المؤلفون: Tandon S; Department of Genetics, University of Delhi South Campus, New Delhi, India., Sarkar S; Department of Genetics, University of Delhi South Campus, New Delhi, India.

المصدر: Nutritional neuroscience [Nutr Neurosci] 2024 Jul; Vol. 27 (7), pp. 783-794. Date of Electronic Publication: 2023 Sep 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 100892202 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-8305 (Electronic) Linking ISSN: 1028415X NLM ISO Abbreviation: Nutr Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Disease Models, Animal* , Drosophila Proteins*/metabolism , Drosophila Proteins*/genetics , Glutamine*/administration & dosage , Glutamine*/metabolism , Insulin*/metabolism , Signal Transduction*/drug effects, Animals ; Humans ; Drosophila ; Drosophila melanogaster ; Neurons/drug effects ; Neurons/metabolism ; Peptides/administration & dosage ; Peptides/pharmacology ; Ribosomal Protein S6 Kinases/metabolism

المؤلفون: Zhu YW; Department of Stomatology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, PR China., Liu CL; Department of Dermatology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, PR China., Li XM; Department of Stomatology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, PR China., Shang Y; Department of Stomatology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, PR China.

المصدر: Toxicology mechanisms and methods [Toxicol Mech Methods] 2024 Jul; Vol. 34 (6), pp. 669-675. Date of Electronic Publication: 2024 May 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 101134521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6524 (Electronic) Linking ISSN: 15376516 NLM ISO Abbreviation: Toxicol Mech Methods Subsets: MEDLINE

مواضيع طبية MeSH: Ferroptosis*/drug effects , Quercetin*/pharmacology , TOR Serine-Threonine Kinases*/metabolism , Mouth Neoplasms*/pathology , Mouth Neoplasms*/drug therapy , Mouth Neoplasms*/metabolism , Amino Acid Transport System y+*/metabolism , Amino Acid Transport System y+*/genetics, Humans ; Cell Line, Tumor ; Signal Transduction/drug effects ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Animals ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/metabolism ; Carcinoma, Squamous Cell/pathology ; Squamous Cell Carcinoma of Head and Neck/drug therapy ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/pathology ; Squamous Cell Carcinoma of Head and Neck/genetics ; Mice, Nude ; Cell Survival/drug effects

المؤلفون: Mi C; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China. Electronic address: mi.chunliu@163.com., Zhang QL; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Sun MJ; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Lv Y; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China; School of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Sun QL; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China; School of Life Sciences and Technology, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Geng SL; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China., Wang TY; International Joint Research Laboratory for Recombinant Pharmaceutical Protein Expression System of Henan, School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China; Department of Biochemistry and Molecular Biology, School of Basic Medicine, Xinxiang Medical University, Xinxiang, 453003, Henan, China. Electronic address: wtianyuncn@126.com.

المصدر: International immunopharmacology [Int Immunopharmacol] 2024 May 30; Vol. 133, pp. 112066. Date of Electronic Publication: 2024 Apr 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis*/drug effects , Hypoxia-Inducible Factor 1, alpha Subunit*/metabolism , Hypoxia-Inducible Factor 1, alpha Subunit*/genetics , Neoplasms*/drug therapy , Neoplasms*/metabolism , Neoplasms*/pathology, Animals ; Humans ; Mice ; Adaptor Proteins, Signal Transducing/metabolism ; Adaptor Proteins, Signal Transducing/genetics ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents, Phytogenic/therapeutic use ; Cell Cycle Proteins/metabolism ; Cell Cycle Proteins/genetics ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Mice, Inbred BALB C ; Mice, Nude ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Valerian/chemistry ; Xenograft Model Antitumor Assays

المؤلفون: Luk IS; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Bridgwater CM; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Yu A; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Boila LD; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Yáñez-Bartolomé M; Preclinical and Translational Research Program, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain., Lampano AE; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Hulahan TS; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Boukhali M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA., Kathiresan M; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA., Macarulla T; Preclinical and Translational Research Program, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain.; Gastrointestinal and Endocrine Tumor Unit, Hospital Universitari Vall d'Hebron, Vall d'Hebron Barcelona Hospital Campus, 08035 Barcelona, Spain., Kenerson HL; Department of Surgery, University of Washington, Seattle, WA 98195, USA., Yamamoto N; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.; Medical Scientist Training Program, University of Washington, Seattle, WA 98195, USA., Sokolov D; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Engstrom IA; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Sullivan LB; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Lampe PD; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Cooper JA; Basic Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Yeung RS; Department of Surgery, University of Washington, Seattle, WA 98195, USA., Tian TV; Preclinical and Translational Research Program, Vall d'Hebron Institute of Oncology (VHIO), 08035 Barcelona, Spain., Haas W; Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA., Saha SK; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA., Kugel S; Human Biology Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.

المصدر: Science translational medicine [Sci Transl Med] 2024 May 15; Vol. 16 (747), pp. eadj7685. Date of Electronic Publication: 2024 May 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Cholangiocarcinoma*/drug therapy , Cholangiocarcinoma*/pathology , Cholangiocarcinoma*/metabolism , Cholangiocarcinoma*/genetics , Dasatinib*/pharmacology , Mutation*/genetics , src-Family Kinases*/metabolism , src-Family Kinases*/antagonists & inhibitors , Adaptor Proteins, Signal Transducing*/metabolism , Isocitrate Dehydrogenase*/metabolism , Isocitrate Dehydrogenase*/genetics, Humans ; Cell Line, Tumor ; Animals ; Cell Adhesion Molecules/metabolism ; Cell Proliferation/drug effects ; Phosphorylation/drug effects ; Signal Transduction/drug effects ; Mice ; Bile Duct Neoplasms/pathology ; Bile Duct Neoplasms/metabolism ; Bile Duct Neoplasms/genetics ; Bile Duct Neoplasms/drug therapy ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism

المؤلفون: Pan J; Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Liu M; Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Duan X; Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Wang D; Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

المصدر: PloS one [PLoS One] 2023 Jun 07; Vol. 18 (6), pp. e0286422. Date of Electronic Publication: 2023 Jun 07 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Osteosarcoma*/metabolism , Osteosarcoma*/pathology , RNA, Long Noncoding* , Cyclic AMP Response Element-Binding Protein*/metabolism , Ribosomal Protein S6 Kinases, 90-kDa*/metabolism , Peptides*/metabolism, Humans ; Cell Line ; Animals ; Mice ; Heterografts ; Neoplasm Transplantation ; Cell Proliferation ; Cell Movement ; Cell Line, Tumor ; Bone Neoplasms/metabolism ; Bone Neoplasms/pathology

المؤلفون: Pfeiffer S; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Tomašcová A; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Biomedical Centre Martin, Comenius University in Bratislava, Bratislava, Slovakia., Mamrak U; Institute for Stroke and Dementia Research (ISD), Munich, Germany., Haunsberger SJ; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Connolly NMC; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Resler A; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Düssmann H; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland., Weisová P; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Jirström E; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro SFI Research Center, Royal College of Surgeons Ireland, Dublin, Ireland., D'Orsi B; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Institute of Neuroscience, Italian National Research Council (CNR), Pisa, Italy., Chen G; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland., Cremona M; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.; Dept of Molecular Medicine (Medical Oncology group), Royal College of Surgeons in Ireland, Dublin, Ireland., Hennessy BT; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.; Dept of Molecular Medicine (Medical Oncology group), Royal College of Surgeons in Ireland, Dublin, Ireland.; Department of Medical Oncology, Beaumont Hospital, Dublin, Ireland., Plesnila N; Institute for Stroke and Dementia Research (ISD), Munich, Germany.; Munich Cluster of Systems Neurology (Synergy), Munich, Germany., Prehn JHM; Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.; Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.; FutureNeuro SFI Research Center, Royal College of Surgeons Ireland, Dublin, Ireland.

المصدر: Journal of neurochemistry [J Neurochem] 2021 Nov; Vol. 159 (4), pp. 710-728. Date of Electronic Publication: 2021 Mar 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE

مواضيع طبية MeSH: AMP-Activated Protein Kinases/*metabolism , Ischemic Stroke/*pathology , MicroRNAs/*genetics , Neurons/*pathology , Phosphatidylinositol 3-Kinases/*genetics , Ribosomal Protein S6 Kinases, 70-kDa/*genetics, Animals ; Cerebral Cortex/pathology ; Computational Biology ; Enzyme Activation ; Female ; Male ; Mice, Inbred C57BL ; PTEN Phosphohydrolase/metabolism ; Polymerase Chain Reaction ; Primary Cell Culture ; Pyruvate Dehydrogenase Acetyl-Transferring Kinase/metabolism ; Ribosomal Protein S6/metabolism ; Signal Transduction ; Mice

المؤلفون: Koutsougianni F; Department of Pharmacology, Faculty of Medicine, Health Sciences School, University of Thessaly, Larissa, Greece., Alexopoulou D; Department of Pharmacology, Faculty of Medicine, Health Sciences School, University of Thessaly, Larissa, Greece., Uvez A; Department of Histology and Embryology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, 34500 Istanbul, Turkey., Lamprianidou A; Department of Pharmacology, Faculty of Medicine, Health Sciences School, University of Thessaly, Larissa, Greece., Sereti E; Dept of Translational Medicine, Medical Faculty, Lund University and Center for Molecular Pathology, Skäne University Hospital, Jan Waldenströms gata 59, SE 205 02 Malmö, Sweden., Tsimplouli C; Department of Pharmacology, Faculty of Medicine, Health Sciences School, University of Thessaly, Larissa, Greece., Ilkay Armutak E; Department of Histology and Embryology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpasa, 34500 Istanbul, Turkey., Dimas K; Department of Pharmacology, Faculty of Medicine, Health Sciences School, University of Thessaly, Larissa, Greece. Electronic address: kdimas@uth.gr.

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2023 Apr; Vol. 210, pp. 115488. Date of Electronic Publication: 2023 Mar 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Carcinogenesis*/drug effects , Molecular Targeted Therapy* , Ribosomal Protein S6 Kinases, 90-kDa*/antagonists & inhibitors , Ribosomal Protein S6 Kinases, 90-kDa*/metabolism , Neoplasms*/drug therapy , Neoplasms*/metabolism , Neoplasms*/pathology, Animals ; Humans ; Enzyme Activation ; Phosphorylation/drug effects ; Signal Transduction/drug effects

المؤلفون: Qin Y; School of Pharmacy, China Medical University, Shenyang 110122, China., Guo X; School of Pharmacy, China Medical University, Shenyang 110122, China., Song W; School of Pharmacy, China Medical University, Shenyang 110122, China., Liang Z; School of Pharmacy, China Medical University, Shenyang 110122, China., Wang Y; School of Pharmacy, China Medical University, Shenyang 110122, China., Feng D; School of Pharmacy, China Medical University, Shenyang 110122, China., Yang Y; School of Pharmacy, China Medical University, Shenyang 110122, China., Li M; School of Pharmacy, China Medical University, Shenyang 110122, China., Gao M; School of Pharmacy, China Medical University, Shenyang 110122, China. Electronic address: mqgao26@cmu.edu.cn.

المصدر: Molecular and cellular neurosciences [Mol Cell Neurosci] 2023 Mar; Vol. 124, pp. 103821. Date of Electronic Publication: 2023 Feb 10.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 9100095 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9327 (Electronic) Linking ISSN: 10447431 NLM ISO Abbreviation: Mol Cell Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Depression*/drug therapy , Depression*/metabolism , Ribosomal Protein S6 Kinases, 70-kDa*/metabolism , Ribosomal Protein S6 Kinases, 70-kDa*/pharmacology, Mice ; Animals ; Antidepressive Agents/pharmacology ; Antidepressive Agents/therapeutic use ; Antidepressive Agents/metabolism ; TOR Serine-Threonine Kinases/metabolism ; Stress, Psychological/metabolism ; Hippocampus/metabolism ; Disease Models, Animal

المؤلفون: Chi OZ; Department of Anesthesiology and Perioperative Medicine, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, Suite 3100, New Brunswick, NJ, 08901-1977, USA. chi@rwjms.rutgers.edu., Liu X; Department of Anesthesiology and Perioperative Medicine, Rutgers Robert Wood Johnson Medical School, 125 Paterson Street, Suite 3100, New Brunswick, NJ, 08901-1977, USA., Fortus H; Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Werlen G; Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Jacinto E; Department of Biochemistry and Molecular Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA., Weiss HR; Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, Piscataway, NJ, 08854, USA.

المصدر: Neuromolecular medicine [Neuromolecular Med] 2024 Apr 04; Vol. 26 (1), pp. 10. Date of Electronic Publication: 2024 Apr 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 101135365 Publication Model: Electronic Cited Medium: Internet ISSN: 1559-1174 (Electronic) Linking ISSN: 15351084 NLM ISO Abbreviation: Neuromolecular Med Subsets: MEDLINE

مواضيع طبية MeSH: Autistic Disorder*/drug therapy , Autistic Disorder*/metabolism , Tuberous Sclerosis*/drug therapy , Tuberous Sclerosis*/metabolism, Animals ; Humans ; Rats ; Mammals/metabolism ; Phosphorylation ; Rats, Long-Evans ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/therapeutic use ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases

المؤلفون: Ge C; Department of Orthopedic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.; Department of Orthopedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Orthopedics, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Liu D; Department of Orthopedic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China., Sun Y; Department of Orthopedic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.

المصدر: British journal of neurosurgery [Br J Neurosurg] 2024 Apr; Vol. 38 (2), pp. 284-292. Date of Electronic Publication: 2020 Dec 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8800054 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1360-046X (Electronic) Linking ISSN: 02688697 NLM ISO Abbreviation: Br J Neurosurg Subsets: MEDLINE

مواضيع طبية MeSH: Myelin Sheath*/metabolism , Spinal Cord Injuries*, Rats ; Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-akt/pharmacology ; Rats, Sprague-Dawley ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/pharmacology ; Signal Transduction ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/pharmacology ; Spinal Cord ; Oligodendroglia/metabolism ; Recovery of Function