المؤلفون: Hongzhou Liu, Song Dong, Hua Yang, Linlin Wang, Jia Liu, Yangfan Du, Jing Liu, Zhaohui Lyu, Yuhan Wang, Li Jiang, Shasha Yu, Xiaomin Fu

المصدر: Journal of International Medical Research, Vol 52 (2024)

مصطلحات موضوعية: Medicine (General), R5-920

الوصف: Objective To evaluate the effectiveness of machine learning (ML) models in predicting 5-year type 2 diabetes mellitus (T2DM) risk within the Chinese population by retrospectively analyzing annual health checkup records. Methods We included 46,247 patients (32,372 and 13,875 in training and validation sets, respectively) from a national health checkup center database. Univariate and multivariate Cox analyses were performed to identify factors influencing T2DM risk. Extreme Gradient Boosting (XGBoost), support vector machine (SVM), logistic regression (LR), and random forest (RF) models were trained to predict 5-year T2DM risk. Model performances were analyzed using receiver operating characteristic (ROC) curves for discrimination and calibration plots for prediction accuracy. Results Key variables included fasting plasma glucose, age, and sedentary time. The LR model showed good accuracy with respective areas under the ROC (AUCs) of 0.914 and 0.913 in training and validation sets; the RF model exhibited favorable AUCs of 0.998 and 0.838. In calibration analysis, the LR model displayed good fit for low-risk patients; the RF model exhibited satisfactory fit for low- and high-risk patients. Conclusions LR and RF models can effectively predict T2DM risk in the Chinese population. These models may help identify high-risk patients and guide interventions to prevent complications and disabilities.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1473-2300

URL الوصول: https://doaj.org/article/bb1f611b351341f990c79dde54fe205f

المؤلفون: Hongzhou Liu, Xinxia Yao, Linlin Wang, Jia Liu, Xiaojing Li, Xiaomin Fu, Jing Liu, Song Dong, Yuhan Wang

المصدر: Frontiers in Endocrinology, Vol 15 (2024)

مصطلحات موضوعية: Mendelian randomization, serum, lipid, diabetic nephropathy, instrumental variable, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: BackgroundSerum lipids were found to be correlated with chronic kidney disease and cardiovascular disease. Here, we aimed to research the potential causal associations between five serum lipid parameters and the risk of diabetic nephropathy using several Mendelian Randomization methods.MethodsGenetic data was obtained from the UK Biobank datasets. Causal effects were estimated using multiple MR methods. Heterogeneity and pleiotropy tests were performed.ResultsMR analysis revealed that HDL-C and TG exhibited causal associations with diabetic nephropathy (P

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2024.1358358/full; https://doaj.org/toc/1664-2392

URL الوصول: https://doaj.org/article/8b87182434ad40bb82cd62c7ace67982

المؤلفون: Si-Yang Liu, Song Dong, Xue-Ning Yang, Ri-Qiang Liao, Ben-Yuan Jiang, Qun Wang, Xiao-Song Ben, Gui-Bin Qiao, Jun-Tao Lin, Hong-Hong Yan, Li-Xu Yan, Qiang Nie, Hai-Yan Tu, Bin-Chao Wang, Jin-Ji Yang, Qing Zhou, Hong-Rui Li, Ke Liu, Wendy Wu, Si-Yang Maggie Liu, Wen-Zhao Zhong, Yi-Long Wu

المصدر: Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-10 (2023)

مصطلحات موضوعية: Medicine, Biology (General), QH301-705.5

الوصف: Abstract This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive (N) and nivolumab–chemotherapy (N/C) combinations based on PD-L1 expression. Eligible patients exhibited resectable clinical stage IIA–IIIB (AJCC 8th edition) NSCLC without EGFR/ALK alterations. Patients received either mono-nivolumab (N) or nivolumab + nab-paclitaxel+ carboplatin (N/C) for three cycles based on PD-L1 expression. The primary endpoint was the major pathological response (MPR). Key secondary endpoints included the pathologic complete response (pCR), objective response rate (ORR), and event-free survival (EFS). Baseline PD-L1 expression and perioperative circulating tumor DNA (ctDNA) status were correlated with pCR and EFS. Fifty-two patients were enrolled, with 46 undergoing surgeries. The MPR was 50.0% (26/52), with 25.0% (13/52) achieving pCR, and 16.7% and 66.7% for patients with PD-L1 ≥ 50% in N and N/C groups, respectively. Thirteen (25.0%) patients experienced grade 3 or higher immune-related adverse events during neoadjuvant treatment. Patients with post-neoadjuvant ctDNA negativity was more likely to have pCR (39.1%) compared with those remained positive (6.7%, odds ratio = 6.14, 95% CI 0.84-Inf, p = 0.077). With a median follow-up of 25.1 months, the 18-month EFS rate was 64.8% (95% CI 51.9–81.0%). For patients with ctDNA– vs. ctDNA + , the 18m-EFS rate was 93.8% vs 47.3% (HR, 0.15; 95% CI 0.04, 0.94; p = 0.005). Immunochemotherapy may serve as an optimal neoadjuvant treatment even for patients with PD-L1 expression ≥ 50%. ctDNA negativity following neoadjuvant treatment and surgery could help identify superior pathological and survival benefits, which requires further confirmation in a prospective clinical trial (NCT04015778).

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2059-3635

URL الوصول: https://doaj.org/article/fac0f07d3dc04d809e388bf7352818af

المؤلفون: GAO Pengcheng, HUANG Qiaogao, SONG Dong, PAN Guang, MA Yunlong

المصدر: Xibei Gongye Daxue Xuebao, Vol 41, Iss 3, Pp 595-600 (2023)

مصطلحات موضوعية: 蝠鲼, 集群滑翔, 编队设置, 水动力特性, 减阻, Motor vehicles. Aeronautics. Astronautics, TL1-4050

الوصف: To investigate the effect of group gliding formation on the hydrodynamic performance of manta rays, numerical simulations were used to investigate the drag, the lift and pressure distribution of multiple manta rays in tandem, triangular and diamond-shaped arrangements. The simulation results show that the leader manta ray at the head of the group always suffers the least drag, and in most cases, the companion manta ray at the tail of the group suffers the most drag. The pressure distribution in the flow field shows that the drag reduction effect mainly comes from the distribution of high pressure and low pressure zones among the individual rays in the cluster, the high pressure zone is beneficial to the manta rays at the front of the group, and under certain circumstances, the presence of low pressure zone generates forward suction to reduce the drag of the manta rays at the end of the group. It is found that when manta rays glide in "two in front and one at the back", four-body diamond, six-body tandem and six-body diamond arrangement, the average drag of the system can be reduced, which provides theoretical guidance for the formation of bionic vehicle groups.

وصف الملف: electronic resource

Relation: https://www.jnwpu.org/articles/jnwpu/full_html/2023/03/jnwpu2023413p595/jnwpu2023413p595.html; https://doaj.org/toc/1000-2758; https://doaj.org/toc/2609-7125

URL الوصول: https://doaj.org/article/3591d6e015a94b44a7d67027e7611785

المؤلفون: Rui Fu, Jun Huang, Xiaoru Tian, Chaoyang Liang, Yuanyuan Xiong, Jia‐Tao Zhang, Benyuan Jiang, Song Dong, Yuhua Gong, Wei Gao, Fang Li, Yonglei Shi, Zhentian Liu, Xuan Gao, Rongrong Chen, Wenzhao Zhong, Yi Zhang

المصدر: Molecular Oncology, Vol 17, Iss 5, Pp 825-838 (2023)

مصطلحات موضوعية: ctDNA, molecular residual disease, non‐tissue‐derived ctDNA mutations, resectable lung cancer, risk stratification, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Circulating tumor DNA (ctDNA) has potential as a promising biomarker for molecular residual disease (MRD) detection in lung cancer. As the next‐generation sequencing standardized panel for ctDNA detection emerges, its clinical utility needs to be validated. We prospectively recruited 184 resectable lung cancer patients from four medical centers. Serial postoperative ctDNAs were analyzed by a standardized panel. A total of 427 postoperative plasma samples from 177 eligible patients were enrolled. ctDNA positivity after surgery was an independent predictor for disease recurrence and preceded radiological recurrence by a median of 6.6 months (range, 0.7–27.0 months). ctDNA‐positive or ‐negative patients with tumors of any stage had similar disease‐free survival (DFS). Patients who received targeted therapy had significantly improved DFS than those not receiving adjuvant therapy or receiving chemotherapy, regardless of baseline/preadjuvant ctDNA status. According to whether the ctDNA variants were detected in its matched tissue, they were classified into tissue derived and non‐tissue derived. Patients with detectable postoperative ctDNA with tissue‐derived mutations had comparable DFS with those with non‐tissue‐derived mutations. Collectively, we demonstrated that postoperative ctDNA has the potential to stratify prognosis and optimize tumor stage in resectable lung cancer. ctDNA variants not identified in tissue samples should be considered in MRD test.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

URL الوصول: https://doaj.org/article/e4f5ea1121974d468711e93147e294cc

المؤلفون: Jia-Tao Zhang, Juan Zhang, Song-Rong Wang, Li-Xu Yan, Jing Qin, Kai Yin, Xiang-Peng Chu, Meng-Min Wang, Hui-Zhao Hong, Zhi-Yi Lv, Song Dong, Ben-Yuan Jiang, Xu-Chao Zhang, Xiang Liu, Qing Zhou, Yi-Long Wu, Wen-Zhao Zhong

المصدر: iScience, Vol 26, Iss 10, Pp 107699- (2023)

مصطلحات موضوعية: Cancer, Omics, Transcriptomics, Science

الوصف: Summary: Pulmonary nodules with part-solid imaging features manifest during the progression from preinvasive to invasive lung adenocarcinoma. To define the spatial composition and evolutionary trajectories of early-stage lung adenocarcinoma, we combined spatial transcriptomics (ST) and pathological annotations from 20 part-solid nodules (PSNs), four of which were matched with single-cell RNA sequencing. Two malignant cell populations (MC1 and MC2) were identified, and a linear evolutionary relationship was observed. Compared to MC2, the pre-existing malignant MC1 exhibited a lower metastatic signature, corresponding to the preinvasive component (lepidic) on pathology and the ground glass component on PSN imaging. Higher immune infiltration was observed among MC1 regions in ST profiles, and further analysis revealed that macrophages may be involved in this process through the CD74 axis. This work provides deeper insights into the evolutionary process and spatial immune cell composition behind PSNs and highlights the mechanisms of immune escape behind this adenocarcinoma trajectory.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223017765; https://doaj.org/toc/2589-0042

URL الوصول: https://doaj.org/article/006216a480c04cc78f0d4e6d7c0343c7

المؤلفون: Xixi Xiang, Fu LI, Xiaojuan Deng, Jun Rao, Jiali LI, Sha Zhou, Hongyun Liu, Shijia Lin, Song Dong, XI Zhang

المصدر: HemaSphere, Vol 7, p e93232bb (2023)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000974632.93232.bb; https://doaj.org/toc/2572-9241

URL الوصول: https://doaj.org/article/a56c5dde02cd4a7bb9e7af550f35254c

المؤلفون: Jiali LI, Fu LI, Xixi Xiang, Jun Rao, Sha Zhou, Song Dong, Shijia Lin, Hongyun Liu, Yunjing Zeng, XI Zhang, LI Gao

المصدر: HemaSphere, Vol 7, p e6281931 (2023)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000975168.62819.31; https://doaj.org/toc/2572-9241

URL الوصول: https://doaj.org/article/07f1b96e10d24310a6adde01f7e8001d

المؤلفون: LI Fu, LI Jiali, Jun Rao, Shijia Lin, Song Dong, Xixi Xiang, LI Gao, XI Zhang

المصدر: HemaSphere, Vol 7, p e4495877 (2023)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000971660.44958.77; https://doaj.org/toc/2572-9241

URL الوصول: https://doaj.org/article/02d3497c2e8d4168bb4a4cd46da3e780

المؤلفون: Can Cui, Dengwen Zhang, Ke Sun, Yi Zhu, Jindong Xu, Yin Kang, Guangyan Zhang, Yujin Cai, Songsong Mao, Ruichun Long, Jue Ma, Song Dong, Yi Sun

المصدر: BMC Immunology, Vol 23, Iss 1, Pp 1-15 (2022)

مصطلحات موضوعية: Lung cancer, Propofol, Elderly, Th17/Treg, γ-aminobutyric acid A receptor, Metastasis, Immunologic diseases. Allergy, RC581-607

الوصف: Abstract Propofol is widely used in clinical anesthesia due to its advantages of rapid onset and less adverse reactions. This study focused on the role of propofol in the balance of Th17/Treg in elderly patients with lung cancer during perioperative period. Patients undergoing lung cancer surgery were anesthetized by propofol or sevoflurane. Veinal blood was collected at different time points to evaluate the changes of Th17/Treg cell. Propofol better maintained the balance of Th17/Treg in vivo. The peripheral blood of patients with lung cancer was collected in vitro before surgery. Cluster of differentiation (CD)4+ T cells were obtained and then treated with propofol at different concentrations and γ-aminobutyric acid A (GABAA) receptor antagonists. Propofol affected Th17/Treg cell balance by increasing Th17 cells, decreasing Treg cells, thus elevating Th17/Treg ratio, and inhibited invasion and migration of lung cancer cells through GABAA receptor, which was counteracted by GABAA receptor inhibitors. Subsequently, tumor in situ model of lung cancer in aged mice was established. Propofol anesthetized mice had lower change of Th17/Treg ratio, higher survival rate and less metastasis. In brief, propofol regulated balance of Th17/Treg in elderly patients undergoing lung cancer surgery through GABAA receptor. Additionally, propofol could inhibit metastasis of lung cancer.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-2172

URL الوصول: https://doaj.org/article/4937b1b161e049399eeba13ea59e66d3