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1دورية أكاديمية
المؤلفون: Jonathan I. Silverberg, MD, PhD, MPH, Angel Cronin, MS, Eric A. Jones, PhD, MPH, Swapna S. Dave, MPH, MBBS, Robert R. McLean, DSc, MPH, Jeffrey Greenberg, MD, MPH, Bruce Strober, MD, PhD, Thomas Bieber, MD, PhD, MDRA, Melinda Gooderham, MSc, MD, Amy S. Paller, MD, Eric L. Simpson, MD
المصدر: JAAD International, Vol 15, Iss , Pp 127-130 (2024)
مصطلحات موضوعية: atopic dermatitis, biologic therapy, biologics, outcomes, QoL, quality of life, Dermatology, RL1-803
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Jonathan I. Silverberg, Evangeline Pierce, Meghan Feely, Amber Reck Atwater, Amy Schrader, Eric A. Jones, Swapna S. Dave, Eric L. Simpson
المصدر: Journal of Dermatological Treatment, Vol 34, Iss 1 (2023)
مصطلحات موضوعية: atopic dermatitis, systemic therapy, disease burden, Dermatology, RL1-803
الوصف: Background Real-world data on the effectiveness of systemic therapy in atopic dermatitis (AD) are limited. Methods Adult patients with AD in the CorEvitas AD registry (2020–2021) who received systemic therapies for 4–12 months prior to enrollment were included based on disease severity: body surface area (BSA) 0%–9% and BSA ≥10%. Demographics, clinical characteristics, and outcomes were assessed using descriptive statistics. Pairwise effect sizes (ES) were used to compare BSA groups. Results The study included 308 patients (BSA 0%–9%: 246 [80%]; BSA ≥10%: 62 [20%]). Despite systemic therapy, both BSA groups reported the use of additional topical therapy and the presence of lesions at difficult locations. Moderate-to-severe AD (vIGA-AD®) was reported by 11% (BSA 0%–9%) and 66% (BSA ≥10%; ES = 0.56) of patients. Mean disease severity scores: total BSA (2% and 22%; ES = 3.59), EASI (1.1 and 11.1; ES = 2.60), and SCORAD (12.1 and 38.0; ES = 1.99). Mean scores for PROs: DLQI (3.7 and 7.5; ES = 0.75), and peak pruritus (2.2 and 4.5; ES = 0.81). Inadequate control of AD was seen in 27% and 53% of patients (ES = 0.23). Conclusions Patients with AD experience a high disease burden despite systemic treatment for 4–12 months. This study provides potential evidence of suboptimal treatment and the need for additional effective treatment options for AD.
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Alka M. Kanaya, Ann Chang, Michael Schembri, Ankita Puri-Taneja, Shweta Srivastava, Swapna S. Dave, Evangeline N. Vijayakumar, Zubaida Qamar, Hemalatha D. Naik, Faiza Siddiqui, Namratha R. Kandula
المصدر: Journal of Clinical and Translational Science, Vol 3, Pp 97-104 (2019)
مصطلحات موضوعية: Ethnic minority, recruitment, retention, longitudinal study, epidemiology, Medicine
الوصف: AbstractIntroduction:There are few longitudinal studies about South Asians (SAs) and little information about recruitment and retention approaches for this ethnic group.Methods:We followed 906 SAs enrolled in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort for 5 years. Surviving participants were invited for a second clinical exam from 2015 to 2018. A new wave of participants was recruited during 2017–2018. We assessed the yields from different methods of recruitment and retention.Results:A total of 759 (83%) completed the second clinical exam, and 258 new participants were enrolled. Providing a nearby community hospital location for the study exam, offering cab/shared ride reimbursement, and conducting home visits were the most effective methods for enhancing retention. New participant recruitment targeted women and individuals with lower socioeconomic status, and we found that participant referrals and active community engagement were most effective. Mailing invitational letters to those identified by electronic health records had very low yield.Conclusion:Recruitment and retention strategies that address transportation barriers and increase community engagement will help increase the representation of SAs in health research.
وصف الملف: electronic resource
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المؤلفون: Anthony Sebba, Clifton O. Bingham, Vivian P. Bykerk, Stefano Fiore, Kerri Ford, Jud C. Janak, Dimitrios A. Pappas, Taylor Blachley, Swapna S. Dave, Joel M. Kremer, Miao Yu, Ernest Choy
المصدر: Clinical Rheumatology.
مصطلحات موضوعية: Rheumatology, General Medicine
الوصف: Objective Randomized controlled trials (RCTs) in biologic-naïve rheumatoid arthritis (RA) patients with high disease activity and inadequate response/intolerance to methotrexate have shown interleukin-6 (IL-6) receptor inhibitors (IL-6Ri) to be superior to tumor necrosis factor inhibitors (TNFi) as monotherapy. This observational study aimed to compare the effectiveness of TNFi vs IL-6Ri as mono- or combination therapy in biologic/targeted synthetic (b/ts) -experienced RA patients with moderate/high disease activity. Methods Eligible b/ts-experienced patients from the CorEvitas RA registry were categorized as TNFi and IL-6Ri initiators, with subgroups initiating as mono- or combination therapy. Mixed-effects regression models evaluated the impact of treatment on Clinical Disease Activity Index (CDAI), patient-reported outcomes, and disproportionate pain (DP). Unadjusted and covariate-adjusted effects were reported. Results Patients initiating IL-6Ri (n = 286) vs TNFi monotherapy (n = 737) were older, had a longer RA history and higher baseline CDAI, and were more likely to initiate as third-line therapy; IL-6Ri (n = 401) vs TNFi (n = 1315) combination therapy initiators had higher baseline CDAI and were more likely to initiate as third-line therapy. No significant differences were noted in the outcomes between TNFi and IL-6Ri initiators (as mono- or combination therapy). Conclusion This observational study showed no significant differences in outcomes among b/ts-experienced TNFi vs IL-6Ri initiators, as either mono- or combination therapy. These findings were in contrast with the previous RCTs in biologic-naïve patients and could be explained by the differences in the patient characteristics included in this study. Further studies are needed to help understand the reasons for this discrepancy in the real-world b/ts-experienced population. Key Points• Patients with rheumatoid arthritis (RA) often require switching between biologics or targeted synthetic (b/ts) disease-modifying anti-rheumatic drugs (DMARDs) to achieve their treatment target.• Head-to-head randomized controlled trials (RCTs) in biologic-naïve RA patients with high disease activity and inadequate response/intolerance to methotrexate have shown interleukin-6 receptor inhibitors (IL-6Ri) to be superior to tumor necrosis factor inhibitors (TNFi) as monotherapy; however, there are no RCTs comparing these therapies in a population previously treated with b/tsDMARDs (i.e., b/ts-experienced patients).• This observational study compared the effectiveness of TNFi vs IL-6Ri (as mono- or combination therapy) in b/ts-experienced RA patients with moderate or high disease activity and found no significant differences in clinical outcomes for the two treatments.• A discrepancy is noted between our study and RCTs, which have shown superiority of IL-6Ri therapy (albeit in biologic-naïve patients). Further analyses may help elucidate the reason for this discrepancy in the real-world b/ts-experienced population.
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المؤلفون: Hisashi Yamanaka, Mitsumasa Kishimoto, Nobuo Nishijima, Katsuhisa Yamashita, Junnosuke Matsushima, Jacqueline O’Brien, Taylor Blachley, Melissa Eliot, Zachary Margolin, Swapna S Dave, Yoshiya Tanaka
المصدر: Modern Rheumatology.
مصطلحات موضوعية: Rheumatology
الوصف: Objectives We evaluate the socioeconomic impact of treatment with biological and targeted synthetic disease–modifying antirheumatic drugs in Japanese patients with rheumatoid arthritis. Methods We analysed data retrospectively from the prospective observational CorEvitas RA Japan Registry (March 2016–February 2020). Patients were categorised into paid workers (PWs) and home workers (HWs) and further based on drug classes. We assessed medication persistence, treatment outcomes, health care resource utilisation, and socioeconomic impact over 12 months, including direct (drugs and health care resource utilisation) and indirect (loss of productivity) costs. Results Overall, 187 PWs and 114 HWs were identified. Over 12 months, medication persistence was high, treatment outcomes improved, and outpatient visits reduced in both groups. Following treatment initiation, direct costs increased, whereas indirect (loss of productivity) costs decreased in both groups. The unadjusted socioeconomic impact [Japanese yen (JPY)] increased across all drug classes in PWs (range: 29,700–151,700) and HWs (range: −28,700 to 83,000). Adjusted change in monthly socioeconomic impact was JPY 29,700–138,900 for PWs and JPY −28,000 to 92,800 for HWs. Conclusions In this study of Japanese patients with rheumatoid arthritis, the socioeconomic burden increased across patient groups and drug classes. The decrease in indirect (loss of productivity) costs partially offset the increase in direct costs.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8e5997305b8b6e402ae8f9ed59332632
https://doi.org/10.1093/mr/roac160 -
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المؤلفون: Swapna S. Dave, Apoorva Ram, Shinu Mammen, Nicola Lancki, Margaret R. Moran, Ankita Puri-Taneja, Alka M. Kanaya, Namratha R. Kandula
المصدر: Ethnicity & health, vol 27, iss 3
Ethn Healthمصطلحات موضوعية: Parents, and promotion of well-being, Immigration, Health Behavior, Cardiovascular, 0302 clinical medicine, Sociology, MASALA, South Asian, 030212 general & internal medicine, Social influence, media_common, Social network, Pediatric, Parental health, Middle Aged, Geography, intergenerational, Public Health and Health Services, Adult Children, Cognitive Sciences, Public Health, 0305 other medical science, social influence, Cultural Studies, Adult, South asia, media_common.quotation_subject, Emigrants and Immigrants, Basic Behavioral and Social Science, Article, 03 medical and health sciences, Arts and Humanities (miscellaneous), Asian People, Clinical Research, Lifestyle intervention, Behavioral and Social Science, Humans, Aged, Nutrition, 030505 public health, business.industry, Prevention, Public Health, Environmental and Occupational Health, lifestyle intervention, Atherosclerosis, Prevention of disease and conditions, South asian immigrants, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, business, Demography
الوصف: Objectives: Examine the social influence of adult children on the cardiovascular-related health behaviors of older South Asian (SA) immigrants to inform lifestyle interventions.Design: This mixed-methods study used data from an ancillary study of social networks (2014-2018) in the Mediators of Atherosclerosis in South Asians Living in America cohort. Phase 1 was a quantitative analysis of self-reported diet and physical activity among SA adults (n = 448, mean age = 58 years, SD 8.4) who named at least one adult child to their social network. The Alternative Healthy Eating Index (AHEI) was used to measure parents' diet; higher numbers indicate a healthier diet (range 0-110). Phase 2 was a thematic content analysis of in-depth qualitative interviews from a subsample of these parents (n = 23, mean age = 55, SD 7.6).Results: Parents with an adult child in their network who consumed uncooked vegetables daily had mean parental AHEI score 1.5 points higher (adjusted p-value = 0.03) than those who had a child in the network who ate uncooked vegetables less often. When at least one adult child in their network ate fresh fruit daily compared to less frequently or when at least one child ate non-SA food daily compared to less frequently, mean parental AHEI scores were higher by 2.0 (adjusted p-value = 0.01) and 1.6 (adjusted p-value = 0.03) points respectively. Parents with an adult child in their network who exercised at least weekly were more likely to meet guideline-recommended physical activity levels than parents with children who exercised less often (76% v. 56%, adjusted p-value = 0.02). Adult children provided social support and were seen as 'role models' for healthy behavior, especially when adopting Western health behaviors.Conclusion: Positive role modeling and support from adult children were important facilitators of healthy behavior change in older SA immigrants and can inform health behavior interventions for SA adults.
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdf76927283d23454a5bb9629431143
https://escholarship.org/uc/item/2m10r3b6 -
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المؤلفون: Peter Lio, Eric Simpson, Evangeline Pierce, Angel Cronin, Robert McLean, Swapna S. Dave, Amy J. Kovacik, Meghan Feely, Jonathan Silverberg
المصدر: Journal of the American Academy of Dermatology. 87:AB174
مصطلحات موضوعية: Dermatology
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المؤلفون: Namratha R. Kandula, Faiza Siddiqui, Hemalatha D Naik, Ann Chang, Swapna S. Dave, Shweta Srivastava, Zubaida Qamar, Ankita Puri-Taneja, Alka M. Kanaya, Michael Schembri, Evangeline N Vijayakumar
المصدر: Journal of Clinical and Translational Science
مصطلحات موضوعية: retention, medicine.medical_specialty, Longitudinal study, 030505 public health, Community engagement, longitudinal study, Ethnic group, Research Methods and Technology, General Medicine, Community hospital, 03 medical and health sciences, 0302 clinical medicine, recruitment, Family medicine, Epidemiology, Cohort, medicine, Ethnic minority, epidemiology, 030212 general & internal medicine, 0305 other medical science, Psychology, Socioeconomic status, Reimbursement, Research Article
الوصف: Introduction:There are few longitudinal studies about South Asians (SAs) and little information about recruitment and retention approaches for this ethnic group.Methods:We followed 906 SAs enrolled in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) cohort for 5 years. Surviving participants were invited for a second clinical exam from 2015 to 2018. A new wave of participants was recruited during 2017–2018. We assessed the yields from different methods of recruitment and retention.Results:A total of 759 (83%) completed the second clinical exam, and 258 new participants were enrolled. Providing a nearby community hospital location for the study exam, offering cab/shared ride reimbursement, and conducting home visits were the most effective methods for enhancing retention. New participant recruitment targeted women and individuals with lower socioeconomic status, and we found that participant referrals and active community engagement were most effective. Mailing invitational letters to those identified by electronic health records had very low yield.Conclusion:Recruitment and retention strategies that address transportation barriers and increase community engagement will help increase the representation of SAs in health research.
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المؤلفون: Catherine Counard, Namratha R. Kandula, Linda Ehrlich-Jones, Nirav Shah, Juned Siddique, Santosh Kumar, Veronica Bernard, Ronald T. Ackermann, Bonnie Spring, Goutham Rao, Swapna S. Dave
المصدر: Contemp Clin Trials
مصطلحات موضوعية: Gerontology, Stress management, Psychological intervention, Motivational interviewing, Emigrants and Immigrants, Context (language use), Blood Pressure, Article, law.invention, Randomized controlled trial, law, Asia, Western, Medicine, Humans, Pharmacology (medical), Healthy Lifestyle, Cultural Competency, Exercise, Health Education, Glycated Hemoglobin, Asian, business.industry, Behavior change, Body Weight, General Medicine, Lipids, United States, Diet, Clinical trial, Cardiovascular Diseases, Heart Disease Risk Factors, Research Design, business, Psychosocial, Stress, Psychological
الوصف: Intensive lifestyle interventions targeting diet and physical activity are recommended for reducing atherosclerotic cardiovascular disease (ASCVD) risk in adults. However, existing interventions often do not reach immigrant populations because of a mismatch between the social, cultural, and environmental context of immigrants and Western bio behavioral models which underpin evidence-based lifestyle interventions. The South Asian Healthy Lifestyle Intervention (SAHELI) study is a type 1 hybrid design randomized controlled trial aimed at reducing ASCVD risk in South Asian Americans, a group at higher ASCVD risk than whites and other Asian Americans. The objective is to evaluate the clinical effectiveness and implementation potential of a community-based, culturally-adapted lifestyle intervention for South Asian adults. Participants (n = 550) will be randomized to printed healthy lifestyle education materials or SAHELI, a group-based lifestyle change program that includes weekly classes for 16 weeks and 4 booster classes though month 11. SAHELI integrates evidence-based behavior change strategies with culturally-adapted strategies and group motivational interviewing to improve diet, physical activity, and stress management. Follow-up assessments will occur at 6 and 12 months. We hypothesize that the SAHELI intervention group will have greater improvements in clinical ASCVD risk factors (weight, blood pressure, glycated hemoglobin, and lipids), physical activity, and psychosocial outcomes than the print material group at 6- and 12- months. We will use mixed-methods to examine SAHELI's potential for reach, adoption, implementation, and maintenance from the perspective of multiple stakeholders. This study offers the potential to increase the reach and effectiveness of evidence-based lifestyle interventions for South Asian adults at increased risk for ASCVD.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20c5da57d35ab55351f0b551e66e4e7
https://europepmc.org/articles/PMC8011000/ -
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المؤلفون: Mitali S. Thanawala, Juned Siddique, Swapna S. Dave, Nicola Lancki, John A. Schneider, Andrew Cooper, Namratha R. Kandula, Alka M. Kanaya
المصدر: J Phys Act Health
مصطلحات موضوعية: Adult, Male, Ethnic group, Metabolic equivalent, Article, Social Networking, Cohort Studies, 03 medical and health sciences, Social support, 0302 clinical medicine, Medicine, Humans, Orthopedics and Sports Medicine, 030212 general & internal medicine, Exercise, Aged, Aged, 80 and over, 030505 public health, Social network, Asian, business.industry, Social environment, Middle Aged, Atherosclerosis, Confidence interval, United States, Cross-Sectional Studies, Spouse, Female, 0305 other medical science, business, Cohort study, Demography
الوصف: Background: Eliminating racial/ethnic disparities in physical activity remains a challenge in the United States. South Asian immigrants in the United States have particularly low physical activity levels, and evidence suggests that social context may be important. This study examined associations between personal social networks and moderate to vigorous leisure-time physical activity (MVPA) among South Asians in the United States. Methods: We used cross-sectional data (2014–2017) from 689 South Asians (aged 43–85 y) who participated in the Mediators of Atherosclerosis in South Asians Living in America study. Self-reported physical activity and egocentric network data were collected from participants about their network members. Regression models were used to determine associations between social network characteristics and participants’ MVPA. Results: Participants were on average 59 years old (SD = 9) and reported 1335 metabolic equivalent minutes per week of MVPA (interquartile range = 735, 2212). Having network members who exercised or who were exercise partners associated with increased MVPA in men (β coefficient = 241 MET min/wk [95% confidence interval, 63 to 419] and β = 520 MET min/wk [95% confidence interval, 322 to 718], respectively). For women, the association was only significant if the exercise partner was a spouse. Conclusion: Physical activity interventions utilizing network members as exercise partners may have potential in South Asians but must consider gender differences.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d53b87eaa4ac041dfc1cbec75071ea9e
https://pubmed.ncbi.nlm.nih.gov/31810059
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