المؤلفون: Rajkumari Bonysana, Kabrambam Dasanta Singh, Wahengbam Deepanita Devi, Arunkumar Singh koijam, Kokho Kapesa, Jatin Kalita, Pulok Kumar Mukherjee, Yallappa Rajashekar

المصدر: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)

مصطلحات موضوعية: Coridius chinensis, Edible insects, Antioxidant activity, Anti-inflammatory activity, Traditional medicine, Medicine, Science

الوصف: Abstract Edible insects possess several health enhancing properties and play an important role in human nutrition. Coridius chinensis is an edible insect that is considered food and claimed as traditional medicine. In the present study, nutritional contents, chemical composition, antioxidant, and anti-inflammatory properties of C. chinensis were analyzed. It was found that the insect sample contains 50.46% moisture, 44.65% protein, 4.45% carbohydrate, 39.42% crude fats, 3.53% ash and 576.11 (Kcal/100 g) energy. Our study highlighted the presence of a significant amount of phenol and flavonoids. The C. chinensis hydro-alcoholic extract showed high antioxidant property and anti-inflammatory activity. GCMS analysis identified 61 volatile compounds. LC–MS analysis of hydroalcoholic extract of C. chinensis revealed the presence of compounds such as etodolac glucuronide, morphine 3-glucuronide, ecgonine, ecgonine methyl ester, sufentanil, and palmitoyl ethanololamide. These findings suggest that C. chinensis species can be employed as a valuable food source with excellent therapeutic properties.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/e75f2e7017d84704b25347f45fb0ae96

المؤلفون: Wahengbam Deepanita Devi, Rajkumari Bonysana, Kabrambam Dasanta Singh, Arunkumar Singh Koijam, Pulok Kumar Mukherjee, Yallappa Rajashekar

المصدر: npj Science of Food, Vol 8, Iss 1, Pp 1-11 (2024)

مصطلحات موضوعية: Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456

الوصف: Abstract Insects are the largest group of arthropods with the highest faunal diversity of over a million species. Apart from many other roles in the environment, the aspect of several insects being used for human consumption (entomophagy) and as traditional medicine (entomotherapy) by different communities of the world holds special significance for countering global food crisis. The enormous insect resources contribute a reasonable share in improving the livelihoods of many entomophagy practicing communities. Considering this significance, the present review emphasizes the bio-economic potential of insect resources. An overview of entomophagy practices in India; benefits towards the environment, humans and animals; insect species used in entomophagy along with therapeutic importance, nutritional, physical, chemical, and microbiological hazards; farming and mass production technologies; legal status and socio-economic implications in Indian scenario have been presented. Traditionally tested and accepted therapeutic use of edible insects have been reported to cure various disease conditions and calls for scientific exploration and validation to rediscover promising medical products of modern medicine. Edible insects as an alternative food need to be popularized in India with a new policy or regulation to harvest and sell insect-derived food products with proper safe consumption demonstrations. Considering the facts that insects reproduce in large numbers at a faster rate, require less land, water and other resources for farming, and economically and ecologically sustainable harvesting can be done in a short time, insect farming can offer revenue and rural job opportunities in developing countries, especially in India. Therefore, the traditional use of insects as food and medicine has tremendous potential to enhance the economy and living standards.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2396-8370

URL الوصول: https://doaj.org/article/aa6a1356f8794feaa68453ce34738ef5

المؤلفون: Surmani Huidrom, Ng Ngashangva, Joshua Khumlianlal, Kongbrailatpam Chandradev Sharma, Pulok Kumar Mukherjee, Sarangthem Indira Devi

المصدر: Frontiers in Microbiology, Vol 15 (2024)

مصطلحات موضوعية: fermented rice beverages, genome, Lactobacillus, probiotic, secondary metabolites, antimicrobial, Microbiology, QR1-502

الوصف: Lactiplantibacillus plantarum BRD3A was isolated from Atingba, a traditional fermented rice-based beverage of Manipur. Its genomic sequence has 13 contigs and its genome size is 3,320,817 bp with a guanine–cytosine (GC) ratio of 44.6%. It comprises 3185 genes including 3112 coding sequences (CDSs), 73 RNAs (including 66 tRNAs and others), and one clustered regularly interspaced short palindromic repeat (CRISPR) array. A comparative and phylogenetic analysis with the Lp. plantarum genome shows that this strain has close similarity with other Lp. plantarum strains and about 99% average nucleotide identity. Functional annotation using evolutionary genealogy of genes—non-supervised orthologous groups (EggNOG) and Kyoto Encyclopedia of Genes and Genomes (KEGG) reveals genes associated with various biological processes such as metabolism, genetic information processing, and transport functions. Furthermore, the strain harbors bacteriocins like plantaricin E, Plantaricin F, and Enterocin X categorized under class IIb by the BAGEL4 database, indicating its potential antimicrobial properties. Additionally, AntiSMASH web server predicted four secondary regions—T3PKS, terpene, cyclic lactone inducer, and ribosomally synthesized and post-translationally modified peptide (RiPP)—suggesting an even higher antimicrobial potential. We validated the antimicrobial activity of Lp. plantarum BRD3A through in vitro experiments in which it exhibited promising bactericidal effects on methicillin-resistant Staphylococcus aureus, inhibiting their biofilm growth. These findings indicate the potential of Lp. plantarum BRD3A to be used as an alternative to conventional antibiotics.

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2024.1357818/full; https://doaj.org/toc/1664-302X

URL الوصول: https://doaj.org/article/15f116f3b52341f4a20c74f35b0e8763

المؤلفون: Wahengbam Deepanita Devi, Rajkumari Bonysana, Kokho Kapesa, Pulok Kumar Mukherjee, Yallappa Rajashekar

المصدر: Future Foods, Vol 7, Iss , Pp 100219- (2023)

مصطلحات موضوعية: Entomophagy, Entomotherapy, Social believe, Traditional knowledge, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456

الوصف: Insects are the largest group of organisms of faunal biodiversity. Among those, several are recognize for human consumptions by different communities of the world. Besides human consumption these insects are traditionally use as medicine and for therapeutic purpose. There are numerous insects which are utilized as a therapeutic component by the local traditional healers around the world. Considering this significance the present review emphasize on the medicinal importance and its therapeutic properties of entomophagy species. The authors provide an overview traditionally therapeutic utilization of entomophagy species in the World and Northeast India scenarios. Entomotherapy practice has been reported to cure various kind of ailment. This traditional therapeutic knowledge can provide a huge contribution in modern medicine by analyzing the therapeutic component of the medicinally valued insects. Moreover, insect's reproduction is faster than plants and can reproduce more in numbers, thus sustainable harvesting of the desire species can be maintained during short duration. Additionally, the present review highlight the traditional social believes of the insects by the society.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666833523000059; https://doaj.org/toc/2666-8335

URL الوصول: https://doaj.org/article/d0d7a41301784613af7e725431429223

المؤلفون: Sayantan Sengupta, Nipun Abhinav, Sabita Singh, Joytri Dutta, Ulaganathan Mabalirajan, Karthigeyan Kaliyamurthy, Pulok Kumar Mukherjee, Parasuraman Jaisankar, Arun Bandyopadhyay

المصدر: Frontiers in Pharmacology, Vol 14 (2023)

مصطلحات موضوعية: Sonneratia apetala Buch.-Ham., neutrophil elastase, lung injury, COPD, ellagic acid, LC-MS/MS, HPLC, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1175091/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/3f2beb5923ce4862909cdccb35652407

المؤلفون: Sayantan Sengupta, Nipun Abhinav, Sabita Singh, Joytri Dutta, Ulaganathan Mabalirajan, Karthigeyan Kaliyamurthy, Pulok Kumar Mukherjee, Parasuraman Jaisankar, Arun Bandyopadhyay

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: Sonneratia apetala Buch.-Ham., neutrophil elastase, lung injury, COPD, ellagic acid, LC-MS-MS, Therapeutics. Pharmacology, RM1-950

الوصف: Chronic obstructive pulmonary disease (COPD) along with asthma is a major and increasing global health problem. Smoking contributes to about 80%–90% of total COPD cases in the world. COPD leads to the narrowing of small airways and destruction of lung tissue leading to emphysema primarily caused by neutrophil elastase. Neutrophil elastase plays an important role in disease progression in COPD patients and has emerged as an important target for drug discovery. Sonneratia apetala Buch.-Ham. is a mangrove plant belonging to family Sonneratiaceae. It is widely found in the Sundarban regions of India. While the fruits of this plant have antibacterial, antifungal, antioxidant and astringent activities, fruit and leaf extracts have been shown to reduce the symptoms of asthma and cough. The aim of this study is to find whether hydro alcoholic fruit extracts of S. apetala inhibit neutrophil elastase and thus prevent the progression of neutrophil elastase-driven lung emphysema. The hydroalcoholic extract, ethanol: water (90:10), of the S. apetala Buch.-Ham. fresh fruits (SAM) were used for neutrophil elastase enzyme kinetic assay and IC50 of the extract was determined. The novel HPLC method has been developed and the extract was standardized with gallic acid and ellagic acid as standards. The extract was further subjected to LC-MS2 profiling to identify key phytochemicals. The standardized SAM extract contains 53 μg/mg of gallic acid and 95 μg/mg of ellagic acid, based on the HPLC calibration curve. SAM also reversed the elastase-induced morphological change of human epithelial cells and prevented the release of ICAM-1 in vitro and an MTT assay was conducted to assess the viability. Further, 10 mg/kg SAM had reduced alveolar collapse induced by neutrophil elastase in the mice model. Thus, in this study, we reported for the first time that S. apetala fruit extract has the potential to inhibit human neutrophil elastase in vitro and in vivo.

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.1011216/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/2d7411a256fc4844858da4811c980fcc

المؤلفون: Anna Rita Bilia, Pulok Kumar Mukherjee, Adolfo Andrade-Cetto, Chandra Kant Katiyar, Sitesh C. Bachar, Motlalepula Gilbert Matsabisa, Subhash C. Mandal

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: herbal medicine, regulatory perspectives, TCM, botanicals, ayurveda, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.989934/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/1f84d2809ef84976bc4728eb40c15418

المؤلفون: Nameirakpam Bunindro Singh, Moirangthem Lakshmipriyari Devi, Thokchom Biona, Nanaocha Sharma, Sudripta Das, Jharna Chakravorty, Pulok Kumar Mukherjee, Yallappa Rajashekar

المصدر: Molecules, Vol 28, Iss 5, p 2279 (2023)

مصطلحات موضوعية: Artemisia vulgaris, essential oil, gas chromatography/mass spectrometry, solid-phase microextraction, eucalyptol, antimicrobial, Organic chemistry, QD241-441

الوصف: Artemisia vulgaris is an enormously useful aromatic plant known for its insecticidal, antifungal, parasiticidal, and medicinal values. The main aim of this study is to investigate phytochemical contents and the potential antimicrobial activities of Artemisia vulgaris essential oil (AVEO) from the fresh leaves of A. vulgaris grown in Manipur. The AVEO isolated by hydro-distillation from A. vulgaris were analyzed by gas chromatography/mass spectrometry and solid-phase microextraction-GC/MS to describe their volatile chemical profile. There were 47 components identified in the AVEO by GC/MS, amounting to 97.66% of the total composition, while 97.35% were identified by SPME-GC/MS. The prominent compounds present in AVEO analyzed by direct injection and SPME methods are found to be eucalyptol (29.91% and 43.70%), sabinene (8.44% and 8.86%), endo-Borneol (8.24% and 4.76%), 2,7-Dimethyl-2,6-octadien-4-ol (6.76% and 4.24%), and 10-epi-γ-Eudesmol (6.50% and 3.09%). The consolidated component in the leaf volatiles comes to the terms of monoterpenes. The AVEO exhibits antimicrobial activities against fungal pathogens such as Sclerotium oryzae (ITCC 4107) and Fusarium oxysporum (MTCC 9913) and bacterial cultures such as Bacillus cereus (ATCC 13061) and Staphylococcus aureus (ATCC 25923). The percent inhibition of AVEO against the S. oryzae and F. oxysporum was found up to 50.3% and 33.13%, respectively. The MIC and MBC of the essential oil tested for B. cereus and S. aureus were found to be (0.3%, 0.63%) and (0.63%, 2.5%), respectively. Finally, the results revealed that the AVEO characterized by the hydro-distillation and SPME extraction yielded the same chemical profile and showed potent antimicrobial activities. Further research into A. vulgaris’s antibacterial properties can be performed in order to use it as a source for natural antimicrobial medications.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/5/2279; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/8f7dd49bebc54829b61cb0ab966db00b

المؤلفون: Sayeed Ahmad, Chandra Kant Katiyar, Gudrun S. Ulrich-Merzenich, Pulok Kumar Mukherjee

المصدر: Frontiers in Pharmacology, Vol 13 (2022)

مصطلحات موضوعية: ethnopharmacology, medicinal plants, AYUSH DRUGS, metabolomics, traditional medicine, herbal medicine, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.851023/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/ba9a7419a7094138b075673f04f8db99

المؤلفون: Motlalepula Gilbert Matsabisa, Asis Bala, Satyajit Tripathy, Michelle Mogomane Digashu, Fanie Rautenbach, Barsha Dassarma, Joseph Omorogiuwa Erhabor, Fernao Castro Braga, Pulok Kumar Mukherjee, Minke Tang, Youngmin Kang

المصدر: Molecules, Vol 27, Iss 11, p 3505 (2022)

مصطلحات موضوعية: indigenous tea, commercial tea, antioxidant capacity, nutritional content, cox activity, Organic chemistry, QD241-441

الوصف: Background: This study comparatively assessed seven indigenous traditional tea plants on several attributes that included antioxidant, nutritional, caffeine contents, and cyclooxygenase activity. Methodology: Nutritional content of all tea plants were determined for energy, fat, carbohydrates, total sugars, dietary fiber and amino acids. Antioxidant potential and the antioxidant potentiating secondary metabolites were also measured and compared. Further, we investigated the tea plants for any role they would have on cyclooxygenase (COX) activity on cobalt chloride (CoCl2) induced human glioma cell lines (U87MG). Results: The tea plants were found non-cytotoxic at concentrations tested against the human Chang liver and HeK 293 kidney cells and were found to be naturally caffeine free. The lowest and highest extraction yield among the tea plants was 7.1% for B. saligna and 15.48% for L. scaberrimma respectively. On average, the flavonol content was 12 to 8 QE/g, ORAC 800 µmol TE/g, TEAC 150 µmol TE/g, FRAP 155 µmol AAE/g, polyphenols 40 mg GAE/g, flavanols 0.35 mg CE/g, flavonols 12 mg QE/g and total flavonoid content (TFC) 180 µg QE/mg. The COX activity has been found to be inhibited by a dose-dependent manner by L. scaberrimma, B. saligna and L. javanica. Conclusion: The results further support competitive value of tea plants and need for improved and further development.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/11/3505; https://doaj.org/toc/1420-3049

URL الوصول: https://doaj.org/article/9843b69fc3dd47559b301f6131adc358