المؤلفون: Johansson, A, Dar, H, Veer, LJV, Tobin, NP, Perez-Tenorio, G, Nordenskjold, A, Johansson, U, Hartman, J, Skoog, L, Yau, C, Benz, CC, Esserman, LJ, Stal, O, Nordenskjold, B, Fornander, T, Lindstrom, LS

المصدر: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 40(35):4071-4082

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:151385502

المؤلفون: Dreher N; University of California San Francisco, 2340 Sutter Street, N415, San Francisco, CA, 94143-0808, USA. Nickolas.Dreher@icahn.mssm.edu.; The Icahn School of Medicine at Mount Sinai, New York, NY, USA. Nickolas.Dreher@icahn.mssm.edu., Matthys M; University of California San Francisco, 2340 Sutter Street, N415, San Francisco, CA, 94143-0808, USA., Hadeler E; University of California San Francisco, 2340 Sutter Street, N415, San Francisco, CA, 94143-0808, USA.; University of Miami Miller School of Medicine, Miami, FL, USA., Shieh Y; University of California San Francisco, 2340 Sutter Street, N415, San Francisco, CA, 94143-0808, USA., Acerbi I; University of California San Francisco, 2340 Sutter Street, N415, San Francisco, CA, 94143-0808, USA., McAuley FM; University of California San Francisco, 2340 Sutter Street, N415, San Francisco, CA, 94143-0808, USA., Melisko M; University of California San Francisco, 2340 Sutter Street, N415, San Francisco, CA, 94143-0808, USA., Eklund M; Karolinska Institutet, Stockholm, Sweden., Tice JA; University of California San Francisco, 2340 Sutter Street, N415, San Francisco, CA, 94143-0808, USA., Esserman LJ; University of California San Francisco, 2340 Sutter Street, N415, San Francisco, CA, 94143-0808, USA., Veer LJV; University of California San Francisco, 2340 Sutter Street, N415, San Francisco, CA, 94143-0808, USA.

المصدر: Breast cancer research and treatment [Breast Cancer Res Treat] 2022 Feb; Vol. 191 (3), pp. 623-629. Date of Electronic Publication: 2021 Nov 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms*/diagnosis , Breast Neoplasms*/epidemiology, Adult ; Aged ; Early Detection of Cancer ; Female ; Humans ; Mammography ; Mass Screening ; Middle Aged ; Odds Ratio

مستخلص: Purpose: The Breast Cancer Surveillance Consortium (BCSC) model is a widely used risk model that predicts 5- and 10-year risk of developing invasive breast cancer for healthy women aged 35-74 years. Women with high BCSC risk may also be at elevated risk to develop interval cancers, which present symptomatically in the year following a normal screening mammogram. We examined the association between high BCSC risk (defined as the top 2.5% by age) and breast cancers presenting as interval cancers.
Methods: We conducted a case-case analysis among women with breast cancer in which we compared the mode of detection and tumor characteristics of patients in the top 2.5% BCSC risk by age with age-matched (1:2) patients in the lower 97.5% risk. We constructed logistic regression models to estimate the odds ratio (OR) of presenting with interval cancers, and poor prognosis tumor features, between women from the top 2.5% and bottom 97.5% of BCSC risk.
Results: Our analysis included 113 breast cancer patients in the top 2.5% of risk for their age and 226 breast cancer patients in the lower 97.5% of risk. High-risk patients were more likely to have presented with an interval cancer within one year of a normal screening, OR 6.62 (95% CI 3.28-13.4, p < 0.001). These interval cancers were also more likely to be larger, node positive, and higher stage than the screen-detected cancers.
Conclusion: Breast cancer patients in the top 2.5% of BCSC risk for their age were more likely to present with interval cancers. The BCSC model could be used to identify healthy women who may benefit from intensified screening.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)