المؤلفون: Wuttke, Matthias, Li, Yong, Li, Man, Sieber, Karsten B., Feitosa, Mary F., Gorski, Mathias, Tin, Adrienne, Wang, Lihua, Chu, Audrey Y., Hoppmann, Anselm, Kirsten, Holger, Giri, Ayush, Chai, Jin-Fang, Sveinbjornsson, Gardar, Tayo, Bamidele O., Nutile, Teresa, Fuchsberger, Christian, Marten, Jonathan, Cocca, Massimiliano, Ghasemi, Sahar, Xu, Yizhe, Horn, Katrin, Noce, Damia, van der Most, Peter J., Sedaghat, Sanaz, Yu, Zhi, Akiyama, Masato, Afaq, Saima, Ahluwalia, Tarunveer S., Almgren, Peter, Amin, Najaf, Ärnlöv, Johan, Bakker, Stephan J. L., Bansal, Nisha, Baptista, Daniela, Bergmann, Sven, Biggs, Mary L., Biino, Ginevra, Boehnke, Michael, Boerwinkle, Eric, Boissel, Mathilde, Bottinger, Erwin P., Boutin, Thibaud S., Brenner, Hermann, Brumat, Marco, Burkhardt, Ralph, Butterworth, Adam S., Campana, Eric, Campbell, Archie, Campbell, Harry, Canouil, Mickaël, Carroll, Robert J., Catamo, Eulalia, Chambers, John C., Chee, Miao-Ling, Chee, Miao-Li, Chen, Xu, Cheng, Ching-Yu, Cheng, Yurong, Christensen, Kaare, Cifkova, Renata, Ciullo, Marina, Pina Concas, Maria, Cook, James P., Coresh, Josef, Corre, Tanguy, Sala, Cinzia Felicita, Cusi, Daniele, Danesh, John, Daw, E. Warwick, de Borst, Martin H., De Grandi, Alessandro, de Mutsert, Renée, de Vries, Aiko P. J., Degenhardt, Frauke, Delgado, Graciela, Demirkan, Ayse, Di Angelantonio, Emanuele, Dittrich, Katalin, Divers, Jasmin, Dorajoo, Rajkumar, Eckardt, Kai-Uwe, Ehret, Georg, Elliott, Paul, Endlich, Karlhans, Evans, Michele K., Felix, Janine F., Foo, Valencia Hui Xian, Franco, Oscar H., Franke, Andre, Freedman, Barry I., Freitag-Wolf, Sandra, Friedlander, Yechiel, Froguel, Philippe, Gansevoort, Ron T., Gao, He, Gasparini, Paolo, Gaziano, J. Michael, Giedraitis, Vilmantas, Gieger, Christian, Girotto, Giorgia, Giulianini, Franco, Gögele, Martin, Gordon, Scott D., Gudbjartsson, Daniel F., Gudnason, Vilmundur, Haller, Toomas, Hamet, Pavel, Harris, Tamara B., Hartman, Catharina A., Hayward, Caroline, Hellwege, Jacklyn N., Heng, Chew-Kiat, Hickst, Andrew A., Hofer, Edith, Huang, Wei, Hutri-Kähönen, Nina, Hwang, Shih-Jen, ikram, M. Arfan, indridason, Olafur S., Ingelsson, Erik, ising, Marcus, Jaddoe, Vincent W. V., Jakobsdottir, Johanna, Jonas, Jost B, Joshi, Peter K., Shilpa Josyula, Navya, Jung, Bettina, Kähönen, Mika, Kamatani, Yoichiro, Kammerer, Candace M., Kanai, Masahiro, Kastarinen, Mika, Kerr, Shona M., Khor, Chiea-Chuen, Kiess, Wieland, Kleber, Marcus E., Koenig, Wolfgang, Kooner, Jaspal S., Körner, Antje, Kovacs, Peter, Kraja, Aldi T., Krajcoviechova, Alena, Kramer, Holly, Krämer, Bernhard K., Kronenberg, Florian, Kubo, Michiaki, Kühnel, Brigitte, Kuokkanen, Mikko, Kuusisto, Johanna, La Bianca, Martina, Laakso, Markku, Lange, Leslie A., Langefeld, Carl D., Jen-Mai Lee, Jeannette, Lehne, Benjamin, Lehtimäki, Terho, Lieb, Wolfgang, Cohort Study, Lifelines, Lim, Su-Chi, Lind, Lars, Lindgren, Cecilia M., Liu, Jun, Liu, Jianjun, Loeffler, Markus, Loos, Ruth J. F., Lucae, Susanne, Ann Lukas, Mary, Lyytikäinen, Leo-Pekka, Mägi, Reedik, Magnusson, Patrik K. E., Mahajan, Anubha, Martin, Nicholas G., Martins, Jade, März, Winfried, Mascalzoni, Deborah, Matsuda, Koichi, Christa Meisinger, Meitinger, Thomas, Melander, Olle, Metspalu, Andres, Mikaelsdottir, Evgenia K., Milaneschi, Yuri, Miliku, Kozeta, Mishra, Pashupati P., Veteran Program, V. A. Million, Mohlke, Karen L., Mononen, Nina, Montgomery, Grant W., Mook-Kanamori, Dennis O., Mychaleckyj, Josyf C., Nadkarni, Girish N, Nalls, Mike A., Nauck, Matthias, Nikus, Kjell, Ning, Boting, Nolte, ilja M., Noordam, Raymond, O’Connell, Jeffrey, O’Donoghue, Michelle L., Olafsson, Isleifur, Oldehinkel, Albertine J., Orho-Melander, Marju, Ouwehand, Willem H., Padmanabhan, Sandosh, Palmer, Nicholette D., Palsson, Runolfur, Penninx, Brenda W. J. H., Perls, Thomas, Perola, Markus, Pirastu, Mario, Pirastu, Nicola, Pistis, Giorgio, Podgornaia, Anna I., Polasek, Ozren, Ponte, Belen, Porteous, David J., Poulain, Tanja, Pramstaller, Peter P., Preuss, Michael H., Prins, Bram P., Province, Michael A., Rabelink, Ton J., Raffield, Laura M., Raitakari, Olli T., Reilly, Dermot F., Rettig, Rainer, Rheinberger, Myriam, Rice, Kenneth M., Ridker, Paul M., Rivadeneira, Fernando, Rizzi, Federica, Roberts, David J., Robino, Antonietta, Rossing, Peter, Rudan, Igor, Rueedi, Rico, Ruggiero, Daniela, Ryan, Kathleen A., Saba, Yasaman, Sabanayagam, Charumathi, Salomaa, Veikko, Salvi, Erika, Saum, Kai-Uwe, Schmidt, Helena, Schmidt, Reinhold, Schöttker, Ben, Schulz, Christina-Alexandra, Schupf, Nicole, Shaffer, Christian M., Shi, Yuan, Smith, Albert V., Smith, Blair H., Soranzo, Nicole, Spracklen, Cassandra N., Strauch, Konstantin, Stringham, Heather M., Stumvoll, Michael, Svensson, Per O., Szymczak, Silke, Tai, E-Shyong, Tajuddin, Salman M., Tan, Nicholas Y. Q., Taylor, Kent D., Teren, Andrej, Tham, Yih-Chung, Thiery, Joachim, Thio, Chris H. L., Thomsen, Hauke, Thorleifsson, Gudmar, Toniolo, Daniela, Tönjes, Anke, Tremblay, Johanne, Tzoulaki, Ioanna, Uitterlinden, André G., Vaccargiu, Simona, van Dam, Rob M., van der Harst, Pim, van Duijn, Cornelia M., Velez Edward, Digna R., Verweij, Niek, Vogelezang, suzanne, Völker, üwe, Vollenweider, Peter, Waeber, Gerard, Waldenberger, Melanie, Wallentin, Lars, Wang, Ya Xing, Wang, Chaolong, Waterworth, Dawn M., Bin Wei, Wen, White, Harvey, Whitfield, John B., Wild, Sarah H., Wilson, James F., Wojczynski, Mary K., Wong, Charlene, Wong, Tien-Yin, Xu, Liang, Yang, Qiong, Yasuda, Masayuki, Yerges-Armstrong, Laura M., Zhang, Weihua, Zonderman, Alan B., Rotter, Jerome I., Bochud, Murielle, Psaty, Bruce M., Vitart, Veronique, Wilson, James G., Dehghan, Abbas, Parsa, Afshin, Chasman, Daniel I., Ho, Kevin, Morris, Andrew P., Devuyst, Olivier, Akilesh, Shreeram, Pendergrass, Sarah A., Sim, Xueling, Böger, Carsten A., Okada, Yukinori, Edwards, Todd L., Snieder, Harold, Stefansson, Kari, Hung, Adriana M., Heid, Iris M., Markus Scholz, Teumer, Alexander, Köttgen, Anna, Pattaro, Cristian

المساهمون: Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Life Course Epidemiology (LCE), Internal Medicine, Epidemiology, Erasmus MC other, Pediatrics, Psychiatry, APH - Mental Health, APH - Digital Health, Wuttke, M, Li, Y, Li, M, Sieber, Kb, Feitosa, Mf, Gorski, M, Tin, A, Wang, L, Chu, Ay, Hoppmann, A, Kirsten, H, Giri, A, Chai, Jf, Sveinbjornsson, G, Tayo, Bo, Nutile, T, Fuchsberger, C, Marten, J, Cocca, M, Ghasemi, S, Xu, Y, Horn, K, Noce, D, van der Most, Pj, Sedaghat, S, Yu, Z, Akiyama, M, Afaq, S, Ahluwalia, T, Almgren, P, Amin, N, Ärnlöv, J, Bakker, Sjl, Bansal, N, Baptista, D, Bergmann, S, Biggs, Ml, Biino, G, Boehnke, M, Boerwinkle, E, Boissel, M, Bottinger, Ep, Boutin, T, Brenner, H, Brumat, M, Burkhardt, R, Butterworth, A, Campana, Eric, Campbell, A, Campbell, H, Canouil, M, Carroll, Rj, Catamo, E, Chambers, Jc, Chee, Ml, Chen, X, Cheng, Cy, Cheng, Y, Christensen, K, Cifkova, R, Ciullo, M, Concas, Mp, Cook, Jp, Coresh, J, Corre, T, Sala, Cf, Cusi, D, Danesh, J, Daw, Ew, de Borst, Mh, De Grandi, A, de Mutsert, R, de Vries, Apj, Degenhardt, F, Delgado, G, Demirkan, A, Di Angelantonio, E, Dittrich, K, Divers, J, Dorajoo, R, Eckardt, Ku, Ehret, G, Elliott, P, Endlich, K, Evans, Mk, Felix, Jf, Foo, Vhx, Franco, Oh, Franke, A, Freedman, Bi, Freitag-Wolf, S, Friedlander, Y, Froguel, P, Gansevoort, Rt, Gao, H, Gasparini, P, Gaziano, Jm, Giedraitis, V, Gieger, C, Girotto, G, Giulianini, F, Gögele, M, Gordon, Sd, Gudbjartsson, Df, Gudnason, V, Haller, T, Hamet, P, Harris, Tb, Hartman, Ca, Hayward, C, Hellwege, Jn, Heng, Ck, Hicks, Aa, Hofer, E, Huang, W, Hutri-Kähönen, N, Hwang, Sj, Ikram, Ma, Indridason, O, Ingelsson, E, Ising, M, Jaddoe, Vwv, Jakobsdottir, J, Jonas, Jb, Joshi, Pk, Josyula, N, Jung, B, Kähönen, M, Kamatani, Y, Kammerer, Cm, Kanai, M, Kastarinen, M, Kerr, Sm, Khor, Cc, Kiess, W, Kleber, Me, Koenig, W, Kooner, J, Körner, A, Kovacs, P, Kraja, At, Krajcoviechova, A, Kramer, H, Krämer, Bk, Kronenberg, F, Kubo, M, Kühnel, B, Kuokkanen, M, Kuusisto, J, La Bianca, M, Laakso, M, Lange, La, Langefeld, Cd, Lee, Jj, Lehne, B, Lehtimäki, T, Lieb, W, Lifelines Cohort, Study, Lim, Sc, Lind, L, Lindgren, Cm, Liu, J, Loeffler, M, Loos, Rjf, Lucae, S, Lukas, Ma, Lyytikäinen, Lp, Mägi, R, Magnusson, Pke, Mahajan, A, Martin, Ng, Martins, J, März, W, Mascalzoni, D, Matsuda, K, Meisinger, C, Meitinger, T, Melander, O, Metspalu, A, Mikaelsdottir, Ek, Milaneschi, Y, Miliku, K, Mishra, Pp, V. A., Million Veteran Program, Mohlke, Kl, Mononen, N, Montgomery, Gw, Mook-Kanamori, Do, Mychaleckyj, Jc, Nadkarni, Gn, Nalls, Ma, Nauck, M, Nikus, K, Ning, B, Nolte, Im, Noordam, R, O'Connell, J, O'Donoghue, Ml, Olafsson, I, Oldehinkel, Aj, Orho-Melander, M, Ouwehand, Wh, Padmanabhan, S, Palmer, Nd, Palsson, R, Penninx, Bwjh, Perls, T, Perola, M, Pirastu, M, Pirastu, N, Pistis, G, Podgornaia, Ai, Polasek, O, Ponte, B, Porteous, Dj, Poulain, T, Pramstaller, Pp, Preuss, Mh, Prins, Bp, Province, Ma, Rabelink, Tj, Raffield, Lm, Raitakari, Ot, Reilly, Df, Rettig, R, Rheinberger, M, Rice, Km, Ridker, Pm, Rivadeneira, F, Rizzi, F, Roberts, Dj, Robino, A, Rossing, P, Rudan, I, Rueedi, R, Ruggiero, D, Ryan, Ka, Saba, Y, Sabanayagam, C, Salomaa, V, Salvi, E, Saum, Ku, Schmidt, H, Schmidt, R, Schöttker, B, Schulz, Ca, Schupf, N, Shaffer, Cm, Shi, Y, Smith, Av, Smith, Bh, Soranzo, N, Spracklen, Cn, Strauch, K, Stringham, Hm, Stumvoll, M, Svensson, Po, Szymczak, S, Tai, E, Tajuddin, Sm, Tan, Nyq, Taylor, Kd, Teren, A, Tham, Yc, Thiery, J, Thio, Chl, Thomsen, H, Thorleifsson, G, Toniolo, D, Tönjes, A, Tremblay, J, Tzoulaki, I, Uitterlinden, Ag, Vaccargiu, S, van Dam, Rm, van der Harst, P, van Duijn, Cm, Velez Edward, Dr, Verweij, N, Vogelezang, S, Völker, U, Vollenweider, P, Waeber, G, Waldenberger, M, Wallentin, L, Wang, Yx, Wang, C, Waterworth, Dm, Bin Wei, W, White, H, Whitfield, Jb, Wild, Sh, Wilson, Jf, Wojczynski, Mk, Wong, C, Wong, Ty, Xu, L, Yang, Q, Yasuda, M, Yerges-Armstrong, Lm, Zhang, W, Zonderman, Ab, Rotter, Ji, Bochud, M, Psaty, Bm, Vitart, V, Wilson, Jg, Dehghan, A, Parsa, A, Chasman, Di, Ho, K, Morris, Ap, Devuyst, O, Akilesh, S, Pendergrass, Sa, Sim, X, Böger, Ca, Okada, Y, Edwards, Tl, Snieder, H, Stefansson, K, Hung, Am, Heid, Im, Scholz, M, Teumer, A, Köttgen, A, Pattaro, C.

المصدر: Nature Genetics
Nature genetics
51 (2019): 957–972. doi:10.1038/s41588-019-0407-x
info:cnr-pdr/source/autori:Wuttke, Matthias; Li, Yong; Li, Man; Sieber, Karsten B.; Feitosa, Mary F.; Gorski, Mathias; Tin, Adrienne; Wang, Lihua; Chu, Audrey Y.; Hoppmann, Anselm; Kirsten, Holger; Giri, Ayush; Chai, Jin-Fang; Sveinbjornsson, Gardar; Tayo, Bamidele O.; Nutile, Teresa; Fuchsberger, Christian; Marten, Jonathan; Cocca, Massimiliano; Ghasemi, Sahar; Xu, Yizhe; Horn, Katrin; Noce, Damia; Van der Most, Peter J.; Sedaghat, Sanaz; Yu, Zhi; Akiyama, Masato; Afaq, Saima; Ahluwalia, Tarunveer S.; Almgren, Peter; Amin, Najaf; Arnlov, Johan; Bakker, Stephan J. L.; Bansal, Nisha; Baptista, Daniela; Bergmann, Sven; Biggs, Mary L.; Biino, Ginevra; Boehnke, Michael; Boerwinkle, Eric; Boissel, Mathilde; Bottinger, Erwin P.; Boutin, Thibaud S.; Brenner, Hermann; Brumat, Marco; Burkhardt, Ralph; Butterworth, Adam S.; Campana, Eric; Campbell, Archie; Campbell, Harry; Canouil, Mickael; Carroll, Robert J.; Catamo, Eulalia; Chambers, John C.; Chee, Miao-Ling; Chee, Miao-Li; Chen, Xu; Cheng, Ching-Yu; Cheng, Yurong; Christensen, Kaare; Cifkova, Renata; Ciullo, Marina; Concas, Maria Pina; Cook, James P.; Coresh, Josef; Corre, Tanguy; Sala, Cinzia Felicita; Cusi, Daniele; Danesh, John; Daw, E. Warwick; De Borst, Martin H.; De Grandi, Alessandro; De Mutsert, Renee; De Vries, Aiko P. J.; Degenhardt, Frauke; Delgado, Graciela; Demirkan, Ayse; Di Angelantonio, Emanuele; Dittrich, Katalin; Divers, Jasmin; Dorajoo, Rajkumar; Eckardt, Kai-Uwe; Ehret, Georg; Elliott, Paul; Endlich, Karlhans; Evans, Michele K.; Felix, Janine F.; Foo, Valencia Hui Xian; Franco, Oscar H.; Franke, Andre; Freedman, Barry I.; Freitag-Wolf, Sandra; Friedlander, Yechiel; Froguel, Philippe; Gansevoort, Ron T.; Gao, He; Gasparini, Paolo; Gaziano, J. Michael; Giedraitis, Vilmantas; Gieger, Christian; Girotto, Giorgia; Giulianini, Franco; Gogele, Martin; Gordon, Scott D.; Gudbjartsson, Daniel F.; Gudnason, Vilmundur; Haller, Toomas; Hamet, Pavel; Harris, Tamara B.; Hartman, Catharina A.; Hayward, Caroline; Hellwege, Jacklyn N.; Heng, Chew-Kiat; Hicks, Andrew A.; Hofer, Edith; Huang, Wei; Hutri-Kahonen, Nina; Hwang, Shih-Jen; Ikram, M. Arfan; Indridason, Olafur S.; Ingelsson, Erik; Ising, Marcus; Jaddoe, Vincent W. V.; Jakobsdottir, Johanna; Jonas, Jost B.; Joshi, Peter K.; Josyula, Navya Shilpa; Jung, Bettina; Kahonen, Mika; Kamatani, Yoichiro; Kammerer, Candace M.; Kanai, Masahiro; Kastarinen, Mika; Kerr, Shona M.; Khor, Chiea-Chuen; Kiess, Wieland; Kleber, Marcus E.; Koenig, Wolfgang; Kooner, Jaspal S.; Korner, Antje; Kovacs, Peter; Kraja, Aldi T.; Krajcoviechova, Alena; Kramer, Holly; Kramer, Bernhard K.; Kronenberg, Florian; Kubo, Michiaki; Kuhnel, Brigitte; Kuokkanen, Mikko; Kuusisto, Johanna; La Bianca, Martina; Laakso, Markku; Lange, Leslie A.; Langefeld, Carl D.; Lee, Jeannette Jen-Mai; Lehne, Benjamin; Lehtimaki, Terho; Lieb, Wolfgang; Lim, Su-Chi; Lind, Lars; Lindgren, Cecilia M.; Liu, Jun; Liu, Jianjun; Loeffler, Markus; Loos, Ruth J. F.; Lucae, Susanne; Lukas, Mary Ann; Lyytikainen, Leo-Pekka; Magi, Reedik; Magnusson, Patrik K. E.; Mahajan, Anubha; Martin, Nicholas G.; Martins, Jade; Marz, Winfried; Mascalzoni, Deborah; Matsuda, Koichi; Meisinger, Christa; Meitinger, Thomas; Melander, Olle; Metspalu, Andres; Mikaelsdottir, Evgenia K.; Milaneschi, Yuri; Miliku, Kozeta; Mishra, Pashupati P.; Program, V. A. Million Veteran; Mohlke, Karen L.; Mononen, Nina; Montgomery, Grant W.; Mook-Kanamori, Dennis O.; Mychaleckyj, Josyf C.; Nadkarni, Girish N.; Nalls, Mike A.; Nauck, Matthias; Nikus, Kjell; Ning, Boting; Nolte, Ilja M.; Noordam, Raymond; O'Connell, Jeffrey; O'Donoghue, Michelle L.; Olafsson, Isleifur; Oldehinkel, Albertine J.; Orho-Melander, Marju; Ouwehand, Willem H.; Padmanabhan, Sandosh; Palmer, Nicholette D.; Palsson, Runolfur; Penninx, Brenda W. J. H.; Perls, Thomas; Perola, Markus; Pirastu, Mario; Pirastu, Nicola; Pistis, Giorgio; Podgornaia, Anna I.; Polasek, Ozren; Ponte, Belen; Porteous, David J.; Poulain, Tanja; Pramstaller, Peter P.; Preuss, Michael H.; Prins, Bram P.; Province, Michael A.; Rabelink, Ton J.; Raffield, Laura M.; Raitakari, Olli T.; Reilly, Dermot F.; Rettig, Rainer; Rheinberger, Myriam; Rice, Kenneth M.; Ridker, Paul M.; Rivadeneira, Fernando; Rizzi, Federica; Roberts, David J.; Robino, Antonietta; Rossing, Peter; Rudan, Igor; Rueedi, Rico; Ruggiero, Daniela; Ryan, Kathleen A.; Saba, Yasaman; Sabanayagam, Charumathi; Salomaa, Veikko; Salvi, Erika; Saum, Kai-Uwe; Schmidt, Helena; Schmidt, Reinhold; Ben Schottker; Schulz, Christina-Alexandra; Schupf, Nicole; Shaffer, Christian M.; Shi, Yuan; Smith, Albert V.; Smith, Blair H.; Soranzo, Nicole; Spracklen, Cassandra N.; Strauch, Konstantin; Stringham, Heather M.; Stumvoll, Michael; Svensson, Per O.; Szymczak, Silke; Tai, E-Shyong; Tajuddin, Salman M.; Tan, Nicholas Y. Q.; Taylor, Kent D.; Teren, Andrej; Tham, Yih-Chung; Thiery, Joachim; Thio, Chris H. L.; Thomsen, Hauke; Thorleifsson, Gudmar; Toniolo, Daniela; Tonjes, Anke; Tremblay, Johanne; Tzoulaki, Ioanna; Uitterlinden, Andre G.; Vaccargiu, Simona; Van Dam, Rob M.; Van der Harst, Pim; Van Duijn, Cornelia M.; Edward, Digna R. Velez; Verweij, Niek; Vogelezang, Suzanne; Volker, Uwe; Vollenweider, Peter; Waeber, Gerard; Waldenberger, Melanie; Wallentin, Lars; Wang, Ya Xing; Wang, Chaolong; Waterworth, Dawn M.; Bin Wei, Wen; White, Harvey; Whitfield, John B.; Wild, Sarah H.; Wilson, James F.; Wojczynski, Mary K.; Wong, Charlene; Wong, Tien-Yin; Xu, Liang; Yang, Qiong; Yasuda, Masayuki; Yerges-Armstrong, Laura M.; Zhang, Weihua; Zonderman, Alan B.; Rotter, Jerome I.; Bochud, Murielle; Psaty, Bruce M.; Vitart, Veronique; Wilson, James G.; Dehghan, Abbas; Parsa, Afshin; Chasman, Daniel I.; Ho, Kevin; Morris, Andrew P.; Devuyst, Olivier; Akilesh, Shreeram; Pendergrass, Sarah A.; Sim, Xueling; Boger, Carsten A.; Okada, Yukinori; Edwards, Todd L.; Snieder, Harold; Stefansson, Kari; Hung, Adriana M.; Heid, Iris M.; Scholz, Markus; Teumer, Alexander; Kottgen, Anna; Pattaro, Cristian/titolo:A catalog of genetic loci associated with kidney function from analyses of a million individuals/doi:10.1038%2Fs41588-019-0407-x/rivista:Nature genetics (Print)/anno:2019/pagina_da:957/pagina_a:972/intervallo_pagine:957–972/volume:51
Nature Genetics, 51(6), 957-+. Nature Publishing Group
Wuttke, M, Li, Y, Li, M, Sieber, K B, Feitosa, M F, Gorski, M, Tin, A, Wang, L, Chu, A Y, Hoppmann, A, Kirsten, H, Giri, A, Chai, J-F, Sveinbjornsson, G, Tayo, B O, Nutile, T, Fuchsberger, C, Marten, J, Cocca, M, Ghasemi, S, Xu, Y, Horn, K, Noce, D, van der Most, P J, Sedaghat, S, Yu, Z, Akiyama, M, Afaq, S, Ahluwalia, T S, Almgren, P, Amin, N, Ärnlöv, J, Bakker, S J L, Bansal, N, Baptista, D, Bergmann, S, Biggs, M L, Biino, G, Boehnke, M, Boerwinkle, E, Boissel, M, Bottinger, E P, Boutin, T S, Brenner, H, Brumat, M, Burkhardt, R, Butterworth, A S, Campana, E, Milaneschi, Y, Penninx, B W J H, Köttgen, A, Pattaro, C, Lifelines Cohort Study & V. A. Million Veteran Program 2019, ' A catalog of genetic loci associated with kidney function from analyses of a million individuals ', Nature Genetics, vol. 51, no. 6, pp. 957-972 . https://doi.org/10.1038/s41588-019-0407-x
Nature Genetics, Vol. 51, No 6 (2019) pp. 957-972
Wuttke, M, Li, Y, Li, M, Sieber, K B, Feitosa, M F, Gorski, M, Tin, A, Wang, L, Chu, A Y, Hoppmann, A, Kirsten, H, Giri, A, Chai, J F, Sveinbjornsson, G, Tayo, B O, Nutile, T, Fuchsberger, C, Marten, J, Cocca, M, Ghasemi, S, Xu, Y, Horn, K, Noce, D, van der Most, P J, Sedaghat, S, Yu, Z, Akiyama, M, Afaq, S, Ahluwalia, T S, Almgren, P, Amin, N, Ärnlöv, J, Bakker, S J L, Bansal, N, Baptista, D, Bergmann, S, Biggs, M L, Biino, G, Boehnke, M, Boerwinkle, E, Boissel, M, Bottinger, E P, Boutin, T, Brenner, H, Brumat, M, Campbell, A, Campbell, H, Hayward, C, Joshi, P K, Kerr, S, Lim, S-C, Lind, L, Lindgren, C M, Liu, J, Liu, J, Loeffler, M, Loos, R J F, Lucae, S, Lukas, M A, Lyytikäinen, L-P, Mägi, R, Magnusson, P K E, Mahajan, A, Martin, N G, Martins, J, März, W, Mascalzoni, D, Matsuda, K, Meisinger, C, Meitinger, T, Melander, O, Metspalu, A, Mikaelsdottir, E K, Milaneschi, Y, Miliku, K, Mishra, P P, Mohlke, K L, Montgomery, G W, Mychaleckyj, J C, Nadkarni, G N, Nalls, M A, Nauck, M, Nikus, K, Ning, B, Nolte, I M, Noordam, R, O’Connell, J R, O'Donoghue, M L, Olafsson, I, Oldehinkel, A J, Orho-Melander, M, Ouwehand, W H, Padmanabhan, S, Palmer, N D, Palsson, R, Penninx, B W J H, Perls, T, Perola, M, Pirastu, M, Pirastu, N, Pistis, G, Podgornaia, A I, Polasek, O, Ponte, B, Porteous, D J, Poulain, T, Pramstaller, P P, Preuss, M H, Prins, B P, Province, M A, Rabelink, T J, Raffield, L M, Raitakari, O T, Reilly, D F, Rettig, R, Rheinberger, M, Rice, K M, Ridker, P M, Rivadeneira, F, Rizzi, F, Roberts, D J, Robino, A, Rossing, P, Rudan, I, Rueedi, R, Ruggiero, D, Ryan, K A, Saba, Y, Sabanayagam, C, Salomaa, V, Salvi, E, Saum, K-U, Schmidt, H, Schmidt, R, Schöttker, B, Schulz, C-A, Schupf, N, Shaffer, C M, Shi, Y, Smith, A V, Smith, B H, Soranzo, N, Spracklen, C N, Strauch, K, Stringham, H M, Stumvoll, M, Svensson, P O, Szymczak, S, Tai, E-S, Tajuddin, S M, Tan, N Y Q, Taylor, K D, Teren, A, Tham, Y-C, Thiery, J, Thio, C H L, Thomsen, H, Thorleifsson, G, Toniolo, D, Tönjes, A, Tremblay, J, Tzoulaki, I, Uitterlinden, A G, Vaccargiu, S, van Dam, R M, van der Harst, P, van Duijn, C M, Velez Edwards, D R, Verweij, N, Vogelezang, S, Völker, U, Vollenweider, P, Waeber, G, Waldenberger, M, Wallentin, L, Wang, Y X, Wang, C, Waterworth, D M, Wei, W B, White, H, Whitfield, J B, Wild, S H, Wilson, J F, Wojczynski, M K, Wong, C, Wong, T-Y, Xu, L, Yang, Q, Yasuda, M, Yerges-Armstrong, L M, Zhang, W, Zonderman, A B, Rotter, J I, Bochud, M, Psaty, B M, Vitart, V, Wilson, J G, Dehghan, A, Parsa, A, Chasman, D I, Ho, K, Morris, A P, Devuyst, O, Akilesh, S, Pendergrass, S A, Sim, X, Böger, C A, Okada, Y, Edwards, T L, Snieder, H, Stefansson, K, Hung, A M, Heid, I M, Scholz, M & Teumer, A & Köttgen, A & Pattaro, C 2019, ' A catalog of genetic loci associated with kidney function from analyses of a million individuals ', Nature Genetics, vol. 51, no. 6, pp. 957-972 . https://doi.org/10.1038/s41588-019-0407-x
Wuttke, M, Li, Y, Li, M, Sieber, K B, Feitosa, M F, Gorski, M, Tin, A, Wang, L, Chu, A Y, Hoppmann, A, Kirsten, H, Giri, A, Chai, J F, Sveinbjornsson, G, Tayo, B O, Nutile, T, Fuchsberger, C, Marten, J, Cocca, M, Ghasemi, S, Xu, Y, Horn, K, Noce, D, van der Most, P J, Sedaghat, S, Yu, Z, Akiyama, M, Afaq, S, Ahluwalia, T S, Almgren, P, Amin, N, Ärnlöv, J, Bakker, S J L, Bansal, N, Baptista, D, Bergmann, S, Biggs, M L, Biino, G, Boehnke, M, Boerwinkle, E, Boissel, M, Bottinger, E P, Boutin, T S, Brenner, H, Brumat, M, Burkhardt, R, Butterworth, A S, Campana, E, Christensen, K, Lifelines Cohort Study & V. A. Million Veteran Program 2019, ' A catalog of genetic loci associated with kidney function from analyses of a million individuals ', Nature Genetics, vol. 51, no. 6, pp. 957-972 . https://doi.org/10.1038/s41588-019-0407-x
Nature Genetics, 51(6), 957-972. Nature Publishing Group
Nature Genetics, 51(6), 957
LifeLines Cohort Study 2019, ' A catalog of genetic loci associated with kidney function from analyses of a million individuals ', Nature Genetics, vol. 51, no. 6, pp. 957-972 . https://doi.org/10.1038/s41588-019-0407-x

مصطلحات موضوعية: catalog, Inheritance Patterns, Hasso-Plattner-Institut für Digital Engineering GmbH, Genome-wide association study, Disease, Kidney Function Tests, Bioinformatics, DISEASE, 0302 clinical medicine, Uromodulin/urine, kidney function, 11 Medical and Health Sciences, Genetics & Heredity, ddc:616, 0303 health sciences, Kidney, Genome-wide association, HERITABILITY, GENOME-WIDE ASSOCIATION, COMMON VARIANTS, RENAL-FUNCTION, TRANS-EQTLS, METAANALYSIS, TRANSPORTER, CLASSIFICATION, INTEGRATION, Chromosome Mapping, 3. Good health, Phenotype, medicine.anatomical_structure, Medical genetics, Common variants, Renal function, Trans-EQTLS, Metaanalysis, Heritability, Transporter, Life Sciences & Biomedicine, Glomerular Filtration Rate, Metaanalysi, medicine.medical_specialty, Genotype, European Continental Ancestry Group, Quantitative Trait Loci, Common variant, Quantitative trait locus, Biology, Polymorphism, Single Nucleotide, Article, White People, V. A. Million Veteran Program, 03 medical and health sciences, Quantitative Trait, Heritable, Lifelines Cohort Study, Uromodulin, Genetics, medicine, Humans, Genetic Predisposition to Disease, Renal Insufficiency, Chronic, Genetic Association Studies, 030304 developmental biology, Genetic association, Science & Technology, urogenital system, association, genetic loci, 06 Biological Sciences, medicine.disease, Renal Insufficiency, Chronic/genetics/physiopathology/urine, Genetic Association Studies/methods, ddc:000, 030217 neurology & neurosurgery, Developmental Biology, Genome-Wide Association Study, Kidney disease

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المؤلفون: Peter Vollenweider, Christophe Tzourio, Stefan Enroth, Cinzia Sala, Mark J. Caulfield, Murielle Bochud, Peter P. Pramstaller, Ozren Polasek, Paul Elliott, Dennis O. Mook-Kanamori, Daniel I. Chasman, Christian Gieger, Harriëtte Riese, Rodney J. Scott, Cristina Menni, Anubha Mahajan, Elizabeth G. Holliday, Ilja M. Nolte, Priyanka Nandakumar, Tatijana Zemunik, Dragana Vuckovic, Tõnu Esko, Franco Giulianini, Michael Boehnke, Antonietta Robino, Anne U. Jackson, Roby Joehanes, Alanna C. Morrison, Kay-Tee Khaw, Alison Pattie, Peter J. van der Most, Mika Kähönen, Rick Jansen, Andrew D. Johnson, John M. Starr, Marcus Dörr, Anders Hamsten, Kenneth Rice, Alice Stanton, James F. Wilson, Nabi Shah, Weihua Zhang, Andrew A. Hicks, Jeffrey Damman, Jing Hua Zhao, Aarno Palotie, Veronique Vitart, Alan J. Gow, Caroline Hayward, Alan James, Ben A. Oostra, Janina S. Ried, John Beilby, David P. Strachan, Martin D. Tobin, Eco J. C. de Geus, Vilmundur Gudnason, Bruce M. Psaty, Zoltán Kutalik, Neil Poulter, Paul M. Ridker, Johan Sundström, Cornelia M. van Duijn, Eleftheria Zeggini, Christopher Oldmeadow, Borbala Mifsud, Giorgia Girotto, Aravinda Chakravarti, Jonathan Marten, Alexander Teumer, Joanne Knight, Robert A. Scott, Vilmantas Giedraitis, Paul F. O'Reilly, Marco Brumat, Brenda W.J.H. Penninx, Peter J. Munson, Olli T. Raitakari, Leo-Pekka Lyytikäinen, He Gao, Massimo Mangino, Benjamin Lehne, J. Wouter Jukema, Paul Knekt, Catharina A. Hartman, Rona J. Strawbridge, Jouke-Jan Hottenga, Jaspal S. Kooner, Nilesh J. Samani, Kristin L. Ayers, A. Mesut Erzurumluoglu, Joshua C. Bis, Archie Campbell, Dan E. Arking, Germaine C. Verwoert, John Attia, Samuli Ripatti, Yuri Milaneschi, Caterina Barbieri, Fabiola M. Del Greco, C M Lindgren, Peter K. Joshi, Helen R. Warren, Nicholas J. Wareham, Simon Thom, Seppo Koskinen, Tamara B. Harris, Ilaria Gandin, Kent D. Taylor, Andrew D. Morris, Anna Morgan, Chiara Batini, Terho Lehtimäki, Walter Palmas, David Conen, Harold Snieder, Martin H. de Borst, Sarah E. Harris, Igor Rudan, Ruth J. F. Loos, Claudia Langenberg, Anuj Goel, Christopher P. Nelson, Peter S. Braund, Rossella Sorice, Yasaman Saba, Oscar H. Franco, Yongmei Liu, Mattias Frånberg, David S. Siscovick, Patricia B. Munroe, Rainer Rettig, Michela Traglia, Daniel Levy, Li Lin, Michael R. Barnes, Elin Org, Anne-Claire Vergnaud, Andres Metspalu, Stéphanie Debette, Yusuf Demirkale, John M. C. Connell, Jian'an Luan, Paolo Gasparini, Tim D. Spector, Marina Ciullo, Antti-Pekka Sarin, Ian J. Deary, Teemu J. Niiranen, Marty Larson, Heather J. Cordell, Jerome I. Rotter, Sekar Kathiresan, Teresa Nutile, Andrew P. Morris, Denis C. Shields, Alan F. Wright, Lorna M. Lopez, Aki S. Havulinna, Gonçalo R. Abecasis, Edith Hofer, Siim Sõber, Sébastien Thériault, Ahmad Vaez, Albert Hofman, Gonneke Willemsen, Lynda M. Rose, John C. Chambers, Peter S. Sever, Maryam Abedi, André G. Uitterlinden, François Mach, Massimiliano Cocca, Sarah H Wild, Reinhold Schmidt, Jaume Marrugat, Marc A. Seelen, Maris Laan, Aude Saint Pierre, David C. Liewald, Pim van der Harst, Sandosh Padmanabhan, Martin Farrall, Georg Ehret, Albert V. Smith, Quang Tri Nguyen, Ulf Gyllensten, Helena Schmidt, Ganesh Chauhan, Jennifer E. Huffman, Morris A. Swertz, Jaakko Tuomilehto, Louise V. Wain, Meixia Ren, Erwin P. Bottinger, Roberto Elosua, Ivana Kolcic, Veikko Salomaa, Stella Trompet, Bernard Keavney, Claudia P. Cabrera, Bram P. Prins, Jennie Hui, Uwe Völker, Albertine J. Oldehinkel, Evangelos Evangelou, Pekka Jousilahti, Dorret I. Boomsma, Harry Campbell, Shih-Jen Hwang, Jie Yao, Francis S. Collins, Chrysovalanto Mamasoula, Kati Kristiansson, Markus Perola, Renée de Mutsert, Xiuqing Guo, Antti Jula, Daniela Toniolo, Ruifang Li-Gao, Åsa Johansson, Nick Shrine, Teresa Ferreira, Lars Lind, David J. Stott, Tineka Blake, Daniela Ruggiero, Mike A. Nalls, Erik Ingelsson, Colin N. A. Palmer, Christopher Newton-Cheh, Marjo-Riitta Järvelin, Guillaume Paré, Joris Deelen, Morris Brown, Gail Davies, Annette Peters, Ioanna Tzoulaki, Alex S. F. Doney, Najaf Amin, Lenore J. Launer, Hugh Watkins, Yingchang Lu

المساهمون: Wain, Lv, Vaez, A, Jansen, R, Joehanes, R, van der Most, Pj, Erzurumluoglu, Am, O'Reilly, Pf, Cabrera, Cp, Warren, Hr, Rose, Lm, Verwoert, Gc, Hottenga, Jj, Strawbridge, Rj, Esko, T, Arking, De, Hwang, Sj, Guo, X, Kutalik, Z, Trompet, S, Shrine, N, Teumer, A, Ried, J, Bis, Jc, Smith, Av, Amin, N, Nolte, Im, Lyytikäinen, Lp, Mahajan, A, Wareham, Nj, Hofer, E, Joshi, Pk, Kristiansson, K, Traglia, M, Havulinna, A, Goel, A, Nalls, Ma, Sõber, S, Vuckovic, Dragana, Luan, J, Del Greco, M. F, Ayers, Kl, Marrugat, J, Ruggiero, D, Lopez, Lm, Niiranen, T, Enroth, S, Jackson, Au, Nelson, Cp, Huffman, Je, Zhang, W, Marten, J, Gandin, I, Harris, Se, Zemunik, T, Lu, Y, Evangelou, E, Shah, N, de Borst, Mh, Mangino, M, Prins, Bp, Campbell, A, Li Gao, R, Chauhan, G, Oldmeadow, C, Abecasis, G, Abedi, M, Barbieri, Cm, Barnes, Mr, Batini, C, Beilby, J, Blake, T, Boehnke, M, Bottinger, Ep, Braund, P, Brown, M, Brumat, M, Campbell, H, Chambers, Jc, Cocca, M, Collins, F, Connell, J, Cordell, Hj, Damman, Jj, Davies, G, de Geus, Ej, de Mutsert, R, Deelen, J, Demirkale, Y, Doney, Asf, Dörr, M, Farrall, M, Ferreira, T, Frånberg, M, Gao, H, Giedraitis, V, Gieger, C, Giulianini, F, Gow, Aj, Hamsten, A, Harris, Tb, Hofman, A, Holliday, Eg, Hui, J, Jarvelin, Mr, Johansson, Å, Johnson, Ad, Jousilahti, P, Jula, A, Kähönen, M, Kathiresan, S, Khaw, Kt, Kolcic, I, Koskinen, S, Langenberg, C, Larson, M, Launer, Lj, Lehne, B, Liewald, Dcm, Lin, L, Lind, L, Mach, F, Mamasoula, C, Menni, C, Mifsud, B, Milaneschi, Y, Morgan, Anna, Morris, Ad, Morrison, Ac, Munson, Pj, Nandakumar, P, Nguyen, Qt, Nutile, T, Oldehinkel, Aj, Oostra, Ba, Org, E, Padmanabhan, S, Palotie, A, Paré, G, Pattie, A, Penninx, Bwjh, Poulter, N, Pramstaller, Pp, Raitakari, Ot, Ren, M, Rice, K, Ridker, Pm, Riese, H, Ripatti, S, Robino, A, Rotter, Ji, Rudan, I, Saba, Y, Saint Pierre, A, Sala, Cf, Sarin, Ap, Schmidt, R, Scott, R, Seelen, Ma, Shields, Dc, Siscovick, D, Sorice, R, Stanton, A, Stott, Dj, Sundström, J, Swertz, M, Taylor, Kd, Thom, S, Tzoulaki, I, Tzourio, C, Uitterlinden, Ag, Völker, U, Vollenweider, P, Wild, S, Willemsen, G, Wright, Af, Yao, J, Thériault, S, Conen, D, Attia, J, Sever, P, Debette, S, Mook Kanamori, Do, Zeggini, E, Spector, Td, van der Harst, P, Palmer, Cna, Vergnaud, Ac, Loos, Rjf, Polasek, O, Starr, Jm, Girotto, Giorgia, Hayward, C, Kooner, J, Lindgren, Cm, Vitart, V, Samani, Nj, Tuomilehto, J, Gyllensten, U, Knekt, P, Deary, Ij, Ciullo, M, Elosua, R, Keavney, Bd, Hicks, Aa, Scott, Ra, Gasparini, Paolo, Laan, M, Liu, Y, Watkins, H, Hartman, Ca, Salomaa, V, Toniolo, D, Perola, M, Wilson, Jf, Schmidt, H, Zhao, Jh, Lehtimäki, T, van Duijn, Cm, Gudnason, V, Psaty, Bm, Peters, A, Rettig, R, James, A, Jukema, Jw, Strachan, Dp, Palmas, W, Metspalu, A, Ingelsson, E, Boomsma, Di, Franco, Oh, Bochud, M, Newton Cheh, C, Munroe, Pb, Elliott, P, Chasman, Di, Chakravarti, A, Knight, J, Morris, Ap, Levy, D, Tobin, Md, Snieder, H, Caulfield, Mj, Ehret, G. b., Home Office, Medical Research Council (MRC), National Institute for Health Research, Imperial College Healthcare NHS Trust- BRC Funding, British Heart Foundation, Life Course Epidemiology (LCE), Groningen Kidney Center (GKC), Lifestyle Medicine (LM), Vascular Ageing Programme (VAP), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Groningen Institute for Organ Transplantation (GIOT), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Cardiovascular Centre (CVC), Epidemiology, Gastroenterology & Hepatology, Clinical Genetics, Internal Medicine, Erasmus MC other, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Epidemiology and Data Science, Division 6, APH - Mental Health, APH - Digital Health, Biological Psychology, APH - Health Behaviors & Chronic Diseases, APH - Personalized Medicine, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Methodology

المصدر: Keavney, B, et al, & Morris, A 2017, ' Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets from Blood and the Kidney ', Hypertension, vol. 70, no. 3, pp. e4-e19 . https://doi.org/10.1161/HYPERTENSIONAHA.117.09438
Wain, L V, Vaez, A, Jansen, R, Joehanes, R, van der Most, P J, Erzurumluoglu, A M, O'Reilly, P F, Cabrera, C P, Warren, H R, Rose, L M, Verwoert, G C, Hottenga, J-J, Strawbridge, R J, Esko, T, Arking, D E, Hwang, S-J, Guo, X, Kutalik, Z, Trompet, S, Shrine, N, Teumer, A, Ried, J S, Bis, J C, Smith, A V, Amin, N, Nolte, I M, Lyytikäinen, L-P, Mahajan, A, Wareham, N J, Hofer, E, Joshi, P K, Kristiansson, K, Traglia, M, Havulinna, A S, Goel, A, Nalls, M A, Sõber, S, Vuckovic, D, Luan, J, Del Greco M, F, Ayers, K L, Marrugat, J, Ruggiero, D, Lopez, L M, Niiranen, T, Enroth, S, Jackson, A U, Nelson, C P, Huffman, J E, Zhang, W, Marten, J, Gandin, I, Harris, S E, Zemunik, T, Lu, Y, Evangelou, E, Shah, N, de Borst, M H, Mangino, M, Prins, B P, Campbell, A, Li-Gao, R, Chauhan, G, Oldmeadow, C, Abecasis, G R, Abedi, M, Barbieri, C M, Barnes, M R, Batini, C, Beilby, J, Blake, T, Boehnke, M, Bottinger, E P, Braund, P S, Brown, M, Brumat, M, Campbell, H, Chambers, J C, Cocca, M, Collins, F S, Connell, J, Cordell, H J, Damman, J J, Davies, G, de Geus, E J, de Mutsert, R, Deelen, J, Demirkale, Y, Doney, A S F, Dörr, M, Farrall, M, Ferreira, T, Frånberg, M, Gao, H, Giedraitis, V, Gieger, C, Giulianini, F, Gow, A J, Hamsten, A, Harris, T B, Hofman, A, Holliday, E G, Hui, J, Jarvelin, M-R, Johansson, Å, Johnson, A D, Jousilahti, P, Jula, A, Kähönen, M, Kathiresan, S, Khaw, K-T, Kolcic, I, Koskinen, S, Langenberg, C, Larson, M, Launer, L J, Lehne, B, Liewald, D C M, Lin, L, Lind, L, Mach, F, Mamasoula, C, Menni, C, Mifsud, B, Milaneschi, Y, Morgan, A, Morris, A D, Morrison, A C, Munson, P J, Nandakumar, P, Nguyen, Q T, Nutile, T, Oldehinkel, A J, Oostra, B A, Org, E, Padmanabhan, S, Palotie, A, Paré, G, Pattie, A, Penninx, B W J H, Poulter, N, Pramstaller, P P, Raitakari, O T, Ren, M, Rice, K, Ridker, P M, Riese, H, Ripatti, S, Robino, A, Rotter, J I, Rudan, I, Saba, Y, Saint Pierre, A, Sala, C F, Sarin, A-P, Schmidt, R E, Scott, R J, Seelen, M A, Shields, D C, Siscovick, D, Sorice, R, Stanton, A, Stott, D J, Sundström, J, Swertz, M A, Taylor, K D, Thom, S, Tzoulaki, I, Tzourio, C, Uitterlinden, A G, Völker, U, Vollenweider, P, Wild, S, Willemsen, G, Wright, A F, Yao, J, Thériault, S, Conen, D, Attia, J R, Sever, P, Debette, S, Mook-Kanamori, D O, Zeggini, E, Spector, T D, van der Harst, P, Palmer, C N A, Vergnaud, A-C, Loos, R J F, Polasek, O, Starr, J M, Girotto, G, Hayward, C, Kooner, J S, Lindgren, C M, Vitart, V, Samani, N J, Tuomilehto, J, Gyllensten, U, Knekt, P, Deary, I J, Ciullo, M, Elosua, R, Keavney, B D, Hicks, A A, Scott, R A, Gasparini, P, Laan, M, Liu, Y, Watkins, H, Hartman, C A, Salomaa, V, Toniolo, D, Perola, M, Wilson, J F, Schmidt, H, Zhao, J H, Lehtimäki, T, van Duijn, C M, Gudnason, V, Psaty, B M, Peters, A, Rettig, R, James, A L, Jukema, J W, Strachan, D P, Palmas, W, Metspalu, A, Ingelsson, E, Boomsma, D I, Franco, O H, Bochud, M, Newton-Cheh, C, Munroe, P B, Elliott, P, Chasman, D I, Chakravarti, A, Knight, J, Morris, A P, Levy, D, Tobin, M D, Snieder, H, Caulfield, M J & Ehret, G B 2017, ' Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney ', Hypertension, vol. 70, no. 3, pp. e4-e19 . https://doi.org/10.1161/HYPERTENSIONAHA.117.09438
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Hypertension, 70(3), E4-+. LIPPINCOTT WILLIAMS & WILKINS
Hypertension, 70(3), E4-+. Lippincott Williams & Wilkins
Hypertension, Vol. 70, No 3 (2017) pp. e4-e19
Wain, L V, Vaez, A, Jansen, R, Joehanes, R, van der Most, P J, Erzurumluoglu, A M, O'Reilly, P F, Cabrera, C P, Warren, H R, Rose, L M, Verwoert, G C, Hottenga, J-J, Strawbridge, R J, Esko, T, Arking, D E, Hwang, S-J, Guo, X, Kutalik, Z, Trompet, S, Shrine, N, Teumer, A, Ried, J S, Bis, J C, Smith, A V, Amin, N, Nolte, I M, Lyytikainen, L-P, Mahajan, A, Wareham, N J, Hofer, E, Joshi, P K, Kristiansson, K, Traglia, M, Marten, J, Harris, S E, Campbell, A, Campbell, H, Davies, G, Liewald, D C M, Morris, A D, Pattie, A, Rudan, I, Wild, S, Wright, A F, Starr, J M, Hayward, C & Vitart, V & Deary, I J & Wilson, J F & Morris, A P 2017, ' Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney ', Hypertension, vol. 70, no. 3, pp. E4-E19 . https://doi.org/10.1161/HYPERTENSIONAHA.117.09438
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HYPERTENSION
Hypertension, 70(3), e4-e19. Lippincott Williams and Wilkins
Hypertension, 70(3), E4
Hypertension (Dallas Tex., 1979) 70 (2017): e4–e19. doi:10.1161/HYPERTENSIONAHA.117.09438
info:cnr-pdr/source/autori:Wain L.V.; Vaez A.; Jansen R.; Joehanes R.; Van Der Most P.J.; Erzurumluoglu A.M.; O'Reilly P.F.; Cabrera C.P.; Warren H.R.; Rose L.M.; Verwoert G.C.; Hottenga J.-J.; Strawbridge R.J.; Esko T.; Arking D.E.; Hwang S.-J.; Guo X.; Kutalik Z.; Trompet S.; Shrine N.; Teumer A.; Ried J.S.; Bis J.C.; Smith A.V.; Amin N.; Nolte I.M.; Lyytikainen L.-P.; Mahajan A.; Wareham N.J.; Hofer E.; Joshi P.K.; Kristiansson K.; Traglia M.; Havulinna A.S.; Goel A.; Nalls M.A.; Sober S.; Vuckovic D.; Luan J.; Del Greco F.M.; Ayers K.L.; Marrugat J.; Ruggiero D.; Lopez L.M.; Niiranen T.; Enroth S.; Jackson A.U.; Nelson C.P.; Huffman J.E.; Zhang W.; Marten J.; Gandin I.; Harris S.E.; Zemunik T.; Lu Y.; Evangelou E.; Shah N.; De Borst M.H.; Mangino M.; Prins B.P.; Campbell A.; Li-Gao R.; Chauhan G.; Oldmeadow C.; Abecasis G.; Abedi M.; Barbieri C.M.; Barnes M.R.; Batini C.; Beilby J.; Blake T.; Boehnke M.; Bottinger E.P.; Braund P.S.; Brown M.; Brumat M.; Campbell H.; Chambers J.C.; Cocca M.; Collins F.; Connell J.; Cordell H.J.; Damman J.J.; Davies G.; De Geus E.J.; De Mutsert R.; Deelen J.; Demirkale Y.; Doney A.S.F.; Dorr M.; Farrall M.; Ferreira T.; Franberg M.; Gao H.; Giedraitis V.; Gieger C.; Giulianini F.; Gow A.J.; Hamsten A.; Harris T.B.; Hofman A.; Holliday E.G.; Hui J.; Jarvelin M.-R.; Johansson A.; Johnson A.D.; Jousilahti P.; Jula A.; Kahonen M.; Kathiresan S.; Khaw K.-T.; Kolcic I.; Koskinen S.; Langenberg C.; Larson M.; Launer L.J.; Lehne B.; Liewald D.C.M.; Lin L.; Lind L.; Mach F.; Mamasoula C.; Menni C.; Mifsud B.; Milaneschi Y.; Morgan A.; Morris A.D.; Morrison A.C.; Munson P.J.; Nandakumar P.; Nguyen Q.T.; Nutile T.; Oldehinkel A.J.; Oostra B.A.; Org E.; Padmanabhan S.; Palotie A.; Pare G.; Pattie A.; Penninx B.W.J.H.; Poulter N.; Pramstaller P.P.; Raitakari O.T.; Ren M.; Rice K.; Ridker P.M.; Riese H.; Ripatti S.; Robino A.; Rotter J.I.; Rudan I.; Saba Y.; Saint Pierre A.; Sala C.F.; Sarin A.-P.; Schmidt R.; Scott R.; Seelen M.A.; Shields D.C.; Siscovick D.; Sorice R.; Stanton A.; Stott D.J.; Sundstrom J.; Swertz M.; Taylor K.D.; Thom S.; Tzoulaki I.; Tzourio C.; Uitterlinden A.G.; Volker U.; Vollenweider P.; Wild S.; Willemsen G.; Wright A.F.; Yao J.; Theriault S.; Conen D.; Attia J.; Sever P.; Debette S.; Mook-Kanamori D.O.; Zeggini E.; Spector T.D.; Van Der Harst P.; Palmer C.N.A.; Vergnaud A.-C.; Loos R.J.F.; Polasek O.; Starr J.M.; Girotto G.; Hayward C.; Kooner J.S.; Lindgren C.M.; Vitart V.; Samani N.J.; Tuomilehto J.; Gyllensten U.; Knekt P.; Deary I.J.; Ciullo M.; Elosua R.; Keavney B.D.; Hicks A.A.; Scott R.A.; Gasparini P.; Laan M.; Liu Y.; Watkins H.; Hartman C.A.; Salomaa V.; Toniolo D.; Perola M.; Wilson J.F.; Schmidt H.; Zhao J.H.; Lehtimaki T.; Van Duijn C.M.; Gudnason V.; Psaty B.M.; Peters A.; Rettig R.; James A.; Jukema J.W.; Strachan D.P.; Palmas W.; Metspalu A.; Ingelsson E.; Boomsma D.I.; Franco O.H.; Bochud M.; Newton-Cheh C.; Munroe P.B.; Elliott P.; Chasman D.I.; Chakravarti A.; Knight J.; Morris A.P.; Levy D.; Tobin M.D.; Snieder H.; Caulfield M.J.; Ehret G.B./titolo:Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets from Blood and the Kidney/doi:10.1161%2FHYPERTENSIONAHA.117.09438/rivista:Hypertension (Dallas Tex., 1979)/anno:2017/pagina_da:e4/pagina_a:e19/intervallo_pagine:e4–e19/volume:70

مصطلحات موضوعية: 0301 basic medicine, cardiovascular risk, Netherlands Twin Register (NTR), hypertension, NETHERLANDS, Sistema cardiovascular -- Malalties, GWAS, blood pressure, complex traits, eSNP, Locus (genetics), Genome-wide association study, Disease, Biology, PERIPHERAL-BLOOD, 1102 Cardiovascular Medicine And Haematology, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Genetic variation, Internal Medicine, Journal Article, Cardiac and Cardiovascular Systems, 1000 Genomes Project, Gene, CENTRIC ARRAY, METAANALYSIS, Genetics, ddc:616, Kardiologi, PULSE PRESSURE, COMMON VARIANTS, 1103 Clinical Sciences, ta3121, 3. Good health, INDIVIDUALS, 030104 developmental biology, Blood pressure, TARGET, Cardiovascular System & Hematology, complex trait, GWAS, blood pressure, cardiovascular risk, complex traits, eSNP, hypertension, Hipertensió, Imputation (genetics), TRAITS

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09b8b2742b2e57504362a7d589fabee4
https://doi.org/10.1161/HYPERTENSIONAHA.117.09438

المؤلفون: Suzuki K; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Hatzikotoulas K; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. konstantinos.hatzikotoulas@helmholtz-munich.de., Southam L; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Taylor HJ; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Yin X; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Lorenz KM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Mandla R; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Huerta-Chagoya A; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Melloni GEM; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kanoni S; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Rayner NW; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Bocher O; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Arruda AL; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Graduate School of Experimental Medicine, Technical University of Munich, Munich, Germany.; Munich School for Data Science, Helmholtz Munich, Neuherberg, Germany., Sonehara K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Namba S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Lee SSK; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Preuss MH; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Petty LE; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Schroeder P; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Vanderwerff B; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Kals M; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Bragg F; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Guo X; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London NorthWest Healthcare NHS Trust, London, UK., Yao J; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, South Korea., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Nano J; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Lamri A; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Moon S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, South Korea., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Cook JP; Department of Health Data Science, University of Liverpool, Liverpool, UK., Lee JJ; Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA., Pan I; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA., Taliun D; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hai Y; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Thorleifsson G; deCODE Genetics, Amgen, Reykjavik, Iceland., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sofer T; Department of Biostatistics, Harvard University, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard University, Boston, MA, USA., Wuttke M; Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Sarnowski C; Department of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Gieger C; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Nousome D; Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands., Kwak SH; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea., Long J; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Sun M; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Tong L; Institute for Population and Precision Health (IPPH), Biological Sciences Division, University of Chicago, Chicago, IL, USA., Chen WM; Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Nongmaithem SS; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India., Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands., Lim VJY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Tam CHT; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Chinese University of Hong Kong, Hong Kong, China., Joo YY; Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea.; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Prins BP; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Nicolas A; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chen G; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Kabagambe E; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Academics, Ochsner Health, New Orleans, LA, USA., An P; Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA., Xiang AH; Department of Research and Evaluation, Division of Biostatistics Research, Kaiser Permanente of Southern California, Pasadena, CA, USA., Choi HS; Department of Biomedical Science, Hallym University, Chuncheon, South Korea., Cade BE; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Tan J; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Broadaway KA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Williamson A; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK., Kamali Z; Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran., Cui J; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Thangam M; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Adeyemo A; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Aguilar-Salinas CA; Unidad de Investigación en Enfermedades Metabólicas and Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Ahluwalia TS; Steno Diabetes Center Copenhagen, Herlev, Denmark.; Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Anand SS; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada., Bertoni A; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brandslund I; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark., Buchanan TA; Department of Medicine, Division of Endocrinology and Diabetes, Keck School of Medicine of USC, Los Angeles, CA, USA., Burant CF; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus, University of Cambridge, Hinxton, UK.; National Institute for Health and Care Research (NIHR) Blood and Transplant Unit (BTRU) in Donor Health and Behaviour, Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Canouil M; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital, Lille, France.; University of Lille, Lille, France., Chan JCN; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, Chinese University of Hong Kong, Hong Kong, China., Chang LC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chee ML; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Chen J; Exeter Centre of Excellence in Diabetes (ExCEeD), Exeter Medical School, University of Exeter, Exeter, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Chen SH; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA., Chen YT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Chuang LM; Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan., Cushman M; Department of Medicine, University of Vermont, Colchester, VT, USA., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; British Heart Foundation Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus, University of Cambridge, Hinxton, UK.; National Institute for Health and Care Research (NIHR) Blood and Transplant Unit (BTRU) in Donor Health and Behaviour, Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Das SK; Section of Endocrinology and Metabolism, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Dedoussis G; Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece., Dimitrov L; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA., Doumatey AP; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Du S; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Duan Q; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Eckardt KU; Department of Nephrology and Medical Intensive Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.; Department of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Emery LS; Department of Biostatistics, University of Washington, Seattle, WA, USA., Evans DS; California Pacific Medical Center Research Institute, San Francisco, CA, USA., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Fischer K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia., Floyd JS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Franco OH; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Freedman BI; Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Genter P; Department of Medicine, Division of Endocrinology and Metabolism, Lundquist Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Gerstein HC; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada., Giedraitis V; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., González-Villalpando C; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Mexico City, Mexico., González-Villalpando ME; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Mexico City, Mexico., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gross M; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Guare LA; Genomics and Computational Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hackinger S; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Hakaste L; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Folkhalsan Research Center, Helsinki, Finland., Han S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, South Korea., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, UK., Herder C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Horikoshi M; Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Howard AG; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hsueh W; Department of Internal Medicine, Diabetes and Metabolism Research Center, Ohio State University Wexner Medical Center, Columbus, OH, USA., Huang M; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.; Center for Global Cardiometabolic Health, Brown University, Providence, RI, USA., Huang W; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China., Hung YJ; Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Hwang MY; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Hwu CM; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Ingelsson M; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Islam MT; University of Chicago Research Bangladesh, Dhaka, Bangladesh., Isono M; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Jang HM; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Jasmine F; Institute for Population and Precision Health (IPPH), Biological Sciences Division, University of Chicago, Chicago, IL, USA., Jiang G; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Chinese University of Hong Kong, Hong Kong, China., Jonas JB; Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland., Jørgensen T; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Medicine, Aalborg University, Aalborg, Denmark., Kamanu FK; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kandeel FR; Department of Clinical Diabetes, Endocrinology and Metabolism, Department of Translational Research and Cellular Therapeutics, City of Hope, Duarte, CA, USA., Kasturiratne A; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Geriatric and General Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan., Kaur V; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Keaton JM; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA., Kho AN; Division of General Internal Medicine and Geriatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Health Information Partnerships, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Kibriya MG; Institute for Population and Precision Health (IPPH), Biological Sciences Division, University of Chicago, Chicago, IL, USA., Kim DH; Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea., Kronenberg F; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Läll K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Lange LA; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Lee KM; VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Lee MS; Soochunhyang Institute of Medi-bio Science and Division of Endocrinology, Department of Internal Medicine, Soochunhyang University College of Medicine, Cheonan, South Korea.; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Lee NR; USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines., Leong A; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China., Li Y; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Ligthart S; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Lindgren CM; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Locke AE; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA.; Department of Medicine, Division of Genomics and Bioinformatics, Washington University School of Medicine, St Louis, MO, USA.; Regeneron Genetics Center, Tarrytown, NY, USA., Louie T; Department of Biostatistics, University of Washington, Seattle, WA, USA., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Luk AO; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Chinese University of Hong Kong, Hong Kong, China., Luo X; Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Lv J; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China., Lynch JA; VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway., Maeda S; Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Nishihara, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Nishihara, Japan., Mamakou V; Dromokaiteio Psychiatric Hospital, National and Kapodistrian University of Athens, Athens, Greece., Mansuri SR; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Matsuda K; Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, University of Tokyo, Tokyo, Japan., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technical University Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Melander O; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mo H; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Morris AD; Usher Institute to the Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Moura FA; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Nadler JL; Department of Medicine and Pharmacology, New York Medical College, Valhalla, NY, USA., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International, Glen Echo, MD, USA.; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA., Nayak U; Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Ntalla I; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University, Suita, Japan., Orozco L; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Patel SR; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Patil S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Pei P; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China., Pereira MA; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Peters A; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität München, Munich, Germany., Pirie FJ; Department of Diabetes and Endocrinology, Nelson R. Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa., Polikowsky HG; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Porneala B; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Prasad G; Academy of Scientific and Innovative Research, CSIR-Human Resource Development Campus, Ghaziabad, India.; Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Reiner AP; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Roden M; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Rohde R; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Roll K; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Sandow K; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Sankareswaran A; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India., Sattar N; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK., Schönherr S; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria., Shahriar M; Institute for Population and Precision Health (IPPH), Biological Sciences Division, University of Chicago, Chicago, IL, USA., Shen B; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Shi J; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai, China., Shin DM; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Shojima N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., So WY; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, Chinese University of Hong Kong, Hong Kong, China., Stančáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Steinthorsdottir V; deCODE Genetics, Amgen, Reykjavik, Iceland., Stilp AM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.; Institute for Medical Biostatistics, Epidemiology, and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Chair of Genetic Epidemiology, Institute of Medical Information Processing, Biometry, and Epidemiology, Faculty of Medicine, Ludwig-Maximilians-Universität München, Munich, Germany., Taylor KD; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Thorand B; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Thorsteinsdottir U; deCODE Genetics, Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tomlinson B; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China.; Faculty of Medicine, Macau University of Science and Technology, Macau, China., Tran TC; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Tsai FJ; Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung, Taiwan., Tuomilehto J; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.; National School of Public Health, Madrid, Spain.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Tusie-Luna T; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Departamento de Medicina Genómica y Toxiología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico., Udler MS; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Valladares-Salgado A; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., van Klinken JB; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Chemistry, Laboratory of Genetic Metabolic Disease, Amsterdam University Medical Center, Amsterdam, The Netherlands., Varma R; Southern California Eye Institute, CHA Hollywood Presbyterian Hospital, Los Angeles, CA, USA., Wacher-Rodarte N; Unidad de Investigación Médica en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Wheeler E; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., van Dijk KW; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands., Witte DR; Department of Public Health, Aarhus University, Aarhus, Denmark.; Danish Diabetes Academy, Odense, Denmark., Yajnik CS; Diabetology Research Centre, King Edward Memorial Hospital and Research Centre, Pune, India., Yamamoto K; Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan., Yamamoto K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan., Yoon K; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Yu C; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Yusuf S; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Ontario, Canada., Zawistowski M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Zhang L; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Zheng W; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Raffel LJ; Department of Pediatrics, Division of Genetic and Genomic Medicine, UCI Irvine School of Medicine, Irvine, CA, USA., Igase M; Department of Anti-Aging Medicine, Ehime University Graduate School of Medicine, Touon, Japan., Ipp E; Department of Medicine, Division of Endocrinology and Metabolism, Lundquist Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, South Korea., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Province MA; Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA., Fornage M; Institute of Molecular Medicine, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Hanis CL; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Ingelsson E; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Wang YX; Beijing Institute of Ophthalmology, Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Becker DM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA., Yokota M; Kurume University School of Medicine, Kurume, Japan., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Engert JC; Department of Medicine, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Bonnefond A; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital, Lille, France.; University of Lille, Lille, France.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Froguel P; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital, Lille, France.; University of Lille, Lille, France.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Wilson JG; Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Sheu WHH; School of Medicine, National Defense Medical Center, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Hayes MG; Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Anthropology, Northwestern University, Evanston, IL, USA., Ma RCW; Department of Medicine and Therapeutics, Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, Chinese University of Hong Kong, Hong Kong, China., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Tuomi T; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Folkhalsan Research Center, Helsinki, Finland.; Department of Endocrinology, Helsinki University Hospital, Helsinki, Finland., Chandak GR; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India.; Science and Engineering Research Board (SERB), Department of Science and Technology, Ministry of Science and Technology, Government of India, New Delhi, India., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Bharadwaj D; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India., Paré G; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Sale MM; Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Ahsan H; Institute for Population and Precision Health (IPPH), Biological Sciences Division, University of Chicago, Chicago, IL, USA., Motala AA; Department of Diabetes and Endocrinology, Nelson R. Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa., Shu XO; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Park KS; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Cruz M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Chen YI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., McKean-Cowdin R; Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA., Grallert H; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Ghanbari M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada., Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Köttgen A; Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Koh WP; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore.; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, University of Dundee, Dundee, UK., Kooner JS; Department of Cardiology, Ealing Hospital, London NorthWest Healthcare NHS Trust, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Kooperberg C; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Liu S; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.; Center for Global Cardiometabolic Health, Brown University, Providence, RI, USA.; Department of Medicine, Brown University Alpert School of Medicine, Providence, RI, USA., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Saleheen D; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Lee J; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Kim BJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Stefansson K; deCODE Genetics, Amgen, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Ahlqvist E; Lund University Diabetes Centre, Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden., Goodarzi MO; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité-Universitätsmedizin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Haiman CA; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Loos RJF; Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai, New York, NY, USA., Florez JC; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Rader DJ; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Division of Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Ritchie MD; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Center for Precision Medicine, University of Pennsylvania - Perelman School of Medicine, Philadelphia, PA, USA.; Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Zöllner S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Marston NA; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Ruff CT; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., van Heel DA; Blizard Institute, Queen Mary University of London, London, UK., Finer S; Institute for Population Health Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Denny JC; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; All of Us Research Program, National Institutes of Health, Bethesda, MD, USA., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.; Toranomon Hospital, Tokyo, Japan., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London NorthWest Healthcare NHS Trust, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Below JE; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Tsao PS; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Chang KM; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Genentech, South San Francisco, CA, USA., Meigs JB; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Spracklen CN; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA., Mercader JM; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Rotter JI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Vujkovic M; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Voight BF; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA. bvoight28@gmail.com.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. bvoight28@gmail.com.; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. bvoight28@gmail.com.; Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. bvoight28@gmail.com., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK. andrew.morris-5@manchester.ac.uk.; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. andrew.morris-5@manchester.ac.uk.; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. andrew.morris-5@manchester.ac.uk., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. eleftheria.zeggini@helmholtz-munich.de.; TUM School of Medicine and Health, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany. eleftheria.zeggini@helmholtz-munich.de.

مؤلفون مشاركون: VA Million Veteran Program

المصدر: Nature [Nature] 2024 Mar; Vol. 627 (8003), pp. 347-357. Date of Electronic Publication: 2024 Feb 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/classification , Diabetes Mellitus, Type 2*/complications , Diabetes Mellitus, Type 2*/genetics , Diabetes Mellitus, Type 2*/pathology , Diabetes Mellitus, Type 2*/physiopathology , Disease Progression* , Genetic Predisposition to Disease*/genetics , Genome-Wide Association Study*, Humans ; Adipocytes/metabolism ; Chromatin/genetics ; Chromatin/metabolism ; Coronary Artery Disease/complications ; Coronary Artery Disease/genetics ; Diabetic Nephropathies/complications ; Diabetic Nephropathies/genetics ; Endothelial Cells/metabolism ; Enteroendocrine Cells ; Epigenomics ; Islets of Langerhans/metabolism ; Multifactorial Inheritance/genetics ; Peripheral Arterial Disease/complications ; Peripheral Arterial Disease/genetics ; Single-Cell Analysis

المؤلفون: Sleiman PM; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Qu HQ; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Connolly JJ; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Mentch F; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Pereira A; Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.; Centro de Pesquisas Clínicas e Epidemiológicas, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil., Lotufo PA; Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.; Centro de Pesquisas Clínicas e Epidemiológicas, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil., Tollman S; MRC/Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Choudhury A; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Ramsay M; Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Kato N; National Center for Global Health and Medicine, Tokyo, Japan., Ozaki K; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan., Mitsumori R; Medical Genome Center, Research Institute, National Center for Geriatrics and Gerontology (NCGG), Obu, Japan., Jeon JP; Korea Biobank Project, Korea National Institute of Health, Osong, South Korea., Hong CH; Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea., Son SJ; Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea., Roh HW; Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea., Lee DG; Department of Psychiatry, Ajou University School of Medicine, Suwon, South Korea.; Department of Biostatistics, Epidemiology and Informatics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Mukadam N; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK., Foote IF; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.; Genes & Health, Blizard Institute, Queen Mary University of London, London, UK., Marshall CR; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.; Genes & Health, Blizard Institute, Queen Mary University of London, London, UK., Butterworth A; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Prins BP; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Glessner JT; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Hakonarson H; The Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Department of Pediatrics, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.; Division of Human Genetics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Division of Pulmonary Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.

مؤلفون مشاركون: Davos Alzheimer Collaborative and IHCC consortium

المصدر: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Dec; Vol. 19 (12), pp. 5765-5772. Date of Electronic Publication: 2023 Jul 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons, Ltd Country of Publication: United States NLM ID: 101231978 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-5279 (Electronic) Linking ISSN: 15525260 NLM ISO Abbreviation: Alzheimers Dement Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease*/genetics , Alzheimer Disease*/epidemiology, Humans ; Female ; Genome-Wide Association Study ; Proteomics ; Genomics ; Risk Assessment

المؤلفون: Dhindsa RS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, US. ryan.dhindsa@astrazeneca.com., Burren OS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Sun BB; Translational Sciences, Research & Development, Biogen Inc., Cambridge, MA, US., Prins BP; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Matelska D; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wheeler E; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Mitchell J; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Oerton E; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Hristova VA; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, US., Smith KR; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Carss K; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wasilewski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Harper AR; Clinical Development, Research and Early Development, Respiratory and Immunology (R&I), BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Paul DS; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Fabre MA; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Runz H; Translational Sciences, Research & Development, Biogen Inc., Cambridge, MA, US., Viollet C; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Challis B; Translational Science and Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Platt A; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Vitsios D; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Ashley EA; Division of Cardiology, Department of Medicine, Stanford University, Palo Alto, CA, USA., Whelan CD; Translational Sciences, Research & Development, Biogen Inc., Cambridge, MA, US., Pangalos MN; BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Wang Q; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, US., Petrovski S; Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. slav.petrovski@astrazeneca.com.; Department of Medicine, Austin Health, University of Melbourne, Melbourne, Victoria, Australia. slav.petrovski@astrazeneca.com.

مؤلفون مشاركون: AstraZeneca Genomics Initiative

المصدر: Nature [Nature] 2023 Oct; Vol. 622 (7982), pp. 339-347. Date of Electronic Publication: 2023 Oct 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Biological Specimen Banks* , Blood Proteins*/analysis , Blood Proteins*/genetics , Genetic Association Studies* , Genomics* , Proteomics*, Humans ; Alleles ; Biomarkers/blood ; Databases, Factual ; Exome/genetics ; Hematopoiesis ; Mutation ; Plasma/chemistry ; United Kingdom

المؤلفون: Suzuki K; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Hatzikotoulas K; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Southam L; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Taylor HJ; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Yin X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing City, China., Lorenz KM; Corporal Michael J Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Mandla R; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Huerta-Chagoya A; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Rayner NW; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Bocher O; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Arruda ALSV; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Sonehara K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Namba S; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan., Lee SSK; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Petty LE; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Schroeder P; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Vanderwerff B; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Kals M; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Bragg F; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hosptial, London NorthWest Healthcare NHS Trust, Middlesex, UK., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, South Korea., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Nano J; Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany., Lamri A; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Moon S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, South Korea., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Cook JP; Department of Health Data Science, University of Liverpool, Liverpool, UK., Lee JJ; Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA., Pan I; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA., Taliun D; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Parra EJ; Department of Anthropology, University of Toronto at Mississsauga, Mississauga, ON, Canada., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hai Y; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Thorleifsson G; deCODE Genetics, Amgen Inc., Reykjavik, Iceland., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sofer T; Department of Biostatistics, Harvard University, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard University, Boston, MA, USA., Wuttke M; Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Sarnowski C; Department of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Gieger C; Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Nousome D; Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands., Kwak SH; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea., Long J; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Sun M; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Tong L; Institute for Population and Precision Health (IPPH), Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Chen WM; Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Nongmaithem SS; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India., Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands., Lim VJY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Tam CHT; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China., Joo YY; Institute of Data Science, Korea University, Seoul, South Korea.; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Prins BP; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Nicolas A; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chen G; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Kabagambe E; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Academics, Ochsner Health, New Orleans, LA, USA., An P; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Xiang AH; Department of Research and Evaluation, Division of Biostatistics Research, Kaiser Permanente of Southern California, Pasadena, CA, USA., Choi HS; Department of Biomedical Science, Hallym University, Chuncheon, South Korea., Cade BE; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Tan J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Broadaway KA; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Williamson A; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Metabolic Research Laboratories, Wellcome Trust-Medical Research Council Institute of Metabolic Science, Department of Clinical Biochemistry, University of Cambridge, Cambridge, UK., Kamali Z; Department of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.; Department of Bioinformatics, Isfahan University of Medical Sciences, Isfahan, Iran., Cui J; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Adeyemo A; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Aguilar-Salinas CA; Unidad de Investigación en Enfermedades Metabólicas and Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Ahluwalia TS; Steno Diabetes Center Copenhagen, Herlev, Denmark.; The Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark., Anand SS; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada., Bertoni A; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brandslund I; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark., Buchanan TA; Department of Medicine, Division of Endocrinology and Diabetes, Keck School of Medicine of USC, Los Angeles, CA, USA., Burant CF; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.; National Institute for Health and Care Research (NIHR) Blood and Transplant Unit (BTRU) in Donor Health and Behaviour, Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Canouil M; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital, Lille, France.; University of Lille, Lille, France., Chan JCN; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Chang LC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chee ML; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Chen J; Exeter Centre of Excellence in Diabetes (ExCEeD), Exeter Medical School, University of Exeter, Exeter, UK.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Chen SH; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA., Chen YT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Chuang LM; Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan., Cushman M; Department of Medicine, University of Vermont, Colchester, VT, USA., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Heart and Lung Research Institute, University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.; British Heart Foundation Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.; National Institute for Health and Care Research (NIHR) Blood and Transplant Unit (BTRU) in Donor Health and Behaviour, Heart and Lung Research Institute, University of Cambridge, Cambridge, UK., Das SK; Section on Endocrinology and Metabolism, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Dedoussis G; Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece., Dimitrov L; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA., Doumatey AP; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Du S; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Duan Q; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Eckardt KU; Department of Nephrology and Medical Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.; Department of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Emery LS; Department of Biostatistics, University of Washington, Seattle, WA, USA., Evans DS; California Pacific Medical Center Research Institute, San Francisco, CA, USA., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Fischer K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia., Floyd JS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Franco OH; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Freedman BI; Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Genter P; Department of Medicine, Division of Endocrinology and Metabolism, Lundquist Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Gerstein HC; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada., Giedraitis V; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., González-Villalpando C; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Mexico City, Mexico., González-Villalpando ME; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Mexico City, Mexico., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gross M; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Guare LA; Genomics and Computational Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Hackinger S; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK., Han S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, South Korea., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, UK., Herder C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Dusseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Horikoshi M; Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan., Howard AG; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hsueh W; Department of Internal Medicine, Diabetes and Metabolism Research Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA., Huang M; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.; Center for Global Cardiometabolic Health, Brown University, Providence, RI, USA., Huang W; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Shanghai, China., Hung YJ; Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Hwang MY; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Hwu CM; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan., Ikram MA; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Ingelsson M; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Islam MT; University of Chicago Research Bangladesh, Dhaka, Bangladesh., Isono M; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Jang HM; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Jasmine F; Institute for Population and Precision Health (IPPH), Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Jiang G; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China., Jonas JB; Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland., Jørgensen T; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Medicine, Aalborg University, Aalborg, Denmark., Kandeel FR; Department of Clinical Diabetes, Endocrinology and Metabolism, Department of Translational Research and Cellular Therapeutics, City of Hope, Duarte, CA, USA., Kasturiratne A; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Geriatric and General Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan., Kaur V; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Keaton JM; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA., Kho AN; Division of General Internal Medicine and Geriatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Health Information Partnerships, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Kibriya MG; Institute for Population and Precision Health (IPPH), Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Kim DH; Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea., Kronenberg F; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Läll K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Lange LA; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Lee KM; VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Lee MS; Severance Biomedical Science Institute and Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Lee NR; USC-Office of Population Studies Foundation Inc., University of San Carlos, Cebu City, Philippines., Leong A; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Li L; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China., Li Y; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Lithgart S; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Lindgren CM; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Big Data Institute, Li Ka Shing Centre For Health Information and Discovery, University of Oxford, Oxford, UK., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Locke AE; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA.; Department of Medicine, Division of Genomics and Bioinformatics, Washington University School of Medicine, St Louis, MO, USA.; Present address: Regeneron Genetics Center, Tarrytown, NY, USA., Louie T; Department of Biostatistics, University of Washington, Seattle, WA, USA., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Luk AO; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China., Luo X; Department of Biostatistics and Data Science, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Lv J; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China., Lynch JA; VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway., Maeda S; Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Okinawa, Japan., Mamakou V; Dromokaiteio Psychiatric Hospital, National and Kapodistrian University of Athens, Athens, Greece., Mansuri SR; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India., Matsuda K; Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technical University Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Mo H; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Morris AD; The Usher Institute to the Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Nadler JL; Department of Medicine and Pharmacology, New York Medical College, Valhalla, NY, USA., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International LLC, Glen Echo, MD, USA.; Center for Alzheimer's and Related Dementias, National Institutes of Health, Bethesda, MD, USA., Nayak U; Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Ntalla I; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Kanagawa, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan., Orozco L; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Patel SR; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Patil S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Pei P; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China., Pereira MA; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Peters A; Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany.; Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians Universität München, Munich, Germany., Pirie FJ; Department of Diabetes and Endocrinology, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa., Polikowsky HG; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Porneala B; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Prasad G; Academy of Scientific and Innovative Research, CSIR-Human Resource Development Campus, Ghaziabad, India.; Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Reiner AP; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Roden M; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Dusseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Rohde R; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Roll K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Sandow K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Sankareswaran A; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Schönherr S; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria., Shahriar M; Institute for Population and Precision Health (IPPH), Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Shen B; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Shi J; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Shanghai, China., Shin DM; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Shojima N; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., So WY; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Stančáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Steinthorsdottir V; deCODE Genetics, Amgen Inc., Reykjavik, Iceland., Stilp AM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Strauch K; Institute of Genetic Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.; Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany.; Chair of Genetic Epidemiology, Institute of Medical Information Processing, Biometry, and Epidemiology, Faculty of Medicine, Ludwig Maximilians Universität München, Munich, Germany., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Thorand B; Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany., Thorsteinsdottir U; deCODE Genetics, Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Tomlinson B; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Faculty of Medicine, Macau University of Science and Technology, Macau, China., Tran TC; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Tsai FJ; Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung, Taiwan., Tuomilehto J; Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland, Finnish Institute for Health and Welfare, Helsinki, Finland.; National School of Public Health, Madrid, Spain.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Tusie-Luna T; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Departamento de Medicina Genómica y Toxiología Ambiental, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico., Udler MS; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Valladares-Salgado A; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., van Klinken JB; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Chemistry, Laboratory of Genetic Metabolic Disease, Amsterdam University Medical Center, Amsterdam, The Netherlands., Varma R; Southern California Eye Institute, CHA Hollywood Presbyterian Hospital, Los Angeles, CA, USA., Wacher-Rodarte N; Unidad de Investigación Médica en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Wheeler E; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., van Dijk KW; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands., Witte DR; Department of Public Health, Aarhus University, Aarhus, Denmark.; Danish Diabetes Academy, Odense, Denmark., Yajnik CS; Diabetology Research Centre, King Edward Memorial Hospital and Research Centre, Pune, India., Yamamoto K; Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan., Yamamoto K; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Suita, Japan.; Department of Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan., Yoon K; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Yu C; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.; Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Yusuf S; Department of Medicine, McMaster University, Hamilton, ON, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada., Zawistowski M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Zhang L; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Zheng W; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Raffel LJ; Department of Pediatrics, Division of Genetic and Genomic Medicine, UCI Irvine School of Medicine, Irvine, CA, USA., Igase M; Department of Anti-Aging Medicine, Ehime University Graduate School of Medicine, Ehime, Japan., Ipp E; Department of Medicine, Division of Endocrinology and Metabolism, Lundquist Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Redline S; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, South Korea., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Province MA; Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA., Fornage M; Institute of Molecular Medicine, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA., Hanis CL; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, US., Ingelsson E; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Systems and Population Health, University of Washington, Seattle, WA, USA., Wang YX; Beijing Institute of Ophthalmology, Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Becker DM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA., Yokota M; Kurume University School of Medicine, Kurume, Japan., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Engert JC; Department of Medicine, McGill University, Montreal, QC, Canada.; Department of Human Genetics, McGill University, Montreal, QC, Canada., Bonnefond A; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital, Lille, France.; University of Lille, Lille, France.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Froguel P; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, Lille University Hospital, Lille, France.; University of Lille, Lille, France.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Sheu WHH; School of Medicine, National Defense Medical Center, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Hayes MG; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Anthropology, Northwestern University, Evanston, IL, USA., Ma RCW; Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, The Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Tuomi T; Department of Endocrinology, Helsinki University Hospital, Helsinki, Finland.; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Folkhalsan Research Center, Helsinki, Finland.; Lund University Diabetes Centre, Malmö, Sweden., Chandak GR; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Bharadwaj D; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India., Paré G; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, ON, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada., Sale MM; Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA.; Deceased., Ahsan H; Institute for Population and Precision Health (IPPH), Biological Sciences Division, The University of Chicago, Chicago, IL, USA., Motala AA; Department of Diabetes and Endocrinology, Nelson R Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa., Shu XO; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Park KS; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.; Netherlands Heart Institute, Utrecht, The Netherlands., Cruz M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., McKean-Cowdin R; Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA., Grallert H; Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Neuherberg, Germany.; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Ghanbari M; Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada., Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Köttgen A; Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Koh WP; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore.; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, University of Dundee, Dundee, UK., Kooner JS; Department of Cardiology, Ealing Hosptial, London NorthWest Healthcare NHS Trust, Middlesex, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Kooperberg C; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Liu S; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.; Center for Global Cardiometabolic Health, Brown University, Providence, RI, USA.; Department of Medicine, Brown University Alpert School of Medicine, Providence, RI, USA., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Saleheen D; Department of Medicine, Columbia University Irving Medical Center, New York, NY, USA.; Department of Cardiology, Columbia University Irving Medical Center, New York, NY, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Wareham NJ; The Usher Institute to the Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Lee J; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Kim BJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Korea., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Stefansson K; deCODE Genetics, Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Goodarzi MO; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge School of Clinical Medicine, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité Universitätsmedizin, Berlin, Germany.; Precision Healthcare University Research Institute, Queen Mary University of London, London, UK., Haiman CA; Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai, New York, NY, USA., Florez JC; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Rader DJ; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Division of Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Ritchie MD; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Center for Precision Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute for Biomedical Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Zöllner S; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Denny JC; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; All of Us Research Program, National Institutes of Health, Bethesda, MD, USA., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.; Toranomon Hospital, Tokyo, Japan., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hosptial, London NorthWest Healthcare NHS Trust, Middlesex, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore., Ng MCY; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Below JE; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Tsao PS; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.; VA Palo Alto Health Care System, Palo Alto, CA, USA.; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA., Chang KM; Corporal Michael J Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hosptial, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Present address: Genentech, South San Francisco, CA, USA., Meigs JB; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Present address: Genentech, South San Francisco, CA, USA., Spracklen CN; Department of Biostatistics and Epidemiology, University of Massachusetts Amherst, Amherst, MA, USA., Mercader JM; Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Vujkovic M; Corporal Michael J Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Division of Epidemiology, Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Voight BF; Corporal Michael J Crescenz VA Medical Center, Philadelphia, PA, USA.; Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Institute for Translational Medicine and Therapeutics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester, Manchester, UK.; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Zeggini E; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany.

مؤلفون مشاركون: VA Million Veteran Program, AMED GRIFIN Diabetes Initiative Japan, Biobank Japan Project, Penn Medicine BioBank, Regeneron Genetics Center, eMERGE Consortium, International Consortium for Blood Pressure (ICBP), Meta-Analyses of Glucose and Insulin-Related Traits Consortium (MAGIC)

المصدر: MedRxiv : the preprint server for health sciences [medRxiv] 2023 Mar 31. Date of Electronic Publication: 2023 Mar 31.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101767986 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: medRxiv Subsets: PubMed not MEDLINE

المؤلفون: Mahajan A; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. mahajan.anubha@gene.com.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. mahajan.anubha@gene.com.; Genentech, South San Francisco, CA, USA. mahajan.anubha@gene.com., Spracklen CN; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Epidemiology and Biostatistics, University of Massachusetts Amherst, Amherst, MA, USA., Zhang W; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK., Ng MCY; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Petty LE; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Kitajima H; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; The Advanced Research Center for Innovations in Next-Generation Medicine (INGEM), Tohoku University, Sendai, Japan.; Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.; Cancer Center, Tohoku University Hospital, Tohoku University, Sendai, Japan., Yu GZ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Rüeger S; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Speidel L; Genetics Institute, University College London, London, UK.; Francis Crick Institute, London, UK., Kim YJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Republic of Korea., Horikoshi M; Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Mercader JM; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Taliun D; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Moon S; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Republic of Korea., Kwak SH; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea., Robertson NR; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Rayner NW; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Loh M; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Translational Laboratory in Genetic Medicine (TLGM), Agency for Science, Technology and Research (A*STAR) and National University of Singapore (NUS), Singapore, Singapore., Kim BJ; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Republic of Korea., Chiou J; Biomedical Sciences Graduate Studies Program, University of California San Diego, La Jolla, CA, USA.; Internal Medicine Research Unit, Pfizer Worldwide Research, Cambridge, MA, USA., Miguel-Escalada I; Regulatory Genomics and Diabetes, Centre for Genomic Regulation, the Barcelona Institute of Science and Technology, Barcelona, Spain.; Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Madrid, Spain., Della Briotta Parolo P; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland., Lin K; Nuffield Department of Population Health, University of Oxford, Oxford, UK., Bragg F; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Preuss MH; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Takeuchi F; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Nano J; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Lamri A; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada., Nakatochi M; Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan., Scott RA; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Lee JJ; Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA., Huerta-Chagoya A; Consejo Nacional de Ciencia y Tecnología (CONACYT), Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Departamento de Medicina Genómica y Toxicologí, a AmbientalInstituto de Investigaciones Biomédicas, UNAM, Ciudad de Mexico, Mexico, Mexico., Graff M; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Chai JF; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Yao J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Bielak LF; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Tabara Y; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Hai Y; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Steinthorsdottir V; deCODE Genetics, Amgen Inc., Reykjavik, Iceland., Cook JP; Department of Health Data Science, University of Liverpool, Liverpool, UK., Kals M; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Schmidt EM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Pan I; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA., Sofer T; Department of Biostatistics, Harvard University, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard University, Boston, MA, USA., Wuttke M; Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Sarnowski C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.; Department of Epidemiology, Human Genetics, and Environmental Sciences, the University of Texas Health Science Center at Houston, School of Public Health, Houston, TX, USA., Gieger C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Nousome D; Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA., Trompet S; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands., Long J; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Sun M; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Tong L; Institute for Population and Precision Health, the University of Chicago, Chicago, IL, USA., Chen WM; Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Ahmad M; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India., Noordam R; Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands., Lim VJY; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Tam CHT; Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, the Chinese University of Hong Kong, Hong Kong, China., Joo YY; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Health and Biomedical Informatics, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Institute of Data Science, Korea University, Seoul, South Korea., Chen CH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Raffield LM; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Lecoeur C; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille, France.; University of Lille, Lille University Hospital, Lille, France., Prins BP; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK., Nicolas A; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA., Yanek LR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Chen G; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Jensen RA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Tajuddin S; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Kabagambe EK; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Division of Academics, Ochsner Health, New Orleans, LA, USA., An P; Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA., Xiang AH; Department of Research and Evaluation, Division of Biostatistics Research, Kaiser Permanente of Southern California, Pasadena, CA, USA., Choi HS; Department of Biomedical Science, Hallym University, Chuncheon, South Korea., Cade BE; Harvard Medical School, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Tan J; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Flanagan J; Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Health Data Science, University of Liverpool, Liverpool, UK., Abaitua F; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Vertex Pharmaceuticals Ltd, Oxford, UK., Adair LS; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Adeyemo A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Aguilar-Salinas CA; Unidad de Investigación en Enfermedades Metabólicas and Departamento de Endocrinología y Metabolismo, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico., Akiyama M; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan., Anand SS; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Bertoni A; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA., Bian Z; Chinese Academy of Medical Sciences, Beijing, China., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brandslund I; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.; Department of Clinical Biochemistry, Vejle Hospital, Vejle, Denmark., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Brummett CM; Department of Anesthesiology, University of Michigan Medical School, Ann Arbor, MI, USA., Buchanan TA; Department of Medicine, Division of Endocrinology and Diabetes, Keck School of Medicine of USC, Los Angeles, CA, USA., Canouil M; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille, France.; University of Lille, Lille University Hospital, Lille, France., Chan JCN; Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, the Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, the Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, the Chinese University of Hong Kong, Hong Kong, China., Chang LC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chee ML; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Chen J; Wellcome Sanger Institute, Hinxton, UK.; Exeter Centre of Excellence in Diabetes (ExCEeD), Exeter Medical School, University of Exeter, Exeter, UK., Chen SH; Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, USA., Chen YT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Chen Z; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Chuang LM; Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan., Cushman M; Department of Medicine, University of Vermont, Colchester, VT, USA., Das SK; Section on Endocrinology and Metabolism, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., de Silva HJ; Department of Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Dedoussis G; Department of Nutrition and Dietetics, Harokopio University of Athens, Athens, Greece., Dimitrov L; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA., Doumatey AP; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Du S; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Duan Q; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Eckardt KU; Department of Nephrology and Medical Intensive Care Medicine, Charité Universitätsmedizin Berlin, Berlin, Germany.; Department of Nephrology and Hypertension, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Emery LS; Department of Biostatistics, University of Washington, Seattle, WA, USA., Evans DS; California Pacific Medical Center Research Institute, San Francisco, CA, USA., Evans MK; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Fischer K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Floyd JS; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Fornage M; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA., Franco OH; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Frayling TM; Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK., Freedman BI; Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA., Fuchsberger C; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck, Bolzano, Italy., Genter P; Department of Medicine, Division of Endocrinology and Metabolism, Lundquist Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Gerstein HC; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Giedraitis V; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., González-Villalpando C; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Mexico City, Mexico., González-Villalpando ME; Centro de Estudios en Diabetes, Unidad de Investigacion en Diabetes y Riesgo Cardiovascular, Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Mexico City, Mexico., Goodarzi MO; Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Gordon-Larsen P; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gorkin D; Center for Epigenomics, University of California San Diego, La Jolla, CA, USA., Gross M; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Guo Y; Chinese Academy of Medical Sciences, Beijing, China., Hackinger S; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK., Han S; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Republic of Korea., Hattersley AT; University of Exeter Medical School, University of Exeter, Exeter, UK., Herder C; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Howard AG; Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Biostatistics, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Hsueh W; Department of Internal Medicine, Diabetes and Metabolism Research Center, the Ohio State University Wexner Medical Center, Columbus, OH, USA., Huang M; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.; Center for Global Cardiometabolic Health, Brown University, Providence, RI, USA., Huang W; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Shanghai, China., Hung YJ; Division of Endocrine and Metabolism, Tri-Service General Hospital Songshan Branch, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan., Hwang MY; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Republic of Korea., Hwu CM; Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan., Ichihara S; Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan., Ikram MA; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Ingelsson M; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Islam MT; University of Chicago Research Bangladesh, Dhaka, Bangladesh., Isono M; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Jang HM; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Republic of Korea., Jasmine F; Institute for Population and Precision Health, the University of Chicago, Chicago, IL, USA., Jiang G; Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, the Chinese University of Hong Kong, Hong Kong, China., Jonas JB; Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland., Jørgensen ME; Steno Diabetes Center Copenhagen, Gentofte, Denmark.; National Institute of Public Health, Southern Denmark University, Copenhagen, Denmark., Jørgensen T; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Faculty of Medicine, Aalborg University, Aalborg, Denmark., Kamatani Y; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory of Complex Trait Genomics, Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, the University of Tokyo, Tokyo, Japan., Kandeel FR; Department of Clinical Diabetes, Endocrinology & Metabolism, Department of Translational Research and Cellular Therapeutics, City of Hope, Duarte, CA, USA., Kasturiratne A; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., Katsuya T; Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Geriatric and General Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan., Kaur V; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Kawaguchi T; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Keaton JM; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Kho AN; Division of General Internal Medicine and Geriatrics, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Health Information Partnerships, Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Khor CC; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore., Kibriya MG; Institute for Population and Precision Health, the University of Chicago, Chicago, IL, USA., Kim DH; Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, South Korea., Kohara K; Department of Regional Resource Management, Ehime University Faculty of Collaborative Regional Innovation, Ehime, Japan.; Ibusuki Kozenkai Hospital, Ibusuki, Japan., Kriebel J; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Kronenberg F; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Kuusisto J; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Läll K; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia., Lange LA; Department of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA., Lee MS; Severance Biomedical Science Institute and Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.; Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Lee NR; USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines., Leong A; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Li L; Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China., Li Y; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Ligthart S; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands., Lindgren CM; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Program in Medical & Population Genetics, Broad Institute, Cambridge, MA, USA.; Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Liu CT; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Liu J; Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Locke AE; McDonnell Genome Institute, Washington University School of Medicine, St Louis, MO, USA.; Department of Medicine, Division of Genomics and Bioinformatics, Washington University School of Medicine, St Louis, MO, USA.; Regeneron Genetics Center, Tarrytown, NY, USA., Louie T; Department of Biostatistics, University of Washington, Seattle, WA, USA., Luan J; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Luk AO; Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, the Chinese University of Hong Kong, Hong Kong, China., Luo X; Department of Biostatistics and Data Science, University of Texas Health Science Center at Houston, Houston, TX, USA., Lv J; Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China., Lyssenko V; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Department of Clinical Science, Center for Diabetes Research, University of Bergen, Bergen, Norway., Mamakou V; Dromokaiteio Psychiatric Hospital, National and Kapodistrian University of Athens, Athens, Greece., Mani KR; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India., Meitinger T; Institute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Institute of Human Genetics, Technical University of Munich, Munich, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Metspalu A; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Morris AD; The Usher Institute to the Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Nadkarni GN; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Digital Health Center, Digital Engineering Faculty of Hasso Plattner Institue and University Potsdam, Potsdam, Germany.; The Division of Data Driven and Digital Medicine (D3M), Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Nadler JL; Department of Medicine and Pharmacology, New York Medical College, Valhalla, NY, USA., Nalls MA; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.; Data Tecnica International LLC, Glen Echo, MD, USA.; Center for Alzheimer's and Related Dementias, National Institutes of Health, Baltimore, MD, USA., Nayak U; Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Nongmaithem SS; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India., Ntalla I; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Okada Y; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI-IFReC), Osaka University, Osaka, Japan.; Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., Orozco L; Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Patel SR; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Pereira MA; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Peters A; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; German Centre for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany., Pirie FJ; Department of Diabetes and Endocrinology, Nelson R. Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa., Porneala B; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Prasad G; Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre Campus, Ghaziabad, India.; Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology, New Delhi, India., Preissl S; Center for Epigenomics, University of California San Diego, La Jolla, CA, USA., Rasmussen-Torvik LJ; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA., Reiner AP; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Roden M; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany., Rohde R; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Roll K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Sabanayagam C; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Sander M; Department of Pediatrics, Pediatric Diabetes Research Center, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA.; Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA., Sandow K; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Sattar N; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Schönherr S; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Schurmann C; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Digital Health Center, Digital Engineering Faculty of Hasso Plattner Institue and University Potsdam, Potsdam, Germany.; Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Shahriar M; Institute for Population and Precision Health, the University of Chicago, Chicago, IL, USA.; Institute for Population and Precision Health (IPPH), Biological Sciences Division, the University of Chicago, Chicago, IL, USA., Shi J; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai (CHGC) and Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Shanghai, China., Shin DM; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Republic of Korea., Shriner D; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Smith JA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., So WY; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, the Chinese University of Hong Kong, Hong Kong, China., Stančáková A; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Stilp AM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Strauch K; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany.; Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center, Johannes Gutenberg University, Mainz, Germany., Suzuki K; Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan., Takahashi A; Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Genomic Medicine, National Cerebral and Cardiovascular Center, Osaka, Japan., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Thorand B; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Thorleifsson G; deCODE Genetics, Amgen Inc., Reykjavik, Iceland., Thorsteinsdottir U; deCODE Genetics, Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Reykjavik, Reykjavik, Iceland., Tomlinson B; Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, China.; Faculty of Medicine, Macau University of Science and Technology, Macau, China., Torres JM; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK., Tsai FJ; Department of Medical Genetics and Medical Research, China Medical University Hospital, Taichung, Taiwan., Tuomilehto J; Department of Health, Finnish Institute for Health and Welfare, Helsinki, Finland.; National School of Public Health, Madrid, Spain.; Department of Neuroscience and Preventive Medicine, Danube University Krems, Krems, Austria.; Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia., Tusie-Luna T; Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Departamento de Medicina Genómica y Toxiología, Ambiental Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico., Udler MS; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Valladares-Salgado A; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico., van Dam RM; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., van Klinken JB; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Clinical Chemistry, Laboratory of Genetic Metabolic Disease, Amsterdam University Medical Center, Amsterdam, the Netherlands., Varma R; Southern California Eye Institute, CHA Hollywood Presbyterian Medical Center, Los Angeles, CA, USA., Vujkovic M; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Wacher-Rodarte N; Unidad de Investigación Médica en Epidemiologia Clinica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico., Wheeler E; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Whitsel EA; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Wickremasinghe AR; Department of Public Health, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka., van Dijk KW; Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands., Witte DR; Department of Public Health, Aarhus University, Aarhus, Denmark.; Danish Diabetes Academy, Odense, Denmark., Yajnik CS; Diabetology Research Centre, King Edward Memorial Hospital and Research Centre, Pune, India., Yamamoto K; Department of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan., Yamauchi T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan., Yengo L; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Yoon K; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Republic of Korea., Yu C; Department of Epidemiology and Biostatistics, Peking University Health Science Centre, Peking University, Beijing, China., Yuan JM; Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Yusuf S; Department of Medicine, McMaster University, Hamilton, Ontario, Canada.; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada., Zhang L; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore., Zheng W; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Raffel LJ; Department of Pediatrics, Division of Genetic and Genomic Medicine, UCI Irvine School of Medicine, Irvine, CA, USA., Igase M; Department of Anti-Aging Medicine, Ehime University Graduate School of Medicine, Ehime, Japan., Ipp E; Department of Medicine, Division of Endocrinology and Metabolism, Lundquist Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA., Redline S; Harvard Medical School, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA.; Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Cho YS; Department of Biomedical Science, Hallym University, Chuncheon, South Korea., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Province MA; Division of Statistical Genomics, Washington University School of Medicine, St Louis, MO, USA., Hanis CL; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Peyser PA; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden., Zonderman AB; Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA., Wang YX; Beijing Institute of Ophthalmology, Ophthalmology and Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China., Rotimi CN; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Becker DM; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Matsuda F; Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan., Liu Y; Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Medicine, Division of Cardiology, Duke University School of Medicine, Durham, NC, USA., Zeggini E; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.; Institute of Translational Genomics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Technical University of Munich (TUM) and Klinikum Rechts der Isar, TUM School of Medicine, Munich, Germany., Yokota M; Kurume University School of Medicine, Kurume, Japan., Rich SS; Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Kooperberg C; Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Pankow JS; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Engert JC; Department of Medicine, McGill University, Montreal, Quebec, Canada.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., Froguel P; Inserm U1283, CNRS UMR 8199, European Genomic Institute for Diabetes, Institut Pasteur de Lille, Lille, France.; University of Lille, Lille University Hospital, Lille, France.; Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Sheu WHH; School of Medicine, National Defense Medical Center, Taipei, Taiwan.; School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.; Division of Endocrinology and Metabolism, Department of Medicine, Taichung Veterans General Hospital, Taichung, Taiwan., Kardia SLR; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA., Wu JY; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan., Hayes MG; Division of Endocrinology, Metabolism, and Molecular Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Center for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Department of Anthropology, Northwestern University, Evanston, IL, USA., Ma RCW; Department of Medicine and Therapeutics, the Chinese University of Hong Kong, Hong Kong, China.; Chinese University of Hong Kong-Shanghai Jiao Tong University Joint Research Centre in Diabetes Genomics and Precision Medicine, the Chinese University of Hong Kong, Hong Kong, China.; Hong Kong Institute of Diabetes and Obesity, the Chinese University of Hong Kong, Hong Kong, China.; Li Ka Shing Institute of Health Sciences, the Chinese University of Hong Kong, Hong Kong, China., Wong TY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Groop L; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Chandak GR; Genomic Research on Complex Diseases (GRC-Group), CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB), Hyderabad, India., Collins FS; Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA., Bharadwaj D; Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre Campus, Ghaziabad, India.; Systems Genomics Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India., Paré G; Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada.; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Sale MM; Department of Public Health Sciences and Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, VA, USA., Ahsan H; Institute for Population and Precision Health, the University of Chicago, Chicago, IL, USA., Motala AA; Department of Diabetes and Endocrinology, Nelson R. Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa., Shu XO; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Park KS; Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, South Korea., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Cruz M; Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, IMSS, Mexico City, Mexico., McKean-Cowdin R; Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA., Grallert H; German Center for Diabetes Research (DZD), Neuherberg, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Cheng CY; Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.; Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Digital Health Center, Digital Engineering Faculty of Hasso Plattner Institue and University Potsdam, Potsdam, Germany.; Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Dehghan A; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK., Tai ES; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.; Duke-NUS Medical School, Singapore, Singapore., Dupuis J; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Kato N; Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan., Laakso M; Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Köttgen A; Institute of Genetic Epidemiology, Department of Data Driven Medicine, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Koh WP; Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore.; Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore., Palmer CNA; Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, University of Dundee, Dundee, UK., Liu S; Department of Epidemiology, Brown University School of Public Health, Providence, RI, USA.; Center for Global Cardiometabolic Health, Brown University, Providence, RI, USA.; Department of Medicine, Brown University Alpert School of Medicine, Providence, RI, USA., Abecasis G; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Kooner JS; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; The Mindich Child Health and Development Institute, Ichan School of Medicine at Mount Sinai, New York, NY, USA., North KE; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Haiman CA; Department of Population and Public Health Sciences, Keck School of Medicine of USC, Los Angeles, CA, USA., Florez JC; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Saleheen D; Division of Translational Medicine and Human Genetics, University of Pennsylvania, Philadelphia, PA, USA.; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Mägi R; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia., Langenberg C; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK.; Computational Medicine, Berlin Institute of Health at Charité Universitätsmedizin, Berlin, Germany., Wareham NJ; MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Maeda S; Laboratory for Genomics of Diabetes and Metabolism, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.; Department of Advanced Genomic and Laboratory Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.; Division of Clinical Laboratory and Blood Transfusion, University of the Ryukyus Hospital, Okinawa, Japan., Kadowaki T; Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.; Toranomon Hospital, Tokyo, Japan., Lee J; Division of Genome Science, Department of Precision Medicine, National Institute of Health, Cheongju-si, Republic of Korea., Millwood IY; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Walters RG; Nuffield Department of Population Health, University of Oxford, Oxford, UK.; Medical Research Council Population Health Research Unit, University of Oxford, Oxford, UK., Stefansson K; deCODE Genetics, Amgen Inc., Reykjavik, Iceland.; Faculty of Medicine, University of Reykjavik, Reykjavik, Iceland., Myers SR; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Ferrer J; Regulatory Genomics and Diabetes, Centre for Genomic Regulation, the Barcelona Institute of Science and Technology, Barcelona, Spain.; Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas asociadas (CIBERDEM), Madrid, Spain.; Section of Genetics and Genomics, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Gaulton KJ; Department of Pediatrics, Pediatric Diabetes Research Center, University of California San Diego, La Jolla, CA, USA.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, USA., Meigs JB; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Division of General Internal Medicine, Massachusetts General Hospital, Boston, MA, USA., Mohlke KL; Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Gloyn AL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.; Division of Endocrinology, Department of Pediatrics, Stanford School of Medicine, Stanford University, Stanford, CA, USA., Bowden DW; Center for Genomics and Personalized Medicine Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.; Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA., Below JE; Vanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, Nashville, TN, USA., Chambers JC; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, London, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, Imperial College London, London, UK., Sim X; Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, the Lundquist Institute for Biomedical Innovation (formerly Los Angeles Biomedical Research Institute) at Harbor-UCLA Medical Center, Torrance, CA, USA., McCarthy MI; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. mccarthy.mark@gene.com.; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. mccarthy.mark@gene.com.; Oxford NIHR Biomedical Research Centre, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. mccarthy.mark@gene.com.; Genentech, South San Francisco, CA, USA. mccarthy.mark@gene.com., Morris AP; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. andrew.morris-5@manchester.ac.uk.; Department of Health Data Science, University of Liverpool, Liverpool, UK. andrew.morris-5@manchester.ac.uk.; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. andrew.morris-5@manchester.ac.uk.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK. andrew.morris-5@manchester.ac.uk.; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK. andrew.morris-5@manchester.ac.uk.

مؤلفون مشاركون: FinnGen, eMERGE Consortium

المصدر: Nature genetics [Nat Genet] 2022 May; Vol. 54 (5), pp. 560-572. Date of Electronic Publication: 2022 May 12.

نوع المنشور: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 2*/epidemiology , Genome-Wide Association Study*, Ethnicity ; Genetic Predisposition to Disease ; Humans ; Polymorphism, Single Nucleotide/genetics ; Risk Factors

المؤلفون: Surendran P; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Rutherford Fund Fellow, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Feofanova EV; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Lahrouchi N; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Amsterdam UMC, University of Amsterdam, Heart Center, Department of Clinical and Experimental Cardiology, Amsterdam Cardiovascular Sciences Amsterdam, Amsterdam, the Netherlands., Ntalla I; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Karthikeyan S; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Cook J; Department of Biostatistics, University of Liverpool, Liverpool, UK., Chen L; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Mifsud B; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; College of Health and Life Sciences, Hamad Bin Khalifa University, Doha, Qatar., Yao C; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Kraja AT; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Cartwright JH; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Hellwege JN; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA., Giri A; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.; Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA., Tragante V; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; deCODE genetics/Amgen, Inc, Reykjavik, Iceland., Thorleifsson G; deCODE genetics/Amgen, Inc, Reykjavik, Iceland., Liu DJ; Institute of Personalized Medicine, Penn State College of Medicine, Hershey, PA, USA., Prins BP; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Stewart ID; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Cabrera CP; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Eales JM; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Akbarov A; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK., Auer PL; Joseph J Zilber School of Public Health, University of Wisconsin, Milwaukee, WI, USA., Bielak LF; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Bis JC; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Braithwaite VS; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; MRC Nutrition and Bone Health Group, University of Cambridge, Cambridge, UK.; MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia., Brody JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA., Daw EW; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Warren HR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Drenos F; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK., Nielsen SF; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Faul JD; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Fauman EB; Internal Medicine Research Unit, Pfizer, Cambridge, MA, USA., Fava C; Department of Medicine, University of Verona, Verona, Italy.; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Ferreira T; The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK., Foley CN; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Franceschini N; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Gao H; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK., Giannakopoulou O; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Centre for Genomic Health, Queen Mary University of London, London, UK.; Division of Psychiatry, University College of London, London, UK., Giulianini F; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA., Gudbjartsson DF; deCODE genetics/Amgen, Inc, Reykjavik, Iceland.; School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland., Guo X; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Harris SE; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK., Havulinna AS; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, UK.; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Helgadottir A; deCODE genetics/Amgen, Inc, Reykjavik, Iceland., Huffman JE; MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK., Hwang SJ; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.; Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA., Kanoni S; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Centre for Genomic Health, Life Sciences, Queen Mary University of London, London, UK., Kontto J; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Larson MG; Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.; Biostatistics Department, Boston University School of Public Health, Boston, MA, USA., Li-Gao R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Lindström J; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Lotta LA; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Lu Y; The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN, USA., Luan J; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Malerba G; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Masca NGD; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK., Mei H; Department of Data Science, School of Population Health, University of Mississippi Medical Center, Jackson, MS, USA., Menni C; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Mook-Kanamori DO; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands., Mosen-Ansorena D; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Müller-Nurasyid M; Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; Department of Medicine I, Ludwig-Maximilians-University Munich, Munich, Germany.; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU, Munich, Germany., Paré G; Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada., Paul DS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Perola M; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; Clinical and Molecular Metabolism Research Program (CAMM), Faculty of Medicine, University of Helsinki, Helsinki, Finland., Poveda A; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden., Rauramaa R; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland., Richard M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA., Richardson TG; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Sepúlveda N; Department of Infection Biology, Faculty of Tropical and Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK.; Centre of Statistics and Applications of University of Lisbon, Lisbon, Portugal., Sim X; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.; Saw Swee Hock School of Public Health, National University of, Singapore, Singapore., Smith AV; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA., Smith JA; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Staley JR; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Stanáková A; University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Sulem P; deCODE genetics/Amgen, Inc, Reykjavik, Iceland., Thériault S; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.; Department of Molecular Biology, Medical Biochemistry and Pathology, Laval University, Quebec City, Quebec, Canada., Thorsteinsdottir U; deCODE genetics/Amgen, Inc, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Trompet S; Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands., Varga TV; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden., Velez Edwards DR; Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Tennessee Valley Health Systems VA, Nashville, TN, USA., Veronesi G; Research Center in Epidemiology and Preventive Medicine, Department of Medicine and Surgery, University of Insubria, Varese, Italy., Weiss S; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Willems SM; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Yao J; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Young R; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Yu B; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Zhang W; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK., Zhao JH; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Zhao W; Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA, USA., Zhao W; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Evangelou E; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Aeschbacher S; Division of Cardiology, University Hospital, Basel, Switzerland., Asllanaj E; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Department of Epidemiology, Erasmus MC, University Medical Centre, Rotterdam, the Netherlands., Blankenberg S; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany.; University Medical Center Hamburg Eppendorf, Hamburg, Germany.; German Centre for Cardiovascular Research (DZHK), partner site Hamburg/Kiel/Lübeck, Hamburg, Germany., Bonnycastle LL; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD, USA., Bork-Jensen J; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Brandslund I; Department of Clinical Biochemistry, Lillebaelt Hospital, Vejle, Denmark.; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark., Braund PS; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK., Burgess S; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Christensen C; Medical Department, Lillebaelt Hospital, Vejle, Denmark., Connell J; University of Dundee, Ninewells Hospital & Medical School, Dundee, UK., Mutsert R; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Dominiczak AF; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK., Dörr M; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Eiriksdottir G; Icelandic Heart Association, Kopavogur, Iceland., Farmaki AE; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.; Department of Population Science and Experimental Medicine, Institute of Cardiovascular Science, University College London, London, UK., Gaziano JM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Grarup N; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Grove ML; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Hallmans G; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Hansen T; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Have CT; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Heiss G; Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA., Jørgensen ME; Steno Diabetes Center, Copenhagen, Gentofte, Denmark., Jousilahti P; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Kajantie E; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; PEDEGO Research Unit, MRC Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.; Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.; Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland., Kamat M; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Käräjämäki A; Department of Primary Health Care, Vaasa Central Hospital, Vaasa, Finland.; Diabetes Center, Vaasa Health Care Center, Vaasa, Finland., Karpe F; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Koistinen HA; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.; Minerva Foundation Institute for Medical Research, Helsinki, Finland., Kovesdy CP; Nephrology Section, Memphis VA Medical Center, Memphis, TN, USA., Kuulasmaa K; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Laatikainen T; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., Lannfelt L; Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden., Lee IT; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, , Chung Shan Medical University, Taichung, Taiwan.; College of Science, Tunghai University, Taichung, Taiwan., Lee WJ; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan.; Department of Social Work, Tunghai University, Taichung, Taiwan., Linneberg A; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Martin LW; George Washington University School of Medicine and Health Sciences, Washington DC, USA., Moitry M; Department of Public health, Strasbourg University Hospital, University of Strasbourg, Strasbourg, France., Nadkarni G; The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Neville MJ; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK., Palmer CNA; Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, Scotland, UK., Papanicolaou GJ; Epidemiology Branch, NHLBI, Bethesda, MD, USA., Pedersen O; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Peters J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Department of Immunology and Inflammation, Imperial College London, London, UK., Poulter N; International Centre for Circulatory Health, Imperial College London, London, UK., Rasheed A; Centre for Non-Communicable Diseases, Karachi, Pakistan., Rasmussen KL; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Rayner NW; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Mägi R; Institute of Genomics, University of Tartu, Tartu, Estonia., Renström F; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Rettig R; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany., Rossouw J; Division of Cardiovascular Sciences, NHLBI, Bethesda, MD, USA., Schreiner PJ; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA., Sever PS; National Heart and Lung Institute, Imperial College London, London, UK., Sigurdsson EL; Department of Family Medicine, University of Iceland, Reykjavik, Iceland.; Development Centre for Primary Health Care in Iceland, Reykjavik, Iceland., Skaaby T; Center for Clinical Research and Disease Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark., Sun YV; Department of Epidemiology, Emory University Rollins School of Public Health, Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA., Sundstrom J; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Thorgeirsson G; deCODE genetics/Amgen, Inc, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.; Department of Internal Medicine, Division of Cardiology, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland., Esko T; Institute of Genomics, University of Tartu, Tartu, Estonia.; Medical and Population Genetics, Broad Institute, Cambridge, MA, USA., Trabetti E; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy., Tsao PS; VA Palo Alto Health Care System, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA., Tuomi T; Folkhälsan Research Centre, Helsinki, Finland.; Department of Endocrinology, Helsinki University Central Hospital, Helsinki, Finland.; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden Institute for Molecular Medicine Helsinki (FIMM), Helsinki University, Helsinki, Finland., Turner ST; Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA., Tzoulaki I; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece., Vaartjes I; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, University of Utrecht, Utrecht, the Netherlands.; Center for Circulatory Health, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands., Vergnaud AC; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK., Willer CJ; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA.; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Wilson PWF; Atlanta VAMC and Emory Clinical Cardiovascular Research Institute, Atlanta, GA, USA., Witte DR; Department of Public Health, Aarhus University, Aarhus, Denmark.; Danish Diabetes Academy, Odense, Denmark.; Steno Diabetes Center Aarhus, Aarhus, Denmark., Yonova-Doing E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Zhang H; Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI, USA., Aliya N; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh., Almgren P; Department of Medicine, Lund University, Malmö, Sweden., Amouyel P; Univ Lille, U1167 - RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.; INSERM, U1167, Lille, France.; CHU Lille, U1167, Lille, France.; Institut Pasteur de Lille, U1167, Lille, France., Asselbergs FW; Department of Cardiology, Division Heart & Lungs, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.; Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.; Health Data Research UK, Institute of Health Informatics, University College London, London, UK., Barnes MR; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Blakemore AI; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.; Section of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK., Boehnke M; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA., Bots ML; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, University of Utrecht, University of Utrecht, Utrecht, the Netherlands.; Center for Circulatory Health, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands., Bottinger EP; The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Buring JE; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chambers JC; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Imperial College Healthcare NHS Trust, London, UK., Chen YI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Chowdhury R; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Centre for Non-communicable Disease Research (CNCR), Dhaka, Bangladesh., Conen D; Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada.; Cardiovascular Research Institute Basel, Basel, Switzerland., Correa A; Jackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., Davey Smith G; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Boer RA; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands., Deary IJ; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Department of Psychology, University of Edinburgh, Edinburgh, UK., Dedoussis G; Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece., Deloukas P; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK.; Centre for Genomic Health, Life Sciences, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Di Angelantonio E; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.; National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK., Elliott P; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.; Health Data Research UK-London at Imperial College London, London, UK.; UKDRI, Dementia Research Institute at Imperial College London, London, UK.; British Heart Foundation (BHF) Centre of Research Excellence, Imperial College London, London, UK., Felix SB; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.; Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany., Ferrières J; Department of Cardiology and Department of Epidemiology, INSERM UMR 1027, Toulouse University Hospital, Toulouse, France., Ford I; Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK., Fornage M; Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA., Franks PW; Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University, Skåne University Hospital Malmö, Malmö, Sweden.; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.; Oxford Center for Diabetes, Endocrinology & Metabolism, Radcliff Department of Medicine, University of Oxford, Oxford, UK., Franks S; Institute of Reproductive & Developmental Biology, Imperial College London, London, UK., Frossard P; Centre for Non-Communicable Diseases, Karachi, Pakistan., Gambaro G; Division of Nephrology, Department of Medicine, University of Verona, Verona, Italy., Gaunt TR; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Groop L; Department of Clinical Sciences, Diabetes and Endocrinology, Lund University Diabetes Centre, Malmö, Sweden.; Institute for Molecular Medicine Helsinki (FIMM), Helsinki University, Helsinki, Finland., Gudnason V; Icelandic Heart Association, Kopavogur, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Harris TB; Laboratory of Epidemiology and Population Sciences, National Institute of Aging, Bethesda, MD, USA., Hayward C; MRC Human Genetics Unit, IGMM, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK., Hennig BJ; MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia.; Wellcome Trust, London, UK., Herzig KH; Institute of Biomedicine, Medical Research Center (MRC), University of Oulu, and University Hospital Oulu, Oulu, Finland.; Department of Gastroenterology and Metabolism, Poznan University of Medical Sciences, Poznan, Poland., Ingelsson E; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.; Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA.; Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA., Tuomilehto J; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland.; Department of Public Health, University of Helsinki, Helsinki, Finland.; Saudi Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.; National Institute of Public Health, Madrid, Spain., Järvelin MR; Department of Life Sciences, College of Health and Life Sciences, Brunel University London, London, UK.; Department of Epidemiology and Biostatistics, MRC Centre for Environment and Health, School of Public Health, Imperial College London, London, UK.; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.; Unit of Primary Care, Oulu University Hospital, Kajaanintie, Oulu, Finland.; Center for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Jukema JW; Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.; Netherlands Heart Institute, Utrecht, the Netherlands., Kardia SLR; Department of Epidemiology, University of Michigan, Ann Arbor, MI, USA., Kee F; Centre for Public Health, Queens University Belfast, Belfast, UK., Kooner JS; National Institute for Health Research (NIHR) Imperial Biomedical Research Centre, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, Middlesex, UK.; National Heart and Lung Institute, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK., Kooperberg C; Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, WA, USA., Launer LJ; Laboratory of Epidemiology and Population Sciences, National Institute of Aging, Bethesda, MD, USA., Lind L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Loos RJF; The Charles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Majumder AAS; National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka, Bangladesh., Laakso M; Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Oxford NIHR Biomedical Research Centre, Oxford University Hospitals Trust, Oxford, UK.; Genentech, South San Francisco, San Francisco, CA, USA., Melander O; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Mohlke KL; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA., Murray AD; The Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, UK., Nordestgaard BG; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, Denmark., Orho-Melander M; Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Packard CJ; University of Glasgow, Glasgow, UK., Padmanabhan S; Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK., Palmas W; Department of Medicine, Columbia University Medical Center, New York, NY, USA., Polasek O; Department of Public Health, University of Split School of Medicine, Split, Croatia., Porteous DJ; Centre for Genomic and Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK., Prentice AM; MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Banjul, Gambia.; MRC International Nutrition Group at London School of Hygiene and Tropical Medicine, Keppel St, London, UK., Province MA; Division of Statistical Genomics, Department of Genetics and Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, MO, USA., Relton CL; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Rice K; Department of Biostatistics, University of Washington, Seattle, WA, USA., Ridker PM; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Rolandsson O; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden., Rosendaal FR; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands., Rotter JI; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Rudan I; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Scotland, UK., Salomaa V; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Samani NJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK., Sattar N; Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK., Sheu WH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.; School of Medicine, National Yang-Ming University, Taipei, Taiwan.; School of Medicine, National Defense Medical Center, Taipei, Taiwan.; Institute of Medical Technology, National Chung-Hsing University, Taichung, Taiwan., Smith BH; Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK., Soranzo N; National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Department of Haematology, University of Cambridge, Cambridge, UK., Spector TD; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK., Starr JM; Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.; Alzheimer Scotland Research Centre, University of Edinburgh, Edinburgh, UK., Sebert S; Center for Life-Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland., Taylor KD; Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA., Lakka TA; Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.; Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio, Finland., Timpson NJ; MRC Integrative Epidemiology Unit (IEU), Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK., Tobin MD; National Institute for Health Research Leicester Biomedical Research Centre, Leicester, UK.; Department of Health Sciences, University of Leicester, Leicester, UK., van der Harst P; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands.; University of Groningen, University Medical Center Groningen, Department of Genetics, Groningen, the Netherlands.; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands., van der Meer P; University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands., Ramachandran VS; Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.; Boston University Schools of Medicine and Public Health, Boston, MA, USA., Verweij N; University Medical Center Groningen, Groningen, the Netherlands., Virtamo J; Department of Public Health Solutions, Finnish Institute for Health and Welfare, Helsinki, Finland., Völker U; Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), partner site Greifswald, Greifswald, Germany., Weir DR; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Zeggini E; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.; Institute of Translational Genomics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.; TUM School of Medicine, Technical University of Munich and Klinikum Rechts der Isar, Munich, Germany., Charchar FJ; Department of Cardiovascular Sciences, University of Leicester, Leicester, UK.; Health Innovation and Transformation Center, Federation University Australia, Ballarat, Victoria, Australia.; Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia., Wareham NJ; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Langenberg C; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK., Tomaszewski M; Division of Cardiovascular Sciences, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, UK.; Division of Medicine, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Butterworth AS; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.; National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK., Caulfield MJ; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK., Danesh J; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.; National Institute for Health Research (NIHR) Blood and Transplant Research Unit (BTRU) in Donor Health and Genomics at the University of Cambridge, Cambridge, UK.; Department of Human Genetics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK., Edwards TL; Division of Epidemiology, Department of Medicine, Institute for Medicine and Public Health, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA., Holm H; deCODE genetics/Amgen, Inc, Reykjavik, Iceland., Hung AM; VA Tennessee Valley Healthcare System, Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt Center for Kidney Disease, Vanderbilt University Medical Center, Nashville, TN, USA., Lindgren CM; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; The Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Liu C; Boston University School of Public Health, Boston, MA, USA., Manning AK; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA., Morris AP; Department of Biostatistics, University of Liverpool, Liverpool, UK.; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, University of Manchester, Manchester, UK., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., O'Donnell CJ; VA Boston Healthcare, Section of Cardiology and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Psaty BM; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Saleheen D; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Center for Non-Communicable Diseases, Karachi, Pakistan., Stefansson K; deCODE genetics/Amgen, Inc, Reykjavik, Iceland.; Faculty of Medicine, University of Iceland, Reykjavik, Iceland., Boerwinkle E; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Levy D; Boston University and National Heart, Lung and Blood Institute Framingham Heart Study, Framingham, MA, USA.; Population Sciences, Branch, National Heart, Lung, and Blood Institute, National Institute of Health, Bethesda, MD, USA., Newton-Cheh C; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Cardiovascular Research Center, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Munroe PB; William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk.; National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, UK. p.b.munroe@qmul.ac.uk., Howson JMM; British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. JMMHowson@gmail.com.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK. JMMHowson@gmail.com.; Department of Genetics, Novo Nordisk Research Centre Oxford, Oxford, UK. JMMHowson@gmail.com.; Novo Nordisk Research Centre Oxford, Novo Nordisk Ltd, Oxford, UK. JMMHowson@gmail.com.

مؤلفون مشاركون: LifeLines Cohort Study, EPIC-CVD, EPIC-InterAct, Understanding Society Scientific Group, Million Veteran Program

المصدر: Nature genetics [Nat Genet] 2021 May; Vol. 53 (5), pp. 762.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Prins BP; MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK., Leitsalu L; Institute of Genomics, University of Tartu, 51010 Tartu, Estonia., Pärna K; Institute of Genomics, University of Tartu, 51010 Tartu, Estonia.; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.; Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia., Fischer K; Institute of Genomics, University of Tartu, 51010 Tartu, Estonia.; Institute of Mathematics and Statistics, University of Tartu, 50409 Tartu, Estonia., Metspalu A; Institute of Genomics, University of Tartu, 51010 Tartu, Estonia., Haller T; Institute of Genomics, University of Tartu, 51010 Tartu, Estonia., Snieder H; Department of Epidemiology, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.

المصدر: Journal of personalized medicine [J Pers Med] 2021 Apr 29; Vol. 11 (5). Date of Electronic Publication: 2021 Apr 29.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101602269 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4426 (Print) Linking ISSN: 20754426 NLM ISO Abbreviation: J Pers Med Subsets: PubMed not MEDLINE

المؤلفون: Gaziano L; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Giambartolomei C; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy.; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA., Pereira AC; Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo, São Paulo, Brazil.; Genetics Department, Harvard Medical School, Harvard University, Boston, MA, USA., Gaulton A; Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Posner DC; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Swanson SA; Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands., Ho YL; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Iyengar SK; Louis Stokes Cleveland VA Medical Center, Cleveland, OH, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University and Louis Stoke, Cleveland VA, Cleveland, OH, USA., Kosik NM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Vujkovic M; The Corporal Michael J. Crescenz VA Medical Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Gagnon DR; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Biostatistics, School of Public Health, Boston University, Boston, MA, USA., Bento AP; Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Barrio-Hernandez I; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Rönnblom L; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Hagberg N; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Lundtoft C; Department of Medical Sciences, Uppsala University, Uppsala, Sweden., Langenberg C; Berlin Institute of Health, Charité University Medicine Berlin, Berlin, Germany.; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Pietzner M; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK., Valentine D; Institute of Health Informatics, University College London, London, UK.; Health Data Research, University College London, London, UK., Gustincich S; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy., Tartaglia GG; Central RNA Lab, Istituto Italiano di Tecnologia, Genoa, Italy., Allara E; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Surendran P; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Burgess S; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; MRC Biostatistics Unit, University of Cambridge, Cambridge, UK., Zhao JH; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Peters JE; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; Centre for Inflammatory Disease, Dept of Immunology and Inflammation, Imperial College, London, UK., Prins BP; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK., Angelantonio ED; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Devineni P; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Shi Y; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Lynch KE; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Department of Internal Medicine, Epidemiology, University of Utah, Salt Lake City, UT, USA., DuVall SL; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.; Department of Internal Medicine, Epidemiology, University of Utah, Salt Lake City, UT, USA., Garcon H; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Thomann LO; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Zhou JJ; Department of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA.; Phoenix VA Health Care System, Phoenix, AZ, USA., Gorman BR; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Huffman JE; Center for Population Genomics, Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., O'Donnell CJ; Cardiology, VA Boston Healthcare System, Boston, MA, USA.; Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Tsao PS; Epidemiology Research and Information Center (ERIC), VA Palo Alto Health Care System, Palo Alto, CA, USA.; Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA., Beckham JC; MIRECC, Durham VA Medical Center, Durham, NC, USA.; Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC, USA., Pyarajan S; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA., Muralidhar S; Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA., Huang GD; Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA., Ramoni R; Office of Research and Development, Department of Veterans Affairs, Washington, DC, USA., Beltrao P; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Danesh J; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK., Hung AM; VA Tennessee Valley Healthcare System, Nashville, TN, USA.; Nephrology & Hypertension, Vanderbilt University, Nashville, TN, USA., Chang KM; Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.; The Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA., Sun YV; Atlanta VA Health Care System, Decatur, GA, USA.; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, USA., Joseph J; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Medicine, Cardiovascular, VA Boston Healthcare System and Brigham & Women's Hospital, Boston, MA, USA., Leach AR; Chemical Biology, European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, UK., Edwards TL; Department of Veterans Affairs, Tennessee Valley Healthcare System, Vanderbilt University, Nashville, TN, USA.; Medicine, Epidemiology, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA., Cho K; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Gaziano JM; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA.; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Butterworth AS; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.; British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.; National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK. asb38@medschl.cam.ac.uk.; National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK. asb38@medschl.cam.ac.uk., Casas JP; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, USA. jpcasasromero@bwh.harvard.edu.; Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. jpcasasromero@bwh.harvard.edu.

مؤلفون مشاركون: VA Million Veteran Program COVID-19 Science Initiative

المصدر: Nature medicine [Nat Med] 2021 Apr; Vol. 27 (4), pp. 668-676. Date of Electronic Publication: 2021 Apr 09.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: Drug Repositioning* , SARS-CoV-2*, COVID-19/*genetics , Mendelian Randomization Analysis/*methods, Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/physiology ; Genome-Wide Association Study ; Humans ; Interleukin-10 Receptor beta Subunit/genetics ; Interleukin-10 Receptor beta Subunit/physiology ; Quantitative Trait Loci ; Receptor, Interferon alpha-beta/genetics ; Receptor, Interferon alpha-beta/physiology ; COVID-19 Drug Treatment