المؤلفون: Padavannil A; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Sarkar P; Department of Biological Sciences, University of Texas at Dallas, Richardson, United States., Kim SJ; Department of Physics, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea., Cagatay T; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Jiou J; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Brautigam CA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States., Sali A; Department of Bioengineering and Therapeutic Sciences, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, United States.; Department of Pharmaceutical Chemistry, California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, United states., D'Arcy S; Department of Chemistry and Biochemistry, University of Texas at Dallas, Richardson, United States., Chook YM; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.

المصدر: ELife [Elife] 2019 Mar 11; Vol. 8. Date of Electronic Publication: 2019 Mar 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Histones/*chemistry , Histones/*metabolism , Karyopherins/*chemistry , Karyopherins/*metabolism, Active Transport, Cell Nucleus ; Animals ; Crystallography, X-Ray ; DNA Mutational Analysis ; Humans ; Karyopherins/genetics ; Molecular Chaperones/chemistry ; Molecular Chaperones/genetics ; Molecular Chaperones/metabolism ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Protein Binding ; Protein Conformation ; Xenopus

المؤلفون: Endapally S; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Frias D; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Grzemska M; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Gay A; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Radhakrishnan A; Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: arun.radhakrishnan@utsouthwestern.edu.

المصدر: Cell [Cell] 2019 Feb 21; Vol. 176 (5), pp. 1040-1053.e17. Date of Electronic Publication: 2019 Jan 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Cell Membrane/*ultrastructure , Sphingomyelins/*metabolism , Sphingomyelins/*physiology, Animals ; Cell Line ; Cell Membrane/metabolism ; Cholesterol/metabolism ; Cholesterol/physiology ; Fungal Proteins/metabolism ; Fungal Proteins/ultrastructure ; Hemolysin Proteins/metabolism ; Hemolysin Proteins/ultrastructure ; Humans ; Membrane Microdomains/metabolism ; Molecular Conformation

المؤلفون: White J; Departments of Chemistry and Global Health , University of Washington , 36 Bagley Hall, 400 15th Avenue NE , Seattle , Washington 98195 , United States., Dhingra SK; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States., Deng X; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., El Mazouni F; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Lee MCS; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States.; Parasites and Microbes Programme , Wellcome Sanger Institute , Hinxton, Cambridgeshire CB10 1SA , U.K., Afanador GA; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Lawong A; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Tomchick DR; Department of Biophysics , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States., Ng CL; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States., Bath J; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States., Rathod PK; Departments of Chemistry and Global Health , University of Washington , 36 Bagley Hall, 400 15th Avenue NE , Seattle , Washington 98195 , United States., Fidock DA; Department of Microbiology & Immunology , Columbia University Irving Medical Center , 701 West 168th Street, HHSC 1502 , New York , New York 10032 , United States.; Division of Infectious Diseases, Department of Medicine , Columbia University Irving Medical Center , PH8-W, 630 West 168th Street, PH 8-West , New York , New York 10032 , United States., Phillips MA; Department of Biochemistry , University of Texas Southwestern Medical Center , 5323 Harry Hines Blvd , Dallas , Texas 75390 , United States.

المصدر: ACS infectious diseases [ACS Infect Dis] 2019 Jan 11; Vol. 5 (1), pp. 90-101. Date of Electronic Publication: 2018 Nov 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Point Mutation*, Antimalarials/*pharmacology , Drug Resistance/*genetics , Oxidoreductases Acting on CH-CH Group Donors/*genetics , Plasmodium falciparum/*drug effects , Plasmodium falciparum/*genetics , Pyrimidines/*pharmacology , Triazoles/*pharmacology, Amino Acid Sequence ; Animals ; Binding Sites ; CRISPR-Cas Systems ; Crystallography, X-Ray ; Dihydroorotate Dehydrogenase ; Gene Editing ; Humans ; Malaria, Falciparum ; Oxidoreductases Acting on CH-CH Group Donors/antagonists & inhibitors ; Plasmodium falciparum/enzymology

المؤلفون: Afanador GA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Phillips MA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: margaret.phillips@utsouthwestern.edu.

المصدر: Structure (London, England : 1993) [Structure] 2018 Nov 06; Vol. 26 (11), pp. 1499-1512.e5. Date of Electronic Publication: 2018 Sep 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

مواضيع طبية MeSH: NAD/*metabolism , Oxidoreductases Acting on CH-NH Group Donors/*chemistry , Oxidoreductases Acting on CH-NH Group Donors/*metabolism , Trypanosoma brucei brucei/*enzymology, Animals ; Catalytic Domain ; Crystallography, X-Ray ; Humans ; Models, Molecular ; Protein Multimerization ; Protozoan Proteins/chemistry ; Species Specificity ; Substrate Specificity ; Trypanosoma brucei brucei/chemistry

المؤلفون: Sreelatha A; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Yee SS; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Lopez VA; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Park BC; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Kinch LN; Howard Hughes Medical Institute, Dallas, TX 75390, USA., Pilch S; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland., Servage KA; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Zhang J; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Jiou J; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Karasiewicz-Urbańska M; Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland., Łobocka M; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland; Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland., Grishin NV; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Orth K; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Howard Hughes Medical Institute, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Kucharczyk R; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland., Pawłowski K; Faculty of Agriculture and Biology, Warsaw University of Life Sciences, Warsaw 02-776, Poland., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Tagliabracci VS; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Electronic address: vincent.tagliabracci@utsouthwestern.edu.

المصدر: Cell [Cell] 2018 Oct 18; Vol. 175 (3), pp. 809-821.e19. Date of Electronic Publication: 2018 Sep 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell

مواضيع طبية MeSH: Catalytic Domain* , Protein Processing, Post-Translational*, Adenosine Monophosphate/*metabolism , Selenoproteins/*metabolism, Conserved Sequence ; Humans ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Oxidative Stress ; Selenoproteins/chemistry

المؤلفون: Bae SJ; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Ni L; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Osinski A; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States., Brautigam CA; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, United States., Luo X; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.

المصدر: ELife [Elife] 2017 Oct 24; Vol. 6. Date of Electronic Publication: 2017 Oct 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Signal Transduction*, Cell Cycle Proteins/*metabolism , Membrane Proteins/*metabolism , Protein Phosphatase 2/*antagonists & inhibitors , Protein Serine-Threonine Kinases/*metabolism, Cell Cycle Proteins/chemistry ; Crystallography, X-Ray ; Hippo Signaling Pathway ; Humans ; Membrane Proteins/chemistry ; Protein Conformation ; Protein Multimerization ; Protein Processing, Post-Translational ; Protein Serine-Threonine Kinases/chemical synthesis ; Serine-Threonine Kinase 3

المؤلفون: Voleti R; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390., Südhof TC; Department of Molecular and Cellular Physiology, Stanford University Medical School, Stanford, CA 94305; tcs1@stanford.edu jose.rizo-rey@UTSouthwestern.edu.; Howard Hughes Medical Institute, Stanford University Medical School, Stanford, CA 94305., Rizo J; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390; tcs1@stanford.edu jose.rizo-rey@UTSouthwestern.edu.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Oct 03; Vol. 114 (40), pp. E8518-E8527. Date of Electronic Publication: 2017 Sep 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Calcium/*metabolism , Cell Membrane/*metabolism , Neurotransmitter Agents/*metabolism , Synaptotagmin I/*metabolism , Synaptotagmins/*metabolism, Animals ; Crystallography, X-Ray ; Liposomes ; Protein Binding ; Protein Domains ; Rats ; Synaptic Transmission ; Synaptotagmin I/chemistry ; Synaptotagmin I/genetics ; Synaptotagmins/chemistry ; Synaptotagmins/genetics

المؤلفون: Brautigam CA; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390.; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390., Deka RK; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390., Liu WZ; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390., Tomchick DR; Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390.; Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390., Norgard MV; Department of Microbiology, The University of Texas Southwestern Medical Center, Dallas, Texas, 75390.

المصدر: Protein science : a publication of the Protein Society [Protein Sci] 2017 Apr; Vol. 26 (4), pp. 847-856. Date of Electronic Publication: 2017 Mar 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

مواضيع طبية MeSH: ATP-Binding Cassette Transporters/*chemistry , Periplasmic Proteins/*chemistry , Treponema pallidum/*chemistry, ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Crystallography, X-Ray ; Periplasmic Proteins/genetics ; Periplasmic Proteins/metabolism ; Protein Domains ; Structure-Activity Relationship ; Treponema pallidum/genetics ; Treponema pallidum/metabolism

المؤلفون: Xu J; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Camacho M; Department of Neurophysiology, NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, Berlin, Germany., Xu Y; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Esser V; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Liu X; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Trimbuch T; Department of Neurophysiology, NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, Berlin, Germany., Pan YZ; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Ma C; Key Laboratory of Molecular Biophysics of the Ministry of Education, Huazhong University of Science and Technology, Wuhan, China.; College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States., Rosenmund C; Department of Neurophysiology, NeuroCure Cluster of Excellence, Charité-Universitätsmedizin Berlin, Berlin, Germany., Rizo J; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.

المصدر: ELife [Elife] 2017 Feb 08; Vol. 6. Date of Electronic Publication: 2017 Feb 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Nerve Tissue Proteins/*chemistry , Nerve Tissue Proteins/*metabolism , Neurotransmitter Agents/*metabolism, Animals ; Cells, Cultured ; Crystallography, X-Ray ; Mice ; Models, Molecular ; Neurons/physiology ; Protein Conformation ; Rats

المؤلفون: Volkov OA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Kinch L; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States., Ariagno C; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Deng X; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Zhong S; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States., Grishin N; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States.; Howard Hughes Medical Institute,University of Texas Southwestern Medical Center, Dallas, United States., Tomchick DR; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States., Chen Z; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, United States., Phillips MA; Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, United States.; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, United States.

المصدر: ELife [Elife] 2016 Dec 15; Vol. 5. Date of Electronic Publication: 2016 Dec 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Activation* , Gene Expression Regulation, Enzymologic*, Adenosylmethionine Decarboxylase/*chemistry , Adenosylmethionine Decarboxylase/*metabolism , Trypanosoma brucei brucei/*enzymology, Allosteric Regulation ; Crystallography, X-Ray ; Models, Molecular ; Protein Conformation ; Protein Multimerization ; Protozoan Proteins/chemistry ; Protozoan Proteins/metabolism