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1دورية أكاديمية
المؤلفون: Qi Zeng, Yuchan Chen, Junfeng Wang, Xuefeng Shi, Yihao Che, Xiayu Chen, Weimao Zhong, Weimin Zhang, Xiaoyi Wei, Fazuo Wang, Si Zhang
المصدر: Marine Drugs, Vol 20, Iss 2, p 150 (2022)
مصطلحات موضوعية: coral-derived fungi, Aspergillus hiratsukae, structure elucidation, bioactivity evaluation, Biology (General), QH301-705.5
الوصف: Three new metabolites, including a cyclic tetrapeptide asperhiratide (1), an ecdysteroid derivative asperhiratine (2), and a sesquiterpene lactone asperhiratone (3), were isolated and identified from the soft coral-derived fungus Aspergillus hiratsukae SCSIO 5Bn1003, together with 10 known compounds. Their structures were elucidated via spectroscopic analysis, X-ray diffraction analysis, and electronic circular dichroism calculations. In addition, the absolute configuration of 1 was determined by Marfey’s technique and an analysis of the acid hydrolysates using a chiral phase HPLC column. Among all the compounds, 6 and 8 showed medium cytotoxic activities against four tumor cell lines (SF-268, HepG-2, MCF-7, and A549), with IC50 values ranging from 31.03 ± 3.04 to 50.25 ± 0.54 µM. Meanwhile, they strongly inhibited α-glucosidase activities, with IC50 values of 35.73 ± 3.94 and 22.00 ± 2.45 µM, which were close to and even stronger than the positive control acarbose (IC50 = 32.92 ± 1.03 µM). Compounds 6–8 showed significant antibacterial activities against Bacillus subtilis, with MIC values of 10.26 ± 0.76 µM, 17.00 ± 1.25 µM, and 5.30 ± 0.29 µM, respectively. Compounds 9 and 12 exhibited potent radical scavenging activities against DPPH, with IC50 values of 12.23 ± 0.78 µM and 7.38 ± 1.16 µM. In addition, asperhiratide (1) was evaluated for anti-angiogenic activities in the in vivo zebrafish model, which showed a weak inhibitory effect on intersegmental vessel (ISV) formation.
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Weimao Zhong, Junfeng Wang, Xiaoyi Wei, Tingdan Fu, Yuchan Chen, Qi Zeng, Zhonghui Huang, Xinan Huang, Weimin Zhang, Si Zhang, Lijuan Long, Fazuo Wang
المصدر: Frontiers in Chemistry, Vol 7 (2019)
مصطلحات موضوعية: Eurotium sp. SCSIO F452, spirocyclic alkaloid enantiomers, antioxidative and cytotoxic activities, Diels-Alder cycloaddition, molecular docking, Chemistry, QD1-999
الوصف: Three pairs of new spirocyclic alkaloid enantiomers eurotinoids A–C (1–3), as well as a known biogenetically related racemate dihydrocryptoechinulin D (4) were isolated from a marine-derived fungus Eurotium sp. SCSIO F452. Their structures were determined by spectroscopic analyses and electronic circular dichroism (ECD) calculations. Compounds 1 and 2 represent the first two “meta” products from a non-stereoselective [4 + 2] Diels-Alder cycloaddition presumably between an enone group of a diketopiperazine alkaloid and a diene group of a benzaldehyde derivative via a new head-to-tail coupling mode biosynthetically, while 3 and 4 were “ortho” products. Their enantiomers exhibited different antioxidative and cytotoxic activities. The modes of action were investigated by a preliminary molecular docking study.
وصف الملف: electronic resource
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3
المؤلفون: Marielle C. Inacio, Weimao Zhong, Ya-Ming Xu, E.M. Kithsiri Wijeratne, Chandrashekhar Madasu, István Molnár, A.A. Leslie Gunatilaka
المصدر: Phytochemistry Letters. 55:124-130
مصطلحات موضوعية: Plant Science, Agronomy and Crop Science, Biochemistry, Biotechnology
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4
المؤلفون: Weimao Zhong, Jessica M. Deutsch, Dongqi Yi, Nadine H. Abrahamse, Ipsita Mohanty, Samuel G. Moore, Andrew C. McShan, Neha Garg, Vinayak Agarwal
المصدر: ChemBioChem.
مصطلحات موضوعية: Organic Chemistry, Molecular Medicine, Molecular Biology, Biochemistry
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5
المؤلفون: Liwen Zhang, Chen Wang, Kang Chen, Weimao Zhong, Yuquan Xu, István Molnár
المصدر: Zhang, L, Wang, C, Chen, K, Zhong, W, Xu, Y & Molnár, I 2022, ' Engineering the biosynthesis of fungal nonribosomal peptides ', Natural Product Reports, vol. 40, pp. 62-88 . https://doi.org/10.1039/d2np00036a
مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry
الوصف: Covering: 2011 up to the end of 2021. Fungal nonribosomal peptides (NRPs) and the related polyketide-nonribosomal peptide hybrid products (PK-NRPs) are a prolific source of bioactive compounds, some of which have been developed into essential drugs. The synthesis of these complex natural products (NPs) utilizes nonribosomal peptide synthetases (NRPSs), multidomain megaenzymes that assemble specific peptide products by sequential condensation of amino acids and amino acid-like substances, independent of the ribosome. NRPSs, collaborating polyketide synthase modules, and their associated tailoring enzymes involved in product maturation represent promising targets for NP structure diversification and the generation of small molecule unnatural products (uNPs) with improved or novel bioactivities. Indeed, reprogramming of NRPSs and recruiting of novel tailoring enzymes is the strategy by which nature evolves NRP products. The recent years have witnessed a rapid development in the discovery and identification of novel NRPs and PK-NRPs, and significant advances have also been made towards the engineering of fungal NRP assembly lines to generate uNP peptides. However, the intrinsic complexities of fungal NRP and PK-NRP biosynthesis, and the large size of the NRPSs still present formidable conceptual and technical challenges for the rational and efficient reprogramming of these pathways. This review examines key examples for the successful (and for some less-successful) re-engineering of fungal NRPS assembly lines to inform future efforts towards generating novel, biologically active peptides and PK-NRPs.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2585d04d9b5d8d035884b51f23f3f4
https://cris.vtt.fi/en/publications/773d14c2-7b1d-408c-888e-f1f9d8b7e518 -
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المؤلفون: Xin-Peng Tian, Weimin Zhang, Qi Zeng, Junfeng Wang, Fa-Zuo Wang, Si Zhang, Yuchan Chen, Xiaoyi Wei, Weimao Zhong
المصدر: Organic Chemistry Frontiers. 8:1466-1473
مصطلحات موضوعية: Circular dichroism, chemistry.chemical_compound, Eurotium sp. SCSIO F452, biology, Salicylaldehyde, Chemistry, Stereochemistry, Organic Chemistry, Fungus, Enantiomer, biology.organism_classification
الوصف: Euroticins C–E (1–3), three pairs of salicylaldehyde derivative enantiomers, were isolated from a marine-derived fungus Eurotium sp. SCSIO F452. They represent two types of salicylaldehyde derivatives bearing unprecedented highly constructed 6/6/6/6 tetracyclic structures. Their structures were established by comprehensive spectroscopic analyses, X-ray diffraction, and electronic circular dichroism calculations. Compounds (+)-1 and (−)-1 showed significant antioxidative activity and moderate cytotoxic activity.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::56ddbbaab1af7cdc9c6d9a37f0f19de4
https://doi.org/10.1039/d0qo01519a -
7
المؤلفون: Zhimao Mai, Junfeng Wang, Yuchan Chen, Si Zhang, Fa-Zuo Wang, Weimao Zhong, Weimin Zhang, Xia-Yu Chen, Qi Zeng, Xiaoyi Wei, Xin-Peng Tian
المصدر: The Journal of Organic Chemistry. 85:12754-12759
مصطلحات موضوعية: Circular dichroism, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Carbon-13 NMR, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, Eurotium sp. SCSIO F452, chemistry.chemical_compound, chemistry, Salicylaldehyde, Enantiomer, Undecane, Derivative (chemistry)
الوصف: Two pairs of salicylaldehyde derivative enantiomers, euroticins A and B (1 and 2), were isolated from a marine-derived fungus Eurotium sp. SCSIO F452. Compound 1 possesses a highly constructed 6/6/6/5/7 pentacyclic structure featuring an unprecedented 2,11-dioxatricyclo[5.3.1.04,8]undecane core. Compound 2 represents the first example of 6/6/6/6 tetracyclic salicylaldehyde derivative. Their structures were established by spectroscopic analyses, X-ray diffraction, and electronic circular dichroism (ECD) and 13C NMR calculations. Compounds (+)-2 and (-)-2 exhibited remarkable antioxidative activities.
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8
المؤلفون: Xin-Peng Tian, Yao Xiang, Junfeng Wang, Lijuan Long, Fa-Zuo Wang, Xiaoyi Wei, Si Zhang, Weimao Zhong, Xia-Yu Chen, Qi Zeng
المصدر: Tetrahedron Letters. 60:1600-1603
مصطلحات موضوعية: Quantum chemical, biology, 010405 organic chemistry, Chemistry, Stereochemistry, Organic Chemistry, Fungus, 010402 general chemistry, biology.organism_classification, 01 natural sciences, Biochemistry, 0104 chemical sciences, Eurotium sp. SCSIO F452, Polyketide, Drug Discovery, Enantiomer, Marine fungi
الوصف: (±)-Eurotone A [(±)- 1 ], a pair of new enantiomeric polyketide dimers, as well as six known biogenetically related polyketides ( 2 – 7 ) were isolated from a marine-derived fungus Eurotium sp. SCSIO F452. Their structures were determined by comprehensive spectroscopic methods, X-ray diffraction and quantum chemical calculations. Compound 1 represented the first pair of spirodihydrobenzanthracene enantiomers isolated from marine fungi with their absolute configurations assigned. A plausible biosynthetic pathway involving a key acid-mediated dimerization was proposed for 1 . The antioxidative activities of the new enantiomers were evaluated.
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9
المؤلفون: Xin-Peng Tian, Weimin Zhang, Yao Xiang, Fa-Zuo Wang, Weimao Zhong, Qi Zeng, Si Zhang, Xia-Yu Chen, Yuchan Chen
المصدر: Natural Product Research. 34:1984-1991
مصطلحات موضوعية: chemistry.chemical_classification, biology, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Plant Science, Fungus, biology.organism_classification, 01 natural sciences, Biochemistry, Deep sea, 0104 chemical sciences, Analytical Chemistry, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Aspergillus terreus, Derivative (chemistry), Lactone, Butenolide
الوصف: A new butenolide derivative (±)-asperteretal F (1) and related congener (2) recently reported containing an unusual 2-benzyl-3-phenyl substituted lactone core, together with five known compounds (3–7) were isolated and characterized from the fungus Aspergillus terreus. SCSIO FZQ028 derived from a deep-sea sediment of South China Sea. Their chemical structures were established on the basis of 1D- and 2D-NMR spectroscopic data, and HR-ESI-MS analysis. Additionally, all the compounds were evaluated for the antioxidative activities against DPPH, cytotoxic activities against two tumor cell lines (SF-268 and HepG-2), and antimicrobial activities. Compounds 2-4, and 7 showed significant activities against DPPH with IC50 ranging from 5.89 to 10.07 μg/mL. Compounds 2 and 4 showed moderate antimicrobial activities against all four tested bacteria.
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10
المؤلفون: Weimao, Zhong, Yuchan, Chen, Zhimao, Mai, Xiaoyi, Wei, Junfeng, Wang, Qi, Zeng, Xiayu, Chen, Xinpeng, Tian, Weimin, Zhang, Fazuo, Wang, Si, Zhang
المصدر: The Journal of organic chemistry. 85(19)
مصطلحات موضوعية: Aldehydes, Molecular Structure, Eurotium, Fungi, Stereoisomerism
الوصف: Two pairs of salicylaldehyde derivative enantiomers, euroticins A and B (
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