المؤلفون: Murugesan P; Division of Molecular Medicine, Department of Anesthesiology, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (P.M., Y.Z., Y.H., N.C.Z., J.Y.Y., H.C.)., Zhang Y; Division of Molecular Medicine, Department of Anesthesiology, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (P.M., Y.Z., Y.H., N.C.Z., J.Y.Y., H.C.)., Huang Y; Division of Molecular Medicine, Department of Anesthesiology, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (P.M., Y.Z., Y.H., N.C.Z., J.Y.Y., H.C.)., Chenggong Zong N; Division of Molecular Medicine, Department of Anesthesiology, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (P.M., Y.Z., Y.H., N.C.Z., J.Y.Y., H.C.)., Youn JY; Division of Molecular Medicine, Department of Anesthesiology, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (P.M., Y.Z., Y.H., N.C.Z., J.Y.Y., H.C.)., Chen W; Peking Union Medical College and Chinese Academy of Medical Sciences, Department of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (W.C., C.W.)., Wang C; Peking Union Medical College and Chinese Academy of Medical Sciences, Department of Respiratory Medicine, China-Japan Friendship Hospital, Beijing (W.C., C.W.)., Loscalzo J; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (J.L.)., Cai H; Division of Molecular Medicine, Department of Anesthesiology, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (P.M., Y.Z., Y.H., N.C.Z., J.Y.Y., H.C.).

المصدر: Circulation research [Circ Res] 2024 Feb 16; Vol. 134 (4), pp. 351-370. Date of Electronic Publication: 2024 Feb 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0047103 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1524-4571 (Electronic) Linking ISSN: 00097330 NLM ISO Abbreviation: Circ Res Subsets: MEDLINE

مواضيع طبية MeSH: Hypertension, Pulmonary*/drug therapy , Hypertension, Pulmonary*/genetics , Tetrahydrofolate Dehydrogenase*/genetics , Tetrahydrofolate Dehydrogenase*/metabolism , Tetrahydrofolate Dehydrogenase*/deficiency, Animals ; Humans ; Mice ; Endothelium/metabolism ; Hypoxia ; Mice, Knockout ; Mice, Transgenic ; Nitric Oxide Synthase Type III/genetics ; Nitric Oxide Synthase Type III/metabolism ; Hypoxanthines ; Disease Models, Animal

المؤلفون: Ju D; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, 48201, USA; Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, 48201, USA; Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI, 48201, USA; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, 48201, USA., Wu S; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, 48201, USA., Li L; Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI, 48201, USA; Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, Detroit, MI, 48201, USA., Xie Y; Department of Oncology, Wayne State University School of Medicine, Detroit, MI, 48201, USA; Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, 48201, USA. Electronic address: youming.xie@wayne.edu.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Apr 02; Vol. 702, pp. 149651. Date of Electronic Publication: 2024 Feb 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Ubiquitin*/metabolism , Tetrahydrofolate Dehydrogenase*/metabolism, Ubiquitination ; Proteins/metabolism ; Proteolysis ; Proteasome Endopeptidase Complex/metabolism

المؤلفون: Papkou A; Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland., Garcia-Pastor L; Departamento de Sanidad Animal and VISAVET Health Surveillance Centre, Universidad Complutense de Madrid, Madrid, Spain., Escudero JA; Departamento de Sanidad Animal and VISAVET Health Surveillance Centre, Universidad Complutense de Madrid, Madrid, Spain., Wagner A; Department of Evolutionary Biology and Environmental Studies, University of Zurich, Zurich, Switzerland.; Swiss Institute of Bioinformatics, Lausanne, Switzerland.; The Santa Fe Institute, Santa Fe, NM, USA.

المصدر: Science (New York, N.Y.) [Science] 2023 Nov 24; Vol. 382 (6673), pp. eadh3860. Date of Electronic Publication: 2023 Nov 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Fitness* , Tetrahydrofolate Dehydrogenase*/chemistry , Tetrahydrofolate Dehydrogenase*/genetics , Escherichia coli Proteins*/chemistry , Escherichia coli Proteins*/genetics, Models, Genetic ; Mutation ; Gene Editing ; CRISPR-Cas Systems ; Selection, Genetic ; Computer Simulation

المؤلفون: Etersque JM; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lee IK; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sharma N; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Xu K; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ruff A; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Northrup JD; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sarkar S; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Nguyen T; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Lauman R; The Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Burslem GM; The Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; The Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Sellmyer MA; Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mark.sellmyer@pennmedicine.upenn.edu.; The Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. mark.sellmyer@pennmedicine.upenn.edu.

المصدر: Nature communications [Nat Commun] 2023 Nov 03; Vol. 14 (1), pp. 7071. Date of Electronic Publication: 2023 Nov 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Tetrahydrofolate Dehydrogenase*/genetics , Tetrahydrofolate Dehydrogenase*/metabolism , Escherichia coli Proteins*/genetics , Escherichia coli Proteins*/metabolism, Animals ; Proteolysis Targeting Chimera ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Trimethoprim/pharmacology ; Proteomics ; Ubiquitin-Protein Ligases/metabolism ; Proteolysis

المؤلفون: Lemay-St-Denis C; PROTEO, The Québec Network for Research on Protein, Function, Engineering and Applications, Quebec, QC, Canada.; CGCC, Center in Green Chemistry and Catalysis, Montreal, QC, Canada.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada., Pelletier JN; PROTEO, The Québec Network for Research on Protein, Function, Engineering and Applications, Quebec, QC, Canada.; CGCC, Center in Green Chemistry and Catalysis, Montreal, QC, Canada.; Department of Biochemistry and Molecular Medicine, Université de Montréal, Montreal, QC, Canada.; Chemistry Department, Université de Montréal, Montreal, QC, Canada. joelle.pelletier@umontreal.ca.

المصدر: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 Oct 19; Vol. 59 (84), pp. 12560-12572. Date of Electronic Publication: 2023 Oct 19.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

مواضيع طبية MeSH: Tetrahydrofolate Dehydrogenase*/chemistry, Mutagenesis, Site-Directed ; Catalytic Domain ; Amino Acid Sequence ; Binding Sites ; Catalysis ; NADP/chemistry ; Kinetics

المؤلفون: Saha S; Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France., Jungas TT; Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France., Ohayon D; Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France., Audouard C; Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France., Ye T; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), INSERM U1258, CNRS UMR7104, Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France., Fawal MA; Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France., Davy A; Molecular, Cellular and Developmental Biology Unit (MCD), Centre de Biologie Intégrative (CBI), Université de Toulouse, CNRS, UPS, 118 route de Narbonne, 31062 Toulouse, France.

المصدر: Development (Cambridge, England) [Development] 2023 Oct 15; Vol. 150 (20). Date of Electronic Publication: 2023 Sep 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Company Of Biologists Limited Country of Publication: England NLM ID: 8701744 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9129 (Electronic) Linking ISSN: 09501991 NLM ISO Abbreviation: Development Subsets: MEDLINE

مواضيع طبية MeSH: Neocortex* , Neurogenesis*/genetics , Tetrahydrofolate Dehydrogenase*/genetics, Animals ; Humans ; Mice ; Carbon ; Folic Acid

المؤلفون: Kazan IC; Center for Biological Physics and Department of Physics, Arizona State University, Tempe, Arizona, USA., Mills JH; School of Molecular Sciences and The Biodesign Center for Molecular Design and Biomimetics, Arizona State University, Tempe, Arizona, USA., Ozkan SB; Center for Biological Physics and Department of Physics, Arizona State University, Tempe, Arizona, USA.

المصدر: Protein science : a publication of the Protein Society [Protein Sci] 2023 Aug; Vol. 32 (8), pp. e4700.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

مواضيع طبية MeSH: Tetrahydrofolate Dehydrogenase*/chemistry , Escherichia coli Proteins*/chemistry, Escherichia coli/metabolism ; Molecular Dynamics Simulation ; Mutation

المؤلفون: Love O; Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT, USA., Pacheco Lima MC; Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT, USA., Clark C; Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT, USA., Cornillie S; Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT, USA., Roalstad S; Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT, USA., Cheatham Iii TE; Department of Medicinal Chemistry, College of Pharmacy, University of Utah, Salt Lake City, UT, USA.

المصدر: Journal of biomolecular structure & dynamics [J Biomol Struct Dyn] 2023 Aug-Sep; Vol. 41 (13), pp. 5946-5960. Date of Electronic Publication: 2022 Jul 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8404176 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-0254 (Electronic) Linking ISSN: 07391102 NLM ISO Abbreviation: J Biomol Struct Dyn Subsets: MEDLINE

مواضيع طبية MeSH: Tetrahydrofolate Dehydrogenase*/chemistry , Molecular Dynamics Simulation*, Protein Structure, Secondary ; Protein Domains

المؤلفون: Williams TL; School of Chemistry and Cardiff Catalysis Institute, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom., Taily IM; School of Chemistry and Cardiff Catalysis Institute, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom., Hatton L; School of Chemistry and Cardiff Catalysis Institute, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom., Berezin AA; School of Chemistry and Cardiff Catalysis Institute, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom., Wu YL; School of Chemistry and Cardiff Catalysis Institute, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom., Moliner V; BioComp Group, Institute of Advanced Materials (INAM), Universitat Jaume I, 12071, Castelló, Spain., Świderek K; BioComp Group, Institute of Advanced Materials (INAM), Universitat Jaume I, 12071, Castelló, Spain., Tsai YH; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Gaoke International Innovation Center, Guangming District, 518132, Shenzhen, Guangdong, China., Luk LYP; School of Chemistry and Cardiff Catalysis Institute, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, United Kingdom.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 May 27; Vol. 63 (22), pp. e202403098. Date of Electronic Publication: 2024 Apr 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Code* , Biocatalysis*, Green Fluorescent Proteins/chemistry ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Protein Engineering ; Lysine/analogs & derivatives ; Lysine/chemistry ; Lysine/metabolism ; Tetrahydrofolate Dehydrogenase/chemistry ; Tetrahydrofolate Dehydrogenase/genetics ; Tetrahydrofolate Dehydrogenase/metabolism

المؤلفون: Narang G; ICMR-National Institute of Malaria Research (NIMR), Sector-8, Dwarka, New Delhi 110077, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India., Jakhan J; ICMR-National Institute of Malaria Research (NIMR), Sector-8, Dwarka, New Delhi 110077, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India., Tamang S; ICMR-National Institute of Malaria Research (NIMR), Sector-8, Dwarka, New Delhi 110077, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India., Yadav K; ICMR-National Institute of Malaria Research (NIMR), Sector-8, Dwarka, New Delhi 110077, India., Singh V; ICMR-National Institute of Malaria Research (NIMR), Sector-8, Dwarka, New Delhi 110077, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad-201002, India. Electronic address: vineetas_2000@yahoo.com.

المصدر: Acta tropica [Acta Trop] 2024 Jul; Vol. 255, pp. 107218. Date of Electronic Publication: 2024 Apr 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0370374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6254 (Electronic) Linking ISSN: 0001706X NLM ISO Abbreviation: Acta Trop Subsets: MEDLINE

مواضيع طبية MeSH: Plasmodium falciparum*/genetics , Plasmodium falciparum*/drug effects , Plasmodium falciparum*/isolation & purification , Drug Resistance*/genetics , Antimalarials*/pharmacology , Plasmodium vivax*/genetics , Plasmodium vivax*/drug effects , Plasmodium vivax*/isolation & purification , Polymorphism, Single Nucleotide* , Malaria, Falciparum*/parasitology , Malaria, Falciparum*/epidemiology , Protozoan Proteins*/genetics , Malaria, Vivax*/parasitology, Humans ; India ; Pyrimethamine/pharmacology ; Mutation ; Tetrahydrofolate Dehydrogenase/genetics ; DNA, Protozoan/genetics ; Sulfadoxine/pharmacology ; Artemisinins/pharmacology ; Male ; Drug Combinations