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المؤلفون: Ayman A. Hussein, Andrea Natale, Walid Saliba, Mohammed A. Chamsi-Pasha, Bruce D. Lindsay, Mohamed Kanj, Oussama M. Wazni, Thomas Callahan, David O. Martin, Lee Joseph, Serge C. Harb, Mandeep Bhargava, Thomas Dresing
المصدر: Journal of the American College of Cardiology. 58(6):596-602
مصطلحات موضوعية: medicine.medical_specialty, business.industry, Radiofrequency ablation, medicine.medical_treatment, Atrial fibrillation, medicine.disease, Ablation, Surgery, law.invention, medicine.anatomical_structure, Mechanical Mitral Valve, law, Internal medicine, Concomitant, cardiovascular system, medicine, Cardiology, Sinus rhythm, cardiovascular diseases, Vein, business, Cardiology and Cardiovascular Medicine, Stroke
الوصف: Objectives The purpose of this study was to evaluate the feasibility, safety, and outcomes of radiofrequency ablation of atrial fibrillation (AF) in patients with mechanical mitral valve replacement (MVR). Background The role of ablative therapy in patients with MVR is not yet established, with safety concerns and very few outcome data. Methods Between January 2003 and December 2008, we followed up 81 patients with MVR undergoing first-time AF ablation (compared with 162 age- and sex-matched controls). Arrhythmia recurrences were identified by symptoms with documentation, event monitoring, Holter monitoring, and electrocardiograms. Results All MVR and control patients underwent ablation under therapeutic international normalized ratio. No entrapment of catheters or stroke occurred. There were no differences in terms of procedure-related complications between the groups (p = NS). Patients with MVR had larger atria (p Conclusions Radiofrequency ablation is feasible and safe for patients with MVR. It allowed restoration of sinus rhythm in a substantial proportion of patients undergoing ablation. An abnormal atrial substrate underlies recurrences in these patients. The ablation procedure needs to be further refined with a focus on extra pulmonary vein triggers and concomitant flutters to improve outcomes.
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المؤلفون: Seby John, Mohammed A. Chamsi-Pasha, Bruce D. Lindsay, Minerva Sherman, Patrick J. Tchou, David O. Martin, Christina Magnelli-Reyes, Oussama M. Wazni, Thomas Callahan, Bryan Baranowski, Mandeep Bhargava, Ayman A. Hussein, Walid Saliba, Mohamed Kanj, Andrea Natale, Thomas Dresing, Michelle Williams-Adrews
المصدر: Circulation: Arrhythmia and Electrophysiology. 4:271-278
مصطلحات موضوعية: Male, medicine.medical_specialty, Time Factors, Heart disease, medicine.medical_treatment, Catheter ablation, Pulmonary vein, Heart Rate, Recurrence, Physiology (medical), Atrial Fibrillation, medicine, Humans, Sinus rhythm, Prospective Studies, Prospective cohort study, Stroke, Vascular disease, business.industry, Atrial fibrillation, Middle Aged, medicine.disease, Surgery, Treatment Outcome, Pulmonary Veins, Catheter Ablation, Female, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies
الوصف: Background— Atrial fibrillation (AF) ablation is increasingly used in clinical practice. We aimed to study the natural history and long-term outcomes of ablated AF. Methods and Results— We followed 831 patients after pulmonary vein isolation (PVI) performed in 2005. We documented clinical outcomes using our prospective AF registry with most recent update on this group of patients in October 2009. In the first year after ablation, 23.8% had early recurrence. Over long-term follow-up (55 months), only 8.9% had late arrhythmia recurrence defined as occurring beyond the first year after ablation. Repeat ablations in patients with late recurrence revealed conduction recovery in at least 1 of the previously isolated PVs in all of them and right-sided triggers with isoproterenol testing in 55.6%. At last follow-up, clinical improvement was 89.9% (79.4% arrhythmia-free off antiarrhythmic drugs and 10.5% with AF controlled with antiarrhythmic drugs). Only 4.6% continued to have drug-resistant AF. It was possible to safely discontinue anticoagulation in a substantial proportion of patients with no recurrence in the year after ablation (CHADS score ≤2, stroke incidence of 0.06% per year). The procedure-related complication rate was very low. Conclusions— Pulmonary vein isolation is safe and efficacious for long-term maintenance of sinus rhythm and control of symptoms in patients with drug-resistant AF. It obviates the need for antiarrhythmic drugs, negative dromotropic agents, and anticoagulants in a substantial proportion of patients.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7a312474a0c3738b589c91b49464d8
https://doi.org/10.1161/circep.111.962100 -
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المؤلفون: Brian Baranowski, Thomas Callahan
المصدر: Cleveland Clinic Journal of Medicine. 78:258-264
مصطلحات موضوعية: medicine.medical_specialty, business.industry, fungi, Anticoagulants, food and beverages, Atrial fibrillation, General Medicine, Newly diagnosed, medicine.disease, Early Diagnosis, Rhythm, Heart Rate, Thromboembolism, Internal medicine, Atrial Fibrillation, Heart rate, medicine, Cardiology, Humans, Sinus rhythm, business, Anti-Arrhythmia Agents
الوصف: The treatment of atrial fibrillation focuses on controlling the heart rate, preventing thromboembolic events, and, depending on the symptoms, restoring and maintaining sinus rhythm. In most cases, the rate or rhythm can be quickly controlled, and a long-term plan can be started that will minimize the impact of this disorder on the life of the patient.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abb7998a692130087e9a9f210ef7082
https://doi.org/10.3949/ccjm.78a.09165 -
64دورية أكاديمية
المؤلفون: Kim Schatzel, Thomas Callahan, Crystal J. Scott, Timothy Davis
المصدر: Taylor & Francis Journals, Journal of Marketing for Higher Education. 21(1):47-60
الوصف: An estimated 21% of 25--34-year-olds in the United States, about eight million individuals, have attended college and quit before completing a degree. These non-traditional students may or may not return to college. Those who return to college are referred to as stopouts, whereas those who do not return are referred to as stayouts. In the face of declining pools of traditional students, colleges and universities have attempted to induce these students to return to higher education. Regrettably, little is known about the intentions and attitudes of these young adults after they have left higher education. This paper uses segmentation and targeting to identify those students who intend to return to college and those who do not. Using demographic and psychographic variables, five unique segments are identified. The study recommends strategies for reaching those segments which are most likely to return to higher education.
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المؤلفون: Thomas Callahan, Conor Barrett, Mandeep Bhargava, Andrea Natale, Bryan Baranowski, David O. Martin, Oussama Wazni, Ayman Hussein, Thomas Dresing, Walid Saliba, Mazen Shaheen, Patrick Tchou, Khaldoun Tarakji, Mohamed Kanj
المصدر: Journal of Cardiovascular Electrophysiology. 20:1193-1196
مصطلحات موضوعية: Male, medicine.medical_specialty, medicine.medical_treatment, Catheter ablation, Physiology (medical), Cardiac tamponade, Atrial Fibrillation, medicine, Humans, Vascular Diseases, Pulmonary vein stenosis, Robotic ablation, business.industry, Body Surface Potential Mapping, Equipment Design, Robotics, Middle Aged, Ablation, medicine.disease, Surgery, Equipment Failure Analysis, Catheter, Surgery, Computer-Assisted, Pericardiocentesis, Catheter Ablation, Female, Tamponade, Cardiology and Cardiovascular Medicine, business
الوصف: Introduction: The Hansen robotic system has only recently been used in the United States for catheter ablation procedures in humans. Atrial fibrillation (AF) ablation may be performed utilizing this system. We report our management of complications with early experience of this system. Methods and Results: All 71 patients in whom the system was utilized were included. In all patients, a 2-operator technique was to be employed; one operator manipulates the ablation catheter via the robot and the other manipulates the circular mapping and intracardiac echocardiogram catheters. There was no procedure-related mortality. All vascular complications occurred in the first 25 procedures performed. There were 6 intraoperative procedural-related complications. These included significant vascular complications (n = 4), one of whom required iliac vein stenting, and 2 cardiac tamponade (one related to a pop-phenomenon)—successfully treated by pericardiocentesis. Early complications (n = 3) were 1 tamponade several hours post-procedure, 1 vascular complication, and 1 pericarditis. Late complications included 5 patients with severe pulmonary vein stenosis (all in first 27 patients) and 1 patient with gastroparesis. All complications were successfully managed without persistent morbidity and occurred earlier in our experience. This led to specific alterations in our vascular access and ablation techniques. These include the use of a longer 14 Fr sheath, through which the robotic sheath is more safely advanced. The choice of ablation catheter and titration of power, particularly when the catheter has a perpendicular orientation to the atrial wall, is also important. Conclusions: The suggested modifications may make the system easier to use with the potential to reduce complications.
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المؤلفون: Oussama M. Wazni, Minerva Sherman, Deven Patel, Michelle Williams-Andrews, David O. Martin, Mustafa Banna, Walid Saliba, Bruce D. Lindsay, Thomas Callahan, Andrea Natale, Salwa Beheiry, Ayman A. Hussein, Mohamed Kanj, Thomas Dresing, Omar Batal, Saima Karim, Mandeep Bhargava, Luigi Di Biase, Patrick J. Tchou
المصدر: Heart Rhythm. 6:1425-1429
مصطلحات موضوعية: Male, medicine.medical_specialty, Radiofrequency ablation, medicine.medical_treatment, Hemorrhage, Pulmonary vein, law.invention, Postoperative Complications, law, Physiology (medical), Atrial Fibrillation, medicine, Humans, cardiovascular diseases, Stroke, business.industry, Warfarin, Anticoagulants, Atrial fibrillation, Heparin, Middle Aged, medicine.disease, Ablation, Surgery, Pulmonary Veins, Catheter Ablation, Female, Tamponade, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies, medicine.drug
الوصف: Background The best periprocedural anticoagulation strategy at the time of pulmonary vein isolation (PVI) is not known. Most centers stop administering warfarin (Coumadin) and use bridging with heparin or enoxaparin. Objective The purpose of this study was to evaluate the efficacy and safety of PVI under therapeutic international normalized ratio (INR). Methods Between January 2005 and December 2008, PVI was performed in 3,052 patients with therapeutic INR (≥1.8) at the time of ablation. All patients were evaluated for ischemic strokes and bleeding complications. Results Mean INR was 2.53 ± 0.62. Only 3 (0.098%) patients had ischemic strokes. One patient had a hemorrhagic stroke on the third day postablation but recovered completely by 1-week follow-up. Bleeding complications occurred in 34 (1.11%) patients; most were minor (0.79%). Major hemorrhagic complications occurred in 10 (0.33%) patients (tamponade in 5, hematomas requiring intervention in 2, transfusion necessary in 3). Conclusion In a large patient population, continuation of Coumadin at a therapeutic INR at the time of PVI without use of heparin or enoxaparin for bridging is a safe and efficacious periprocedural anticoagulation strategy. It is an acceptable and potentially better alternative to strategies that use bridging with heparin or enoxaparin.
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المؤلفون: roBert shuPe, Thomas Callahan, John J. Dennehy, Paul Buttars, D. James Harris, Bryce Lunt, Markus Mika, Jonathon C. Marshall
المصدر: Israel Journal of Ecology and Evolution. 55:381-392
مصطلحات موضوعية: ComputingMilieux_THECOMPUTINGPROFESSION, Ecology (disciplines), ComputingMilieux_COMPUTERSANDEDUCATION, Animal Science and Zoology, Environmental ethics, Ecology and Evolutionary Biology, Job market, Ecology, Evolution, Behavior and Systematics
الوصف: Over the last several decades, the percentage of permanent faculty positions at universities has declined significantly. Increasingly, courses are taught by adjunct instructors, graduate students, and postdoctoral fellows rather than by permanent faculty members. This creates intense competition for permanent positions. Data summarizing the general qualifications of newly hired first-time professors in permanent jobs are valuable for students contemplating graduate school and academic careers. These data should also help graduate students and postdoctoral fellows set goals that will enable them to be competitive for permanent academic jobs. Here we present data collected in a survey from 181 newly hired faculty members in the fields of ecology and evolutionary biology from around the world. We report the average number of publications, courses taught, years as postdoctoral fellows, and research grants received for successful job applicants. Our results indicate an extremely competitive environment for permanent academic jobs in the fields of ecology and evolutionary biology.
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المصدر: Glia. 56:1428-1437
مصطلحات موضوعية: Nervous system, Cell signaling, medicine.medical_specialty, Glial Cell Line-Derived Neurotrophic Factor Receptors, SOX10, Mice, Transgenic, Biology, Mice, Cellular and Molecular Neuroscience, Pregnancy, Internal medicine, medicine, Glial cell line-derived neurotrophic factor, Animals, Glial Cell Line-Derived Neurotrophic Factor, Mice, Knockout, Ganglia, Sympathetic, Tyrosine hydroxylase, Neural crest, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, Endocrinology, nervous system, Neurology, embryonic structures, biology.protein, Neuroglia, Female, lipids (amino acids, peptides, and proteins), Neural cell adhesion molecule
الوصف: The phenotypic development of satellite cells in mouse sympathetic ganglia was examined by localizing the transcription factors, Sox10 and Phox2b, the neuronal marker, tyrosine hydroxylase (TH), and brain-derived fatty acid binding protein (B-FABP), which identifies glial precursors and mature glia. In E10.5 mice, most cells in the sympathetic chain expressed both Sox10 and Phox2b, with a minority of cells expressing Sox10 only or Phox2b only. In E11.5 mice, the majority of cells expressed Sox10 only or Phox2b only. B-FABP was colocalized with Sox10 in satellite glial precursors, which were located on the periphery of the ganglion. There was no overlap between B-FABP and Phox2b or B-FABP and TH. During subsequent development, the number of B-FABP+ cells increased and they became more common deep within the ganglion. In E12.5 and E18.5 mice, there was no overlap between Sox10 and Phox2b, and 98% of Sox10 cells were also B-FABP+. Satellite glial precursors in E11.5-E15.5 mice also expressed the GDNF-binding molecule, GFRalpha1. B-FABP immunoreactive cells did not express Ret or NCAM, two potential signaling molecules for GDNF/GFRalpha1. In E12.5 and E18.5 mice lacking GFRalpha1 or GDNF, the development of B-FABP immunoreactive satellite cells was normal, and hence neither GDNF or GFRalpha1 are essential for the development of satellite glia in sympathetic ganglia.
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المؤلفون: Thomas Callahan, Andrea Natale
المصدر: Medical Clinics of North America. 92:179-201
مصطلحات موضوعية: medicine.medical_specialty, business.industry, medicine.medical_treatment, Atrial fibrillation, Catheter ablation, General Medicine, medicine.disease, Pulmonary vein, Angina, Treatment Outcome, Heart Conduction System, Heart Rate, Internal medicine, Heart failure, Atrial Fibrillation, Catheter Ablation, cardiovascular system, medicine, Cardiology, Humans, Sinus rhythm, cardiovascular diseases, business, Stroke, Antrum
الوصف: Atrial fibrillation is a common arrhythmia associated with significant morbidity including angina, heart failure and stroke. Medical therapy remains suboptimal with significant side effects and toxicities, as well as a high recurrence rate. Catheter ablation or modification of the atrio-ventricular node with pacemaker implantation provides rate control but subjects the patient to the risks of an implantable device and does nothing to reduce the risk of stroke. Pulmonary vein antrum isolation offers a nonpharmacologic means of restoring sinus rhythm, thereby eliminating the morbidity of atrial fibrillation and the need for anti-arrhythmic drugs.
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المؤلفون: Niraj Varma, Walid Saliba, Bryan Baranowski, Oussama M. Wazni, Thomas Callahan, Mina K. Chung, Shadi Al Halabi, Daniel J. Cantillon, M. Chadi Alraies, Mohamed Kanj, Mohammed Qintar, Mandeep Bhargava, Khaldoun G. Tarakji
المصدر: Journal of the American College of Cardiology. 65(10)
مصطلحات موضوعية: medicine.medical_specialty, business.industry, Ablation of atrial fibrillation, medicine.disease, law.invention, Randomized controlled trial, law, Heart failure, Meta-analysis, Internal medicine, medicine, Cardiology, business, Cardiology and Cardiovascular Medicine
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