المؤلفون: Klionsky, DJ, Abdalla, FC, Abeliovich, H, Abraham, RT, Acevedo-Arozena, A, Adeli, K, Agholme, L, Agnello, M, Agostinis, P, Aguirre-Ghiso, JA, Ahn, HJ, Ait-Mohamed, O, Ait-Si-Ali, S, Akematsu, T, Akira, S, Al-Younes, HM, Al-Zeer, MA, Albert, ML, Albin, RL, Alegre-Abarrategui, J, Aleo, MF, Alirezaei, M, Almasan, A, Almonte-Becerril, M, Amano, A, Amaravadi, R, Amarnath, S, Amer, AO, Andrieu-Abadie, N, Anantharam, V, Ann, DK, Anoopkumar-Dukie, S, Aoki, H, Apostolova, N, Arancia, G, Aris, JP, Asanuma, K, Asare, NYO, Ashida, H, Askanas, V, Askew, DS, Auberger, P, Baba, M, Backues, SK, Baehrecke, EH, Bahr, BA, Bai, XY, Bailly, Y, Baiocchi, R, Baldini, G, Balduini, W, Ballabio, A, Bamber, BA, Bampton, ETW, Banhegyi, G, Bartholomew, CR, Bassham, DC, Bast, RC, Batoko, H, Bay, BH, Beau, I, Bechet, DM, Begley, TJ, Behl, C, Behrends, C, Bekri, S, Bellaire, B, Bendall, LJ, Benetti, L, Berliocchi, L, Bernardi, H, Bernassola, F, Besteiro, S, Bhatia-Kissova, I, Bi, XN, Biard-Piechaczyk, M, 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المصدر: Autophagy. 8(4):445-544

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:125366149

المؤلفون: Hirsch, E, Barberis, L, Brancaccio, M, Azzolino, O, Xu, DZ, Kyriakis, JM, Silengo, L, Giancotti, FG, Tarone, G, Fässler, Reinhard, Altruda, F

المصدر: Journal of Cell Biology. 157(3):481-492

مصطلحات موضوعية: cytodomain, integrin, MAPK, RAC, proliferation, Medicin och hälsovetenskap, Klinisk medicin, Cancer och onkologi, Medical and Health Sciences, Clinical Medicine, Cancer and Oncology

الوصف: Cell matrix adhesion is required for cell proliferation and survival. Here we report that mutation by gene targeting of the cytoplasmic tail of beta(1) integrin leads to defective proliferation and survival both in vivo and in vitro. Primary murine embryonic fibroblasts (MEFs) derived from mutant homozygotes display defective cell cycle coupled to impaired activation of the FAK-P13K-Akt and Rac-JNK signaling pathways. Expression in homozygous MEFs of a constitutively active form of Rac is able to rescue proliferation, survival, and JNK activation. Moreover, although showing normal Erk phosphorylation, mutant cells fail to display Erk nuclear translocation upon fibronectin adhesion. However, expression of the constitutively activated form of Rac restores Erk nuclear localization, suggesting that adhesion-dependent Rac activation is necessary to integrate signals directed to promote MAPK activity. Altogether, our data provide the evidence for an epistatic interaction between the beta(1) integrin cytoplasmic domain and Rac, and indicate that this anchorage-dependent signaling pathway is crucial for cell growth control.

URL الوصول: https://lup.lub.lu.se/record/334829
http://dx.doi.org/10.1083/jcb.200111065

المؤلفون: Fang Ql, Zhang Hy, Ma Ql, Li Gy, Wu Xm, Li Mf, Li Ls, Xu Dz

المصدر: Contraception. 41(6)

مصطلحات موضوعية: Adult, medicine.medical_specialty, Tetracaine, Lidocaine, medicine.drug_class, Cervix Uteri, Placebo, law.invention, Randomized controlled trial, law, Pregnancy, medicine, Humans, Randomized Controlled Trials as Topic, Clinical Trials as Topic, business.industry, Local anesthetic, Obstetrics and Gynecology, Abortion, Induced, medicine.disease, Dilatation, Surgery, Clinical trial, Parity, Pregnancy Trimester, First, Reproductive Medicine, Anesthesia, Vaginal Creams, Foams, and Jellies, Gestation, Female, business, medicine.drug

الوصف: A randomized triple-blind and placebo-controlled clinical trial on the effect of lidocaine and Anodyne-lubricant jelly (ALJ) containing dicaine on cervical dilatation is reported. Three-hundred-seventy-two consecutive cases were randomly allocated to 4 groups. The four groups were given: ALJ and placebo (placebo 1); and lidocaine and placebo (placebo 2). ALJ and placebo 1 treatment was by topical application, and lidocaine and placebo 2 by injection. In parous women, a significant difference was found for satisfactory dilatation (SD) rate (p less than 0.01) among four groups. It was unexpected that there were no significant differences between drug and placebo groups, neither between ALJ treatment group and placebo 1 group (p greater than 0.5), nor between lidocaine and placebo 2 (p greater than 0.75). However, the combined SD rate was 60.9% for the topical groups compared with 39.0% for the injection groups (p less than 0.005). The findings suggested that the effect of ALJ on cervical dilatation was not mainly due to dicaine, but associated with the lubricant and the topical treatment.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cf69255be5d77d67bdc3158fbfab584
https://pubmed.ncbi.nlm.nih.gov/2193774

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لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.