المؤلفون: Yamba Yamba, Linda, Uddén, Fabian, Fuursted, Kurt, Ahl, Jonas, Slotved, Hans-Christian, Riesbeck, Kristian

المصدر: Frontiers in cellular and infection microbiology EpiHealth: Epidemiology for Health. 12:1-11

مصطلحات موضوعية: Anti-Bacterial Agents/pharmacology, Drug Resistance, Multiple, Bacterial/genetics, Humans, Microbial Sensitivity Tests, Pneumococcal Infections/epidemiology, Pneumococcal Vaccines, Respiratory System, Serogroup, Serotyping, Streptococcus pneumoniae, Sweden/epidemiology, Virulence Factors/genetics, Medicin och hälsovetenskap, Klinisk medicin, Infektionsmedicin, Medical and Health Sciences, Clinical Medicine, Infectious Medicine

الوصف: Background/Objective: The frequencies of non-susceptibility against common antibiotics among pneumococci vary greatly across the globe. When compared to other European countries antibiotic resistance against penicillin and macrolides has been uncommon in Sweden in recent years. Multidrug resistance (MDR) is, however, of high importance since relevant treatment options are scarce. The purpose of this study was to characterize the molecular epidemiology, presence of resistance genes and selected virulence genes of extensively drug-resistant (XDR) (n=15) and MDR (n=10) Streptococcus pneumoniae detected in clinical respiratory tract samples isolated from patients in a southern Swedish county 2016-2018. With the aim of relating them to global MDR pneumococci.Methods: Whole genome sequencing (WGS) was performed to determine molecular epidemiology, resistance genes and presence of selected virulence factors. Antimicrobial susceptibility profiles were determined using broth microdilution testing. Further analyses were performed on isolates from the study and from the European nucleotide archive belonging to global pneumococcal sequence cluster (GPSC) 1 (n=86), GPSC9 (n=55) and GPSC10 (n=57). Bacteria were analyzed regarding selected virulence determinants (pilus islet 1, pilus islet 2 and Zinc metalloproteinase C) and resistance genes.Results: Nineteen of 25 isolates were related to dominant global MDR lineages. Seventeen belonged to GPSC1, GPSC9 or GPSC10 with MDR non-PCV serotypes in GPSC9 (serotype 15A and 15C) as well as GPSC10 (serotype 7B, 15B and serogroup 24). Pilus islet-1 and pilus islet-2 were present in most sequence types belonging to GPSC1 and in two isolates within GPSC9 but were not detected in isolates belonging to GPSC10. Zinc metalloproteinase C was well conserved within all analyzed isolates belonging to GPSC9 but were not found in isolates from GPSC1 or GPSC10.Conclusions: Although MDR S. pneumoniae is relatively uncommon in Sweden compared to other countries, virulent non-PCV serotypes that are MDR may become an increasing problem, particularly from clusters GPSC9 and GPSC10. Since the incidence of certain serotypes (3, 15A, and 19A) found among our MDR Swedish study isolates are persistent or increasing in invasive pneumococcal disease further surveillance is warranted.

URL الوصول: https://lup.lub.lu.se/record/e6131daf-86cd-4b3f-9b60-d76434a30c35
http://dx.doi.org/10.3389/fcimb.2022.824449

المؤلفون: Charalambous, Bambos M.

مصطلحات موضوعية: Pneumonia, Pneumococcal., Streptococcus pneumoniae., Pneumococcal Infections -- epidemiology., Pneumococcal Infections -- microbiology., Pneumococcal Infections -- prevention & control., Pneumococcal Vaccines., Streptococcus pneumoniae -- classification., Streptococcus pneumoniae -- genetics., Streptococcus pneumoniae -- immunology.

مصطلحات موضوعية: Streptococcus pneumoniae, pneumococcal infections epidemiology, antibiotic resistance, эпидемиология пневмококковых инфекций, pneumonia, пневмония, антибиотикорезистентность

الوصف: Целью исследования являлось определение частоты и спектра инфекций, вызываемых Streptococcus pneumoniae, у взрослых пациентов многопрофильного стационара, а также чувствительности выделенных изолятов к антибиотикам (АБ). В исследование включались взрослые пациенты с выявленным в клинических образцах S. pneumoniae либо положительным тестом на пневмококковую антигенурию. Идентификация S. pneumoniae и определение его чувствительности к АБ проводились с использованием системы BD Phoenix (ВD, США). Интерпретация результатов определения чувствительности к АБ проводилась в соответствии со стандартами EUCAST (European Committee on Antimicrobial Susceptibility Testing – Европейский комитет по тестированию на чувствительность к противомикробным препаратам) v. 11.0. Дополнительно регистрировались клинико-демографические данные пациентов, факторы риска инфицирования пенициллинорезистентными пневмококками (ПРП), исход лечения в стационаре. В исследование было включено 180 больных (63,3% мужчин) в возрасте от 19 до 95 лет. Наиболее частым проявлением пневмококковой инфекции (ПИ) была внебольничная пневмония – 62,2%, затем следовали нозокомиальные инфекции нижних дыхательных путей (13,3%); в 7,8% случаев выявлена бактериемия. Большинство пациентов имели хронические сопутствующие заболевания, чаще всего артериальную гипертонию (67,2%), ишемическую болезнь сердца (32,2%) и хроническую сердечную недостаточность (23,9%). Госпитальная летальность составила 37,2%, летальность, обусловленная ПИ, – 5,0%. Вакцинированы против ПИ до госпитализации были 6,1% пациентов. Среди факторов риска инфицирования ПРП наиболее распространенными являлись хронические сопутствующие заболевания (86,1%) и возраст старше 65 лет (48,9%). Всего 23,7% изолятов S. pneumoniae были резистентны к пенициллину, 21,9% – к эритромицину, 11,8% – к цефтриаксону. Таким образом, ПИ представляют актуальную проблему для многопрофильного стационара c точки зрения частоты встречаемости и прогноза. Отмечена крайне низкая частота специфической профилактики ПИ в группах риска, широкая распространенность факторов риска инфицирования ПРП и высокая частота выявления изолятов S. pneumoniae, резистентных к пенициллинам, макролидам и цефалоспоринам III поколения
The aim of this study was to determine the incidence and range of infections caused by Streptococcus pneumoniae in adult patients of a multidisciplinary hospital, as well as to assess the sensitivity of identified isolates to antibiotics (ABs). The study included adult patients with S. pneumoniae identified in clinical samples or positive pneumococcal urinary antigen test. The identification of S. pneumoniae and determination of its sensitivity to ABs were performed using BD Phoenix system (BD, USA). The interpretation of results of AB sensitivity determination was conducted in accordance with European Committee on Antimicrobial Susceptibility Testing (EUCAST v. 11.0) standards. Additionally, clinical and demographic data of patients were recorded, along with the risk factors for penicillin-resistant pneumococci (PRP), and stationary treatment outcomes. The study included 180 patients (63.3% men) aged 19 to 95 years. The most common manifestations of pneumococcal infection (PI) were community-acquired pneumonia (62.2%), followed by nosocomial lower respiratory tract infections (13.3%), and bacteremia in 7.8% of cases. The majority of patients had chronic comorbid conditions, most frequently, hypertension (67.2%), coronary artery disease (32.2%), and heart failure (23.9%). The hospital mortality rate was 37.2% and mortality due to PI was 5.0%. Before hospitalization 6.1% of patients were vaccinated against PI. The most common risk factors of PRP infection were chronic concomitant conditions (86.1%) and age above 65 years (48.9%). The total of 23.7% of S. pneumoniae isolates were resistant to penicillin, 21.9% – to erythromycin, and 11.8% – to ceftriaxone. Pneumococcal infection is an urgent problem for multidisciplinary hospitals, taken their incidence and prognosis. An extremely low incidence of specific prevention of PI was found in all risk groups, along with a high prevalence of risk factors of PRP infection, and high identification frequency of S. pneumoniae isolates resistant to penicillin, macrolides, and third generation cephalosporins.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d6bd88f8280fdbf27cf6d8280958389e

المؤلفون: Browall, Sarah

مصطلحات موضوعية: Pneumococcal Infections -- epidemiology, Streptococcus pneumoniae -- genetics, Streptococcus pneumoniae -- isolation & purification, Virulence, Vaccination

Degree: Diss. (sammanfattning) Stockholm : Karolinska Institutet, 2015

المؤلفون: Backhaus, Erik

مصطلحات موضوعية: Pneumococcal infections -- epidemiology, Pneumonia, bacterial, Pneumococcal vaccines, Child

جغرافية الموضوع: Sweden

URL الوصول: http://hdl.handle.net/2077/27821

Degree: Diss. (sammanfattning) Göteborg : Göteborgs universitet,

المؤلفون: Sjöström, Karin

مصطلحات موضوعية: Pneumococcal infections -- epidemiology, Pneumococcal infections -- microbiology, Carrier state -- microbiology, Streptococcus pneumoniae -- classification, Serotyping, Bacterial capsules -- classification

URL الوصول: http://diss.kib.ki.se/2007/978-91-7357-094-7/

Degree: Diss. (sammanfattning) Stockholm : Karolinska institutet, 2007

المؤلفون: Högberg, Liselotte

مصطلحات موضوعية: Penicillin resistance, Pneumococcal infections -- epidemiology, Pneumococcal infections -- prevention & control, Streptococcus pneumoniae -- drug effects, Child day care centers, Communicable disease control

URL الوصول: http://diss.kib.ki.se/2006/91-7140-526-7/

Degree: Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006

المؤلفون: Gulin, Marijana, Čivljak, Rok, Bubić, Ivan, Knotek, Mladen, Miletić-Medved, Marica

المصدر: Liječnički vjesnik
Volume 141
Issue 3-4

مصطلحات موضوعية: SMJERNICE, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, KRONIČNA BUBREŽNA BOLEST – komplikacije, PNEUMOKOKNE INFEKCIJE – epidemiologija, prevencija, PNEUMOKOKNA CJEPIVA – primjena, KONJUGIRANA CJEPIVA – primjena, PLAN IMUNIZACIJE, ČIMBENICI RIZIKA, VACCINES, CONJUGATE – administration and dosage, RENAL INSUFFICIENCY, CHRONIC – complications, PNEUMOCOCCAL INFECTIONS – epidemiology, prevention and control, PNEUMOCOCCAL VACCINES – administration and dosage, IMMUNIZATION SCHEDULE, RISK FACTORS, PRACTICE GUIDELINES AS TOPIC, kronična bubrežna bolest - komplikacije, pneumokokne infekcije - epidemiologija, prevencija, pneumokokna cjepiva - primjena, konjugirana cjepiva - primjena, plan imunizacije, čimbenici rizika, smjernice, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine

الوصف: S obzirom na zabilježene slučajeve invazivne pneumokokne bolesti u bolesnika s kroničnom bubrežnom bolesti uznapredovala stadija, Upravni odbor Hrvatskog društva za nefrologiju, dijalizu i transplantaciju (HDNDT) Hrvatskoga liječničkog zbora donio je u svibnju 2017. godine odluku o izradi Preporuka/Smjernica za prevenciju pneumokoknih bolesti cijepljenjem u bolesnika s kroničnom bubrežnom bolesti. Preporuke/Smjernice temelje se na relevantnoj medicinskoj literaturi: smjernicama Europskog društva za kliničku mikrobiologiju i zarazne bolesti i Svjetskog udruženja za zarazne bolesti i imunosne poremećaje te na Programu imunizacije, seroprofilakse i kemoprofilakse za posebne skupine stanovništva Hrvatskog zavoda za javno zdravstvo. U njihovoj su izradi sudjelovali nefrolozi, infektolozi i epidemiolozi. U Republici Hrvatskoj dostupne su dvije vrste pneumokoknog cjepiva koje se mogu primijeniti u odraslih: konjugirano cjepivo PCV13 i polisaharidno cjepivo PPSV23. U Preporukama/Smjernicama navedena je detaljna shema cijepljenja koje se preporučuje provesti u bolesnika s kroničnom bubrežnom bolesti koji bubrežnu funkciju nadomještaju hemodijalizom, peritonealnom dijalizom, kandidati su za transplantacijsko liječenje ili su transplantirani i imaju jedan ili više komorbiditeta (šećernu bolest, kroničnu plućnu bolest, kroničnu srčanožilnu bolest, kroničnu uznapredovalu jetrenu bolest, kronični bubrežni bolesnici sa solidnim ili hematološkim tumorima te splenektomirani).
Considering the reported cases of invasive pneumococcal disease in advanced chronic kidney disease patients, in May 2017 the Steering Board of the Croatian Society of Nephrology, Dialysis and Transplantation (CSNDT) of the Croatian Medical Association issued a decision on the preparation of Guidelines for the prevention of pneumococcal diseases in patients with chronic kidney disease. The Guidelines are based on relevant medical literature, Guidelines of the European Society of Clinical Microbiology and Infectious Diseases, the World Association for Infectious Diseases and Immunological Disorders, and the Program for immunization, seroprophylaxis and chemoprophylaxis for special population groups of the Croatian Institute of Public Health. Nephrologists, infectologists and epidemiologists were involved in their development. There are two types of pneumococcal vaccine available in Croatia that can be used for adults, conjugated vaccine PCV13 and polysaccharide vaccine PPSV23. The Guidelines include planning and implementation of vaccination in chronic kidney disease patients who replace kidney function with hemodialysis, peritoneal dialysis, renal transplant, or are candidates for treatment by transplantation, having one or more comorbidities: diabetes mellitus, chronic pulmonary disease, chronic cardiovascular disease, chronic advanced liver disease, chronic kidney disease with solid or hematological tumors, and splenectomy.

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3d81d3cf8732c37df504c5b17b890065
https://repository.medri.uniri.hr/islandora/object/medri:3073

المؤلفون: Burman, Lars Å.

مصطلحات موضوعية: Pneumococcal infections: epidemiology, Streptococcus pneumoniae: immunology

URL الوصول: http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102563

Degree: Diss. (sammanfattning) Umeå : Umeå universitet, 1993

المؤلفون: Timothy J. Mitchell, Giles Edwards, Karen E. Lamb, Jim McMenamin, Andrew Smith, David G. Greenhalgh, Johanna M.C. Jefferies, Stefan Flasche, Chris Robertson, Donald Inverarity, Barbara Denham, Eisin McDonald, Matthew A. Diggle, Stuart C. Clarke

المساهمون: Health Protection Scotland, International Prevention Research Institute (IPRI), University of Strathclyde [Glasgow]

المصدر: Vaccine
Vaccine, 2014, 32 (34), pp.4356-63. ⟨10.1016/j.vaccine.2013.05.079⟩

مصطلحات موضوعية: Serotype, Pediatrics, Heptavalent Pneumococcal Conjugate Vaccine, Pneumococcal conjugate vaccine, Pneumococcal Vaccines, Medicine, Child, Incidence, Invasive pneumococcal disease, PCV7, Middle Aged, 3. Good health, Vaccination, Streptococcus pneumoniae, Infectious Diseases, Child, Preschool, Population Surveillance, Conjugate/administration & dosage Young Adult, symbols, Molecular Medicine, medicine.drug, Adult, Sequence type, medicine.medical_specialty, Pneumococcal disease, Adolescent, Serogroup, complex mixtures, Pneumococcal Infections, Young Adult, symbols.namesake, stomatognathic system, QA273, Immunology and Microbiology(all), Post vaccination, Humans, Poisson regression, Typing, Serotyping, Newborn Logistic Models Middle Aged Pneumococcal Infections/*epidemiology/prevention & control Pneumococcal Vaccines/*administration & dosage Population Surveillance Scotland/epidemiology Serogroup Serotyping Streptococcus pneumoniae/*classification Vaccines, Aged, QR355, Vaccines, Conjugate, General Veterinary, General Immunology and Microbiology, business.industry, Adolescent Adult Aged Child Child, Infant, Newborn, Public Health, Environmental and Occupational Health, Infant, Sequence types, veterinary(all), Preschool Humans Incidence Infant Infant, Logistic Models, Scotland, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business

الوصف: Lamb, Karen E Flasche, Stefan Diggle, Mathew Inverarity, Donald Greenhalgh, David Jefferies, Johanna M Smith, Andrew Edwards, Giles F S Denham, Barbara McMenamin, Jim McDonald, Eisin Mitchell, Tim J Clarke, Stuart C Robertson, Chris eng Netherlands 2013/06/29 06:00 Vaccine. 2014 Jul 23;32(34):4356-63. doi: 10.1016/j.vaccine.2013.05.079. Epub 2013 Jun 24.; International audience; INTRODUCTION: The 7-valent pneumococcal conjugate vaccine (Prevenar((R)), Wyeth; PCV7) was introduced to the UK paediatric immunisation schedule in 2006. This study investigates trends in serotypes and multi locus sequence types (STs) among cases of invasive pneumococcal disease (IPD) in Scotland prior to, and following, the introduction of PCV7. METHODS: Scottish Invasive Pneumococcal Disease Enhanced Surveillance has records of all cases of IPD in Scotland since 1999. Cases diagnosed from blood or cerebrospinal fluid isolates until 2010 were analysed. Logistic and poisson regression modelling was used to assess trends prior to and following the introduction of PCV7. RESULTS: Prior to PCV7 use, on average 650 cases of IPD were reported each year; 12% occurred in those aged

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0bf78667a754247c59962520eb295c