المؤلفون: Dzul-Rosado K; Hideyo Noguchi Regional Investigation Center, Faculty of Medicine, Autonomous University of Yucatan, Mérida, México. Electronic address: karla.dzul@correo.uady.mx., Lavín-Sánchez DG; Hideyo Noguchi Regional Investigation Center, Faculty of Medicine, Autonomous University of Yucatan, Mérida, México., Hernández GÁ; Department of Medicine and Health Sciences, University of Sonora, Sonora, México., Gómez-Carro S; Agustín O' Horan General Hospital, Department of Health, Mérida, Yucatán, México., Puerto-Manzano FI; Hideyo Noguchi Regional Investigation Center, Faculty of Medicine, Autonomous University of Yucatan, Mérida, México.

المصدر: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2024 Jan-Feb; Vol. 28 (1), pp. 103707. Date of Electronic Publication: 2023 Dec 06.

نوع المنشور: Case Reports

بيانات الدورية: Publisher: Elsevier Editora Country of Publication: Brazil NLM ID: 9812937 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4391 (Electronic) Linking ISSN: 14138670 NLM ISO Abbreviation: Braz J Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Rickettsia rickettsii* , Rickettsia typhi* , Systemic Inflammatory Response Syndrome*, COVID-19/*complications, Child ; Humans ; Child, Hospitalized ; Mexico ; Pandemics ; Fever

مستخلص: Multisystem Inflammatory Syndrome in Children (MIS-C) presents with fever, fatigue, elevated inflammatory markers (acute phase reactants), and a history of exposure to SARS-CoV-2 or positive antibodies to SARS-CoV-2. As the COVID-19 pandemic unfolded, the risk of MIS-C in the pediatric population increased. However, exposure to other viruses and the presence of SARS-CoV-2 positive antibodies in children hospitalized for various pathogen-associated illnesses will also remain common and may complicate differential diagnoses with diseases endemic to the region such as rickettsial diseases. The objective was to highlight the desirability of medical personnel systematically incorporating rickettsiosis as a differential diagnosis for MIS-C when studying a child with fever, non-specific symptoms, and elevated inflammatory markers. In conclusion MIS-C should be considered in children with elevated inflammatory markers when there is a history of COVID-19 and they also meet criteria that have already been established by international agencies, such as CDC and WHO.
Competing Interests: Conflicts of interest The authors declare no conflicts of interest.
(Copyright © 2023 Sociedade Brasileira de Infectologia. Published by Elsevier España, S.L.U. All rights reserved.)

SCR Disease Name: pediatric multisystem inflammatory disease, COVID-19 related

المؤلفون: Penteado RF; Department of Chemistry, State University of Ponta Grossa, Ponta Grossa, PR, 84030-900, Brazil., Iulek J; Department of Chemistry, State University of Ponta Grossa, Ponta Grossa, PR, 84030-900, Brazil. Electronic address: iulek@uepg.br.

المصدر: Biochimie [Biochimie] 2024 Apr; Vol. 219, pp. 63-73. Date of Electronic Publication: 2023 Sep 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 1264604 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1638-6183 (Electronic) Linking ISSN: 03009084 NLM ISO Abbreviation: Biochimie Subsets: MEDLINE

مواضيع طبية MeSH: Methionine-tRNA Ligase*/chemistry , Methionine-tRNA Ligase*/genetics , Methionine-tRNA Ligase*/metabolism, Animals ; Mice ; Amino Acids ; Rickettsia typhi/metabolism ; X-Ray Diffraction ; Methionine/metabolism

مستخلص: Rickettsia typhi is the causative agent of murine typhus (endemic typhus), a febrile illness that can be self-contained, though in some cases it can progress to death. The three dimensional structure of Methionyl-tRNA Synthetase from R. typhi (RtMetRS) in complex with its substrate l-methionine was solved by molecular replacement and refined at 2.30 Å resolution in space group P1 from one X-ray diffraction dataset. Processing and refinement trials were decisive to establish the lower symmetry space group and indicated the presence of twinning with four domains. RtMetRS belongs to the MetRS1 family and was crystallized with the CP domain in an open conformation, what is distinctive from other MetRS1 enzymes whose structures were solved with a bound L-methionine (therefore, in a closed conformation). This conformation resembles the ones observed in the MetRS2 family.
Competing Interests: Declaration of competing interest We have no conflict of interest to declare.
(Copyright © 2023 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.)

المؤلفون: Laukaitis-Yousey HJ; Department of Microbiology and Immunology, Frederick P. Whiddon College of Medicine, University of South Alabama, Mobile, Alabama, USA.; Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA., Macaluso KR; Department of Microbiology and Immunology, Frederick P. Whiddon College of Medicine, University of South Alabama, Mobile, Alabama, USA.

المصدر: Vector borne and zoonotic diseases (Larchmont, N.Y.) [Vector Borne Zoonotic Dis] 2024 Apr; Vol. 24 (4), pp. 201-213. Date of Electronic Publication: 2024 Mar 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 100965525 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7759 (Electronic) Linking ISSN: 15303667 NLM ISO Abbreviation: Vector Borne Zoonotic Dis Subsets: MEDLINE

مواضيع طبية MeSH: Rickettsia felis* , Ctenocephalides*/microbiology , Coinfection*/veterinary , Rickettsia* , Siphonaptera*/microbiology , Flea Infestations*/veterinary , Felis* , Cat Diseases*, Animals ; Humans ; Cats ; Rickettsia typhi

مستخلص: Purpose: Flea-borne rickettsioses, collectively referred to as a term for etiological agents Rickettsia felis , Rickettsia typhi , and RFLOs ( R. felis -like organisms), has become a public health concern around the world, specifically in the United States. Due to a shared arthropod vector (the cat flea) and clinical signs, discriminating between Rickettsia species has proven difficult. While the effects of microbial coinfections in the vector can result in antagonistic or synergistic interrelationships, subsequently altering potential human exposure and disease, the impact of bacterial interactions within flea populations remains poorly defined. Methods: In this study, in vitro and in vivo systems were utilized to assess rickettsial interactions in arthropods. Results: Coinfection of both R. felis and R. typhi within a tick-derived cell line indicated that the two species could infect the same cell, but distinct growth kinetics led to reduced R. felis growth over time, regardless of infection order. Sequential flea coinfections revealed the vector could acquire both Rickettsia spp. and sustain coinfection for up to 2 weeks, but rickettsial loads in coinfected fleas and feces were altered during coinfection. Conclusion: Altered rickettsial loads during coinfection suggest R. felis and R. typhi interactions may enhance the transmission potential of either agent. Thus, this study provides a functional foundation to disentangle transmission events propelled by complex interspecies relationships during vector coinfections.

المؤلفون: Hsueh YL; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China., Chen HF; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China., Chang MC; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China., Yen TY; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China., Su CL; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China., Chiu HC; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China., Hu HC; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China., Chung YT; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China., Shu PY; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China., Yang SL; Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taiwan, Republic of China.

المصدر: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2024 Mar 12; Vol. 110 (4), pp. 768-778. Date of Electronic Publication: 2024 Mar 12 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE

مواضيع طبية MeSH: Typhus, Endemic Flea-Borne*/diagnosis , Orientia tsutsugamushi* , Scrub Typhus*/diagnosis, Male ; Animals ; Mice ; Humans ; Female ; Taiwan/epidemiology ; Zoonoses/epidemiology ; Rickettsia typhi

مستخلص: Murine typhus is a flea-borne disease caused by Rickettsia typhi infection. The disease is a notifiable infectious disease in Taiwan. Specimens from suspected cases are required to be sent to the Taiwan Centers for Disease Control and Prevention for laboratory diagnosis. In this study, 204 cases of murine typhus were identified by bacterial isolation, real-time polymerase chain reaction, or indirect immunofluorescence assay between 2013 and 2020. The average incidence rate was 0.11/100,000 person-years (95% CI: 0.08-0.13). Murine typhus occurred throughout the year, but it was most prevalent in summer (May to August). The majority of patients were males (75%), residents of Kaohsiung city (31%), and worked in agriculture, forestry, fishing, and animal husbandry (27%). Fever was the most common symptom, present in 95.6% of patients, followed by headache (41%), myalgia (33%), and liver dysfunction (33%). Only 13% of patients had a rash. Up to 80% of cases were among hospitalized patients, and 43% of patients developed severe manifestations. Serological assays also indicated coinfection events. Seven patients showed a 4-fold increase in antibody titers against Orientia tsutsugamushi (N = 2), Coxiella burnetii (n = 2), and Leptospira (N = 3). In conclusion, murine typhus is an endemic and important zoonotic rickettsial disease in Taiwan that cannot be ignored. Further epidemiological surveillance and clinical characteristics should be continuously investigated to prevent and control murine typhus.

المؤلفون: Chinchilla D, Sánchez I, Chung I, Gleaton AN, Kato CY

المصدر: Emerging infectious diseases [Emerg Infect Dis] 2023 Nov; Vol. 29 (11), pp. 2374-2376.

نوع المنشور: Letter

بيانات الدورية: Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Typhus, Endemic Flea-Borne*/diagnosis , Typhus, Endemic Flea-Borne*/epidemiology , Typhus, Endemic Flea-Borne*/microbiology , Rickettsia*, Animals ; Mice ; Humans ; Costa Rica/epidemiology ; Rickettsia typhi/genetics

مستخلص: Murine typhus is a febrile, fleaborne disease caused by infection with Rickettsia typhi bacteria. Cases can range from mild and nonspecific to fatal. We report 2 cases of murine typhus in Costa Rica, confirming the presence and circulation of R. typhi causing severe disease in the country.

المؤلفون: Yomogida K; Center for Animal Disease Modeling and Surveillance, School of Veterinary Medicine, University of California, Davis, California.; Vector-Borne Disease Section, California Department of Public Health, Sacramento, California., Kjemtrup A; Vector-Borne Disease Section, California Department of Public Health, Sacramento, California., Martínez-López B; Center for Animal Disease Modeling and Surveillance, School of Veterinary Medicine, University of California, Davis, California., Ibrahim M; Los Angeles County Department of Public Health, Acute Communicable Disease Control Program - Morbidity Unit, Los Angeles, California., Contreras Z; Los Angeles County Department of Public Health, Acute Communicable Disease Control Program - Morbidity Unit, Los Angeles, California., Ngo V; Los Angeles County Department of Public Health, Acute Communicable Disease Control Program - Morbidity Unit, Los Angeles, California., Halai UA; Los Angeles County Department of Public Health, Acute Communicable Disease Control Program - Morbidity Unit, Los Angeles, California., Balter S; Los Angeles County Department of Public Health, Acute Communicable Disease Control Program - Morbidity Unit, Los Angeles, California., Feaster M; City of Pasadena Public Health Department, Pasadena, California., Zahn M; Orange County Health Care Agency, Santa Ana, California., Shearer E; Orange County Health Care Agency, Santa Ana, California., Sorvillo R; Orange County Health Care Agency, Santa Ana, California., Balanji N; Long Beach Department of Health and Human Services, Communicable Disease Control Program, Long Beach, California., Torres C; Long Beach Department of Health and Human Services, Communicable Disease Control Program, Long Beach, California., Prado B; Long Beach Department of Health and Human Services, Communicable Disease Control Program, Long Beach, California., Porse C; Vector-Borne Disease Section, California Department of Public Health, Sacramento, California., Kramer V; Vector-Borne Disease Section, California Department of Public Health, Sacramento, California.

المصدر: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2023 Dec 18; Vol. 110 (1), pp. 142-149. Date of Electronic Publication: 2023 Dec 18 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE

مواضيع طبية MeSH: Typhus, Endemic Flea-Borne*/diagnosis , Typhus, Epidemic Louse-Borne* , Siphonaptera*/microbiology, Animals ; Mice ; Humans ; Rickettsia typhi ; California/epidemiology

مستخلص: Flea-borne typhus (FBT), also referred to as murine typhus, is an acute febrile disease in humans caused by the bacteria Rickettsia typhi. Currently, cases of FBT are reported for public health surveillance purposes (i.e., to detect incidence and outbreaks) in a few U.S. states. In California, healthcare providers and testing laboratories are mandated to report to their respective local public health jurisdictions whenever R. typhi or antibodies reactive to R. typhi are detected in a patient, who then report cases to state health department. In this study, we characterize the epidemiology of flea-borne typhus cases in California from 2011 to 2019. A total of 881 cases were reported during this period, with most cases reported among residents of Los Angeles and Orange Counties (97%). Demographics, animal exposures, and clinical courses for case patients were summarized. Additionally, spatiotemporal cluster analyses pointed to five areas in southern California with persistent FBT transmission.

المؤلفون: Blanton LS; Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas.

المصدر: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2023 Dec 18; Vol. 110 (1), pp. 1-2. Date of Electronic Publication: 2023 Dec 18 (Print Publication: 2024).

نوع المنشور: Editorial; Comment

بيانات الدورية: Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE

مواضيع طبية MeSH: Siphonaptera*/microbiology , Typhus, Endemic Flea-Borne*/epidemiology , Typhus, Endemic Flea-Borne*/microbiology , Rickettsia Infections*/microbiology , Rickettsia* , Rickettsia felis*, Animals ; Humans ; Rickettsia typhi ; California/epidemiology

المؤلفون: Olivo-Freites C; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California., Davar K; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California., Gallardo-Huizar O; Internal Medicine Department, Olive View Medical Center, University of California, Los Angeles, California., Vijayan T; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California., Younes R; Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California.

المصدر: The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2023 Dec 04; Vol. 110 (1), pp. 150-154. Date of Electronic Publication: 2023 Dec 04 (Print Publication: 2024).

نوع المنشور: Review; Case Reports

بيانات الدورية: Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE

مواضيع طبية MeSH: Typhus, Epidemic Louse-Borne*/drug therapy , Typhus, Endemic Flea-Borne*/diagnosis , Siphonaptera*/microbiology, Humans ; Animals ; Rickettsia typhi ; Anti-Bacterial Agents/therapeutic use

مستخلص: Flea-borne typhus is a vector-borne disease caused by Rickettsia typhi that occurs worldwide, except in Antarctica. In the United States, most cases are restricted to California, Hawaii, and Texas. The syndrome is characterized by nonspecific signs and symptoms: fever, headache, rash, arthralgia, cough, hepatosplenomegaly, diarrhea, and abdominal pain. Although flea-borne typhus can cause pulmonary, neurological, and renal complications, the cardiovascular system is rarely affected. We present a case of endocarditis resulting from flea-borne typhus diagnosed by blood microbial cell-free DNA testing that required valve replacement and antibiotic therapy for 6 months. In addition, we review 20 cases of presumed and confirmed cardiovascular manifestations resulting from flea-borne typhus in the literature.

المؤلفون: Griffiths J; Environmental Health Institute, National Environment Agency, Singapore, Singapore., Yeo HL; Environmental Health Institute, National Environment Agency, Singapore, Singapore. Yeo_Hui_Ling@nea.gov.sg., Yap G; Environmental Health Institute, National Environment Agency, Singapore, Singapore., Mailepessov D; Environmental Health Institute, National Environment Agency, Singapore, Singapore., Johansson P; Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Singapore., Low HT; Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Singapore., Siew CC; Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore, Singapore., Lam P; SAF Biodefence Centre, Force Medical Protection Command, HQ Medical Corps, Singapore Armed Forces, Singapore, Singapore., Ng LC; Environmental Health Institute, National Environment Agency, Singapore, Singapore. Ng_Lee_Ching@nea.gov.sg.

المصدر: Scientific reports [Sci Rep] 2022 Feb 17; Vol. 12 (1), pp. 2692. Date of Electronic Publication: 2022 Feb 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Disease Reservoirs* , Rickettsia typhi* , Seoul virus*, Zoonoses/*epidemiology, Animals ; Humans ; Leptospira ; Rodentia ; Seroepidemiologic Studies ; Singapore/epidemiology

مستخلص: Rodents living alongside humans increases the probability of encounter and also the transmission of rodent-borne diseases. Singapore's cosmopolitan urban landscape provides a perfect setting to study the prevalence of four rodent-borne pathogens: Seoul hantavirus (SEOV), Leptospira species, Rickettsia typhi and Yersinia pestis, and identify the potential risk factors which may influence rodent density and transmission of rodent-borne diseases. A total of 1143 rodents were trapped from 10 unique landscape structures throughout Singapore. Real-time quantitative Polymerase Chain Reactions were used to detect pathogenic and intermediate Leptospira spp. and Yersinia pestis, whereas the seroprevalence of SEOV and R. typhi were analysed by Enzyme-Linked Immunosorbent Assay and Immunofluorescence Assay respectively. Multivariable logistic regression analysis was used to evaluate the association between prevalence of infection in rodent reservoirs and risk factors. Most of the rodents were caught in public residential developments (62.2%). Among the tested rodents, 42.4% were infected with Leptospira spp., while 35.5% and 32.2% were seropositive for SEOV and R. typhi respectively, whereas Yersinia pestis was not detected. Furthermore, risk factors including habitat, species, gender, and weight of rodents, influenced prevalence of infection to a varying extent. This study highlights the presence of Leptospira spp., SEOV and R. typhi in Singapore's rodent population, suggesting the need for effective rodent management and sanitation strategies to prevent further circulation and transmission to humans.
(© 2022. The Author(s).)

عنوان ترانسليتريتد: Rickettsia rickettsii y Rickettsia typhi en habitantes de una comunidad rural del sureste de México.

المؤلفون: Torres-Castro M; Universidad Autónoma de Yucatán, Mérida, México., Reyes-Novelo E; Universidad Autónoma de Yucatán, Mérida, México., Noh-Pech H; Universidad Autónoma de Yucatán, Mérida, México., Sánchez-Montes S; Universidad Veracruzana, Veracruz, México., Colunga-Salas P; Universidad Veracruzana, Veracruz, México., Lugo-Caballero C; Universidad Autónoma de Yucatán, Mérida, México., Rodríguez-Vivas RI; Universidad Autónoma de Yucatán, Mérida, México.

المصدر: Revista peruana de medicina experimental y salud publica [Rev Peru Med Exp Salud Publica] 2022 Jan-Mar; Vol. 39 (1), pp. 124-125. Date of Electronic Publication: 2022 Jun 24.

نوع المنشور: Letter

بيانات الدورية: Publisher: Instituto Nacional de Salud Country of Publication: Peru NLM ID: 101227566 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1726-4642 (Electronic) Linking ISSN: 17264634 NLM ISO Abbreviation: Rev Peru Med Exp Salud Publica Subsets: MEDLINE

مواضيع طبية MeSH: Rickettsia* , Rickettsia typhi*, Humans ; Mexico ; Rickettsia rickettsii ; Rural Population