المؤلفون: Taylor Adrian H, Thompson Tom P, Streeter Adam, Chynoweth Jade, Snowsill Tristan, Ingram Wendy, Ussher Michael, Aveyard Paul, Murray Rachael L, Harris Tess, Green Colin, Horrell Jane, Callaghan Lynne, Greaves Colin J, Price Lisa, Cartwright Lucy, Wilks Jonny, Campbell Sarah, Preece Dan, Creanor Siobhan

المصدر: Health Technology Assessment, Vol 27, Iss 04 (2023)

مصطلحات موضوعية: smoking, reduction, quitting, abstinence, physical activity, exercise, accelerometer, adult, cost-benefit analysis, behaviour change, motivational support, motivational interviewing, mediation, primary health care, process evaluation, qualitative, quality of life, quality-adjusted life-years, self-determination theory, self-monitoring, goal-setting, rct, Medical technology, R855-855.5

الوصف: Background: Physical activity can support smoking cessation for smokers wanting to quit, but there have been no studies on supporting smokers wanting only to reduce. More broadly, the effect of motivational support for such smokers is unclear. Objectives The objectives were to determine if motivational support to increase physical activity and reduce smoking for smokers not wanting to immediately quit helps reduce smoking and increase abstinence and physical activity, and to determine if this intervention is cost-effective. Design This was a multicentred, two-arm, parallel-group, randomised (1 : 1) controlled superiority trial with accompanying trial-based and model-based economic evaluations, and a process evaluation. Setting and participants Participants from health and other community settings in four English cities received either the intervention (n = 457) or usual support (n = 458). Intervention The intervention consisted of up to eight face-to-face or telephone behavioural support sessions to reduce smoking and increase physical activity. Main outcome measures The main outcome measures were carbon monoxide-verified 6- and 12-month floating prolonged abstinence (primary outcome), self-reported number of cigarettes smoked per day, number of quit attempts and carbon monoxide-verified abstinence at 3 and 9 months. Furthermore, self-reported (3 and 9 months) and accelerometer-recorded (3 months) physical activity data were gathered. Process items, intervention costs and cost-effectiveness were also assessed. Results The average age of the sample was 49.8 years, and participants were predominantly from areas with socioeconomic deprivation and were moderately heavy smokers. The intervention was delivered with good fidelity. Few participants achieved carbon monoxide-verified 6-month prolonged abstinence [nine (2.0%) in the intervention group and four (0.9%) in the control group; adjusted odds ratio 2.30 (95% confidence interval 0.70 to 7.56)] or 12-month prolonged abstinence [six (1.3%) in the intervention group and one (0.2%) in the control group; adjusted odds ratio 6.33 (95% confidence interval 0.76 to 53.10)]. At 3 months, the intervention participants smoked fewer cigarettes than the control participants (21.1 vs. 26.8 per day). Intervention participants were more likely to reduce cigarettes by ≥ 50% by 3 months [18.9% vs. 10.5%; adjusted odds ratio 1.98 (95% confidence interval 1.35 to 2.90] and 9 months [14.4% vs. 10.0%; adjusted odds ratio 1.52 (95% confidence interval 1.01 to 2.29)], and reported more moderate-to-vigorous physical activity at 3 months [adjusted weekly mean difference of 81.61 minutes (95% confidence interval 28.75 to 134.47 minutes)], but not at 9 months. Increased physical activity did not mediate intervention effects on smoking. The intervention positively influenced most smoking and physical activity beliefs, with some intervention effects mediating changes in smoking and physical activity outcomes. The average intervention cost was estimated to be £239.18 per person, with an overall additional cost of £173.50 (95% confidence interval −£353.82 to £513.77) when considering intervention and health-care costs. The 1.1% absolute between-group difference in carbon monoxide-verified 6-month prolonged abstinence provided a small gain in lifetime quality-adjusted life-years (0.006), and a minimal saving in lifetime health-care costs (net saving £236). Conclusions There was no evidence that behavioural support for smoking reduction and increased physical activity led to meaningful increases in prolonged abstinence among smokers with no immediate plans to quit smoking. The intervention is not cost-effective. Limitations Prolonged abstinence rates were much lower than expected, meaning that the trial was underpowered to provide confidence that the intervention doubled prolonged abstinence. Future work Further research should explore the effects of the present intervention to support smokers who want to reduce prior to quitting, and/or extend the support available for prolonged reduction and abstinence. Trial registration This trial is registered as ISRCTN47776579. Funding This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 27, No. 4. See the NIHR Journals Library website for further project information. Plain language summary: NHS pharmacological and behavioural support helps smokers wanting to quit, and physical activity may also help. It is unclear if behavioural support for those not ready to quit may lead to more quit attempts and abstinence from smoking. A total of 915 smokers who wanted to reduce their smoking, but who had not yet quit, were recruited and randomised to receive an intervention or brief support as usual (brief advice to quit), in Plymouth, London, Oxford and Nottingham. The intervention involved up to eight sessions (by telephone or in person) of motivational support to reduce smoking and increase physical activity (and more sessions to support a quit attempt). Participants self-reported smoking and physical activity information at the start of the trial and after 3 and 9 months. Self-reported quitters confirmed their abstinence with a biochemical test of expired air or saliva. Our main interest was in whether or not the groups differed in the proportion who remained abstinent for at least 6 months. Overall, only 1–2% remained abstinent for 6 months. Although it appeared that a greater proportion did so after receiving the intervention, because few participants were abstinent, the results are not conclusive. However, the intervention had beneficial effects on less rigorous outcomes, including a reduction in the self-reported number of cigarettes smoked, and a greater proportion of intervention than control participants with self-reported and biochemically verified abstinence at 3 months. The intervention also helped participants to reduce, by at least half, the number of cigarettes they smoked at 3 and 9 months, and to report more physical activity, but only at 3 months. Despite reasonable intervention engagement and some short-term changes in smoking and physical activity, the trial does not provide evidence that this intervention would help smokers to quit for at least 6 months nor would it be cost-effective, with an average cost of £239 per smoker. Scientific summary: Background Behavioural support to aid smoking cessation is an effective and cost-effective intervention for smokers wanting to quit. Motivational support can reduce smoking, with greater reductions leading to successful quitting, but the evidence is fairly weak for those not wanting to immediately quit. Smoking reduction studies may involve two types of smokers: (1) those who want to quit and are willing to reduce first rather than quit abruptly and (2) those who do not want to quit (immediately) but are interested in smoking reduction or harm reduction. At least four studies have investigated the effects of behavioural support for smokers wanting to reduce but not quit, and provide imprecise or no evidence of effects on smoking reduction, quitting and sustained abstinence. Exercise has been shown to aid smoking cessation for those wanting to quit, but there is only exploratory evidence that promoting physical activity (PA) and supporting smoking reduction can facilitate smoking reduction and quitting. A definitive study is needed to determine the effectiveness and cost-effectiveness of behavioural support for smoking reduction and increasing PA, on smoking outcomes, especially prolonged, carbon monoxide-verified smoking abstinence. Objectives The overall aim of the Trial of physical Activity-assisted Reduction of Smoking (TARS) was to determine if adding a motivational intervention to reduce smoking and increase PA to usual support was more effective and cost-effective in facilitating carbon monoxide-verified 6-month floating prolonged abstinence. The specific research questions were as follows. Compared with usual support, did the TARS intervention: increase the proportion of participants achieving carbon monoxide-verified 6-month floating prolonged abstinence at 9 months post baseline? increase the proportion of participants reporting a ≥ 50% reduction in the number of cigarettes smoked (between baseline and 3 months, and baseline and 9 months)? increase the proportion of participants achieving carbon monoxide-verified 12-month floating prolonged abstinence at 15 months post baseline? increase the proportion of participants achieving self-reported and carbon monoxide-verified point prevalence abstinence at 3 and 9 months post baseline? increase self-reported PA at 3 and 9 months post baseline, and accelerometer-assessed PA at 3 months post baseline? improve body mass index, quality of life, sleep, cigarette cravings and other beliefs about smoking and PA at 3 and 9 months post baseline? What were the intervention, health-care and social care costs, compared with support as usual, at 9 months post baseline? Was the intervention cost-effective, compared with usual support, (1) at 9 months, and (2) over a longer-term/lifetime horizon? Were the trial methods and intervention acceptable and feasible, based on an embedded internal pilot phase? Did the intervention demonstrate good fidelity (design, training, delivery, receipt and enactment) and acceptability and what were the mechanisms of action of the intervention? Methods The study involved a multicentred, parallel, two-group, individually randomised controlled, superiority trial with a mixed-methods embedded process evaluation and economic evaluations. Recruitment took place over 16 months from January 2018, with follow-up assessments ending in October 2020 (with only minimal overlap with COVID-19 restrictions) around four English cities: Plymouth, Nottingham, London and Oxford. Intervention participants were offered up to eight face-to-face or telephone behavioural support sessions to reduce smoking and increase PA, with up to six additional sessions if a participant wanted support with cessation. Substantial patient and public involvement supported both the development and evaluation of a pilot trial of the intervention, and adaptations for the present intervention. An intervention manual underpinned the training and remote supervision of eight health trainers (HTs) across four sites, and all aspects of intervention fidelity (design, training, receipt, delivery and enactment) were assessed. The client-centred intervention was informed by motivational interviewing and linked to self-determination theory. It aimed to empower participants to decide what support they required, and where, when and for how long, and, if the participant became ready to quit, to provide appropriate support. Control participants received brief advice on smoking cessation. Participants were recruited from primary and secondary care and community settings. Participants were adult smokers (≥ 18 years) who smoked ≥ 10 cigarettes per day (for at least 1 year), who wanted to reduce smoking but not quit immediately. Smokers were ineligible if they were unable to engage in at least 15 minutes of moderate-intensity PA, had any illness or injury that might be exacerbated by exercise, or were unable to engage in the trial and/or the intervention because of a language barrier or for other reasons. Following screening and consent, participants completed baseline assessments face to face or via telephone. At 3 and 9 months post baseline, participants were posted a questionnaire (and an accelerometer at 3 months for a random sample). Participants reporting having made a quit attempt and not having smoked at follow-up were invited to complete a biochemical verification of abstinence. Most did this with a carbon monoxide expired air test, but a few were posted a saliva cotinine test kit late in the trial as a result of COVID-19 restrictions. Those with carbon monoxide-verified abstinence at 9 months were also followed up at 15 months. The primary outcome was carbon monoxide-verified 6-month floating prolonged (i.e. with no fixed quit date) abstinence between 3 and 9 months. Other smoking measures were carbon monoxide-verified 12-month floating prolonged abstinence, point prevalence self-reported abstinence and number of cigarettes smoked per day, and carbon monoxide-verified abstinence and number of quit attempts at both 3 and 9 months. Analyses of smoking abstinence outcomes were in line with the Russell Standard, with non-responders assumed to be still smoking. Self-reported (3 and 9 months) and accelerometer-recorded (3 months) PA, body mass index, sleep and quality of life were also assessed at 3 and 9 months. The embedded mixed-methods process evaluation was split into two phases: (1) an initial evaluation linked to the internal pilot phase and (2) the subsequent main trial phase, with four workstreams as follows – (1) data related to levels of intervention engagement; (2) assessment of intervention delivery, receipt and enactment fidelity, using survey items related to the intervention logic model and recorded intervention sessions; (3) mediation analyses of changes in PA and process measures on outcomes; and (4) an embedded qualitative study with HT and intervention participant interviews. The health economic evaluation included an estimation of the cost of delivering the intervention from data collected during the trial, supplemented by investigator estimates. A trial-based economic evaluation was conducted using patient-reported resource use and health-related quality of life (EuroQol-5 Dimensions, five-level version), collected in questionnaire booklets at baseline and at 3 and 9 months post randomisation. Aggregate costs and quality-adjusted life-years (QALYs) over a 9-month time horizon were estimated and regression methods were used to adjust for potential confounders. A decision-analytic model was developed following a review of the existing literature. Smoking cessation rates were assumed to affect rates of coronary obstructive pulmonary disease, coronary heart disease, stroke and lung cancer, as well as quality of life and other smoking-related causes of mortality. Lifetime costs and QALYs were estimated. Results The sample (n = 915) had a mean age of 49.8 [standard deviation (SD) 13.9] years; 55% were female and 85% identified as white. Sixty per cent lived within one of the four highest-ranked deciles for social deprivation. They initially smoked an average of 18.0 cigarettes daily, with 77.68% smoking within 30 minutes of waking, and reported doing a median of 337 minutes of moderate to vigorous physical activity (MVPA) weekly. Primary analysis Using the Russell Standard, assuming missing participant data at follow-up implied continued smoking, 0.9% (n = 4) of control and 2.0% (n = 9) of intervention participants achieved carbon monoxide-verified 6-month floating prolonged abstinence between 3 and 9 months. This difference was not statistically significant [fully adjusted estimated odds ratio 2.30, 95% confidence interval (CI) 0.70 to 7.56; p = 0.169]. Including participants who achieved the outcome between 9 and 15 months increased this to 2.2% (n = 10) and 3.1% (n = 14) in the control and intervention groups, respectively, which was also not statistically significantly different (fully adjusted estimated odds ratio 1.43, 95% CI 0.62 to 3.26; p = 0.398). For the 19 and 20 participants followed up at 15 months, 0.2% (n = 1) and 1.3% (n = 6) of the overall control and intervention groups, respectively, achieved carbon monoxide-verified 12-month floating prolonged abstinence, which was also not statistically significantly different (fully adjusted estimated odds ratio 6.3, 95% CI 0.8 to 53.1; p = 0.089). Secondary outcomes The intervention had weak effects on self-reported 7-day point prevalence abstinence at 3 months (5.5% vs. 2.9%, adjusted odds ratio 1.99, 95% CI 1.00 to 3.94; p = 0.049), but there was no evidence of a statistically significant effect on carbon monoxide-verified point prevalence abstinence at 3 months (3.7% vs. 1.8%, adjusted odds ratio 2.19, 95% CI 0.93 to 5.14; p = 0.071). Nor was there an intervention effect at 9 or 15 months, compared with control, for either of these outcomes. The intervention group reported smoking fewer cigarettes daily than the control group at 3 months (adjusted mean difference –5.62, 95% CI –9.80 to –1.44; p = 0.009), but not at 9 months (adjusted mean difference 0.95, 95% CI –5.37 to 3.46; p = 0.671). A greater proportion of intervention participants reported having reduced their daily number of cigarettes smoked by at least 50%, up to 3 months (18.9% vs. 10.5%, adjusted odds ratio 1.98, 95% CI 1.35 to 2.90; p

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1366-5278; https://doaj.org/toc/2046-4924

URL الوصول: https://doaj.org/article/e8322d7c4e7e467b866a628f1408a8ae

المؤلفون: Los, E. E., Arran, C., Gerstmayr, E., Streeter, M. J. V., Najmudin, Z., Ridgers, C. P., Sarri, G., Mangles, S. P. D

مصطلحات موضوعية: Physics - Data Analysis, Statistics and Probability

الوصف: Recent experiments aiming to measure phenomena predicted by strong field quantum electrodynamics have done so by colliding relativistic electron beams and high-power lasers. In such experiments, measurements of the collision parameters are not always feasible, however, precise knowledge of these parameters is required for accurate tests of strong-field quantum electrodynamics. Here, we present a novel Bayesian inference procedure which infers collision parameters that could not be measured on-shot. This procedure is applicable to all-optical non-linear Compton scattering experiments investigating radiation reaction. The framework allows multiple diagnostics to be combined self-consistently and facilitates the inclusion of prior or known information pertaining to the collision parameters. Using this Bayesian analysis, the relative validity of the classical, quantum-continuous and quantum-stochastic models of radiation reaction were compared for a series of test cases, which demonstrate the accuracy and model selection capability of the framework and and highlight its robustness in the event that the experimental values of fixed parameters differ from their values in the models.
Comment: 31 pages, 19 figures

URL الوصول: http://arxiv.org/abs/2406.19420

المؤلفون: Mazin, Vladimir, Cree, Michael J., Streeter, Lee, Nezhivleva, Ksenia, Mozhaeva, Anastasia

المصدر: 2023 33rd Conference of Open Innovations Association (FRUCT) Open Innovations Association (FRUCT), 2023 33rd Conference of. :192-197 May, 2023

Relation: 2023 33rd Conference of Open Innovations Association (FRUCT)

المؤلفون: Fruhling, Kyle, Streeter, Alenna, Mardanya, Sougata, Wang, Xiaoping, Baral, Priya, Zaharko, Oksana, Mazin, Igor I., Chowdhury, Sugata, Ratcliff, William D., Tafti, Fazel

مصطلحات موضوعية: Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Strongly Correlated Electrons

الوصف: Topological Hall effect (THE) is a hallmark of scalar spin chirality, which is found in static skyrmion lattices. Recent theoretical works have shown that scalar spin chirality could also emerge dynamically from thermal spin fluctuations. Evidence of such a mechanism was found in the kagome magnet YMn6Sn6 where fluctuations arise from frustrated exchange interactions between Mn kagome layers. In YMn6Sn6, the rare-earth ion Y3+ is non-magnetic. When it is replaced by a magnetic ion (Gd3+-Ho3+), the intrinsically antiferromagnetic Mn-Mn interlayer coupling is overwhelmed by the indirect ferromagnetic Mn-R-Mn one, relieving frustration. This generates interesting anomalous Hall conductivity, but not THE. Here we show that Er lies in an intermediate regime where direct and indirect interactions closely compete, so that ErMn6Sn6 can switch from one regime to the other by temperature, i.e., from a collinear ferrimagnetic ground state to a spiral antiferromagnet at 78 K. The AFM phase forms a dome in the temperature-field phase diagram. Close to the boundary of this dome, we find a sizable fluctuations-driven THE, thus underscoring the universality of this chiral fluctuation mechanism for generating non-zero scalar spin chirality.
Comment: Main Text: 8 pages, 4 figures Supplemental: 13 pages, 13 figures, 4 tables; Version 2: Reformatted and changed x-axis labels in figure 2c,e Version 3: Figure 2 split into figures 2 & 3, title changed, significant additions to text to provide more details on experimental methods and findings

URL الوصول: http://arxiv.org/abs/2401.17449

المؤلفون: Roussel, Ryan, Edelen, Auralee L., Boltz, Tobias, Kennedy, Dylan, Zhang, Zhe, Ji, Fuhao, Huang, Xiaobiao, Ratner, Daniel, Garcia, Andrea Santamaria, Xu, Chenran, Kaiser, Jan, Pousa, Angel Ferran, Eichler, Annika, Lubsen, Jannis O., Isenberg, Natalie M., Gao, Yuan, Kuklev, Nikita, Martinez, Jose, Mustapha, Brahim, Kain, Verena, Lin, Weijian, Liuzzo, Simone Maria, John, Jason St., Streeter, Matthew J. V., Lehe, Remi, Neiswanger, Willie

مصطلحات موضوعية: Physics - Accelerator Physics

الوصف: Accelerator physics relies on numerical algorithms to solve optimization problems in online accelerator control and tasks such as experimental design and model calibration in simulations. The effectiveness of optimization algorithms in discovering ideal solutions for complex challenges with limited resources often determines the problem complexity these methods can address. The accelerator physics community has recognized the advantages of Bayesian optimization algorithms, which leverage statistical surrogate models of objective functions to effectively address complex optimization challenges, especially in the presence of noise during accelerator operation and in resource-intensive physics simulations. In this review article, we offer a conceptual overview of applying Bayesian optimization techniques towards solving optimization problems in accelerator physics. We begin by providing a straightforward explanation of the essential components that make up Bayesian optimization techniques. We then give an overview of current and previous work applying and modifying these techniques to solve accelerator physics challenges. Finally, we explore practical implementation strategies for Bayesian optimization algorithms to maximize their performance, enabling users to effectively address complex optimization challenges in real-time beam control and accelerator design.

URL الوصول: http://arxiv.org/abs/2312.05667

المؤلفون: Barlow, Duncan, Colaïtis, A., Viala, D., Rosenberg, M. J., Igumenshchev, I., Goncharov, V., Ceurvorst, L., Radha, P. B., Theobald, W., Craxton, R. S., Streeter, M. J. V., Chapman, T., Mathiaud, J., Scott, R. H. H., Glize, K.

مصطلحات موضوعية: Physics - Plasma Physics

الوصف: A new, efficient, algorithmic approach to create illumination configurations for laser driven high energy density physics experiments is proposed. The method is applied to a polar direct drive solid target experiment at the National Ignition Facility (NIF), where it is simulated to create more than x2 higher peak pressure and x1.4 higher density by maintaining better shock uniformity. The analysis is focused on projecting shocks into solid targets at the NIF, but with minor adaptations the method could be applied to implosions, other target geometries and other facilities.

URL الوصول: http://arxiv.org/abs/2311.18342

المؤلفون: Timme, Maximilian^{Aff1, IDs00414024031845_cor1}, Steffens, Laurin, Viktorov, Jan, Streeter, Adam, Karch, André, Schmeling, Andreas

المصدر: International Journal of Legal Medicine. 138(4):1523-1531

المؤلفون: Timme, Maximilian^{Aff1, IDs0041402403251x_cor1}, Viktorov, Jan, Steffens, Laurin, Streeter, Adam, Karch, André, Smit, Chané, Robinson, Liam, Bernitz, Herman, Schmeling, Andreas

المصدر: International Journal of Legal Medicine. :1-8

المؤلفون: Timme, Maximilian^{Aff1, IDs12024024008209_cor1}, Viktorov, Jan, Steffens, Laurin, Streeter, Adam, Karch, André, Guo, Yu-Cheng^{Aff3, IDs12024024008209_cor6}, Schmeling, Andreas

المصدر: Forensic Science, Medicine and Pathology. :1-10

المؤلفون: Lee, J., Botello, G.S., Streeter, R., Popovic, Z.

المصدر: IEEE Microwave and Wireless Technology Letters IEEE Microw. Wireless Tech. Lett. Microwave and Wireless Technology Letters, IEEE. 33(6):927-930 Jun, 2023