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المؤلفون: Mira Goldberg, Jidapa Bridhikitti, Atif J. Khan, Paul McGale, Timothy J. Whelan
المصدر: International Journal of Radiation Oncology*Biology*Physics. 115:60-72
مصطلحات موضوعية: Cancer Research, Radiation, Oncology, Radiology, Nuclear Medicine and imaging
الوصف: Partial breast irradiation (PBI) is the delivery of radiation therapy (RT) limited to the tumor bed after breast conserving surgery. The results of recent trials of PBI compared with whole breast irradiation (WBI) have suggested conflicting results with respect to local control and toxicity. The purpose of this meta-analysis was to assess effectiveness of PBI and to compare the different techniques.A meta-analysis of aggregate data from published randomized trials was performed to examine the effectiveness of PBI compared with WBI in patients with invasive breast cancer and ductal carcinoma in situ. Relevant data were extracted. The primary outcome was any ipsilateral breast event (invasive or noninvasive). Secondary outcomes included acute and late toxicity. The results of randomized trials were pooled using a fixed effects model and the inverse variance method.Fifteen trials involving 16,474 patients were identified. The majority of enrolled patients were60 years of age and had T1N0 grade 1 to 2 disease treated with hormone therapy. The percent of ipsilateral breast events was higher in patients treated with PBI compared with WBI (5.0% vs 2.8%; risk ratio [RR], 1.72; 95% confidence interval [CI], 1.47-2.02). Heterogeneity (P = .0002) was observed between the 4 PBI techniques: external beam RT without computed tomography (CT) planning (RR, 2.06; 95% CI, 1.36-3.12); brachytherapy (RR, 1.21; 95% CI, 0.65-2.25); intraoperative RT (RR, 2.79; 95% CI, 2.08-3.73); and external beam RT with CT planning (RR, 1.25; 95% CI, 0.99-1.58). When external beam RT without CT planning and intraoperative RT trials were excluded, the percent of ipsilateral breast events was 3.3% versus 2.6%, respectively (RR, 1.25; 95% CI, 1.00-1.55; P = .05), and no heterogeneity was observed (P = .92). Overall, acute toxicity was less with PBI, and the effect on late toxicity varied by technique.Overall, WBI was more effective than PBI, but the effectiveness of PBI was technique related. PBI was less effective when given by external beam RT without CT planning or intraoperative therapy. Although PBI given by multicatheter brachytherapy or external beam RT with CT planning tended to be statistically less effective than WBI, the absolute difference between groups for ipsilateral breast events was very small (1%), supporting these approaches for women considering PBI.
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2Adjuvant and neoadjuvant breast cancer treatments: A systematic review of their effects on mortality
المؤلفون: Amanda J. Kerr, David Dodwell, Paul McGale, Francesca Holt, Fran Duane, Gurdeep Mannu, Sarah C. Darby, Carolyn W. Taylor
مصطلحات موضوعية: Tamoxifen, Oncology, Chemotherapy, Adjuvant, Humans, Breast Neoplasms, Female, Radiology, Nuclear Medicine and imaging, General Medicine, Mastectomy, Neoadjuvant Therapy
الوصف: Background Adjuvant and neoadjuvant breast cancer treatments can reduce breast cancer mortality but may increase mortality from other causes. Information regarding treatment benefits and risks is scattered widely through the literature. To inform clinical practice we collated and reviewed the highest quality evidence. Methods Guidelines were searched to identify adjuvant or neoadjuvant treatment options recommended in early invasive breast cancer. For each option, systematic literature searches identified the highest-ranking evidence. For radiotherapy risks, searches for dose-response relationships and modern organ doses were also undertaken. Results Treatment options recommended in USA and elsewhere included chemotherapy (anthracycline, taxane, platinum, capecitabine), anti-human epidermal growth factor 2 therapy (trastuzumab, pertuzumab, trastuzumab emtansine, neratinib), endocrine therapy (tamoxifen, aromatase inhibitor, ovarian ablation/suppression with varying durations) and bisphosphonates. Radiotherapy options were after breast conserving surgery (whole breast, partial breast, tumour bed boost, regional nodes) and after mastectomy (chest wall, regional nodes). Treatment options were supported by randomised evidence, including >10,000 women for eight treatment comparisons, 1,000-10,000 for fifteen and
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172a2ee32be93d934851d6cb10f78bbe
https://ora.ox.ac.uk/objects/uuid:b8786492-9812-45e0-97b9-1847e443ec91 -
3
المؤلفون: Rosie Bradley, Jeremy Braybrooke, Richard Gray, Robert Hills, Zulian Liu, Richard Peto, Lucy Davies, David Dodwell, Paul McGale, Hongchao Pan, Carolyn Taylor, Stewart Anderson, Richard Gelber, Luca Gianni, William Jacot, Heikki Joensuu, Alvaro Moreno-Aspitia, Martine Piccart, Michael Press, Edward Romond, Dennis Slamon, Vera Suman, Richard Berry, Clare Boddington, Mike Clarke, Christina Davies, Fran Duane, Vaughan Evans, Jo Gay, Lucy Gettins, Jon Godwin, Sam James, Hui Liu, Elizabeth MacKinnon, Gurdeep Mannu, Theresa McHugh, Philip Morris, Simon Read, Ewan Straiton, Yaochen Wang, John Crown, Evandro de Azambuja, Suzette Delaloge, Helena Fung, Charles Geyer, Marc Spielmann, Pinuccia Valagussa, Kathy Albain, Rodrigo Arriagada, John Bartlett, Elizabeth Bergsten-Nordström, Judith Bliss, Etienne Brain, Lisa Carey, Robert Coleman, Jack Cuzick, Nancy Davidson, Lucia Del Mastro, Angelo Di Leo, James Dignam, Mitch Dowsett, Bent Ejlertsen, Prue Francis, Michael Gnant, Matthew Goetz, Pam Goodwin, Pat Halpin-Murphy, Dan Hayes, Catherine Hill, Reshma Jagsi, Wolfgang Janni, Sibylle Loibl, Eleftherios P Mamounas, Miguel Martín, Hirofumi Mukai, Valentina Nekljudova, Larry Norton, Yasuo Ohashi, Lori Pierce, Philip Poortmans, Vinod Raina, Daniel Rea, Meredith Regan, John Robertson, Emiel Rutgers, Tanja Spanic, Joseph Sparano, Guenther Steger, Gong Tang, Masakazu Toi, Andrew Tutt, Giuseppe Viale, Xiang Wang, Tim Whelan, Nicholas Wilcken, Norman Wolmark, David Cameron, Jonas Bergh, Kathleen I Pritchard, Sandra M Swain
المساهمون: Bradley, R, Braybrooke, J, Gray, R, Hills, R, Liu, Z, Peto, R, Dodwell, D, McGale, P, Pan, H, Taylor, C, Clarke, M, MacKinnon, E, Early Breast Cancer Trialists’ Collaborative group (EBCTCG)
المصدر: The Lancet. Oncology
The lancet oncology
Early Breast Cancer Trialists’ Collaborative group (EBCTCG) 2021, ' Trastuzumab for early-stage, HER2-positive breast cancer : a meta-analysis of 13 864 women in seven randomised trials ', The Lancet Oncology, vol. 22, no. 8, pp. 1139-1150 . https://doi.org/10.1016/S1470-2045(21)00288-6مصطلحات موضوعية: Oncology, medicine.medical_specialty, Receptor, ErbB-2, medicine.medical_treatment, Breast cancer mortality, Breast Neoplasms, breast cancer, Breast cancer, Antineoplastic Agents, Immunological, Trastuzumab, HER2 Positive Breast Cancer, Internal medicine, medicine, Humans, Stage (cooking), skin and connective tissue diseases, Chemotherapy, business.industry, adjuvant therapy, Articles, medicine.disease, Meta-analysis, Female, Human medicine, business, breast cancer, adjuvant therapy, trastuzumab, Adjuvant, medicine.drug
الوصف: Background: Trastuzumab targets the extracellular domain of the HER2 protein. Adding trastuzumab to chemotherapy for patients with early-stage, HER2-positive breast cancer reduces the risk of recurrence and death, but is associated with cardiac toxicity. We investigated the long-term benefits and risks of adjuvant trastuzumab on breast cancer recurrence and cause-specific mortality. Methods: We did a collaborative meta-analysis of individual patient data from randomised trials assessing chemotherapy plus trastuzumab versus the same chemotherapy alone. Randomised trials that enrolled women with node-negative or node-positive, operable breast cancer were included. We collected individual patient-level data on baseline characteristics, dates and sites of first distant breast cancer recurrence and any previous local recurrence or second primary cancer, and the date and underlying cause of death. Primary outcomes were breast cancer recurrence, breast cancer mortality, death without recurrence, and all-cause mortality. Standard intention-to-treat log-rank analyses, stratified by age, nodal status, oestrogen receptor (ER) status, and trial yielded first-event rate ratios (RRs). Findings: Seven randomised trials met the inclusion criteria, and included 13 864 patients enrolled between February, 2000, and December, 2005. Mean scheduled treatment duration was 14·4 months and median follow-up was 10·7 years (IQR 9·5 to 11·9). The risks of breast cancer recurrence (RR 0·66, 95% CI 0·62 to 0·71; p Interpretation: Adding trastuzumab to chemotherapy for early-stage, HER2-positive breast cancer reduces recurrence of, and mortality from, breast cancer by a third, with worthwhile proportional reductions irrespective of recorded patient and tumour characteristics.
وصف الملف: application/pdf
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المؤلفون: Rosie Bradley, Jeremy Braybrooke, Richard Gray, Robert K Hills, Zulian Liu, Hongchao Pan, Richard Peto, David Dodwell, Paul McGale, Carolyn Taylor, Prudence A Francis, Michael Gnant, Francesco Perrone, Meredith M Regan, Richard Berry, Clare Boddington, Mike Clarke, Christina Davies, Lucy Davies, Fran Duane, Vaughan Evans, Jo Gay, Lucy Gettins, Jon Godwin, Sam James, Hui Liu, Elizabeth MacKinnon, Gurdeep Mannu, Theresa McHugh, Philip Morris, Simon Read, Ewan Straiton, Raimund Jakesz, Christian Fesl, Olivia Pagani, Richard Gelber, Michelino De Laurentiis, Sabino De Placido, Ciro Gallo, Kathy Albain, Stewart Anderson, Rodrigo Arriagada, John Bartlett, Elizabeth Bergsten-Nordström, Judith Bliss, Etienne Brain, Lisa Carey, Robert Coleman, Jack Cuzick, Nancy Davidson, Lucia Del Mastro, Angelo Di Leo, James Dignam, Mitch Dowsett, Bent Ejlertsen, Matthew Goetz, Pam Goodwin, Pat Halpin-Murphy, Dan Hayes, Catherine Hill, Reshma Jagsi, Wolfgang Janni, Sibylle Loibl, Eleftherios P Mamounas, Miguel Martín, Hirofumi Mukai, Valentina Nekljudova, Larry Norton, Yasuo Ohashi, Lori Pierce, Philip Poortmans, Kathleen I Pritchard, Vinod Raina, Daniel Rea, John Robertson, Emiel Rutgers, Tanja Spanic, Joseph Sparano, Guenther Steger, Gong Tang, Masakazu Toi, Andrew Tutt, Giuseppe Viale, Xiang Wang, Tim Whelan, Nicholas Wilcken, Norman Wolmark, David Cameron, Jonas Bergh, Sandra M Swain
المساهمون: Bradley, R., Braybrooke, J., Gray, R., Hills, R. K., Liu, Z., Pan, H., Peto, R., Dodwell, D., Mcgale, P., Taylor, C., Francis, P. A., Gnant, M., Perrone, F., Regan, M. M., Berry, R., Boddington, C., Clarke, M., Davies, C., Davies, L., Duane, F., Evans, V., Gay, J., Gettins, L., Godwin, J., James, S., Liu, H., Mackinnon, E., Mannu, G., Mchugh, T., Morris, P., Read, S., Straiton, E., Jakesz, R., Fesl, C., Pagani, O., Gelber, R., De Laurentiis, M., De Placido, S., Gallo, C., Albain, K., Anderson, S., Arriagada, R., Bartlett, J., Bergsten-Nordstrom, E., Bliss, J., Brain, E., Carey, L., Coleman, R., Cuzick, J., Davidson, N., Del Mastro, L., Di Leo, A., Dignam, J., Dowsett, M., Ejlertsen, B., Goetz, M., Goodwin, P., Halpin-Murphy, P., Hayes, D., Hill, C., Jagsi, R., Janni, W., Loibl, S., Mamounas, E. P., Martin, M., Mukai, H., Nekljudova, V., Norton, L., Ohashi, Y., Pierce, L., Poortmans, P., Pritchard, K. I., Raina, V., Rea, D., Robertson, J., Rutgers, E., Spanic, T., Sparano, J., Steger, G., Tang, G., Toi, M., Tutt, A., Viale, G., Wang, X., Whelan, T., Wilcken, N., Wolmark, N., Cameron, D., Bergh, J., Swain, S. M., Bradbury, R, Braybrooke, J, Gray, R, Hills, R, Liu, Z, Pan, H, Peto, R, Dodwell, D, McGale, P
المصدر: Bradley, R, Braybrooke, J, Gray, R, Hills, R K, Liu, Z, Pan, H, Peto, R, Dodwell, D, McGale, P, Taylor, C, Francis, P A, Gnant, M, Perrone, F, Regan, M M, Berry, R, Boddington, C, Clarke, M, Davies, C, Davies, L, Duane, F, Evans, V, Gay, J, Gettins, L, Godwin, J, James, S, Liu, H, MacKinnon, E, Mannu, G, McHugh, T, Morris, P, Read, S, Straiton, E, Jakesz, R, Fesl, C, Pagani, O, Gelber, R, De Laurentiis, M, De Placido, S, Gallo, C, Albain, K, Anderson, S, Arriagada, R, Bartlett, J, Bergsten-Nordström, E, Bliss, J, Brain, E, Carey, L, Coleman, R, Cuzick, J, Ejlertsen, B & Early Breast Cancer Trialists' Collaborative Group (EBCTCG) 2022, ' Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression : a patient-level meta-analysis of 7030 women from four randomised trials ', The Lancet Oncology, vol. 23, no. 3, pp. 382-392 . https://doi.org/10.1016/S1470-2045(21)00758-0
Bradley, R, Braybrooke, J, Gray, R, Hills, R K, Liu, Z, Pan, H, Peto, R, Dodwell, D, Mcgale, P, Taylor, C, Francis, P A, Gnant, M, Perrone, F, Regan, M M, Berry, R, Boddington, C, Clarke, M, Davies, C, Davies, L, Duane, F, Evans, V, Gay, J, Gettins, L, Godwin, J, James, S, Liu, H, Mackinnon, E, Mannu, G, Mchugh, T, Morris, P, Read, S, Straiton, E, Jakesz, R, Fesl, C, Pagani, O, Gelber, R, De Laurentiis, M, De Placido, S, Gallo, C, Albain, K, Anderson, S, Arriagada, R, Bartlett, J, Bergsten-nordström, E, Bliss, J, Brain, E, Carey, L, Coleman, R, Cuzick, J, Davidson, N, Del Mastro, L, Di Leo, A, Dignam, J, Dowsett, M, Ejlertsen, B, Goetz, M, Goodwin, P, Halpin-murphy, P, Hayes, D, Hill, C, Jagsi, R, Janni, W, Loibl, S, Mamounas, E P, Martín, M, Mukai, H, Nekljudova, V, Norton, L, Ohashi, Y, Pierce, L, Poortmans, P, Pritchard, K I, Raina, V, Rea, D, Robertson, J, Rutgers, E, Spanic, T, Sparano, J, Steger, G, Tang, G, Toi, M, Tutt, A, Viale, G, Wang, X, Whelan, T, Wilcken, N, Wolmark, N, Cameron, D, Bergh, J & Swain, S M 2022, ' Aromatase inhibitors versus tamoxifen in premenopausal women with oestrogen receptor-positive early-stage breast cancer treated with ovarian suppression: a patient-level meta-analysis of 7030 women from four randomised trials ', The Lancet Oncology, vol. 23, no. 3, pp. 382-392 . https://doi.org/10.1016/S1470-2045(21)00758-0مصطلحات موضوعية: Breast Neoplasms/pathology, Antineoplastic Agents, Hormonal/therapeutic use, Antineoplastic Agents, Hormonal, Aromatase Inhibitors, Breast Neoplasms, Tamoxifen, Neoplasm Recurrence, Local/drug therapy, Tamoxifen/therapeutic use, Oncology, Receptors, Estrogen, Chemotherapy, Adjuvant, Humans, Aromatase Inhibitor, Female, Aromatase Inhibitors/adverse effects, Neoplasm Recurrence, Local, Human, Randomized Controlled Trials as Topic
الوصف: Background: For women with early-stage oestrogen receptor (ER)-positive breast cancer, adjuvant tamoxifen reduces 15-year breast cancer mortality by a third. Aromatase inhibitors are more effective than tamoxifen in postmenopausal women but are ineffective in premenopausal women when used without ovarian suppression. We aimed to investigate whether premenopausal women treated with ovarian suppression benefit from aromatase inhibitors. Methods: We did a meta-analysis of individual patient data from randomised trials comparing aromatase inhibitors (anastrozole, exemestane, or letrozole) versus tamoxifen for 3 or 5 years in premenopausal women with ER-positive breast cancer receiving ovarian suppression (goserelin or triptorelin) or ablation. We collected data on baseline characteristics, dates and sites of any breast cancer recurrence or second primary cancer, and dates and causes of death. Primary outcomes were breast cancer recurrence (distant, locoregional, or contralateral), breast cancer mortality, death without recurrence, and all-cause mortality. As distant recurrence invariably results in death from breast cancer several years after the occurrence, whereas locoregional recurrence and new contralateral breast cancer are not usually fatal, the distant recurrence analysis is shown separately. Standard intention-to-treat log-rank analyses estimated first-event rate ratios (RR) and their confidence intervals (CIs). Findings: We obtained data from all four identified trials (ABCSG XII, SOFT, TEXT, and HOBOE trials), which included 7030 women with ER-positive tumours enrolled between June 17, 1999, and Aug 4, 2015. Median follow-up was 8·0 years (IQR 6·1–9·3). The rate of breast cancer recurrence was lower for women allocated to an aromatase inhibitor than for women assigned to tamoxifen (RR 0·79, 95% CI 0·69–0·90, p=0·0005). The main benefit was seen in years 0–4 (RR 0·68, 99% CI 0·55–0·85; p Interpretation: Using an aromatase inhibitor rather than tamoxifen in premenopausal women receiving ovarian suppression reduces the risk of breast cancer recurrence. Longer follow-up is needed to assess any impact on breast cancer mortality.
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099cd29eddf49f551ce58241f52c0672
https://curis.ku.dk/portal/da/publications/aromatase-inhibitors-versus-tamoxifen-in-premenopausal-women-with-oestrogen-receptorpositive-earlystage-breast-cancer-treated-with-ovarian-suppression(f389c226-4a8e-4bac-aa3d-555d87bfdfab).html -
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المؤلفون: Paul McGale, John Broggio, Sarah C. Darby, David Dodwell, Carolyn W. Taylor
المصدر: Clinical Oncology. 32:217-220
مصطلحات موضوعية: Radiation therapy, medicine.medical_specialty, Oncology, business.industry, General surgery, medicine.medical_treatment, medicine, MEDLINE, Radiology, Nuclear Medicine and imaging, business, Partial breast
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المؤلفون: Mathewos Assefa, Walburga Yvonne Joko-Fru, Isabelle Soerjomataram, Tatenda Chingonzoh, Marcel Egue, Shyam Manraj, Henry Wabinga, Carla Carrilho, Biying Liu, Eric Chokunonga, Ntuthu Somdyala, Rolf Hansen, Guy N'da, Donald Maxwell Parkin, Eva Johanna Kantelhardt, Marie‐Thérèse Akele‐Akpo, Adalberto Miranda-Filho, Margaret Borok, Paul McGale, Bakarou Kamate, Cheick Bougadari Traore, Anne Korir, Nathan Buziba, Anne Finesse, Cesaltina Lorenzoni
المصدر: International Journal of Cancer
مصطلحات موضوعية: Cancer Research, Colorectal cancer, Population, Breast Neoplasms, Kaplan-Meier Estimate, survival, Risk Assessment, Health Services Accessibility, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Breast cancer, parasitic diseases, medicine, Humans, Breast, Registries, Stage (cooking), education, Africa South of the Sahara, Neoplasm Staging, Cervical cancer, education.field_of_study, Relative survival, business.industry, Age Factors, Cancer, Middle Aged, medicine.disease, stage, Quality Improvement, Cancer registry, Survival Rate, Socioeconomic Factors, Oncology, human development index, 030220 oncology & carcinogenesis, Africa, Female, business, Cancer Epidemiology, Follow-Up Studies, Demography
الوصف: Breast cancer is the leading cancer diagnosis and second most common cause of cancer deaths in sub‐Saharan Africa (SSA). Yet, there are few population‐level survival data from Africa and none on the survival differences by stage at diagnosis. Here, we estimate breast cancer survival within SSA by area, stage and country‐level human development index (HDI). We obtained data on a random sample of 2,588 breast cancer incident cases, diagnosed in 2008–2015 from 14 population‐based cancer registries in 12 countries (Benin, Cote d'Ivoire, Ethiopia, Kenya, Mali, Mauritius, Mozambique, Namibia, Seychelles, South Africa, Uganda and Zimbabwe) through the African Cancer Registry Network. Of these, 2,311 were included for survival analyses. The 1‐, 3‐ and 5‐year observed and relative survival (RS) were estimated by registry, stage and country‐level HDI. We equally estimated the excess hazards adjusting for potential confounders. Among patients with known stage, 64.9% were diagnosed in late stages, with 18.4% being metastatic at diagnosis. The RS varied by registry, ranging from 21.6%(8.2–39.8) at Year 3 in Bulawayo to 84.5% (70.6–93.5) in Namibia. Patients diagnosed at early stages had a 3‐year RS of 78% (71.6–83.3) in contrast to 40.3% (34.9–45.7) at advanced stages (III and IV). The overall RS at Year 1 was 86.1% (84.4–87.6), 65.8% (63.5–68.1) at Year 3 and 59.0% (56.3–61.6) at Year 5. Age at diagnosis was not independently associated with increased mortality risk after adjusting for the effect of stage and country‐level HDI. In conclusion, downstaging breast cancer at diagnosis and improving access to quality care could be pivotal in improving breast cancer survival outcomes in Africa.
What's new? Breast cancer is the leading cancer diagnosis and second most common cause of cancer deaths in sub‐Saharan Africa (SSA). Yet there have been few studies in this region on survival differences by stage at diagnosis. Here, the authors used cancer registry data to analyze differences in breast‐cancer survival by age, stage at diagnosis and country‐level human development index. They conclude that downstaging and improving access to quality care could be pivotal in improving breast‐cancer survival outcomes in Africa. -
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المؤلفون: Richard Gray, Rosie Bradley, Jeremy Braybrooke, Zulian Liu, Richard Peto, Lucy Davies, David Dodwell, Paul McGale, Hongchao Pan, Carolyn Taylor, William Barlow, Judith Bliss, Paolo Bruzzi, David Cameron, George Fountzilas, Sibylle Loibl, John Mackey, Miguel Martin, Lucia Del Mastro, Volker Möbus, Valentina Nekljudova, Sabino De Placido, Sandra Swain, Michael Untch, Kathleen I Pritchard, Jonas Bergh, Larry Norton, Clare Boddington, Julie Burrett, Mike Clarke, Christina Davies, Fran Duane, Vaughan Evans, Lucy Gettins, Jon Godwin, Robert Hills, Sam James, Hui Liu, Elizabeth MacKinnon, Gurdeep Mannu, Theresa McHugh, Philip Morris, Simon Read, Yaochen Wang, Zhe Wang, Peter Fasching, Nadia Harbeck, Pascal Piedbois, Michael Gnant, Guenther Steger, Angelo Di Leo, Stella Dolci, Prue Francis, Denis Larsimont, Jean Marie Nogaret, Catherine Philippson, Martine Piccart, Sabine Linn, Petronella Peer, Vivianne Tjan-Heijnen, Sonja Vliek, Dennis Slamon, John Bartlett, Vivien H Bramwell, Bingshu Chen, Stephen Chia, Karen Gelmon, Paul Goss, Mark Levine, Wendy Parulekar, Joseph Pater, Eileen Rakovitch, Lois Shepherd, Dongsheng Tu, Tim Whelan, Don Berry, Gloria Broadwater, Constance Cirrincione, Hyman Muss, Raymond Weiss, Yi Shan, Yong Fu Shao, Xiang Wang, Binghe Xu, Dong-Bing Zhao, Harry Bartelink, Nina Bijker, Jan Bogaerts, Fatima Cardoso, Tanja Cufer, Jean-Pierre Julien, Philip Poortmans, Emiel Rutgers, Cornelis van de Velde, Eva Carrasco, Miguel Angel Segui, Jens Uwe Blohmer, Serban Costa, Bernd Gerber, Christian Jackisch, Gunter von Minckwitz, Mario Giuliano, Michele De Laurentiis, Christina Bamia, Georgia-Angeliki Koliou, Dimitris Mavroudis, Roger A'Hern, Paul Ellis, Lucy Kilburn, James Morden, John Yarnold, Mohammad Sadoon, Augustinus H Tulusan, Stewart Anderson, Gordon Bass, Joe Costantino, James Dignam, Bernard Fisher, Charles Geyer, Eleftherios P Mamounas, Soon Paik, Carol Redmond, D Lawrence Wickerham, Marco Venturini, Claudia Bighin, Simona Pastorino, Paolo Pronzato, Mario Roberto Sertoli, Theodorus Foukakis, Kathy Albain, Rodrigo Arriagada, Elizabeth Bergsten Nordström, Francesco Boccardo, Etienne Brain, Lisa Carey, Alan Coates, Robert Coleman, Candace Correa, Jack Cuzick, Nancy Davidson, Mitch Dowsett, Marianne Ewertz, John Forbes, Richard Gelber, Aron Goldhirsch, Pamela Goodwin, Daniel Hayes, Catherine Hill, James Ingle, Reshma Jagsi, Wolfgang Janni, Hirofumi Mukai, Yasuo Ohashi, Lori Pierce, Vinod Raina, Peter Ravdin, Daniel Rea, Meredith Regan, John Robertson, Joseph Sparano, Andrew Tutt, Giuseppe Viale, Nicholas Wilcken, Norman Wolmark, Wiliam Wood, Milvia Zambetti
المساهمون: Gray, R., Bradley, R., Braybrooke, J., Liu, Z., Peto, R., Davies, L., Dodwell, D., Mcgale, P., Pan, H., Taylor, C., Barlow, W., Bliss, J., Bruzzi, P., Cameron, D., Fountzilas, G., Loibl, S., Mackey, J., Martin, M., Del Mastro, L., Mobus, V., Nekljudova, V., De Placido, S., Swain, S., Untch, M., Pritchard, K. I., Bergh, J., Norton, L., Boddington, C., Burrett, J., Clarke, M., Davies, C., Duane, F., Evans, V., Gettins, L., Godwin, J., Hills, R., James, S., Liu, H., Mackinnon, E., Mannu, G., Mchugh, T., Morris, P., Read, S., Wang, Y., Wang, Z., Fasching, P., Harbeck, N., Piedbois, P., Gnant, M., Steger, G., Di Leo, A., Dolci, S., Francis, P., Larsimont, D., Nogaret, J. M., Philippson, C., Piccart, M., Linn, S., Peer, P., Tjan-Heijnen, V., Vliek, S., Slamon, D., Bartlett, J., Bramwell, V. H., Chen, B., Chia, S., Gelmon, K., Goss, P., Levine, M., Parulekar, W., Pater, J., Rakovitch, E., Shepherd, L., Tu, D., Whelan, T., Berry, D., Broadwater, G., Cirrincione, C., Muss, H., Weiss, R., Shan, Y., Shao, Y. F., Wang, X., Xu, B., Zhao, D. -B., Bartelink, H., Bijker, N., Bogaerts, J., Cardoso, F., Cufer, T., Julien, J. -P., Poortmans, P., Rutgers, E., van de Velde, C., Carrasco, E., Segui, M. A., Blohmer, J. U., Costa, S., Gerber, B., Jackisch, C., von Minckwitz, G., Giuliano, M., De Laurentiis, M., Bamia, C., Koliou, G. -A., Mavroudis, D., A'Hern, R., Ellis, P., Kilburn, L., Morden, J., Yarnold, J., Sadoon, M., Tulusan, A. H., Anderson, S., Bass, G., Costantino, J., Dignam, J., Fisher, B., Geyer, C., Mamounas, E. P., Paik, S., Redmond, C., Wickerham, D. L., Venturini, M., Bighin, C., Pastorino, S., Pronzato, P., Sertoli, M. R., Foukakis, T., Albain, K., Arriagada, R., Bergsten Nordstrom, E., Boccardo, F., Brain, E., Carey, L., Coates, A., Coleman, R., Correa, C., Cuzick, J., Davidson, N., Dowsett, M., Ewertz, M., Forbes, J., Gelber, R., Goldhirsch, A., Goodwin, P., Hayes, D., Hill, C., Ingle, J., Jagsi, R., Janni, W., Mukai, H., Ohashi, Y., Pierce, L., Raina, V., Ravdin, P., Rea, D., Regan, M., Robertson, J., Sparano, J., Tutt, A., Viale, G., Wilcken, N., Wolmark, N., Wood, W., Zambetti, M.
المصدر: The Lancet, vol. 393, no. 10179, pp. 1440-1452, 2019.
Cameron, D 2019, ' Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient level meta-analysis of 37,298 women with early breast cancer in 26 randomised trials ', The Lancet . https://doi.org/10.1016/S0140-6736(18)33137-4مصطلحات موضوعية: Oncology, treatment schedule, medicine.medical_specialty, Anthracycline, medicine.medical_treatment, novotvorbe dojk, Antineoplastic Agents, Breast Neoplasms, režim zdravljenja, Disease, randomized trials, 030204 cardiovascular system & hematology, chemotherapy, meta-analiza, klinični protokoli, Drug Administration Schedule, randomizirane raziskave, Antineoplastic Agent, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Breast cancer, Internal medicine, breast neoplasms, medicine, Humans, clinical protocols, terapija z zdravili, 030212 general & internal medicine, Early breast cancer, Chemotherapy, Taxane, business.industry, rak dojk, kemoterapija, General Medicine, medicine.disease, Dose intensity, udc:618.19-006, drug therapy, meta-analysis, Meta-analysis, Female, women, ženske, business, Breast Neoplasm
الوصف: Background Increasing the dose intensity of cytotoxic therapy by shortening the intervals between cycles, or by giving individual drugs sequentially at full dose rather than in lower-dose concurrent treatment schedules, might enhance efficacy. Methods To clarify the relative benefits and risks of dose-intense and standard-schedule chemotherapy in early breast cancer, we did an individual patient-level meta-analysis of trials comparing 2-weekly versus standard 3-weekly schedules, and of trials comparing sequential versus concurrent administration of anthracycline and taxane chemotherapy. The primary outcomes were recurrence and breast cancer mortality. Standard intention-to-treat log-rank analyses, stratified by age, nodal status, and trial, yielded dose-intense versus standard-schedule first-event rate ratios (RRs). Findings Individual patient data were provided for 26 of 33 relevant trials identified, comprising 37 298 (93%) of 40 070 women randomised. Most women were aged younger than 70 years and had node-positive disease. Total cytotoxic drug usage was broadly comparable in the two treatment arms; colony-stimulating factor was generally used in the more dose-intense arm. Combining data from all 26 trials, fewer breast cancer recurrences were seen with dose-intense than with standard-schedule chemotherapy (10-year recurrence risk 28·0% vs 31·4%; RR 0·86, 95% CI 0·82–0·89; p Interpretation Increasing the dose intensity of adjuvant chemotherapy by shortening the interval between treatment cycles, or by giving individual drugs sequentially rather than giving the same drugs concurrently, moderately reduces the 10-year risk of recurrence and death from breast cancer without increasing mortality from other causes.
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المؤلفون: Per Hall, Paul McGale, Ebbe Laugaard Lorenzen, Kazem Rahimi, Marianne Ewertz, Z Wang, F. Duane, C Correa, Dorthe Scavenius Brønnum, Jensen M-B., David J. Cutter, Sarah C. Darby, Carolyn W. Taylor, Bruna Gigante
المصدر: Taylor, C, McGale, P, Brønnum, D, Correa, C, Cutter, D, Duane, F K, Gigante, B, Jensen, M B, Lorenzen, E, Rahimi, K, Wang, Z, Darby, S C, Hall, P & Ewertz, M 2018, ' Cardiac structure injury after radiotherapy for breast cancer : Cross-sectional study with individual patient data ', Journal of Clinical Oncology, vol. 36, no. 22, pp. 2288-2296 . https://doi.org/10.1200/JCO.2017.77.6351
مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, Cross-sectional study, Heart Ventricles, medicine.medical_treatment, Breast Neoplasms, 030218 nuclear medicine & medical imaging, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, medicine, Humans, Radiation Injuries, business.industry, Coronary Stenosis, Cancer, Dose-Response Relationship, Radiation, Heart, ORIGINAL REPORTS, medicine.disease, Radiation therapy, Regimen, Stenosis, Cross-Sectional Studies, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Cardiology, Female, Radiotherapy, Adjuvant, business, Artery
الوصف: Purpose Incidental cardiac irradiation can cause cardiac injury, but little is known about the effect of radiation on specific cardiac segments. Methods For 456 women who received breast cancer radiotherapy between 1958 and 2001 and then later experienced a major coronary event, information was obtained on the radiotherapy regimen they received and on the location of their cardiac injury. For 414 women, all with documented location of left ventricular (LV) injury, doses to five LV segments were estimated. For 133 women, all with documented location of coronary artery disease with ≥ 70% stenosis, doses to six coronary artery segments were estimated. For each segment, numbers of women with left-sided and right-sided breast cancer were compared. Results Of women with LV injury, 243 had left-sided breast cancer and 171 had right-sided breast cancer (ratio of left v right, 1.42; 95% CI, 1.17 to 1.73), reflecting the higher typical LV radiation doses in left-sided cancer (average dose left-sided, 8.3 Gy; average dose right-sided, 0.6 Gy; left minus right dose difference, 7.7 Gy). For individual LV segments, the ratios of women with left- versus right-sided radiotherapy were as follows: inferior, 0.94 (95% CI, 0.70 to 1.25); lateral, 1.42 (95% CI, 1.04 to 1.95); septal, 2.09 (95% CI, 1.37 to 3.19); anterior, 1.85 (95% CI, 1.39 to 2.46); and apex, 4.64 (95% CI, 2.42 to 8.90); corresponding left-minus-right dose differences for these segments were 2.7, 4.9, 7.2, 10.4, and 21.6 Gy, respectively ( Ptrend < .001). For women with coronary artery disease, the ratios of women with left- versus right-radiotherapy for individual coronary artery segments were as follows: right coronary artery proximal, 0.48 (95% CI, 0.26 to 0.91); right coronary artery mid or distal, 1.69 (95% CI, 0.85 to 3.36); circumflex proximal, 1.46 (95% CI, 0.72 to 2.96); circumflex distal, 1.11 (95% CI, 0.45 to 2.73); left anterior descending proximal, 1.89 (95% CI, 1.07 to 3.34); and left anterior descending mid or distal, 2.33 (95% CI, 1.19 to 4.59); corresponding left-minus-right dose differences for these segements were −5.0, −2.5, 1.6, 3.5, 9.5, and 38.8 Gy ( Ptrend = .002). Conclusion For individual LV and coronary artery segments, higher radiation doses were strongly associated with more frequent injury, suggesting that all segments are sensitive to radiation and that doses to all segments should be minimized.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57cc30763db5be8e09005708fe7b2e1
https://doi.org/10.1200/jco.2017.77.6351 -
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المؤلفون: Paul McGale, Biying Liu, Elima Jedy-Agba, Ahmedin Jemal, Henry Wabinga, Nontuthuzelo Somdyala, Anne Korir, Walburga Yvonne Joko-Fru, Shyam Manraj, Donald Maxwell Parkin, Anne Finesse, Charles Dzamalala, Olufemi Ogunbiyi, Freddie Bray, Eric Chokunonga
مصطلحات موضوعية: Cancer Research, Sub saharan, Population, Cancer registration, Breast Neoplasms, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Risk Factors, medicine, Humans, Registries, education, Epidemics, education.field_of_study, business.industry, Incidence (epidemiology), Incidence, Age Factors, Middle Aged, medicine.disease, Calendar period, Cancer registry, Oncology, Premenopause, 030220 oncology & carcinogenesis, Cohort, Africa, Female, business, Demography
الوصف: Breast cancer (BC) is the leading cause of cancer in sub-Saharan Africa (SSA) with rapidly increasing incidence rates reported in Uganda and Zimbabwe. However, the magnitude of these rising trends in premenopausal and postmenopausal women is unknown in most African countries. We used data from the African Cancer Registry Network on incident breast cancers in women from 11 population-based cancer registries in 10 countries representing each of the four SSA regions. We explored incidence changes among women before and after age 50 by calendar period and, where possible, generational effects in this unique sub-Saharan African cohort. Temporal trends revealed increasing incidence rates in all registries during the study period, except in Nairobi where rates stabilised during 2010 to 2014 after rapidly increasing from 2003 to 2010 (APC = 8.5 95%, CI: 3.0-14.2). The cumulative risk varied between and within regions, with the highest risks observed in Nairobi-Kenya, Mauritius and the Seychelles. There were similar or more rapidly increasing incidence rates in women aged 50+ compared to women
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e51b0a16fe3444fc51137aa6eb689f
https://ora.ox.ac.uk/objects/uuid:c8c6b885-119c-4c50-84be-f46398b3c502 -
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المؤلفون: Sandra M. Swain, Zhe Wang, Yixin Wang, Stewart J. Anderson, Richard Peto, Paul McGale, F. Duane, Timothy J. Whelan, Carolyn W. Taylor, Reshma Jagsi, C Correa, Marianne Ewertz, Lori J. Pierce
المصدر: Cancer Research. 76:S5-08
مصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Heart disease, business.industry, medicine.medical_treatment, Mortality rate, Incidence (epidemiology), Cancer, medicine.disease, Surgery, Radiation therapy, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Breast cancer, 030220 oncology & carcinogenesis, Internal medicine, Relative risk, medicine, business, Lung cancer
الوصف: Introduction Breast cancer radiotherapy cures many women, but, as with other therapies, can cause late side-effects. Methods We undertook meta-analyses of individual patient data from the trials of breast cancer radiotherapy, relating various characteristics of the regimens tested to cause-specific mortality rate ratios (RRs) and second cancer incidence RRs. Doses to cardiac structures were calculated for trials with some heart disease death(s), lung doses were calculated for megavoltage trials with some lung cancer(s) in the second decade after radiotherapy, and oesophagus doses were calculated for megavoltage trials with some oesophageal cancer(s). Trial radiotherapy regimens were reconstructed for a woman with typical anatomy using virtual simulation and 3-dimensional CT planning (and, for a few regimens, manual planning). Results Information was available on 40,781 women in 75 evenly randomised comparisons of radiotherapy versus not. Median follow-up was 9.7 years and 20,345 died, 6064 without recurrence. Smoking information for included women was unavailable. Mean normal tissue radiation doses for irradiated women were: heart 6.3 Gy (range Allocation to radiotherapy increased non-breast-cancer mortality (RR=1.15, 95% CI 1.09–1.22, 2p Second cancer incidence was increased (RR=1.23, 1.12–1.36, 2p Conclusions Since these trials, normal tissue doses from breast cancer radiotherapy have at least halved so the excess relative risks will be at least halved. Background disease rates have also changed, so the absolute risks will be different for women today. Modelling the effects of such changes suggests that for women who have smoked throughout adult life and will continue smoking, even modern radiotherapy may cause an absolute lung cancer risk of a few per cent, making this the main late side-effect in smokers. However, for non-smokers (and ex-smokers) with healthy hearts who would, under current guidelines, be offered radiotherapy, the expected reduction in breast cancer mortality greatly outweighs any increase in other mortality. Citation Format: Taylor C, Correa C, Anderson S, Duane F, Ewertz M, Jagsi R, Pierce L, Swain S, Whelan T, Wang Z, Wang Y, Peto R, McGale P. Late side-effects of breast cancer radiotherapy: Second cancer incidence and non-breast-cancer mortality among 40,000 women in 75 trials. [abstract]. In: Proceedings of the Thirty-Eighth Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2015 Dec 8-12; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2016;76(4 Suppl):Abstract nr S5-08.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b811f14b40839ddce46e5bed7e44e8cf
https://doi.org/10.1158/1538-7445.sabcs15-s5-08
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