المؤلفون: Wentao Hu, Yufeng Shi, Cuixia Chen, Ze Chen

المصدر: Mathematical Biosciences and Engineering, Vol 18, Iss 6, Pp 9525-9562 (2021)

مصطلحات موضوعية: pandemic mitigation, human mobility, sir model, covid-19, Biotechnology, TP248.13-248.65, Mathematics, QA1-939

الوصف: This paper presents a model for finding optimal pandemic control policy considering cross-region human mobility. We extend the baseline susceptible-infectious-recovered (SIR) epidemiology model by including the net human mobility from a severely-impacted region to a mildly-affected region. The strategic optimal mitigation policy combining testing and lockdown in each region is then obtained with the goal of minimizing economic cost under the constraint of limited resources. We parametrize the model using the data of the COVID-19 pandemic and show that the optimal response strategy and mitigation outcome greatly rely on the mitigation duration, available resources, and cross-region human mobility. Furthermore, we discuss the economic impact of travel restriction policies through a quantitative analysis.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/1551-0018

URL الوصول: https://doaj.org/article/6bd1adfd50134b4c9dfa81526206839c

المؤلفون: Qingping Liu, Wentao Hu, Yaling Zhang, Jie Ning, Yaxian Pang, Huaifang Hu, Meiyu Chen, Mengqi Wu, Mengruo Wang, Peihao Yang, Lei Bao, Yujie Niu, Rong Zhang

المصدر: Toxics, Vol 11, Iss 7, p 600 (2023)

مصطلحات موضوعية: nano-polystyrene, depression-like responses, LncRNA, RNA-sequencing, ceRNA, Chemical technology, TP1-1185

الوصف: Plastics in the environment can break down into nanoplastics (NPs), which pose a potential threat to public health. Studies have shown that the nervous system constitutes a significant target for nanoplastics. However, the potential mechanism behind nanoplastics’ neurotoxicity remains unknown. This study aimed to investigate the role of lncRNA in the depressive-like responses induced by exposure to 25 nm polystyrene nanoplastics (PS NPs). Forty mice were divided into four groups administered doses of 0, 10, 25, and 50 mg/kg via gavage for 6 months. After conducting behavioral tests, RNA sequencing was used to detect changes in mRNAs, miRNAs, and lncRNAs in the prefrontal cortex of the mice in the 0 and 50 mg/kg PS NPs groups. The results revealed that mice exposed to chronic PS NPs developed depressive-like responses in a dose-dependent manner. It was demonstrated that 987 mRNAs, 29 miRNAs, and 116 lncRNAs were significantly different between the two groups. Then, a competing endogenous RNA (ceRNA) network containing 6 lncRNAs, 18 miRNAs, and 750 mRNAs was constructed. Enrichment results suggested that PS NPs may contribute to the onset of depression-like responses through the activation of axon guidance, neurotrophin-signaling pathways, and dopaminergic synapses. This study provided evidence of the molecular relationship between PS NPs and depression-like responses.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2305-6304/11/7/600; https://doaj.org/toc/2305-6304

URL الوصول: https://doaj.org/article/84d28b662ee34c7183965454a71b8da2

المؤلفون: Jie Luo, Wentao Hu

المصدر: Forests, Vol 14, Iss 7, p 1320 (2023)

مصطلحات موضوعية: n/a, Plant ecology, QK900-989

الوصف: Forests are vital ecosystems, covering a significant portion of the Earth’s land area and providing essential ecological services and valuable products for human society [...]

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1999-4907/14/7/1320; https://doaj.org/toc/1999-4907

URL الوصول: https://doaj.org/article/2231b848ed8041669dbaebeb634d4783

المؤلفون: Lin Zhao, Dongxu Wu, Wentao Hu, Jiajie Li, Zhengyang Zhang, Feihua Yang, Zhaojia Wang, Wen Ni

المصدر: Minerals, Vol 13, Iss 6, p 795 (2023)

مصطلحات موضوعية: steel slag, carbon dioxide, aggregate, carbonization, stability, Mineralogy, QE351-399.2

الوصف: Crude steel production in China exceeds 1 billion tons per year, and steel slag production accounts for 10%–15% of the crude steel mass. Although slag presents certain hydration activity, it is still difficult to be used as a building material because the particles contain a large amount of active calcium oxide and magnesium oxide, which are easy to hydrate and expand besides presenting low stability. The heap stock is increasing at a rate of 80 Mt/a because of the limitation of application scenarios. Moreover, every 1 ton of crude steel is associated with an emission of 1.8 tons of carbon dioxide (CO2), which becomes a greenhouse gas, because it cannot be reused at the moment. In this investigation, CO2 was used to cure steel slag particles, and the coupling mineralization reaction between them was used to convert active calcium oxide and magnesium oxide in steel slag into carbonate forms and, thus, allow the processing of steel slag particles into fine building aggregate. Two particle size ranges of 0.6–2.36 and 2.36–4.75 mm were selected as representative particle sizes. Mineralization was carried out under a temperature of 25 °C, relative humidity of 75%, a CO2 concentration of 20%, and a time of 24 h. The carbon fixation rate of steel slag was 9.68%. The quality of steel slag fine aggregate as a product met the GB/T 14684-2011 construction sand grade II standard. The application of this technology is expected to improve the stability of steel slag particles, the utilization rate as a building material, and the resource utilization level of CO2. It is expected to realize the full, high-value-added resource utilization of steel slag and CO2 absorption and solve the supply shortage problem of fine aggregate for construction in China, which has potential economic and environmental benefits.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2075-163X/13/6/795; https://doaj.org/toc/2075-163X

URL الوصول: https://doaj.org/article/a71e3a3a4dbd466dad60d7c5753b7278

المؤلفون: Zi Guo, Guangming Zhou, Wentao Hu

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 32, Iss , Pp 100828- (2022)

مصطلحات موضوعية: Carcinogenesis, Heavy ions, Risk assessment, Space flight, Space radiation, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: The carcinogenic risk from space radiation has always been a health risk issue of great concern during space exploration. In recent years, a large number of cellular and animal experiments have demonstrated that space radiation, composed of high-energy protons and heavy ions, has shown obvious carcinogenicity. However, different from radiation on Earth, space radiation has the characteristics of high energy and low dose rate. It is rich in high-atom-number and high-energy particles and, as it is combined with other space environmental factors such as microgravity and a weak magnetic field, the study of its carcinogenic effects and mechanisms of action is difficult, which leads to great uncertainty in its carcinogenic risk assessment. Here, we review the latest progress in understanding the effects and mechanisms of action related to cell transformation and carcinogenesis induced by space radiation in recent years and summarize the prediction models of cancer risk caused by space radiation and the methods to reduce the uncertainty of prediction to provide reference for the research and risk assessment of space radiation.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558622000550; https://doaj.org/toc/1476-5586

URL الوصول: https://doaj.org/article/26ade013b7724e1bbfb972782f14cc82

المؤلفون: Wentao Hu, Yue Huang, Meng Yuan, Jiaying Zhang, Alekhin V.N.

المصدر: Case Studies in Thermal Engineering, Vol 35, Iss , Pp 102148- (2022)

مصطلحات موضوعية: Wall insulation materials, Self-insulating hollow block, Thermal performance, Hot and cold box-heat flow meter method, Engineering (General). Civil engineering (General), TA1-2040

الوصف: The self-insulation wall is widely used in the field of architecture because it involves a simple construction process, saves resources, and reduces environmental pollution. In this study, self-insulating block experimental groups of different filling rates and filling place positions were made to obtain the most suitable filling scheme for self-insulating hollow blocks in cold climates and intermittent running of air-conditioning. The working conditions of different types of self-insulating block groups were simulated and recorded using hot and cold box-heat flow meter methods in a cold climate and intermittent operation of air-conditioning. The results show that some previous research conclusions are still applicable in a cold climate and intermittent running of air-conditioning. The experimental group filled with insulation materials in the middle of the hole showed a better thermal performance at a filling rate of 25%; the experimental group filled with insulation materials in both sides of the hole exhibited better thermal properties at a filling rate of 50%. When compared with 5 other types of cases, the average heat flow of Case 2 was the smallest and was between 18.36 W/m2 and 21.89 W/m2, therefore, the intermittent running mode of Case 2 was found to be the best.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214157X2200394X; https://doaj.org/toc/2214-157X

URL الوصول: https://doaj.org/article/251eef7ea77b43908f3665124ae3324b

المؤلفون: Fusheng Xiao, Wentao Hu, Jianqi Zhao, Hongmin Zhu

المصدر: Metals, Vol 13, Iss 4, p 779 (2023)

مصطلحات موضوعية: NdFeB, magnet scrap, rare earths, recycling, Mining engineering. Metallurgy, TN1-997

الوصف: In recent years, under the background of global low-carbon development, the production of NdFeB magnets has increased dramatically. With the end of magnet life, a large number of discarded products will be produced in the future. At the same time, 6–73% of industrial waste will be produced in the manufacturing process of magnets. The rare earth content (about 30 wt.%) of these magnet scraps is generally higher than that of raw ore, and the recovery of rare earth elements from them helps to stabilize the global rare earth supply chain. In addition, NdFeB scrap contains about 70 wt.% of iron, which is currently unable to be utilized with high added value. If iron can be recycled based on recycling rare earth elements, it is expected to realize the full component recycling of NdFeB waste and reduce the full life cycle environmental load of NdFeB products. This paper summarizes the properties, recycling potential, and existing recycling technologies of NdFeB waste, and it summarizes the principles, advantages, and disadvantages of various recycling methods, such as direct reuse, pyrometallurgy, hydrometallurgy, and electrochemistry. Among them, the electrochemical recovery method was emphatically reviewed as a newly proposed method. On this basis, the future development direction of NdFeB waste recycling has been prospected, and the research idea of avoiding the shortcomings of various recycling methods through the combined process is proposed. It is proposed that low environmental hazards, low energy consumption, and a closed-loop process are the main goals to be achieved in the recycling process.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2075-4701/13/4/779; https://doaj.org/toc/2075-4701

URL الوصول: https://doaj.org/article/147e2446509a472b9dade6548bbf81fb

المؤلفون: Ying Xu, Weiwei Pei, Wentao Hu

المصدر: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

مصطلحات موضوعية: microgravity, space radiation, hypomagnetic field, space exploration, combined biological effect, Biology (General), QH301-705.5

الوصف: Distinct from Earth’s environment, space environmental factors mainly include space radiation, microgravity, hypomagnetic field, and disrupted light/dark cycles that cause physiological changes in astronauts. Numerous studies have demonstrated that space environmental factors can lead to muscle atrophy, bone loss, carcinogenesis, immune disorders, vascular function and cognitive impairment. Most current ground-based studies focused on single environmental factor biological effects. To promote manned space exploration, a better understanding of the biological effects of the spaceflight environment is necessary. This paper summarizes the latest research progress of the combined biological effects of double or multiple space environmental factors on mammalian cells, and discusses their possible molecular mechanisms, with the hope of providing a scientific theoretical basis to develop appropriate countermeasures for astronauts.

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2022.861006/full; https://doaj.org/toc/2296-634X

URL الوصول: https://doaj.org/article/9cc8daa74fe44a1f9beba4973a7416ad

المؤلفون: Meng Hu, Shuangshuang Zhang, Bing Liu, Yingju Wu, Kun Luo, Zihe Li, Mengdong Ma, Dongli Yu, Lingyu Liu, Yufei Gao, Zhisheng Zhao, Yoshio Kono, Ligang Bai, Guoyin Shen, Wentao Hu, Yang Zhang, Ralf Riedel, Bo Xu, Julong He, Yongjun Tian

المصدر: Journal of Materiomics, Vol 7, Iss 1, Pp 177-184 (2021)

مصطلحات موضوعية: Glassy carbon, Industrially achievable pressure, sp2–sp3 intermediate carbon, Hardness, Strength, Elasticity, Materials of engineering and construction. Mechanics of materials, TA401-492

الوصف: Glassy carbon (GC) is a type of non-graphitizing disordered carbon material at ambient pressure and high temperatures, which has been widely used due to its excellent mechanical properties. Here we report the changes in the microstructure and mechanical properties of GC treated at high pressures (up to 5 GPa) and high temperatures. The formation of intermediate sp2–sp3 phases is identified at moderate treatment temperatures before the complete graphitization of GC, by analyzing synchrotron X-ray diffraction, Raman spectra, and transmission electron microscopy images. The intermediate metastable carbon materials exhibit superior mechanical properties with hardness reaching up to 10 GPa and compressive strength reaching as high as 2.5 GPa, nearly doubling those of raw GC, and improving elasticity and thermal stability. The synthesis pressure used in this study can be achieved in the industry on a commercial scale, enabling the scalable synthesis of this type of strong, hard, and elastic carbon materials.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352847820301684; https://doaj.org/toc/2352-8478

URL الوصول: https://doaj.org/article/7e4a326c908047dea28c5d4a02aff296

المؤلفون: Yuxuan Kuang, Xue Li, Zhihao Wang, Xinyang Wang, Hongjian Wei, Hui Chen, Wentao Hu, Ming Tang

المصدر: Journal of Fungi, Vol 9, Iss 2, p 140 (2023)

مصطلحات موضوعية: cadmium stress, arbuscular mycorrhizal fungi, Eucalyptus grandis, cellular ultrastructure, Biology (General), QH301-705.5

الوصف: Eucalyptus grandis (E. grandis) has been reported to form a symbiosis with arbuscular mycorrhizal fungi (AMF), which plays an important role in improving plant tolerance of heavy metal. However, the mechanism of how AMF intercept and transport cadmium (Cd) at the subcellular level in E. grandis still remains to be researched. In this study, a pot experiment was conducted to investigate the growth performance of E. grandis under Cd stress and Cd absorption resistance of AMF and explored the Cd localization in the root by using transmission electron microscopy and energy dispersive X-ray spectroscopy. The results showed that AMF colonization could enhance plant growth and photosynthetic efficiency of E. grandis and reduce the translocation factor of Cd under Cd stress. After being treated with 50, 150, 300, and 500 μM Cd, the translocation factor of Cd in E. grandis with AMF colonization decreased by 56.41%, 62.89%, 66.67%, and 42.79%, respectively. However, the mycorrhizal efficiency was significant only at low Cd concentrations (50, 150, and 300 μM). Under 500 μM Cd concentration condition, the colonization of AMF in roots decreased, and the alleviating effect of AMF was not significant. Ultrastructural observations showed that Cd is abundant in regular lumps and strips in the cross-section of E. grandis root cell. AMF protected plant cells by retaining Cd in the fungal structure. Our results suggested that AMF alleviated Cd toxicity by regulating plant physiology and altering the distribution of Cd in different cell sites.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2309-608X/9/2/140; https://doaj.org/toc/2309-608X

URL الوصول: https://doaj.org/article/189646118ae84f2c8f5fc80aa8b0ea0e