المؤلفون: Woroud Yassin, Roni Nasser, Ella Veitsman, Tarek Saadi

المصدر: The Turkish Journal of Gastroenterology, Vol 35, Iss 3, Pp 232-238 (2024)

مصطلحات موضوعية: Diseases of the digestive system. Gastroenterology, RC799-869

وصف الملف: electronic resource

Relation: https://www.turkjgastroenterol.org/en/the-effectiveness-of-measuring-thiopurine-metabolites-in-the-treatment-of-autoimmune-hepatitis-patients-137206; https://doaj.org/toc/2148-5607

URL الوصول: https://doaj.org/article/42f81bc534da46e6befa643f2e51f324

المؤلفون: Roni Nasser, Mohammad E. Naffaa, Tanya Mashiach, Zaher S. Azzam, Eyal Braun

المصدر: BMC Infectious Diseases, Vol 18, Iss 1, Pp 1-7 (2018)

مصطلحات موضوعية: Pneumonia, Hypomagnesemia, Hypermagnesemia, Mortality, Infectious and parasitic diseases, RC109-216

الوصف: Abstract Background Community acquired pneumonia (CAP) is a common illness affecting hundreds of millions worldwide. Few studies have investigated the relationship between serum magnesium levels and outcomes of these patients. We aimed to study the association between serum magnesium levels and 30-day mortality among patients with CAP. Methods Retrospective overview of patients hospitalized with CAP between January 1, 2010 and December 31, 2016. Participants were analyzed retrospectively in order to identify the risk factors for a primary endpoint of 30-day mortality. Normal levels of magnesium levels in our laboratory varies between 1.35 and 2.4 mg/dl. Results 3851 patients were included in our cohort. Age > 75 years, blood urea nitrogen (BUN) > 20 mg/dl, hypoalbuminemia, and abnormal levels of magnesium were all associated with increased risk of 30-day mortality. Normal magnesium levels were associated with the lowest mortality rate (14.7%). Notably, within the normal levels, high normal magnesium levels (2–2.4 mg/dl) were correlated with higher mortality rates (30.3%) as compared to levels that ranged between 1.35–2 mg/dl (12.9%). Hypomagnesemia and hypermagnesemia were both associated with excess of 30-day mortality, 18.4 and 50%, respectively. Conclusion Hypomagnesemia and hypermagnesemia on admission were associated with an increased rate of 30-day mortality among adult patients hospitalized with CAP. Interestingly, magnesium levels within the upper normal limits were associated with higher mortality.

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12879-018-3627-2; https://doaj.org/toc/1471-2334

URL الوصول: https://doaj.org/article/39a3524a38da432189e908dbc83d1c92

المؤلفون: Tarek Saadi, Ella Veitsman, Nemer Sayed Ahmad, Roni Nasser

المصدر: Journal of Gastrointestinal and Liver Diseases. 32:119-120

مصطلحات موضوعية: Gastroenterology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::846a4a49a1ce5048e98c5e09b702f3ea
https://doi.org/10.15403/jgld-4717

المؤلفون: Razi, Even Dar, Jasmin, Khateeb, Roni, Nasser, Zaher, Azzam, Mogher, Khamaisi

المصدر: Harefuah. 160(8)

مصطلحات موضوعية: Physicians, Surveys and Questionnaires, Internal Medicine, Humans, Workload, Burnout, Professional, Job Satisfaction

الوصف: In recent years, the status of Internal Medicine has been constantly wearing down. There has been a dramatic decrease in the number of internal medicine students and residents planning to pursue careers in internal medicine. This is mainly due to a higher workload, as well as physical and professional exhaustion leading to work dissatisfaction and provision of suboptimal patient care. Therefore, an increased tendency towards selecting a career in internal medicine sub-specialties has been noted. In this paper, we will present an open and sincere talk with three young internal medicine specialists, who willingly decided to keep working in internal medicine departments despite the challenging work environment. We will discuss the burnout associated with poor work-life/home balance and disruptive work environment and suggest measurements that may enhance the educational and professional experience and career satisfaction and increase the well-being of internal medicine specialists in the future. We aim to promote awareness to the importance of maintaining high-quality senior physicians working in Internal Medicine departments.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::76e445b00769cedbb0dbfa326fcf0646
https://pubmed.ncbi.nlm.nih.gov/34396732

المؤلفون: Ella Veitsman, Roni Nasser, Afif Yaacob, Tarek Saadi, Daniel Kurnik, Matti Waterman, Yael Lurie, Laila Nassar

المصدر: Clinics and Research in Hepatology and Gastroenterology. 44:e29-e31

مصطلحات موضوعية: Hepatology, Thiopurine methyltransferase, biology, business.industry, Gastroenterology, biology.protein, MEDLINE, Medicine, Bioinformatics, business, medicine.disease, Cholestasis of pregnancy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::2b1dfed4bfef0c550264c5fc533cff0a
https://doi.org/10.1016/j.clinre.2019.04.004

المؤلفون: Subhi Mansour, Kamel Yasin, Roni Nasser, Safi Khuri, Hayim Gilshtein, Giuseppe Borzellino

المصدر: Journal of Clinical Medicine Research

مصطلحات موضوعية: Weakness, medicine.medical_specialty, Extra-hepatic cholangiocarcinoma, Disease, Review, Gastroenterology, Primary sclerosing cholangitis, 03 medical and health sciences, 0302 clinical medicine, Fibrosis, Internal medicine, parasitic diseases, medicine, Autoimmune pancreatitis, business.industry, Bile duct, Organ dysfunction, fungi, General Medicine, medicine.disease, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Etiology, 030211 gastroenterology & hepatology, medicine.symptom, business, Immunoglobulin G4 sclerosing cholangitis

الوصف: Immunoglobulin G4 sclerosing cholangitis (IgG4-SC), firstly described in 2004, is the biliary manifestation of a recently described multisystem immune-mediated disease known as IgG4-related disease. IgG4-SC is a unique and rare type of cholangitis of unknown etiology and its precise prevalence rate is still unclear. It is characterized by bile duct wall thickening and high levels of systemic serum IgG4 plasma cells. Differential diagnoses for IgG4-SC include benign (primary sclerosing cholangitis) as well as malignant (extra-hepatic cholangiocarcinoma) diseases. Discrimination between these entities is very important, due to the fact that they have different biological behaviors and different therapeutic strategies. The rare IgG4-SC subgroup with its puzzling manifestations carries a hefty diagnostic challenge for the treating physicians, and inaccurate diagnosis can lead to unnecessary morbid surgical procedures. With the paucity and relative weakness of available data in the current literature, one needs to carefully review all available parameters. A low threshold of suspicion is required to try and prevent missing IgG4-SC. IgG4-SC is highly responsive to steroid treatment, especially during the early inflammatory phase, while delay in management could lead to fibrosis and organ dysfunction. On the other hand, cholangiocarcinoma is treated by means of surgery and/or chemotherapeutic agents.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06daac1525549221ba386884008be8e3
http://hdl.handle.net/11562/1075089

المؤلفون: Ido Solt, Yaakov Dickstein, Amjad Mousa, Stav Rakedzon, Neta Peterisel, Tzah Feldman, Ami Neuberger, Roni Nasser

المصدر: Journal of Travel Medicine. 27

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, Influenza vaccine, Yellow fever vaccine, Meningococcal vaccine, Rubella, Measles, Typhoid fever, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, medicine, Humans, 030212 general & internal medicine, Japanese encephalitis vaccine, Vaccines, 030219 obstetrics & reproductive medicine, business.industry, Vaccination, Hepatitis A, General Medicine, medicine.disease, Female, Travel-Related Illness, business, Travel Medicine, medicine.drug

الوصف: Pregnant travellers and their offspring are vulnerable to severe outcomes following a wide range of infections. Vaccine-preventable diseases can have a particularly severe course in pregnant women, but little is known about the safety of travel vaccines in pregnant women. We performed a systematic review of all published literature concerning the safety of vaccines frequently given to travellers such as yellow fever, MMR (mumps, measles and rubella), influenza, Tdap (tetanus, diphtheria and pertussis), meningococcus, hepatitis A and B, rabies, polio, typhoid fever, tick-borne encephalitis and Japanese encephalitis vaccines. We included case series, cohort studies and randomized controlled trials (RCTs). For the meta-analysis, we included only RCTs that compared the administration of a vaccine to placebo or to no vaccine. Outcome measures included severe systemic adverse events, maternal outcomes related to the course of pregnancy, neonatal outcomes and local adverse events. We calculated the risk ratio and its 95% confidence interval as the summary measure. The safety of influenza vaccine is supported by high-quality evidence. For Tdap vaccine, no evidence of any harm was found in the meta-analysis of RCTs. A slight increase in chorioamnionitis rate was reported in 3 out of 12 observational studies. However, this small possible risk is far outweighed by a much larger benefit in terms of infant morbidity and mortality. Meningococcal vaccines are probably safe during pregnancy, as supported by RCTs comparing meningococcal vaccines to other vaccines. Data from observational studies support the safety of hepatitis A, hepatitis B and rabies vaccines, as well as that of the live attenuated yellow fever vaccine. We found little or no data about the safety of polio, typhoid, Japanese encephalitis, tick-borne encephalitis and MMR vaccines during pregnancy.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b59478b5b9c93190b4734e790d9ea7
https://doi.org/10.1093/jtm/taz074

المؤلفون: Itai, Ghersin, Omar, Abu Alheija, Zaher S, Azzam, Roni, Nasser

المصدر: The Israel Medical Association journal : IMAJ. 21(10)

مصطلحات موضوعية: Heart Failure, Male, Magnetic Resonance Imaging, Cine, Amyloidosis, Prognosis, Listeria monocytogenes, Patient Care Management, Electrocardiography, Immunocompromised Host, Fatal Outcome, Echocardiography, Humans, Pericarditis, Listeriosis, Hypotension, Aged

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::049d2ad7b1348551e59a63a7683e43df
https://pubmed.ncbi.nlm.nih.gov/31599514

المؤلفون: David Azoulay, Rivka Sharon, Netanel A. Horowitz, Roni Nasser, Ety Shaoul, Luiza Akria, Liya Simanovich

المصدر: British Journal of Haematology. 185:175-177

مصطلحات موضوعية: Male, 0301 basic medicine, Vincristine, Genotype, Lymphoma, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Polymorphism (computer science), medicine, Humans, In patient, Allele, Alleles, business.industry, Brain-Derived Neurotrophic Factor, Peripheral Nervous System Diseases, Hematology, medicine.disease, 030104 developmental biology, Peripheral neuropathy, Amino Acid Substitution, Cancer research, Female, Disease Susceptibility, business, 030217 neurology & neurosurgery, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4434d380cfa798e501aa7a6c3dfe434
https://doi.org/10.1111/bjh.15428

المؤلفون: Rivka Sharon, David Azoulay, Roni Nasser, Netanel A. Horowitz, Sami Giryes

المصدر: Journal of Clinical Neurology (Seoul, Korea)

مصطلحات موضوعية: Oncology, medicine.medical_specialty, Vincristine, medicine.medical_treatment, 03 medical and health sciences, 0302 clinical medicine, Neurotrophic factors, Internal medicine, medicine, 030212 general & internal medicine, Multiple myeloma, Chemotherapy, Bortezomib, business.industry, non-Hodgkin lymphoma, medicine.disease, Lymphoma, multiple myeloma, Val66Met single-nucleotide polymorphism, Peripheral neuropathy, BDNF, Neurology, Chemotherapy-induced peripheral neuropathy, Original Article, Neurology (clinical), business, 030217 neurology & neurosurgery, medicine.drug, chemotherapy-induced peripheral neuropathy

الوصف: Background and purpose Brain-derived neurotrophic factor (BDNF) is a neuronal growth factor that plays an essential role in the maintenance of the nervous system. We have evaluated the peripheral blood protein levels of BDNF and the valine-to-methionine substitution at codon 66 (Val66Met) single-nucleotide polymorphism (SNP) as potential biomarkers for the early recognition of chemotherapy-induced peripheral neuropathy (CIPN) in non-Hodgkin lymphoma and multiple myeloma patients. Methods CIPN was assessed in 45 patients at the diagnosis and during vincristine or bortezomib-based therapy using objective [reduced version of the Total Neuropathy Score (TNSr)] and subjective (FACT-GOG-NTx) tools. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9) questionnaire. BDNF protein levels and the Val66Met SNP were determined using ELISA and Sanger sequencing. Results The pretreatment BDNF protein level was inversely correlated with the maximum TNSr, FACT-GOG-NTx, and PHQ-9 scores in both genotypes. BDNF patients with the Val/Val genotype demonstrated significantly higher maximum FACT-GOG-NTx and PHQ-9 scores than those with the Val/Met and Met/Met genotypes (Met-BNDF carriers). Correlations between PHQ-9 and TNSr score were found only in Met-BDNF carriers, suggesting that peripheral neuropathy and depression coincide in Met-BDNF carriers. Conclusions Determining the BDNF protein levels before initiating chemotherapy might be a useful tool for CIPN risk assessment and preemptive dose modification. The present data should be validated in larger studies that include other neurotoxic agents.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520f28c5a5e9b1f44e2a8b4b28a460a9
https://pubmed.ncbi.nlm.nih.gov/31591840