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المؤلفون: Abel J. P. Gomes, Fernando Ferreira, N. Dourado, Nguyen Trong Quyen
المساهمون: Universidade do Minho
المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: strain smoothing technique, Computer science, Engenharia e Tecnologia::Engenharia Mecânica, Modal analysis, Engenharia e Tecnologia::Outras Engenharias e Tecnologias, 01 natural sciences, Biomaterials, Shear-locking, Engenharia e Tecnologia::Engenharia Civil, 0103 physical sciences, Engenharia dos Materiais [Engenharia e Tecnologia], Smoothed finite element method, Electrical and Electronic Engineering, 010301 acoustics, 010302 applied physics, Science & Technology, business.industry, Mindlin–Reissner theory of plates, Engenharia Mecânica [Engenharia e Tecnologia], Structural engineering, Computer Science Applications, gradient, Engenharia e Tecnologia::Engenharia dos Materiais, Non-woven fabric, Mechanics of Materials, Modeling and Simulation, Gradient/strain smoothing technique, Engenharia Civil [Engenharia e Tecnologia], Outras Engenharias e Tecnologias [Engenharia e Tecnologia], business, Cell based
الوصف: The combination of a 4-node quadrilateral mixed interpolation of tensorial components element (MITC4) and the cell-based smoothed finite element method (CSFEM) was formulated and implemented in this work for the analysis of free vibration and unidirectional buckling of shell structures. This formulation was applied to numerous numerical examples of non-woven fabrics. As CSFEM schemes do not require coordinate transformation, spurious modes and numerical instabilities are prevented using bilinear quadrilateral element subdivided into two, three and four smoothing cells. An improvement of the original CSFEM formulation was made regarding the calculation of outward unit normal vectors, which allowed to remove the integral operator in the strain smoothing operation. This procedure conducted both to the simplification of the developed formulation and the reduction of computational cost. A wide range of values for the thickness-to-length ratio and edge boundary conditions were analysed. The developed numerical model proved to overcome the shear locking phenomenon with success, revealing both reduced implementation effort and computational cost in comparison to the conventional FEM approach. The cell-based strain smoothing technique used in this work yields accurate results and generally attains higher convergence rate in energy at low computational cost
This work was supported by the Portuguese Foundation for Science and Technology (FCT) through project UID/CTM/00264/2019 of 2C2T-Centro de Ciencia e Tecnologia Textil, hold by National Founds of FCT/MCTES, and project UID/EEA/04436/2013, COMPETE 2020 with the code POCI-01-0145-FEDER-006941.وصف الملف: application/epub+zip; application/pdf
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المؤلفون: Matos, Luís Miguel
المساهمون: Cortez, Paulo, Mendes, Rui, Universidade do Minho
المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: Big Data, Engenharia e Tecnologia::Outras Engenharias e Tecnologias, Categorical Transformation, Outras Engenharias e Tecnologias [Engenharia e Tecnologia], Conversion Rate (CVR), Ordinal Classification, Classification, Intelligent Decision Support System (IDSS), Deep Multilayer Perceptron
الوصف: Tese de doutoramento em Information Systems
Mobile devices (e.g., smartphones, tablets) are becoming commonplace and thus, mobile performance marketing is nowadays witnessing a considerable growth. In this type of marketing, real-time bidding is typically implemented by using a Demand-Side Platform (DSP) that matches users to ads. If there is a product purchase (conversion), the DSP facilitates a monetization exchange by returning a percentage of the sale revenue to the publishers. Under this context, a critical DSP issue is the prediction of the user Conversion Rate (CVR), often modeled as a classification task and where the goal is to estimate if there will be a purchase when a user clicks on a dynamic link and then views an ad. The main objective of this study is the development of an Intelligent Decision Support System (IDSS), which can be integrated into an existing DSP. The IDSS is particularly focused on predicting the CVR, which can be used as a way to select the best advertisements for users (e.g., with the highest conversion probability). In this work, the IDSS was built using big data which in turn is generated from a DSP that operates at a global level. In a first phase, a stream processing engine was developed in order to obtain data samples from a complete set of events generated by DSP. This sample data included redirects and sales events collected between 2017 and 2019. Next, several Machine Learning (ML) methods, including Deep Learning (DL), balancing and pre-processing methods were explored. The experimental results demonstrate that the proposed ML approach, which includes a pre-processing of Percentage Categorical Pruned (PCP) and a reuse learning of the Deep Feedfoward Network (DFFN) model, obtained the best predictions of CVR (for both binary and multi-class classification), requiring a computational effort that is manageable by DSP. Additionally, the IDSS developed, based on the proposed ML approach, proved to provide a valuable potential impact on the analyzed mobile marketing domain.
Os dispositivos móveis (e.g., smartphone, tablet, smart TV) têm vindo a tornar-se cada vez mais comuns, fazendo com que o mercado mobile testemunhe um crescimento enorme nos dias de hoje. Neste tipo de marketing, o leilão é tipicamente implementado usando um Demand-Side Platform (DSP) que interliga os utilizadores aos anúncios. Se existir a compra de um produto (conversão), o DSP facilita o fluxo de dinheiro, retornando assim uma percentagem da venda aos publishers. Sobre este conceito, o factor chave do DSP é a previsão do Conversion Rate (CVR), que é geralmente abordado como uma tarefa de classificação cujo o objectivo é estimar se irá ocorrer uma compra quando o utilizador (user) clique num dynamic link e veja a publicidade. O principal objectivo deste estudo é o desenvolvimento de um Sistema de Apoio à Decisão Inteligente (IDSS em inglês), que possa ser integrado num DSP já existente. O IDSS é particularmente focado em prever o CVR, que pode ser utilizado como forma de selecionar as melhores publicidades aos utilizadores (e.g., com a maior probabilidade de conversão). Neste trabalho, o IDSS foi construído utilizando big data que por sua vez for gerada de um DSP que opera a nível global. Numa primeira fase, foi desenvolvido um stream processing engine com o objetivo de obter amostras de dados de um conjunto completo de eventos gerado pelo o DSP. Esta amostra de dados incluiu eventos de redirects e de vendas coletadas entre os 2017 e 2019. De seguida, vários métodos de Machine Learning (ML), incluindo Deep Learning (DL), balanceamento e métodos de pré-processamentos foram explorados. Os resultados experimentais demonstram que a abordagem de ML proposta, que inclui um pré-processamento de Percentage Categorical Pruned (PCP) e uma aprendizagem reuse do modelo Deep Feedfoward Network (DFFN), obteve as melhores previsões de CVR (tanto para classificação binária como multi-classe), exigindo um esforço computacional comportável pelo DSP. Adicionalmente, o IDSS desenvolvido, baseado na abordagem de ML proposta, demonstrou fornecer um impacto potencial valioso no domínio do mobile marketing analisado.
PROMOS – Previsão e otimização de campanhas publicitárias Para Dispositivos móveis em modelo de Subscrição, NORTE-01-0247-FEDER-017497وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6e035b28494d9666d81b7d59b4072016
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المؤلفون: Souza, Thiago Antonio
المساهمون: Lima, Rui M., Vaccaro, Guilherme L. R., Universidade do Minho
المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: Hospital operations management, Melhoria contínua, Continuous improvement, Gestão hospitalar, Engenharia e Tecnologia::Outras Engenharias e Tecnologias, Outras Engenharias e Tecnologias [Engenharia e Tecnologia], Lean Healthcare, Gestão da mudança, Change management, Gestão de operações hospitalares, Hospital management
الوصف: Tese de doutoramento em Engenharia Industrial e de Sistemas
Hospitais são estruturas complexas com o objetivo de prover atendimento de qualidade, segurança, fiabilidade e eficiente aos seus pacientes. Entretanto, estas organizações vêm sofrendo pressões para redução de custos, melhoria de operações e garantia da qualidade devido a problemas em fluxos como esperas, cancelamentos, defeitos, absenteísmo, aumento da procura, falhas na gestão e aumento de preços. Neste contexto, a pandemia pelo novo coronavírus (COVID-19) evidencia alguns problemas existentes nos sistemas de saúde, e em particular aos hospitais, unidades de estudo desta tese e estabelece a necessidade cada vez maior de evolução na gestão hospitalar. Assim, gestores de saúde têm adotado técnicas de gestão de outras indústrias com o objetivo de melhorar suas operações, e assim, a área de Gestão de Operações emerge como dimensão importante para a evolução gerencial de hospitais. A Gestão de Operações aborda temas como a gestão da capacidade produtiva, cadeias de fornecimento, planeamento e qualidade das organizações, além da implementação de iniciativas de melhoria, como o Lean Healthcare. O Pensamento Lean se originou na manufatura com foco na eliminação de desperdícios e melhoria contínua dos fluxos da organização, podendo ser aplicado em operações de saúde. Entretanto, investigações que intercetam tais temas ainda se apresentam iniciais e pontuais em suas implementações em casos de melhoria de operações hospitalares. Assim, esta tese se orienta por uma abordagem qualitativa utilizando técnicas e metodologias como workshops com profissionais de saúde, análise documental, entrevistas com especialistas e estudo de múltiplos casos analisando vinte projetos em quatro hospitais de grande porte baseados em Portugal e Brasil. Por meio deste design de investigação, este trabalho contribui com a academia e organizações hospitalares por meio do desenvolvimento de um framework de gestão de operações hospitalares sob a ótica do Lean Healthcare. Além de adaptar as principais dimensões da Gestão de Operações para o ambiente hospitalar, levantar oportunidades e melhores práticas nos hospitais estudados, e apresentar ferramentas, áreas e indicadores norteadores para a implementação sistemática e integrada da Gestão de Operações e Lean Healthcare.
Hospitals are complex structures with the objective of providing quality, safe, reliable and efficient care to their patients. However, these organizations have been under pressure to reduce costs, improve operations and guarantee quality due to problems in flows such as waiting, cancellations, defects, absenteeism, increased demand, management failures and price increases. In this context, the pandemic caused by the new coronavirus (COVID-19) highlights some existing problems in health systems, and in particular in hospitals, units of study of this thesis, and establishes the growing need for evolution in hospital management. Thus, health managers have adopted management techniques from other industries in order to improve their operations, and thus, the area of Operations Management emerges as an important dimension for the management evolution of hospitals. Operations Management addresses topics such as managing production capacity, supply chains, planning and organizational quality, in addition to implementing improvement initiatives, such as Lean Healthcare. Lean Thinking originated in manufacturing with a focus on eliminating waste and continuously improving organizational flows and can be applied in healthcare operations. However, investigations that intersect such themes are still initial and punctual in their implementation in cases of improvement of hospital operations. Thus, this thesis is guided by a qualitative approach using techniques and methodologies such as workshops with health professionals, document analysis, interviews with experts and multiple case studies analyzing twenty projects in four large hospitals based in Portugal and Brazil. Through this research design, this work contributes to academia and hospital organizations through the development of a framework for managing hospital operations from the perspective of Lean Healthcare. In addition to adapting the main dimensions of Operations Management to the hospital environment, raising opportunities and best practices in the hospitals studied, and presenting tools, areas and guiding indicators for the systematic and integrated implementation of Operations Management and Lean Healthcare.
Este trabalho foi parcialmente financiado por uma bolsa no contexto do Projeto POCI-01-0145-FEDER- 030299, financiado pela FCT – Fundação para a Ciência e Tecnologia, no âmbito do programa FCT / COMPETE2020 / POCI Projetos de Investigação Científica e Desenvolvimento Tecnológico (IC&DT) - 02/SAICT/2017.وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7c42cd8c763242b916db945cb6008907
https://hdl.handle.net/1822/75833 -
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المؤلفون: Priscila Lucena, Ricardo Pessoa, Filipe Lima, Alison Burrows, Lídia Lemos, Paula Trigueiros, Rui José
المساهمون: Universidade do Minho
المصدر: Springer Series in Design and Innovation ISBN: 9783030897345
Springer Series in Design and Innovation
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: Computer science, 05 social sciences, Engenharia e Tecnologia::Outras Engenharias e Tecnologias, 020207 software engineering, 02 engineering and technology, Trabalho digno e crescimento económico, Indústria, inovação e infraestruturas, Educação de qualidade, Engineering management, Artes [Humanidades], Multidisciplinary approach, 0502 economics and business, Outras Engenharias e Tecnologias [Engenharia e Tecnologia], 0202 electrical engineering, electronic engineering, information engineering, Humanidades::Outras Humanidades, Humanidades::Artes, Outras Humanidades [Humanidades], 050203 business & management
الوصف: Trabalho apresentado na: "DIGICOM 2021 – 5th International Conference on Design and Digital Communication", 4-6 November 2021, Teatro Gil Vicente, Barcelos, Portugal.
The purpose of this article is to provide a better understanding of how to effectively develop design projects that simultaneously leverage industry and academic partners, participants from various disciplinary backgrounds, and vari- ous levels of expertise to solve complex problems. The article reports a single case of an ongoing project focused on designing smart and connected devices for mobility, which integrates the dimensions of interest. Our findings highlight the importance of careful planning of the collaborative process, contemplating of- fline and real-time communication opportunities, identifying cross-boundary roles, and considering the development of shared expertise and knowledge within the team. By confronting these findings with key literature, we offer five recom- mendations to inform similar future projects.
This work is supported by European Structural and Investment Funds in the FEDER component, through the Operational Competitiveness and Internationalization Pro- gramme (COMPETE 2020) [Project no 039334; Funding Reference: POCI-01-0247- FEDER-039334]. This work has additional financial support from Project Lab2PT - Landscapes, Heritage and Territory laboratory - AUR/04509, with financial support from FCT/MCTES through national funds (PIDDAC) and co-financing from the Eu- ropean Regional Development Fund (FEDER) POCI-01-0145-FEDER-007528, in line with the new partnership agreement PT2020 through COMPETE 2020 – Compet- itiveness and Internationalization Operational Program (POCI).وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e6c9d16ae8874eb934d4df08008842f
https://hdl.handle.net/1822/74974 -
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المؤلفون: Vítor Sá, Manuel Figueiredo, Isabel Lopes
المساهمون: Universidade do Minho
المصدر: International Journal of Industrial Engineering and Management, Vol 11, Iss 1, Pp 3-18 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: 0209 industrial biotechnology, Criticality evaluation, lcsh:T55.4-60.8, Computer science, Equipment classification, Engenharia e Tecnologia::Outras Engenharias e Tecnologias, equipment prioritization, performance ranking, 0211 other engineering and technologies, 02 engineering and technology, Industrial and Manufacturing Engineering, 020901 industrial engineering & automation, equipment classification, lcsh:Industrial engineering. Management engineering, Science & Technology, 021103 operations research, maintenance management, Manufacturing systems, Equipment prioritization, Performance ranking, Risk analysis (engineering), Criticality, Outras Engenharias e Tecnologias [Engenharia e Tecnologia], Business, Management and Accounting (miscellaneous), criticality evaluation, Maintenance management
الوصف: This paper focuses on criticality evaluation for supporting daily equipment maintenance management and the definition of medium and long-term maintenance actions to improve equipment and, therefore, productivity. These two different purposes led to the development of two different methods for criticality evaluation, using criteria adjusted for each case. The first method is based on rules for defining priorities for corrective and preventive maintenance tasks. Since a failure mode of critical equipment is not necessarily critical, priorities for maintenance tasks are assigned to tasks rather than to equipment. The second method uses Analytic Hierarchy Process to prioritize equipment based on its performance. This method is based on the indicators commonly monitored by maintenance departments. In addition to assessing equipment performance, it considers the maintenance effort made to achieve the evaluated performance. The selection of the criticality criteria and the development of the methods was based on literature review and triggered by a case study in a multinational automotive company. With the integration of the proposed methods in a computerized maintenance management system, maintenance technicians and managers are able to know in real time the tasks that should be performed first and to monitor the overall performance of equipment in the plant, focusing improvements where they are more required.
This research is sponsored by the Portugal Incentive System for Research and Technological Development. Project in co-promotion n degrees 002814/2015 (iFACTORY 2015-2018) and has been partially supported by COMPETE: POCI-01- 0145-FEDER-007043 and FCT - Fundacao para a Ciencia e Tecnologia within the Project Scope: UID/CEC/00319/2013.وصف الملف: application/pdf
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المؤلفون: Camilo Micán, Gabriela Fernandes, Madalena Araújo
المساهمون: Universidade do Minho
المصدر: International Journal of Information Systems and Project Management, Vol 08, Iss 03, Pp 67-84 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: research opportunities, Information Systems and Management, lcsh:Management. Industrial management, Strategy and Management, Engenharia e Tecnologia::Outras Engenharias e Tecnologias, 0211 other engineering and technologies, Social Sciences, structured literature review, 02 engineering and technology, Management Information Systems, portfolio success, 021105 building & construction, 0502 economics and business, Risk management, business.industry, 05 social sciences, project portfolio risk management, Research opportunities, Engineering management, project portfolio management, Systematic review, lcsh:HD28-70, Outras Engenharias e Tecnologias [Engenharia e Tecnologia], Business, Project portfolio management, 050203 business & management
الوصف: Project Portfolio Risk Management (PPRM) has been identified as a relevant area regarding project portfolio success. This paper reports on a structured literature review of PPRM. A structured search and selection process was carried out and conventional content analysis was conducted in the literature analysis of 62 papers published in international journals. PPRM has its theoretical and practical bases in the modem theory of portfolios, decision theory and risk management (RM). The content analysis reveals four main recurrent topics in PPRM: (1) The influence of RM on project portfolio success, based on project portfolio impact level, moderators or contingency factors between RM and project portfolio success, and PPRM dimensions; (2) risk and project interdependencies, highlighting resources, technology, outcome, value, and accomplishment project interdependencies; (3) project portfolio risk (PPR) identification, where four main risk source categories are identified; and (4) PPR assessment, composed of risk measures and the main methods used for risk assessment. Therefore, this study provides an overview of PPRM as a research field, while it also promotes four future research directions: (1) PPRM as part of organizational RM (2) RM, success dimensions and strategic impact; (3) mechanisms for PPR assessment, and (4) PPRM as a complex and dynamic system.
This research was sponsored by the University of Valle, Colombia, and Colfuturo-Colciencias, Colombia.وصف الملف: application/pdf
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المؤلفون: Castillo, Cristian dos Santos
المساهمون: Arezes, P., Shahriari, Mohammed, Casarejos, Fabricio, Universidade do Minho
المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: Engenharia e Tecnologia::Outras Engenharias e Tecnologias, Outras Engenharias e Tecnologias [Engenharia e Tecnologia]
الوصف: Programa doutoral em Engenharia Industrial e de Sistemas
Enquanto stakeholders ainda têm expectativas sobre uma melhor prevenção de lesões e doenças, e sobre a melhoria das condições de trabalho, sugere-se que novas abordagens sejam agora necessárias para garantir a efetividade de sistemas de gestão de segurança e saúde ocupacionais. Estas abordagens incluem o desenvolvimento de novos métodos que facilitariam a medição do estado pró-ativo operacional do sistema de gestão de segurança e saúde ocupacionais destinada à genuína melhoria das práticas em segurança e saúde ocupacionais. Este estudo trata da construção e verificação de uma ferramenta contendo indicadores pró-ativos operacionais em segurança e saúde ocupacionais, com o objetivo principal de priorizar tais indicadores em função da opinião consensual de grupos de peritos em segurança e saúde ocupacionais. O estudo incluiu uma identificação destes indicadores na literatura especializada, e com uma lista reduzida destes indicadores, realizou-se um estudo focado na análise dos principais indicadores que possuam comprovada aplicabilidade empresarial. O método Delphi foi aplicado para esta lista gerenciável a fim de priorizar os indicadores através de 3 rondas, um consenso foi obtido sobre quais indicadores são mais pertinentes para os grupos individuais de peritos e os que são importantes para todos os grupos. Esta ferramenta permite que cada empresa possa personalizar os indicadores que sejam mais apropriados para sua própria realidade ao considerar o relatório destes indicadores. Esta ferramenta pode ser parte de um modelo de safety dashboard que é baseado no princípio do balanced scorecard e considera apenas os indicadores mais importantes, isto é, os que resultam de um consenso alargado através dos peritos.
While stakeholders still have expectations concerning better prevention of injuries and diseases and the improvement of working conditions, it is suggested that new approaches are now necessary to ensure the effectiveness of an occupational safety and health management system. These approaches include the development of new methods that would facilitate the measurement of the proactive operational status of the occupational safety and health management system aimed at the genuine improvement of occupational safety and health practices. This study addresses the development of a tool that contains leading operational indicators in occupational safety and health, with the main objective of prioritizing these indicators according to the consensual opinion of groups of experts in the occupational safety and health field. The study included an identification of these indicators in the specialized literature, and with a short list of these indicators, a study was performed focused on the analysis of the main indicators that have proven to be applicable in companies. The Delphi method was applied to this manageable list to prioritize the indicators through three rounds, and a consensus was obtained on which indicators are most relevant, both for each individual group of experts and for all experts. This tool allows each company to customize the indicators that are most appropriate for its own reality by considering the report of these indicators. This tool can be a part of a safety dashboard model that is based on the balanced scorecard principle and considers only the most relevant indicators, that is, those resulting from a broad consensus among experts.
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::8d79d85c66d4e01f837ce9c923aadca6
https://hdl.handle.net/1822/75745 -
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المؤلفون: Guedes, Marta Cristina Alves Moreira
المساهمون: Neves, N. M., Ferreira, Helena Susana Costa Machado, Universidade do Minho
المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: Anti-inflammatory activity, Fish roe, Atividade antioxidante, Lipossomas, Ovas de peixe, Antioxidant activity, Atividade anti-inflamatória, Liposomes, Engenharia e Tecnologia::Outras Engenharias e Tecnologias, Outras Engenharias e Tecnologias [Engenharia e Tecnologia], Inflammatory diseases, Doenças inflamatórias
الوصف: Tese de doutoramento em Engenharia de Tecidos, Medicina Regenerativa e Células Estaminais
The search for natural products with important biological activities and low toxicity and costs is of great interest for the development of new formulations for biomedical applications. Natural products can be obtained from several nature sources. Specifically, oceans occupy more than 70% of the Earth’s surface and present a high level of biodiversity, making them a valuable target for looking for novel and promising compounds. For instance, fish roes are important fish products, owing to their high nutritional value and health benefits. Considering these features, this PhD work explored lipidic and aqueous extracts of fish roe, envisioning its potential as a source of promising molecules for biomedical applications. The species of fish used are common on the Portuguese mainland coast and of great economic importance, namely sardine, horse mackerel and sea bass. Methyl-tert-butyl ether (MTBE) extraction method was used to obtain lipid- and water-soluble compounds. The fatty acids analysis and the identification of the hydrophilic compounds were performed by chromatographic techniques coupled to a mass spectrometer. Lipidic and aqueous extracts of fish roe were used to generate liposomes, namely multilamellar vesicles (MLVs) and large unilamellar vesicles (LUVs) or fishroesomes. The physicochemical and in vitro biological parameters of the distinct developed formulations were assessed. Additionally, in vivo safety and efficacy of the formulations were evaluated. The presence of several fatty acids (e.g., ω3 polyunsaturated fatty acids – PUFA), as well as of numerous bioactive compounds (e.g., essential amino acids and gadusol) was demonstrated. Sardine roe-derived MLVs and LUVs were able to encapsulate and control the release of celecoxib. Relevant antioxidant and anti-inflammatory properties of the developed formulations were reported at non-toxic levels for fibroblasts, macrophages and chondrocytes. Moreover, synergistic actions were observed for LUVs combined with aqueous extracts or encapsulating the anti-inflammatory drug. Finally, in vivo studies demonstrated the safety and enhanced therapeutic efficacy of the celecoxib-loaded fishroesomes. In conclusion, these novel liposomes may enhance the drugs therapeutic index and exhibit bioactivity per se. Thus, they have potential to be applied in the biomedical field, particularly as a natural alternative for the treatment of inflammatory conditions.
A procura de produtos naturais com atividades biológicas importantes, e de toxicidade e custos baixos, é de grande interesse para o desenvolvimento de novas formulações com aplicações biomédicas promissoras. Especificamente, os oceanos ocupam mais de 70% da superfície da Terra e têm um nível de biodiversidade elevado, tornando-os uma fonte valiosa para a procura de compostos novos. Por exemplo, as ovas de peixe têm um valor nutricional elevado e apresentam importantes benefícios para a saúde. Assim, este trabalho de doutoramento explorou os extratos lipídicos e aquosos das ovas de peixe no desenvolvimento de novas formulações para aplicações biomédicas. As espécies de peixe usadas são comuns na costa continental portuguesa e de grande importância económica, nomeadamente a sardinha, o carapau e o robalo. O método de extração éter metil-terc butílico foi usado para obter compostos lipo- e hidrossolúveis. A análise dos ácidos gordos e a identificação dos compostos hidrofílicos foram realizadas por técnicas cromatográficas acopladas a um espectro de massa. Os extratos lipídicos e aquosos das ovas de peixe foram usados para preparar lipossomas, nomeadamente vesículas multilamelares (MLVs) e vesículas unilamelares grandes (LUVs). As propriedades físico-químicas e biológicas in vitro das várias formulações desenvolvidas foram analisadas. Adicionalmente, a segurança e eficácia in vivo das formulações foram avaliadas. A presença de diversos ácidos gordos, por exemplo ácidos gordos polinsaturados, bem como de outros compostos bioativos, tais como aminoácidos essenciais e gadusol, foi demonstrada. Os MLVs e os LUVs derivados de ovas de sardinha foram capazes de encapsular e controlar a libertação de celecoxibe. Estes sistemas de transporte apresentaram propriedades antioxidantes e anti-inflamatórias relevantes em níveis não tóxicos para fibroblastos, macrófagos e condrócitos. Além disso, LUVs combinados com os extratos aquosos ou o fármaco apresentaram atividades sinérgicas. Finalmente, os estudos in vivo revelaram a segurança e a eficácia terapêutica superior dos LUVs incorporando celecoxibe. Em conclusão, estes novos lipossomas com significante bioatividade intrínseca podem aumentar o índice terapêutico dos fármacos encapsulados. Consequentemente, estes sistemas têm potencial para serem aplicados na área biomédica, em particular como uma alternativa natural para o tratamento de doenças inflamatórias.
Fundação para a Ciência e a Tecnologia (FCT)وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0f542725e7f31117ce95d124a4d3dca6
https://hdl.handle.net/1822/75616 -
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المؤلفون: Dranka, Géremi Gilson
المساهمون: Ferreira, Paula Varandas, Vaz, A. Ismael F.
المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: Generation Expansion Planning (GEP), Renewable Energies, Setor Elétrico Brasileiro, Brazilian Power Sector, Demand-side Management (DSM), Co-otimização, Outras Engenharias e Tecnologias [Engenharia e Tecnologia], Energias Renováveis, Gestão da Procura, Co-optimization, ComputingMilieux_MISCELLANEOUS, Planeamento de Expansão da Produção
الوصف: Doctoral Program in Industrial and Systems Engineering (PDEIS)
URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3056::ac9cf0088413b12fbc2b63062973e032
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المؤلفون: Cecília Castro, Jose Bruno Santos Pinheiro, Marta Azevedo
المساهمون: Universidade do Minho
المصدر: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAPمصطلحات موضوعية: Artificial intelligence, Computer science, business.industry, Natural language processing, LinguaKit, Sentiment analysis, Engenharia e Tecnologia::Outras Engenharias e Tecnologias, Trabalho digno e crescimento económico, computer.software_genre, Computing Methodologies, language.human_language, Computing methodologies, language, Outras Engenharias e Tecnologias [Engenharia e Tecnologia], Portuguese, business, computer
الوصف: The motivation for this study was to measure the impact that Twitter publications have on voting and the choosing of winners. To this end, an experimental study was carried out based on a set of data collected from tweets (published on Twitter) related to the reality show “Big Brother - A Revolução”, broadcast on a television station in Portugal, TVI. The procedure adopted for conducting the experiment consisted of creating a completely self-contained service, built from scratch for this project, and the correspondent implementation, in order to allow the collection, storage, cleaning, pre-processing and analysis of as many tweets as possible, as long as they are associated with the program. A tool to analyze the polarity (positive, negative or neutral) of the sentiment was implemented and applied to the phrase (or phrases) contained in the tweet and stored in a database. Then, running in the database, the tweets were divided according to how they referred to one or more competitors. Throughout the time that the reality show existed, the results of this experiment were public presented in daily/weekly summaries and posted on Twitter through a “Twitter bot”.
FCT-CEECIND/04331/2017وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::551efa668345e763cb53f7db1daec1a5
