lack of available learning resources as barriers. The knowledge gained from this study will assist with developing guidelines and policies to guide providers on the return of SFs in sub-Saharan Africa and across the continent.