المؤلفون: Santos, S, Voerman, E, Amiano, P, Barros, H, Beilin, LJ, Bergstrom, A, Charles, MA, Chatzi, L, Chevrier, C, Chrousos, GP, Corpeleijn, E, Costa, O, Costet, N, Crozier, S, Devereux, G, Doyon, M, Eggesbo, M, Fantini, MP, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, KM, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hivert, MF, Hryhorczuk, D, Huang, RC, Inskip, H, Karvonen, AM, Kenny, LC, Koletzko, B, Kupers, LK, Lagstrom, H, Lehmann, I, Magnus, P, Majewska, R, Makela, J, Manios, Y, McAuliffe, FM, McDonald, SW, Mehegan, J, Melen, E, Mommers, M, Morgen, CS, Moschonis, G, Murray, D, Ni Chaoimh, C, Nohr, EA, Andersen, AMN, Oken, E, Oostvogels, AJJM, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, SL, Roeleveld, N, Ronfani, L, Santos, AC, Standl, M, Stigum, H, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, SC, Trnovec, T, Turner, S, van Gelder, MMHJ, van Rossem, L, von Berg, A, Vrijheid, M, Vrijkotte, TGM, West, J, Wijga, AH, Wright, J, Zvinchuk, O, Sorensen, TIA, Lawlor, DA, Gaillard, R, Jaddoe, VWV

المصدر: BJOG : an international journal of obstetrics and gynaecology. 126(8):984-995

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:141067677

المؤلفون: Voerman, E, Santos, S, Golab, BP, Amiano, P, Ballester, F, Barros, H, Bergstrom, A, Charles, MA, Chatzi, L, Chevrier, C, Chrousos, GP, Corpeleijn, E, Costet, N, Crozier, S, Devereux, G, Eggesbo, M, Ekstrom, S, Fantini, MP, Farchi, S, Forastiere, F, Georgiu, V, Godfrey, KM, Gori, D, Grote, V, Hanke, W, Hertz-Picciotto, I, Heude, B, Hryhorczuk, D, Huang, RC, Inskip, H, Iszatt, N, Karvonen, AM, Kenny, LC, Koletzko, B, Kupers, LK, Lagstrom, H, Lehmann, I, Magnus, P, Majewska, R, Makela, J, Manios, Y, McAuliffe, FM, McDonald, SW, Mehegan, J, Mommers, M, Morgen, CS, Mori, TA, Moschonis, G, Murray, D, Chaoimh, CN, Nohr, EA, Andersen, AMN, Oken, E, Oostvogels, AJJM, Pac, A, Papadopoulou, E, Pekkanen, J, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Rifas-Shiman, SL, Ronfani, L, Santos, AC, Standl, M, Stoltenberg, C, Thiering, E, Thijs, C, Torrent, M, Tough, SC, Trnovec, T, Turner, S, Van Rossem, L, Von Berg, A, Vrijheid, M, Vrijkotte, TGM, West, J, Wijga, A, Wright, J, Zvinchuk, O, Sorensen, TIA, Lawlor, DA, Gaillard, R, Jaddoe, VWV

المصدر: PLoS medicine. 16(2):e1002744

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:140418334

المؤلفون: Elhakeem, A, Taylor, AE, Inskip, HM, Huang, J, Tafflet, M, Vinther, JL, Asta, F, Erkamp, JS, Gagliardi, L, Guerlich, K, Halliday, J, Harskamp-van Ginkel, MW, He, J-R, Jaddoe, VWV, Lewis, S, Maher, GM, Manios, Y, Mansell, T, McCarthy, FP, McDonald, SW, Medda, E, Nisticò, L, de Moira, AP, Popovic, M, Reiss, IKM, Rodrigues, C, Salika, T, Smith, A, Stazi, MA, Walker, C, Wu, M, Åsvold, BO, Barros, H, Brescianini, S, Burgner, D, Chan, JKY, Charles, M-A, Eriksson, JG, Gaillard, R, Grote, V, Håberg, SE, Heude, B, Koletzko, B, Morton, S, Moschonis, G, Murray, D, O'Mahony, D, Porta, D, Qiu, X, Richiardi, L, Rusconi, F, Saffery, R, Tough, SC, Vrijkotte, TGM, Nelson, SM, Nybo Andersen, A-M, Magnus, MC, Lawlor, DA, Assisted Reproductive Technology and Future Health (ART-Health) Cohort Collaboration

مصطلحات موضوعية: Adult, Male, 42 Health sciences, Adolescent, Reproductive Techniques, Assisted, Infant, 32 Biomedical and clinical sciences, Embryo Transfer, Cohort Studies, Pregnancy, Semen, Child, Preschool, Humans, Female, Obesity, Child, Adiposity

الوصف: IMPORTANCE: People conceived using assisted reproductive technology (ART) make up an increasing proportion of the world's population. OBJECTIVE: To investigate the association of ART conception with offspring growth and adiposity from infancy to early adulthood in a large multicohort study. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used a prespecified coordinated analysis across 26 European, Asia-Pacific, and North American population-based cohort studies that included people born between 1984 and 2018, with mean ages at assessment of growth and adiposity outcomes from 0.6 months to 27.4 years. Data were analyzed between November 2019 and February 2022. EXPOSURES: Conception by ART (mostly in vitro fertilization, intracytoplasmic sperm injection, and embryo transfer) vs natural conception (NC; without any medically assisted reproduction). MAIN OUTCOMES AND MEASURES: The main outcomes were length / height, weight, and body mass index (BMI; calculated as weight in kilograms divided by height in meters squared). Each cohort was analyzed separately with adjustment for maternal BMI, age, smoking, education, parity, and ethnicity and offspring sex and age. Results were combined in random effects meta-analysis for 13 age groups. RESULTS: Up to 158 066 offspring (4329 conceived by ART) were included in each age-group meta-analysis, with between 47.6% to 60.6% females in each cohort. Compared with offspring who were NC, offspring conceived via ART were shorter, lighter, and thinner from infancy to early adolescence, with differences largest at the youngest ages and attenuating with older child age. For example, adjusted mean differences in offspring weight were -0.27 (95% CI, -0.39 to -0.16) SD units at age younger than 3 months, -0.16 (95% CI, -0.22 to -0.09) SD units at age 17 to 23 months, -0.07 (95% CI, -0.10 to -0.04) SD units at age 6 to 9 years, and -0.02 (95% CI, -0.15 to 0.12) SD units at age 14 to 17 years. Smaller offspring size was limited to individuals conceived by fresh but not frozen embryo transfer compared with those who were NC (eg, difference in weight at age 4 to 5 years was -0.14 [95% CI, -0.20 to -0.07] SD units for fresh embryo transfer vs NC and 0.00 [95% CI, -0.15 to 0.15] SD units for frozen embryo transfer vs NC). More marked differences were seen for body fat measurements, and there was imprecise evidence that offspring conceived by ART developed greater adiposity by early adulthood (eg, ART vs NC difference in fat mass index at age older than 17 years: 0.23 [95% CI, -0.04 to 0.50] SD units). CONCLUSIONS AND RELEVANCE: These findings suggest that people conceiving or conceived by ART can be reassured that differences in early growth and adiposity are small and no longer evident by late adolescence.

وصف الملف: Electronic; application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______363::09888b77ec3894421a5e3b913ea82586
https://hdl.handle.net/10453/171152

المؤلفون: Metcalfe, A, Lix, LM, Johnson, J‐A, Currie, G, Lyon, AW, Bernier, F, Tough, SC, Lix, L M, Johnson, J-A, Lyon, A W, Tough, S C

المصدر: BJOG: An International Journal of Obstetrics & Gynaecology; Dec2015, Vol. 122 Issue 13, p1748-1755, 8p

مصطلحات موضوعية: OBSTETRICS, COMORBIDITY, PREGNANCY, DISEASE prevalence, PREGNANT women, LOGISTIC regression analysis, RECEIVER operating characteristic curves, COMPARATIVE studies, DELIVERY (Obstetrics), HOSPITAL care, LENGTH of stay in hospitals, LABOR complications (Obstetrics), RESEARCH methodology, MEDICAL cooperation, HEALTH outcome assessment, PHARMACOKINETICS, RESEARCH, RESEARCH funding, EVALUATION research, SEVERITY of illness index, STANDARDS

مصطلحات جغرافية: CANADA

مستخلص: Objectives: An obstetric comorbidity index has been developed recently with superior performance characteristics relative to general comorbidity measures in an obstetric population. This study aimed to externally validate this index and to examine the impact of including hospitalisation/delivery records only when estimating comorbidity prevalence and discriminative performance of the obstetric comorbidity index.Design: Validation study.Setting: Alberta, Canada.Population: Pregnant women who delivered a live or stillborn infant in hospital (n = 5995).Methods: Administrative databases were linked to create a population-based cohort. Comorbid conditions were identified from diagnoses for the delivery hospitalisation, all hospitalisations and all healthcare contacts (i.e. hospitalisations, emergency room visits and physician visits) that occurred during pregnancy and 3 months pre-conception. Logistic regression was used to test the discriminative performance of the comorbidity index.Main Outcome Measures: Maternal end-organ damage and extended length of stay for delivery.Results: Although prevalence estimates for comorbid conditions were consistently lower in delivery records and hospitalisation data than in data for all healthcare contacts, the discriminative performance of the comorbidity index was constant for maternal end-organ damage [all healthcare contacts area under the receiver operating characteristic curve (AUC) = 0.70; hospitalisation data AUC = 0.67; delivery data AUC = 0.65] and extended length of stay for delivery (all healthcare contacts AUC = 0.60; hospitalisation data AUC = 0.58; delivery data AUC = 0.58).Conclusions: The obstetric comorbidity index shows similar performance characteristics in an external population and is a valid measure of comorbidity in an obstetric population. Furthermore, the discriminative performance of the comorbidity index was similar for comorbidities ascertained at the time of delivery, in hospitalisation data or through all healthcare contacts. [ABSTRACT FROM AUTHOR]

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