-
1دورية أكاديمية
المؤلفون: Jacopo Vannucci, Franco Ruberto, Daniele Diso, Gioacchino Galardo, Claudio M. Mastroianni, Giammarco Raponi, Massimiliano Bassi, Giancarlo Ceccarelli, Massimo Mancone, Guido Antonelli, Federico Venuta, Francesco Pugliese, Alida Albante, Francesco Alessandri, Davide Amore, Marco Anile, Maria Gloria Antognoli, Fabio Araimo Morselli, Daniela Auricchio, Martina Bianco, Federico Bilotta, Lucia Ilaria Birtolo, Matteo Brisciani, Katia Bruno, Maurizio Bufi, Sara Cagnetti, Elena Calzecchi, Alessandro Cappannoli, Carolina Carillo, Romina Casaretti, Carlo Catalano, Paola Celli, Stella Consolo, Claudia Croce, Beatrice Crocitti, Enrica Cuscianna, Federica Gilda D’Agostino, Tiziano De Giacomo, Daniela De Lauri, Francesco De Lazzaro, Maurizio Del Monte, Gabriella D’Ettorre, Valerio Di Bella, Francesco Fedele, Massimo Gentile, Giovanni Giordano, Stefano Ianni, Carmela Imperiale, Fabio Infusino, Cinzia Loiacono, Viviana Maestrini, Eugenia Magnanimi, Federica Maldarelli, Sara Mantovani, Sabina Martelli, Paolo Messercola, Teresa Messina, Emilia Mottola, Valeria Pati, Elisa Pattelli, Filippo Pecorari, Ylenia Pecoraro, Serena Maria Perrella, Mario Piazzolla, Valeria Pietropaolo, Camilla Poggi, Monica Portieri, Fabiola Ratini, Claudia Ricci, Paolo Ricci, Mario Rumori, Gianluca Russo, Pietro Santopietro, Guglielmo Tellan, Luca Titi, Paolo Tordiglione, Antonella Tosi, Silvia Tosti, Fausto Trigilia, Ombretta Turriziani, Paola Vaccaro, Noemi Verduci, Gabriella Vivino
المصدر: Journal of Global Antimicrobial Resistance, Vol 23, Iss , Pp 67-69 (2020)
مصطلحات موضوعية: COVID-19, Bronchoalveolar lavage, Bronchoscopy, Interstitial pneumonia, Coronavirus, SARS-CoV-2, Microbiology, QR1-502
وصف الملف: electronic resource
-
2The role of hypothermic machine perfusion in selecting renal grafts with advanced histological score
المؤلفون: Franco Ruberto, Quirino Lai, Mario Piazzolla, Matteo Brisciani, Renzo Pretagostini, Manuela Garofalo, Francesco Giovanardi, Francesco Nudo, Luca Poli, Veronica Zullino, Pietro Santopietro, Massimo Rossi, Pasquale B. Berloco, Francesco Pugliese
المصدر: Artificial Organs. 46:1771-1782
مصطلحات موضوعية: Graft Survival, Biomedical Engineering, Delayed Graft Function, Medicine (miscellaneous), Bioengineering, Organ Preservation, General Medicine, Kidney, Kidney Transplantation, Tissue Donors, Perfusion, Biomaterials, Humans, Retrospective Studies
الوصف: Few studies explored the role of hypothermic machine perfusion (HMP) in the sub-group of non-standard renal grafts with a biopsy-proven advanced histological impairment. This study aimed to investigate the role of HMP in grafts with a Karpinski Score 3 in terms of the need for dialysis, creatinine reduction ratio at day-7 (CRR7), and 3-year graft survival.Twenty-three perfused grafts with Karpinski Score 3 evaluated between November 2017 and December 2018 were retrospectively analyzed and compared with a control group of 32 non-perfused grafts transplanted between January 2014 and October 2017.After transplantation, perfused grafts had fewer cases requiring dialysis (8.7% vs. 34.4%; p = 0.051), a better reduction in serum creatinine (median at 7 days: 2.2 vs. 4.3 mg/dl; p = 0.045), and shorter length of hospital stay (median 11 vs. 15 days; p = 0.01). Three-year death-censored graft survival was better in the perfused cases (91.3% vs. 77.0%; p = 0.16). In perfused grafts, initial renal resistance (RR) had the best predictive value for renal function recovery after the first week, as defined by CRR7 ≤ 70% (AUC = 0.83; p = 0.02). A cut-off value of 0.5 mm Hg/ml/min showed a sensitivity of 82.4%, a specificity of 83.3%, and diagnostic odds ratio = 23.4. After dividing the entire population into a Low-RR (n = 8) and a High-RR Group (n = 15), more cases with CRR7 ≤ 70% were reported in the latter group (86.7 vs. 13.3%; p = 0.03).HMP yielded promising results in kidneys with Karpinski Score 3. Initial RR should be of interest in selecting non-standard organs for single kidney transplantation even in impaired histology.
Full Text via ClinicalKey 
Full Text Finder