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المؤلفون: Ashwin Abhang, Oly Katari, Rohan Ghadi, Dasharath Chaudhari, Sanyog Jain
الوصف: Breast cancer is challenging to treat accompanied with poor clinical outcomes. Paclitaxel (PTX) is a first-line chemotherapeutic agent, but possesses limitations due to side effects, high dose, non-specific tissue distribution, and drug resistance. An epigenetic modulator, Vorinostat (VOR) is known to enhance PTX efficacy and therefore to resolve the issues of conventional PTX formulations we designed PTX-and VOR-bound albumin nanoparticles (PTX-VOR-BSA-NPs) using antisolvent precipitation technique where albumin is used as a carrier and a targeting agent. The PTX-VOR-BSA-NPs were of 140 nm size, PDI around 0.18, and about 78% and 68% of entrapment efficiency for PTX and VOR, respectively. A bi-pattern release of both PTX and VOR was observed from PTX-VOR-BSA-NPs with a burst release for 2 h succeeded by sustained release till 24 h. A significantly lower %cell viability was observed in MCF-7 cell lines, while efficient cellular drug uptake was found in MDA-MB-231 cells. Furthermore, a greater apoptotic index was found compared to free PTX and VOR because of the synergistic activity of these drugs. PTX-VOR-BSA-NPs had better PTX pharmacokinetic profile than Intaxel® with ~1.4-fold improved AUC. The self-targeting property of BSA along with the synergistic action of PTX and VOR from PTX-VOR-BSA-NPs aided in noteworthy reduction in the tumor volume compared to Intaxel®. Further, the PTX-VOR-BSA-NPs showed similar levels of toxicity biomarkers as that of control. Overall, the developed PTX-VOR-BSA-NPs were found to have less toxicity and more effectiveness compared to the marketed formulation, thus affirming the generation of a potent as well as and safe product.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b9f5632142a0789084bf12995b0e86e4
https://doi.org/10.21203/rs.3.rs-2928600/v1 -
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المؤلفون: Mukta Agrawal, Junia Akhtar, Amit Alexander, Gulin Amasya, Taruna Arora, Kajal Bagri, Sanya Batheja, Zerrin Sezgin Bayindir, Jayant Singh Bhardwaj, Abhay Bhardwaj, Swapnali Vasant Birajdar, Antonio Camins, Amanda Cano, Akash Chaurasiya, Rusham Das, Rahul Deshmukh, Sunil Kumar Dubey, Marta Espina, Gerard Esteruelas, Miren Ettcheto, Maria Luisa García, Goutam Ghosh, Amit Kumar Goyal, Deepika Grewal, Umesh Gupta, Sanyog Jain, Biswakanth Kar, Oly Katari, Sumeet Katke, Prashant Kesharwani, Sanskruti Santosh Kharavtekar, Vinay Kumar, Shilpa Kumari, Priyanka Kumari, Shobha Kumari, Farhan Mazahir, Manisha Mulchandani, Jayabalan Nirmal, Kanan Panchal, Tushar Kanti Rajwar, Goutam Rath, Shreyasi Ghosh Ray, Upal Roy, Rakesh Kumar Sahoo, Eliana B. Souto, Elena Sánchez-López, Rajeev Taliyan, Awesh K. Yadav, Sheetal Yadav, Nilufer Yuksel
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d262762f7ad2d06c0d06e52b8f6e15b3
https://doi.org/10.1016/b978-0-12-824331-2.00046-7 -
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المؤلفون: Reena Sharma, Sheetal Yadav, Vivek Yadav, Junia Akhtar, Oly Katari, Kaushik Kuche, Sanyog Jain
المصدر: Advanced Drug Delivery Reviews. :114901
مصطلحات موضوعية: Pharmaceutical Science
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المؤلفون: Rahul R. Rajendran, A. Deepak, Ravi Manne, Sijo Joy Edapully, Oly Katari, Sheersha Pramanik, Triveni Patil, Sourav Mohanto
المصدر: Molecular Pharmaceutics. 18:3671-3718
مصطلحات موضوعية: Lung Diseases, medicine.medical_specialty, COPD, Lung, Inhalation, business.industry, Pharmaceutical Science, medicine.disease, Cystic fibrosis, Bronchodilator Agents, Idiopathic pulmonary fibrosis, medicine.anatomical_structure, Chronic Disease, Drug Discovery, Drug delivery, medicine, Humans, Molecular Medicine, Nanoparticle Drug Delivery System, Intensive care medicine, Magic bullet, business, Asthma
الوصف: Chronic pulmonary diseases encompass different persistent and lethal diseases, including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), cystic fibrosis (CF), asthma, and lung cancers that affect millions of people globally. Traditional pharmacotherapeutic treatment approaches (i.e., bronchodilators, corticosteroids, chemotherapeutics, peptide-based agents, etc.) are not satisfactory to cure or impede diseases. With the advent of nanotechnology, drug delivery to an intended site is still difficult, but the nanoparticle's physicochemical properties can accomplish targeted therapeutic delivery. Based on their surface, size, density, and physical-chemical properties, nanoparticles have demonstrated enhanced pharmacokinetics of actives, achieving the spotlight in the drug delivery research field. In this review, the authors have highlighted different nanoparticle-based therapeutic delivery approaches to treat chronic pulmonary diseases along with the preparation techniques. The authors have remarked the nanosuspension delivery via nebulization and dry powder carrier is further effective in the lung delivery system since the particles released from these systems are innumerable to composite nanoparticles. The authors have also outlined the inhaled particle's toxicity, patented nanoparticle-based pulmonary formulations, and commercial pulmonary drug delivery devices (PDD) in other sections. Recently advanced formulations employing nanoparticles as therapeutic carriers for the efficient treatment of chronic pulmonary diseases are also canvassed.
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المؤلفون: Rajappa Margret Chandira, Oly Katari, Abhinab Goswami, Tamilvanan Shunmugaperumal, Thenrajan Raja Sekharan, Datta Maroti Pawde, Syed Nazrin Ruhina Rahman
المصدر: Drug Discovery Today. 26:1702-1711
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, chemistry.chemical_classification, Active ingredient, Drug Industry, business.industry, Extraction (chemistry), Supercritical fluid, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Drug development, 030220 oncology & carcinogenesis, Drug Discovery, Ionic liquid, Solvents, Organic chemistry, Volatile organic compound, business, Pharmaceutical industry
الوصف: The utilization of either aqueous or conventional/traditional volatile organic compound-based extraction/product development processes in the pharmaceutical industry has become questionable because of the water solubility limitations of active pharmaceutical ingredients (APIs) and stringent regulatory issues concerning the safety aspect of volatile organic compounds (VOCs). The use of neoteric solvents (nonconventional/nontraditional) is being encouraged during API extraction from whole plants or plant tissues and for during pharmaceutical product development. In this review, we provide an overview of the utilization of four neoteric solvents (supercritical fluids, fluorous solvents, ionic liquids, and deep eutectic solvents) in API extraction and pharmaceutical product development processes. Our review highlights solvent-less or solvent-free reactions, which could replace neoteric solvents in drug development in the future.
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المؤلفون: Dasharath Chaudhari, Oly Katari, Rohan Ghadi, Kaushik Kuche, Tushar Date, Nallamothu Bhargavi, Sanyog Jain
المصدر: ACS biomaterials scienceengineering. 8(8)
مصطلحات موضوعية: Biomaterials, Adenosine, Paclitaxel, Liposomes, Biomedical Engineering, Humans, Triple Negative Breast Neoplasms, Hydrogen-Ion Concentration
الوصف: Triple-negative breast cancer (TNBC) belongs to the category of the most destructive forms of breast cancer. Being a highly potent chemotherapeutic agent, paclitaxel (PTX) is extensively utilized in the management of various cancers. Commercially available PTX formulations contain non-targeted drug carriers that result in low antitumor activity because of non-specific tissue distribution. Thus, to resolve this issue, we designed PTX-loaded pH-sensitive liposomes (pH Lipos) in the present investigation and used adenosine (ADN) as a targeting ligand. Further, d-α-tocopheryl polyethylene glycol succinate (TPGS) was incorporated into the liposomes to impart a stealth effect to the system. For the development of these pH Lipos, different conjugates were synthesized (ADN-CHEMS and TPGS-ADN) and further utilized for the preparation of ADN-PEG-pH Lipo and ADN-pH Lipo by a thin-film hydration method. DOPE:HSPC:CHEMS:cholesterol at a molar ratio of 3:3:2:2 was selected for the preparation of pH-Lipo possessing 7.5% w/w drug loading. They showed a particle size below 140 nm, a PDI below 0.205, and a % EE greater than 60%. All of the pH Lipos displayed a biphasic pattern of PTX release at pH 7.4 and 5.5. However, the percent drug release at pH 5.5 was substantially greater because of the pH-sensitive nature of the liposomes. The MDA MB 231 and 4T1 cell lines depicted improvement in the qualitative as well as quantitative cellular uptake of PTX ADN-PEG-pH Lipo with a substantial decrease in the IC
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المؤلفون: Oly Katari, Tamilvanan Shunmugaperumal
المصدر: Oil‐in‐Water Nanosized Emulsions for Drug Delivery and Targeting. :169-223
مصطلحات موضوعية: Oil in water, Environmental science, Pulp and paper industry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b0510aa9078295a0809920ea9af0b8c5
https://doi.org/10.1002/9781119585275.ch4 -
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المصدر: Oil‐in‐Water Nanosized Emulsions for Drug Delivery and Targeting. :369-422
مصطلحات موضوعية: Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4971961dc56ce3539cbba05784a8da41
https://doi.org/10.1002/9781119585275.ch8 -
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المؤلفون: Tamilvanan Shunmugaperumal, Oly Katari
المصدر: Oil‐in‐Water Nanosized Emulsions for Drug Delivery and Targeting. :259-285
مصطلحات موضوعية: Oil in water, Chemistry, Pulp and paper industry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::a3fcd224ba56629fed11ad03552b4404
https://doi.org/10.1002/9781119585275.ch6
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