المؤلفون: Kun Qin, Du Lei, Jing Yang, Wenbin Li, Maxwell J. Tallman, Luis Rodrigo Patino Duran, Thomas J. Blom, Kaitlyn M. Bruns, Sian Cotton, John A. Sweeney, Qiyong Gong, Melissa P. DelBello

المصدر: BMC Psychiatry, Vol 21, Iss 1, Pp 1-10 (2021)

مصطلحات موضوعية: Resting-state functional magnetic resonance imaging, Graph theory, Emotion regulation, Psychoradiology, Bipolar disorder, Familial risk, Psychiatry, RC435-571

الوصف: Abstract Background Given that psychopharmacological approaches routinely used to treat mood-related problems may result in adverse outcomes in mood dysregulated adolescents at familial risk for bipolar disorder (BD), Mindfulness-Based Cognitive Therapy for Children (MBCT-C) provides an alternative effective and safe option. However, little is known about the brain mechanisms of beneficial outcomes from this intervention. Herein, we aimed to investigate the network-level neurofunctional effects of MBCT-C in mood dysregulated adolescents. Methods Ten mood dysregulated adolescents at familial risk for BD underwent a 12-week MBCT-C intervention. Resting-state functional magnetic resonance imaging (fMRI) was performed prior to and following MBCT-C. Topological metrics of three intrinsic functional networks (default mode network (DMN), fronto-parietal network (FPN) and cingulo-opercular network (CON)) were investigated respectively using graph theory analysis. Results Following MBCT-C, mood dysregulated adolescents showed increased global efficiency and decreased characteristic path length within both CON and FPN. Enhanced functional connectivity strength of frontal and limbic areas were identified within the DMN and CON. Moreover, change in characteristic path length within the CON was suggested to be significantly related to change in the Emotion Regulation Checklist score. Conclusions 12-week MBCT-C treatment in mood dysregulated adolescents at familial risk for BD yield network-level neurofunctional effects within the FPN and CON, suggesting enhanced functional integration of the dual-network. Decreased characteristic path length of the CON may be associated with the improvement of emotion regulation following mindfulness training. However, current findings derived from small sample size should be interpreted with caution. Future randomized controlled trials including larger samples are critical to validate our findings.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1471-244X

URL الوصول: https://doaj.org/article/058eeeb422ca40aab176aed8750fed82

المؤلفون: Duncan C. Honeycutt, Melissa P. DelBello, Jeffrey R. Strawn, Laura B. Ramsey, Luis R. Patino, Kyle Hinman, Jeffrey Welge, David J. Miklowitz, Booil Jo, Thomas J. Blom, Kaitlyn M. Bruns, Sarah K. Hamill Skoch, Nicole Starace, Maxwell J. Tallman, Manpreet K. Singh

المصدر: Journal of Personalized Medicine, Vol 12, Iss 6, p 1006 (2022)

مصطلحات موضوعية: bipolar risk, hyperarousal, depression, anxiety, adolescent, neuroimaging, Medicine

الوصف: Antidepressants are standardly used to treat moderate to severe symptoms of depression and/or anxiety in youth but may also be associated with rare but serious psychiatric adverse events such as irritability, agitation, aggression, or suicidal ideation. Adverse events are especially common in youth with a family history of bipolar disorder (BD) who are at heightened risk for dysfunction in neurobiological systems that regulate emotion and arousal. To further understand this phenomenon, this study will examine (a) baseline risk factors associated with dysfunctional arousal in a sample of youth at high-risk for BD treated with or without an antidepressant, (b) whether antidepressant-related changes in arousal are mediated by changes in prefrontal-limbic circuitry, and (c) whether pharmacogenetic factors influence antidepressant-related changes in arousal. High-risk youth (aged 12–17 years with moderate to severe depressive and/or anxiety symptoms and at least one first-degree relative with bipolar I disorder) will be randomized to receive psychotherapy plus escitalopram or psychotherapy plus placebo. Neuroimaging and behavioral measures of arousal will be collected prior to randomization and at 4 weeks. Samples for pharmacogenetic analysis (serum escitalopram concentration, CYP2C19 metabolizer phenotype, and HTR2A and SLC6A4 genotypes) will be collected at 8 weeks. Youth will be followed for up to 16 weeks to assess change in arousal measures.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2075-4426/12/6/1006; https://doaj.org/toc/2075-4426

URL الوصول: https://doaj.org/article/65c3fdc454c04a299a797d8ee926c34a

المؤلفون: Du Lei, Wenbin Li, Kun Qin, Yuan Ai, Maxwell J. Tallman, L. Rodrigo Patino, Jeffrey A. Welge, Thomas J. Blom, Christina C. Klein, David E. Fleck, Qiyong Gong, Caleb M. Adler, Jeffrey R. Strawn, John A. Sweeney, Melissa P. DelBello

المصدر: Neuropsychopharmacology. 48:615-622

مصطلحات موضوعية: Pharmacology, Psychiatry and Mental health

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f48840e29cc9b00f8e66b5e9e5e41414
https://doi.org/10.1038/s41386-022-01463-6

المؤلفون: Jeffrey A. Welge, Christoph U. Correll, Michael T. Sorter, Victor M. Fornari, Thomas J. Blom, Adam C. Carle, Bin Huang, Christina C. Klein, Melissa P. DelBello

المصدر: JAACAP Open.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b27e1d1023663d211a365f3c751aa06e
https://doi.org/10.1016/j.jaacop.2023.03.004

المؤلفون: Manuel Gardea-Resendez, Colin L. Colby, Alfredo B. Cuellar-Barboza, Marin Veldic, Francisco Romo-Nava, Nicolas A. Nunez, Miguel L. Prieto, Susan L. McElroy, Brian E. Martens, Mark A. Frye, Balwinder Singh, Joanna M. Biernacka, Thomas J. Blom, Nicole Mori, Oluwole Awosika, Ayşegül Özerdem

المصدر: Journal of Affective Disorders. 295:156-162

مصطلحات موضوعية: Male, Clinical interview, medicine.medical_specialty, Bipolar Disorder, business.industry, Migraine Disorders, MEDLINE, Comorbidity, medicine.disease, Causality, Biobank, Phenotype, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Migraine, Internal medicine, Prevalence, medicine, Humans, Female, Bipolar disorder, business

الوصف: To evaluate the prevalence and clinical correlates of lifetime migraine among patients with bipolar disorder (BD).In a cross-sectional study, we evaluated 721 adults with BD from the Mayo Clinic Bipolar Disorder Biobank and compared clinical correlates of those with and without a lifetime history of migraine. A structured clinical interview (DSM-IV) and a clinician-assessed questionnaire were utilized to establish a BD diagnosis, lifetime history of migraine, and clinical correlates.Two hundred and seven (29%) BD patients had a lifetime history of migraine. BD patients with migraine were younger and more likely to be female as compared to those without migraine (p values0.01). In a multivariate logistic regression model, younger age (OR=0.98, p0.01), female sex (OR=2.02, p0.01), higher shape/weight concern (OR=1.04, p=0.02), greater anxiety disorder comorbidities (OR=1.24, p0.01), and evening chronotype (OR=1.65, p=0.03) were associated with migraine. In separate regression models for each general medical comorbidity (controlled for age, sex, and site), migraines were significantly associated with fibromyalgia (OR=3.17, p0.01), psoriasis (OR=2.65, p=0.03), and asthma (OR=2.0, p0.01). Participants with migraine were receiving ADHD medication (OR=1.53, p=0.05) or compounds associated with weight loss (OR=1.53, p=0.02) at higher rates compared to those without migraine.Study design precludes determination of causality. Migraine subtypes and features were not assessed.Migraine prevalence is high in BD and is associated with a more severe clinical burden that includes increased comorbidity with pain and inflammatory conditions. Further study of the BD-migraine phenotype may provide insight into common underlying neurobiological mechanisms.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66973bf4fd9ce2f0ef9a7e1409632b4e
https://doi.org/10.1016/j.jad.2021.08.026

المؤلفون: Francisco Romo-Nava, Oluwole O. Awosika, Ishita Basu, Thomas J. Blom, Jeffrey Welge, Abhishek Datta, Alexander Guillen, David E. Fleck, Georgi Georgiev, Nicole Mori, Luis R. Patino, Melissa P. DelBello, Robert K. McNamara, Ruud M. Buijs, Mark A. Frye, Susan L. McElroy

المصدر: Biological Psychiatry. 93:S69

مصطلحات موضوعية: Biological Psychiatry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3e2a2c6592102466f8974608f1bf0cee
https://doi.org/10.1016/j.biopsych.2023.02.185

المؤلفون: Constance Chen, Maxwell J. Tallman, Kim M. Cecil, Luis Rodrigo Patino, Thomas J. Blom, Melissa P. DelBello, Robert K. McNamara

المصدر: Journal of attention disorders. 26(13)

مصطلحات موضوعية: Clinical Psychology, Bipolar Disorder, Adolescent, Attention Deficit Disorder with Hyperactivity, Developmental and Educational Psychology, Humans, Central Nervous System Stimulants, Neurochemistry, Choline

الوصف: Objective: To identify clinical and central features that differentiate ADHD youth with and without familial risk for bipolar I disorder (BD). Methods: Psychostimulant-free ADHD youth (10–18 years) with and without a first-degree relative with BD and healthy controls were enrolled. Bilateral ventrolateral prefrontal cortex (VLPFC) proton magnetic resonance spectroscopy (1H MRS) scans and a range of symptom ratings were performed. Results: A total of n = 145 youth were enrolled. ADHD youth with a family history of BD exhibited greater manic and depressive symptom severity, ADHD hyperactivity/impulsive symptom severity, and higher parent-reported ratings of dysregulation compared with ADHD youth without a BD family history. Although VLPFC metabolite levels did not differ across groups, choline levels in the left VLPFC correlated with different symptom ratings. Conclusion: Symptom profiles including more severe mood and externalizing symptoms, but not VLPFC neurochemistry, differentiate psychostimulant-free ADHD youth with and without a family history of BD.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df312a3bfa18c8e131f03a4fefcccce
https://pubmed.ncbi.nlm.nih.gov/35658594

المؤلفون: Christina C Klein, Kaitlyn M Bruns, Laura E McLaughlin, Thomas J Blom, Luis Rodrigo Patino Duran, Melissa P DelBello

المصدر: Clinical Child Psychology and Psychiatry. :135910452211417

مصطلحات موضوعية: Psychiatry and Mental health, Clinical Psychology, Pediatrics, Perinatology and Child Health, General Medicine

الوصف: Background The purpose is to compare youth- and caregiver-reported characteristics of family environment, within and between families with a child experiencing a first manic episode of bipolar disorder (BPD), and families without a child with BPD or familial history of psychiatric disorders (HF). Methods Family environment of 61 families with a child with BPD and 44 HF were assessed with Family Environment Scale (FES). We compared FES subscale scores between families with BPD and HF, and caregiver- and youth-rated scores. Results Families with BPD differed significantly from HF on 8/10 FES subscales scores. Youth differed significantly from their caregivers on 7/10 subscales. An interaction effect was observed such that youth with BPD reported lower cohesion and organization, and higher conflict than their caregivers; however, HF did not differ significantly on these domains. Conclusions Our results suggest that families with BPD have higher conflict and lower cohesion and organization compared to HF. Results also indicate differences between youth and caregiver perspectives in both groups, which may contribute to family discord. Interventions targeting areas of cohesion, organization, and conflict may be beneficial for youth with BPD and their families, specifically those that identify and bridge perceptual divides.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c61bb209f1d978b585ad504a5f6e08e7
https://doi.org/10.1177/13591045221141773

المؤلفون: Kun Qin, Sian Cotton, Luis Rodrigo Patino Duran, Xueling Suo, Thomas J. Blom, Du Lei, John A. Sweeney, Wenbin Li, Qiyong Gong, Maxwell J Tallman, Jing Yang, Kaitlyn M. Bruns, Melissa P. DelBello

المصدر: Early intervention in psychiatryREFERENCES. 16(9)

مصطلحات موضوعية: Mindfulness, Bipolar Disorder, Adolescent, medicine.medical_treatment, Grey matter, Limbic system, Neuroimaging, medicine, Humans, Genetic Predisposition to Disease, Bipolar disorder, Child, Biological Psychiatry, Mindfulness-based cognitive therapy, Cognitive Behavioral Therapy, business.industry, Brain, medicine.disease, Psychiatry and Mental health, medicine.anatomical_structure, Mood, Cognitive therapy, Pshychiatric Mental Health, business, Clinical psychology

الوصف: Background Mindfulness-based cognitive therapy for children (MBCT-C), as a psychotherapeutic intervention, has been shown to be effective for treating mood dysregulation (MD). While previous neuroimaging studies of MD have reported both pre-treatment structural and functional alterations, the effects of MBCT-C on brain morphological network organisation has not been investigated. Methods We investigated brain morphological network organisation in 10 mood-dysregulated youth with familial risk for bipolar disorder and 15 matched healthy comparison youth (HC). Effects of 12 weeks of MBCT-C were examined in the mood-dysregulated youth. Topological properties of brain networks used for analyses were constructed based on morphological similarities in regional grey matter using a graph-theory approach using MRI data. Results At baseline, compared with the HC group, the mood-dysregulated group exhibited increased global efficiency (Eglob ), decreased path length (Lp ), and abnormal nodal properties, mainly in the limbic system. Right temporal pole alterations at baseline predicted change in Child and Adolescent Mindfulness Measure scores after treatment. The mood-dysregulated group showed significant decreases in both the Eglob and Lp metrics after MBCT-C, suggesting an improved capacity for optimal information processing. Changes in Lp were correlated with changes in Emotion Regulation Checklist scores. Our results show significant topological alterations in the mood-dysregulated group as compared to controls at baseline. After MBCT-C, disrupted topological properties in the mood-dysregulated group were significantly reduced. Conclusion MBCT-C may facilitate clinically meaningful changes in the brain structural network in mood-dysregulated individuals.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecfd64923967142bdb506fe65f2ec93
https://pubmed.ncbi.nlm.nih.gov/34808702

المؤلفون: Christina Klein, Maxwell J Tallman, Jeffrey A. Welge, Luis R. Patino, Melissa P. DelBello, Jeffrey R. Strawn, Thomas J. Blom, Caleb M. Adler

المصدر: J Child Adolesc Psychopharmacol

مصطلحات موضوعية: Male, Pediatrics, medicine.medical_specialty, Bipolar I disorder, Bipolar Disorder, Lithium (medication), Adolescent, Lithium, law.invention, Double blind, Quetiapine Fumarate, Randomized controlled trial, Double-Blind Method, law, mental disorders, Medicine, Humans, Pharmacology (medical), Bipolar disorder, Psychiatric Status Rating Scales, business.industry, Original Articles, medicine.disease, Psychiatry and Mental health, Mania, Treatment Outcome, Tolerability, Pediatrics, Perinatology and Child Health, Quetiapine, Female, medicine.symptom, business, medicine.drug, Antipsychotic Agents

الوصف: Objective: To compare the efficacy and tolerability of lithium versus quetiapine for the treatment of manic or mixed episodes in youths with early course bipolar I disorder. Methods: Six-week, randomized, double-blind clinical trial of lithium versus quetiapine for the treatment of adolescents with acute manic/mixed episode. Target dose of quetiapine dose was adjusted to a target dose of 400–600 mg and target serum level for lithium was 1.0–1.2 mEq/L. Primary outcome measure was baseline-to-endpoint change in the Young Mania Rating Scale (YMRS). Secondary outcomes were treatment response (50% or more decrease from baseline in YMRS score) and remission (YMRS score ≤12, Children's Depression Rating Scale-Revised [CDRS-R] total score ≤28 and Clinical Global Impression Bipolar Severity Scale [CGI-BP-S] overall score of ≤3, respectively). Results: A total of 109 patients were randomized (quetiapine = 58 and lithium = 51). Participants in the quetiapine treatment group showed a significantly greater reduction in YMRS score than those in the lithium group (−11.0 vs. −13.2; p

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d1d863c94082bc436ffac29877464e
https://pubmed.ncbi.nlm.nih.gov/34520250