المؤلفون: Os, C. H. van (Charles Hendrik), b. 1891

المساهمون: Universiteit van Amsterdam

Degree: doctoral -- Universiteit van Amsterdam -- 1916.

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المؤلفون: van Os, C. H.

المصدر: Journal of Membrane Biology; Dec2001, Vol. 184 Issue 3, p219-223, 5p

مصطلحات موضوعية: INFLUENCE, CYTOSOL, SODIUM, EPITHELIAL cells, SODIUM channels, FROGS, SKIN

People: USSING, Hans

مستخلص: This article focuses on some of researcher Hans Ussing's papers and ideas that were most influential at the start of the author's career. The author states that it is now well accepted that any maneuver that brings about an increase in the cytosolic sodium (Na) concentration results in a decrease in active Na transport and Na conductance. Ussing was the first to report observations on the effect of ouabain on frog skin and had already hinted at some form of negative feedback. The author comments that the story becomes now more complex because, recently, as a laboratory experiment was able to demonstrate also an effect of intracellular Na on the aldosterone-induced synthesis of an epithelial Na channel subunit as a clear form of negative feedback.

المؤلفون: Marr, N., Kamsteeg, E. J., van Raak, M., van Os, C. H, Deen, P. M. T.

المصدر: Pflügers Archiv: European Journal of Physiology; Apr2001, Vol. 442 Issue 1, p73-77, 5p

مصطلحات موضوعية: AQUAPORINS, MEMBRANE proteins, GLYCOPROTEINS, DIABETES, CARBOHYDRATE intolerance, ENDOCRINE diseases, NUTRITION disorders

مستخلص: Aquaporin-2 (AQP2) missense mutants in recessive nephrogenic diabetes insipidus (NDI) are all retained in the endoplasmic reticulum (ER), but some could function as water channels. No conclusions could be drawn about the water permeability (Pf) of others, because there was no method for quantifying AQP2 expression in the plasma membrane. We recently developed such a method, which has allowed us to study the functionality of these AQP2 mutants. Immunoblot analysis of membranes of injected oocytes revealed that all mutants (AQP2-G64R, AQP2-N68S, AQP2-T126M, AQP2-A147T, AQP2-R187C, AQP2-S216P) are expressed as unglycosylated and high-mannose glycosylated AQP2. The level of the high-mannose form of AQP2-A147T in the plasma membranes was low, indicating that this mutation has a less severe effect on proper folding. Analysis of Pf values and plasma membrane expression levels reveals that AQP2-N68S, AQP2-R187C and AQP2-S216P are non-functional, AQP2-A147T is as functional as wt-AQP2, while AQP2-T126M and AQP2-G64R retain 20% of the permeability of wt-AQP2. Since G64 is highly conserved between AQPs and expected to form essential interactions with other amino acids within AQP1, the residual functionality of AQP2-G64R is surprising. Our data furthermore indicate that an eventual therapy with chemical chaperones that restores the routing of AQP2 mutants to the apical membrane of collecting ducts cells might relieve NDI in patients encoding AQP2-A147T, and to a lesser extent AQP2-T126M and AQP2-G64R, but not in patients encoding AQP2-N68S, AQP2-R187C or AQP2-S216P. [ABSTRACT FROM AUTHOR]

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المؤلفون: RAAT, N. J. H., VAN OS, C. H., BINDELS, R. J. M.

المصدر: American Journal of Physiology: Renal, Fluid & Electrolyte Physiology; Aug1995, Vol. 38 Issue 2, pF205-F211, 7p

المؤلفون: RAAT, N. J. H., HARTOG, A., VAN OS, C. H., BINDELS, R. J. M.

المصدر: American Journal of Physiology: Renal, Fluid & Electrolyte Physiology; Jul1994, Vol. 36 Issue 1, pF63-f69, 7p

المؤلفون: BINDELS, R. J. M., HARTOG, A., ABRAHAMSE, S. L., VAN OS, C. H.

المصدر: American Journal of Physiology: Renal, Fluid & Electrolyte Physiology; Apr1994, Vol. 35 Issue 4, pF620-F627, 8p

المؤلفون: BINDELS, R. J. M., HARTOG, A., TIMMERMANS, J., VAN OS, C. H.

المصدر: American Journal of Physiology: Renal, Fluid & Electrolyte Physiology; Nov1991, Vol. 30 Issue 5, pF799-F807, 9p

المؤلفون: BINDELS, R. J. M., GEERTSEN, J. A. M., VAN OS, C. H.

المصدر: American Journal of Physiology: Renal, Fluid & Electrolyte Physiology; Mar1986, Vol. 19 Issue 3, pF470-F475, 6p

المؤلفون: Peters, S. M. A., Rauen, U., Tijsen, M. J. H., Bindels, R. J. M., van Os, C. H., de Groot, H., Wetzels, J. F. M.

المصدر: Transplantation; Mar98, Vol. 65 Issue 5, p625, 7p