المؤلفون: Zhou, Zichuan, Kassem, Amany, Seddon, James, Sillekens, Eric, Darwazeh, Izzat, Bayvel, Polina, Liu, Zhixin

المصدر: 2024 Optical Fiber Communications Conference and Exhibition (OFC) Optical Fiber Communications Conference and Exhibition (OFC), 2024. :1-3 Mar, 2024

Relation: 2024 Optical Fiber Communications Conference and Exhibition (OFC)

المؤلفون: Morse, Rachel M, Myburgh, Hanlie, Reubi, David, Archey, Ava E, Busakwe, Leletu, Garcia-Prats, Anthony J, Hesseling, Anneke C, Jacobs, Stephanie, Mbaba, Sharon, Meyerson, Kyla, Seddon, James A, van der Zalm, Marieke M, Wademan, Dillon T, Hoddinott, Graeme

المصدر: JMIR mHealth and uHealth, Vol 8, Iss 11, p e19154 (2020)

مصطلحات موضوعية: Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270

الوصف: Tuberculosis is the number one infectious cause of death globally. Young children, generally those younger than 5 years, are at the highest risk of progressing from tuberculosis infection to tuberculosis disease and of developing the most severe forms of tuberculosis. Most current tuberculosis drug formulations have poor acceptability among children and require consistent adherence for prolonged periods of time. These challenges complicate children’s adherence to treatment and caregivers’ daily administration of the drugs. Rapid developments in mobile technologies and apps present opportunities for using widely available technology to support national tuberculosis programs and patient treatment adherence. Pilot studies have demonstrated that mobile apps are a feasible and acceptable means of enhancing children’s treatment adherence for other chronic conditions. Despite this, no mobile apps that aim to promote adherence to tuberculosis treatment have been developed for children. In this paper, we draw on our experiences carrying out research in clinical pediatric tuberculosis studies in South Africa. We present hypothetical scenarios of children’s adherence to tuberculosis medication to suggest priorities for behavioral and educational strategies that a mobile app could incorporate to address some of the adherence support gaps faced by children diagnosed with tuberculosis. We argue that a mobile app has the potential to lessen some of the negative experiences that children associate with taking tuberculosis treatment and to facilitate a more positive treatment adherence experience for children and their caregivers.

وصف الملف: electronic resource

Relation: https://mhealth.jmir.org/2020/11/e19154; https://doaj.org/toc/2291-5222

URL الوصول: https://doaj.org/article/3bebcd4c111c4aeba7aa0e175866b5b8

المؤلفون: Zhou, Zichuan, Kassem, Amany, Seddon, James, Sillekens, Eric, Darwazeh, Izzat, Bayvel, Polina, Liu, Zhixin

مصطلحات موضوعية: Electrical Engineering and Systems Science - Signal Processing, Electrical Engineering and Systems Science - Systems and Control, Physics - Optics

الوصف: We generate and transmit 75-GHz-bandwidth OFDM signals over the air using three mutually frequency-locked lasers, achieving minimal frequency gap between the wireless W and D bands using optical-assisted approaches, resulting in 173.5 Gb/s detected capacity.
Comment: 3 pages, 2 figures, conference submission

URL الوصول: http://arxiv.org/abs/2311.04223

المؤلفون: Gohil, Himanshu, Wang, Hui, Pardo, Diego, Seddon, James, Renaud, Cyril, Huggard, Peter G.

المصدر: 2023 48th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), 2023 48th International Conference on. :1-2 Sep, 2023

Relation: 2023 48th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)

المؤلفون: Georgiades, Marie-Leonie, Seddon, James, Renaud, Cyril

المصدر: 2023 48th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), 2023 48th International Conference on. :1-2 Sep, 2023

Relation: 2023 48th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)

المؤلفون: Belio-Apaolaza, Inigo, Seddon, James, Perez-Escudero, Jose M., Ederra, Inigo, Renaud, Cyril C.

المصدر: 2023 48th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), 2023 48th International Conference on. :1-2 Sep, 2023

Relation: 2023 48th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)

المؤلفون: Seddon, James, Hale, Lucy, Jung, Hyunseung, Norman, Sarah, Addamane, Sadhvikas, Brener, Igal, Renaud, Cyril, Mitrofanov, Oleg

المصدر: 2023 48th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz) Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), 2023 48th International Conference on. :1-2 Sep, 2023

Relation: 2023 48th International Conference on Infrared, Millimeter, and Terahertz Waves (IRMMW-THz)

المؤلفون: Tough, Euan J., Fice, Martyn J., Renaud, Cyril C., Seddon, James, Seeds, Alwyn J., Graham, Chris, Balakier, Katarzyna, Carpintero, Guillermo

المصدر: 2021 International Topical Meeting on Microwave Photonics (MWP) Microwave Photonics (MWP), 2021 International Topical Meeting on. :1-4 Nov, 2021

Relation: 2021 International Topical Meeting on Microwave Photonics (MWP)

المؤلفون: Seddon, James, Graham, Chris, Georgiades, Marie, Renaud, Cyril, Seeds, Alwyn

مصطلحات موضوعية: Physics - Optics, Physics - Instrumentation and Detectors

الوصف: Continuous Wave (CW) Terahertz spectroscopy enabled by photomixing is a promising high precision spectroscopic tool for the examination of a wide variety of samples including biological, chemical, and solid state. However, often it would be of interest to examine isolated samples free from bulk effects that broaden spectral features. In this form samples with low concentrations of absorbers have a reduced cross section making coupling to an external driving field a challenge. By utilising THz metamaterials one can borrow the concepts of surface enhanced Raman spectroscopy to confine and concentrate the THz fields to increase sensitivity for samples with a small cross section. Our work combines high-speed photodiode technology and THz metamaterials to offer a solution to this challenge. We present here a proof of concept on-chip THz spectrometer integrated with a metamaterial waveguide.

URL الوصول: http://arxiv.org/abs/2212.02215

المؤلفون: Huerga, Helena, Villalba, Julian, Grandjean, Louis, Sotgiu, Giovanni, Egere, Uzochukwu, Singh, Sarman, Zhu, Limei, Lienhardt, Christian, Denholm, Justin, Seddon, James, Whalen, Christopher, García-Basteiro, Alberto, Triasih, Rina, Chen, Cheng, Singh, Jitendra, Huang, Li-Min, Sharma, Surendra, Hannoun, Djohar, Del Corral, Helena, Mandalakas, Anna, Malone, LaShaunda, Ling, Du-Lin, Kritski, Afrânio, Stein, Catherine, Vashishtha, Richa, Boulahbal, Fadila, Fang, Chi-Tai, Boom, W, Netto, Eduardo, Lemos, Antonio, Hesseling, Anneke, Kay, Alexander, Jones-López, Edward, Horsburgh, C, Lange, Christoph, Andrews, Jason, Martinez, Leonardo, Cords, Olivia, Liu, Qiao, Acuna-Villaorduna, Carlos, Bonnet, Maryline, Fox, Greg, Carvalho, Anna, Chan, Pei-Chun, Croda, Julio, Hill, Philip, Lopez-Varela, Elisa, Donkor, Simon, Fielding, Katherine, Graham, Stephen, Espinal, Marcos, Kampmann, Beate, Reingold, Arthur

المصدر: The Lancet Global Health. 10(9)

مصطلحات موضوعية: Adolescent, Adult, Aged, BCG Vaccine, Child, Child, Preschool, Humans, Infant, Infant, Newborn, Retrospective Studies, Tuberculosis, Tuberculosis, Pulmonary, Vaccination

الوصف: BACKGROUND: BCG vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children and adults. We therefore aimed to investigate the age-specific impact of infant BCG vaccination on tuberculosis (pulmonary and extrapulmonary) development and mortality. METHODS: In this systematic review and individual participant data meta-analysis, we searched MEDLINE, Web of Science, BIOSIS, and Embase without language restrictions for case-contact cohort studies of tuberculosis contacts published between Jan 1, 1998, and April 7, 2018. Search terms included mycobacterium tuberculosis, TB, tuberculosis, and contact. We excluded cohort studies that did not provide information on BCG vaccination or were done in countries that did not recommend BCG vaccination at birth. Individual-level participant data for a prespecified list of variables, including the characteristics of the exposed participant (contact), the index case, and the environment, were requested from authors of all eligible studies. Our primary outcome was a composite of prevalent (diagnosed at or within 90 days of baseline) and incident (diagnosed more than 90 days after baseline) tuberculosis in contacts exposed to tuberculosis. Secondary outcomes were pulmonary tuberculosis, extrapulmonary tuberculosis, and mortality. We derived adjusted odds ratios (aORs) using mixed-effects, binary, multivariable logistic regression analyses with study-level random effects, adjusting for the variable of interest, baseline age, sex, previous tuberculosis, and whether data were collected prospectively or retrospectively. We stratified our results by contact age and Mycobacterium tuberculosis infection status. This study is registered with PROSPERO, CRD42020180512. FINDINGS: We identified 14 927 original records from our database searches. We included participant-level data from 26 cohort studies done in 17 countries in our meta-analysis. Among 68 552 participants, 1782 (2·6%) developed tuberculosis (1309 [2·6%] of 49 686 BCG-vaccinated participants vs 473 [2·5%] of 18 866 unvaccinated participants). The overall effectiveness of BCG vaccination against all tuberculosis was 18% (aOR 0·82, 95% CI 0·74-0·91). When stratified by age, BCG vaccination only significantly protected against all tuberculosis in children younger than 5 years (aOR 0·63, 95% CI 0·49-0·81). Among contacts with a positive tuberculin skin test or IFNγ release assay, BCG vaccination significantly protected against tuberculosis among all participants (aOR 0·81, 95% CI 0·69-0·96), participants younger than 5 years (0·68, 0·47-0·97), and participants aged 5-9 years (0·62, 0·38-0·99). There was no protective effect among those with negative tests, unless they were younger than 5 years (0·54, 0·32-0·90). 14 cohorts reported on whether tuberculosis was pulmonary or extrapulmonary (n=57 421). BCG vaccination significantly protected against pulmonary tuberculosis among all participants (916 [2·2%] in 41 119 vaccinated participants vs 334 [2·1%] in 16 161 unvaccinated participants; aOR 0·81, 0·70-0·94) but not against extrapulmonary tuberculosis (106 [0·3%] in 40 318 vaccinated participants vs 38 [0·2%] in 15 865 unvaccinated participants; 0·96, 0·65-1·41). In the four studies with mortality data, BCG vaccination was significantly protective against death (0·25, 0·13-0·49). INTERPRETATION: Our results suggest that BCG vaccination at birth is effective at preventing tuberculosis in young children but is ineffective in adolescents and adults. Immunoprotection therefore needs to be boosted in older populations. FUNDING: National Institutes of Health.

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/01b0v9mg