المؤلفون: Wulipan Fulati, Jiexian Ma, Min Wu, Wensi Qian, Pingping Chen, Yingwei Hu, Mingyue Chen, Yu Xu, Zilan Huang, Hongdi Zhang, Yanhui Xie, Lin Shen

المصدر: Frontiers in Immunology, Vol 15 (2024)

مصطلحات موضوعية: peripheral T cell lymphoma, autologous hematopoietic stem cell transplantation, pegylated liposomal doxorubicin, survival analysis, prognosis, Immunologic diseases. Allergy, RC581-607

الوصف: BackgroundThere was little evidence of autologous stem cell transplantation (ASCT) as consolidation therapy after remission of induction for patients with Peripheral T-cell lymphoma (PTCL). In this study, we conducted a comparative analysis of real-world survival outcomes between consolidation therapy and observation in patients with PTCL.MethodsA total of 92 patients with peripheral T-cell lymphoma (PTCL) who were admitted to the Department of Hematology, Huadong Hospital Affiliated with Fudan University from January 2013 to April 2019 were divided into two groups based on whether they were treated with high-dose therapy (HDT) followed by autologous hematopoietic stem cell transplantation (ASCT): ASCT as consolidation therapy (n=30) and observation (n=62). Clinical characteristics, treatment patterns, and survival outcomes were analyzed between the two groups. Univariate and Cox multivariate regression analyses were also performed to detect prognostic factors of survival.ResultsWith a median follow-up time of 41 months, the median overall survival (OS) of peripheral T-cell lymphoma patients treated with ASCT was not reached; the median progression-free survival (PFS) was 77.0 months, which was much higher than that of patients without ASCT (p

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1382189/full; https://doaj.org/toc/1664-3224

URL الوصول: https://doaj.org/article/71b0239115fa4a17a8e5582ea9059405

المؤلفون: Shunrong Sun, Wulipan Fulati, Lin Shen, Min Wu, Zilan Huang, Wensi Qian, Pingping Chen, Yingwei Hu, Mingyue Chen, Yu Xu, Hongdi Zhang, Jiexian Ma, Yanhui Xie

المصدر: Cancer Medicine, Vol 12, Iss 12, Pp 12975-12985 (2023)

مصطلحات موضوعية: B‐cell lymphoma, lenalidomide, maintenance therapy, rhGM‐CSF, rituximab, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background The treatment of high‐risk B‐cell lymphoma (BCL) remains a challenge, especially in the elderly. Methods A total of 83 patients (median age 65 years), who have achieved a complete response after induction therapy, were divided into two groups: R2 + GM‐CSF regimen (lenalidomide, rituximab, granulocyte‐macrophage colony‐stimulating factor [GM‐CSF]) as maintenance therapy (n = 39) and observation (n = 44). The efficacy of the R2 + GM‐CSF regimen as maintenance in patient with high‐risk BCL was analyzed and compared with observation. Results The number of natural killer cells in patients increased after R2 + GM‐CSF regimen administration (0.131 × 109/L vs. 0.061 × 109/L, p = 0.0244). Patients receiving the R2 + GM‐CSF regimen as maintenance therapy had longer remission (duration of response: 18.9 vs. 11.3 months, p = 0.001), and longer progression‐free survival (not reached (NR) vs. 31.7 months, p = 0.037), and overall survival (OS) (NR vs. NR, p = 0.015). The R2 + GM‐CSF regimen was safe and well tolerated. High international prognostic index score (p = 0.012), and high tumor burden (p = 0.005) appeared to be independent prognostic factors for worse PFS. Conclusions The maintenance therapy of R2 + GM‐CSF regimen may improve survival in high‐risk BCL patients, which might be modulated by amplification of natural killer cells. The efficacy of the R2 + GM‐CSF maintenance regimen has to be further validated in prospective random clinical trials.

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-7634

URL الوصول: https://doaj.org/article/9d89548b2759476bbbbc7754b6c08614

المؤلفون: Genhui Teng, Baorui Liu, Zhe Kang, Yanhui Xie, Dongying Hu, Dawei Zhao

المصدر: Resources Chemicals and Materials, Vol 2, Iss 1, Pp 1-10 (2023)

مصطلحات موضوعية: Ni-doping, Biomass-derived carbon, Dye-sensitized solar cell, N-doped carbon nanotubes, Chemical technology, TP1-1185

الوصف: The technical bottleneck of carbon materials as counter electrodes (CEs) lies in their limited electrical conductivity, extended ion diffusion paths, poor dispersion, and high contact resistance. Problem-oriented in-situ self-grown N-doped CNTs-coated Ni nanoparticles based on N-doped carbonaceous structures derived from pitaya peel (PC) are adopted to construct Ni-N-C hybrid 3D ionized network sites (Ni@NCNTs/PC-4) as CEs. Structural characterization, micromorphological and chemical composition analyses revealed the 3D network structure of Ni@NCNTs/PC-4 with abundant active sites. They effectively shorten the diffusion distance of I3− ions with a smaller charge transfer resistance (5.21 Ω) than that of PC (12.53 Ω). DSSCs based on Ni@NCNTs/PC-4 display good optoelectronic properties, in which the short-circuit current density (Jsc) is 13.27 mA/cm2, higher than those of Pt (11.66 mA/cm2) and PC (6.99 mA/cm2). The PCE value (5.13%) of DSSCs based on Ni@NCNTs/PC-4 is also higher than that of DSSCs based on PC (2.47%). Overall, this work provides a preliminary research and new ideas for further in-depth study of biomass-derived 3D structured-carbons that contribute to key electrodes in DSSCs.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772443322000563; https://doaj.org/toc/2772-4433

URL الوصول: https://doaj.org/article/53aa4ad91ab7450182df928b4d00568c

المؤلفون: Yanhui XIE, Jiaqiao LI, Zeen SI, Shuyin ZHENG, Jianfang LIU, Na ZHANG

المصدر: Haiyang Kaifa yu guanli, Vol 39, Iss 2, Pp 95-99 (2022)

مصطلحات موضوعية: ship ballast water, biological invasion, ecological safety, customs, supervise, Oceanography, GC1-1581

الوصف: In order to ensure the safety of marine ecology and aquaculture in China, this paper introduced the biological invasion caused by ship ballast water discharge and its related international standards and legal provisions, and put forward some suggestions for the regulation of ship ballast water, for China is the third largest shipping country in the world. The results showed that the biological invasion caused by ship ballast water mainly included plankton and microorganisms. At present, the international ballast water discharge was mainly implemented by D-2 standard, and many countries regulated the ballast water by legal means. While accelerating the legislation of ship ballast water, China should strengthen basic data research, formulate unified norms and standards, and expand the fields of concern.

وصف الملف: electronic resource

Relation: http://www.haiyangkaifayuguanli.com/hykfyglen/ch/reader/view_abstract.aspx?file_no=20220215&flag=1; https://doaj.org/toc/1005-9857

URL الوصول: https://doaj.org/article/f1f05ad7c23c4954b9293a6f811e3e70

المؤلفون: Yanhui Xie, Min Chen, Shuting Zhang, Jiancheng Shi, Ruixia Liu

المصدر: Remote Sensing, Vol 14, Iss 22, p 5637 (2022)

مصطلحات موضوعية: atmospheric motion vectors, FY-4A, data assimilation, rainstorm forecast, Science

الوصف: Atmospheric motion vectors (AMVs) derived from images of the geostationary satellite, Fengyun-4A (FY-4A), can provide high-spatiotemporal-resolution wind observations in the atmospheric middle and upper levels. To explore the potential benefits of these data for the numerical forecasting of severe weather events, the characteristics of FY-4A AMVs in different channels were analyzed and three groups of assimilation experiments were conducted in this study. The impacts of FY-4A AMVs on the forecasts of the rainstorm that occurred in Henan province in China on 20 July 2021, were investigated based on the Weather Research and Forecasting (WRF) model. The results show that FY-4A AMVs with a higher quality indicator (QI) exhibited a lower error characteristic at the cost of a reduced sample size. The assimilation of FY-4A AMVs reduced the error of the upper-level wind fields in 24 h forecasts. A positive impact could also be obtained for 10 m wind in 24 h forecasts, with an improvement of up to 9.74% for the mean bias and 3.0% for the root-mean-square error due to the inclusion of FY-4A AMVs with a QI > 70. Assimilating the AMVs with a QI > 80, there was an overall positive impact on the CSI score skills of 6 h accumulated precipitation above 1.0 mm in the 24 h forecast. A significant improvement could be found in the forecasting of heavy rainfall above 25.0 mm after 6 h of the forecast. The spatial distribution of the 24 h accumulated heavy rainfall zone was closer to the observations with the assimilation of the FY-4A AMVs. The adjustment of the initial wind fields resulting from the FY-4A AMVs brought a clear benefit to the quantitative precipitation forecasting skills in the event of the Henan 7.20 rainstorm; however, the AMV data assimilation still had difficulty in capturing the hourly maximum rainfall and intensity well.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2072-4292/14/22/5637; https://doaj.org/toc/2072-4292

URL الوصول: https://doaj.org/article/64820c29c99742b7889ad0c21bb711a5

المؤلفون: Song Wang, Ning Jiang, Wenhao Shi, Hang Yin, Xiaojuan Chi, Yanhui Xie, Jingyun Hu, Yanwei Zhang, Huangping Li, Ji-Long Chen

المصدر: Frontiers in Microbiology, Vol 12 (2021)

مصطلحات موضوعية: influenza A virus, Escherichia coli, co-infection, cytokine, nitric oxide synthase 2, Microbiology, QR1-502

الوصف: Pathogens that cause respiratory diseases in poultry are highly diversified, and co-infections with multiple pathogens are prevalent. The H9N2 strain of avian influenza virus (AIV) and Escherichia coli (E. coli) are common poultry pathogens that limit the development of the poultry industry. This study aimed to clarify the interaction between these two pathogens and their pathogenic mechanism using a mouse model. Co-infection with H9N2 AIV and E. coli significantly increased the mortality rate of mice compared to single viral or bacterial infections. It also led to the development of more severe lung lesions compared to single viral or bacterial infections. Co-infection further causes a storm of cytokines, which aggravates the host’s disease by dysregulating the JAK/STAT/SOCS and ERK1/2 pathways. Moreover, co-infection mutually benefited the virus and the bacteria by increasing their pathogen loads. Importantly, nitric oxide synthase 2 (NOS2) expression was also significantly enhanced by the co-infection. It played a key role in the rapid proliferation of E. coli in the presence of the co-infecting H9N2 virus. Therefore, our study underscores the role of NOS2 as a determinant for bacteria growth and illustrates its importance as an additional mechanism that enhances influenza virus-bacteria synergy. It further provides a scientific basis for investigating the synergistic infection mechanism between viruses and bacteria.

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2021.670688/full; https://doaj.org/toc/1664-302X

URL الوصول: https://doaj.org/article/3b46d5717ee94af88259d859455138dc

المؤلفون: Song Wang, Lanlan Zhang, Rong Zhang, Xiaojuan Chi, Zhou Yang, Yanhui Xie, Sicheng Shu, Yuan Liao, Ji-Long Chen

المصدر: Veterinary Research, Vol 49, Iss 1, Pp 1-14 (2018)

مصطلحات موضوعية: Veterinary medicine, SF600-1100

الوصف: Abstract The emerging avian-origin H7N9 influenza A virus, which causes mild to lethal human respiratory disease, continues to circulate in China, posing a great threat to public health. Influenza NS1 protein plays a key role in counteracting host innate immune responses, allowing the virus to efficiently replicate in the host. In this study, we compared NS1 amino acid sequences of H7N9 influenza A virus with those of other strains, and determined NS1 protein variability within the H7N9 virus and then evaluated the impact of amino acid substitutions on ability of the NS1 proteins to inhibit host innate immunity. Interestingly, the amino acid residue S212 was identified to have a profound effect on the primary function of NS1, since S212P substitution disabled H7N9 NS1 in suppressing the host RIG-I-dependent interferon response, as well as the ability to promote the virus replication. In addition, we identified another amino acid residue, I178, serving as a key site to keep NS1 protein high steady-state levels. When the isoleucine was replaced by valine at 178 site (I178V mutation), NS1 of H7N9 underwent rapid degradation through proteasome pathway. Furthermore, we observed that P212S and V178I mutation in NS1 of PR8 virus enhanced virulence and promoted the virus replication in vivo. Together, these results indicate that residues I178 and S212 within H7N9 NS1 protein are critical for stability and functioning of the NS1 protein respectively, and may contribute to the enhanced pathogenicity of H7N9 influenza virus.

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s13567-018-0594-y; https://doaj.org/toc/1297-9716

URL الوصول: https://doaj.org/article/072fa3406f21485cbda34b52552250eb

المؤلفون: Yanhui Xie, Lu Mao, Min Chen, Jiancheng Shi, Shuiyong Fan, Ruixia Liu

المصدر: Remote Sensing, Vol 14, Iss 2, p 275 (2022)

مصطلحات موضوعية: MWHS-2, radiance data assimilation, RMSPS-ST, short-range forecast, Science

الوصف: Currently, humidity information can be obtained from the Microwave Humidity Sounder-2 (MWHS-2) mounted on the polar-orbiting satellites FY-3C and FY-3D. However, making full use of the MWHS-2 data remains a challenge, particularly in the application of regional numerical weather models. This study is the first to include MWHS-2 radiance data in the Rapid-refresh Multi-scale Analysis and Prediction System—Short-term (RMAPS-ST) regional model. The results and impact of MWHS-2 radiance data assimilation were investigated and evaluated. It is found that MWHS-2 radiance data can be effectively assimilated in the RMAPS-ST after a series of quality control and variational bias correction. Benefits could be obtained in the reduction of background departures for each humidity sounding channel. Assimilation experiments over a period of one month were carried out, and the impacts of MWHS-2 radiances were quantitatively analyzed on the forecasts of RMAPS-ST system. The results showed that MWHS-2 saw a small but significant improvement for low-level humidity of short-range forecast, by 16.5% and 3.2% in terms of mean bias and root-mean-square error, respectively. The positive impact on short-range forecast also can be found for middle and low level temperature and wind. For quantitative precipitation forecast, the assimilation of MWHS-2 radiances increased the score skills of different rainfall levels in the first 12 h forecast by an average of 1.4%. There was a slight overall improvement in the 24-h precipitation forecast for over-estimation and false alarm of 3-h accumulated rainfall below 1.0 mm, with 0.75% and 0.36%, respectively. The addition of MWHS-2 radiance data gives a small positive impact on low-level humidity, temperature, and wind in the RMAPS-ST regional model, and it also improves short-range forecast of rainfall, particularly in the first 12 h of the forecast.

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2072-4292/14/2/275; https://doaj.org/toc/2072-4292

URL الوصول: https://doaj.org/article/5f569cbb871c4ba9a2e56e602fb4519c

المؤلفون: Jiexian Ma, Kefei Wu, Weiya Bai, Xiaoxian Cui, Yan Chen, Youhua Xie, Yanhui Xie

المصدر: EBioMedicine, Vol 20, Iss C, Pp 70-78 (2017)

مصطلحات موضوعية: Lenalidomide, Dexamethasone, Cereblon, MCL, IL-6/STAT3, Medicine, Medicine (General), R5-920

الوصف: At our center, relapsed mantle cell lymphoma (MCL) can be treated with maintenance therapy composed of consecutive low-dose lenalidomide and short-term, high-dose dexamethasone (LD regimen), which achieves good responses (longer overall survival and progression-free survival) and low toxicity. Cereblon is probably targeted by both lenalidomide and dexamethasone, which leads to synergistic cytotoxicity in MCL by inhibiting the interleukin-6/signal transducer and activator of transcription 3 (IL-6/STAT3), phosphatidylinositol 3-kinase (PI3K)/AKT and AKT2/Forkhead box O3 (FOXO3A)/BCL2-like 11 (BIM) pathways. The two drugs synergistically inhibit the same pathways, but through different sites. Cereblon was found expressed in most of the MCL tissues (91.3% positivity). Moreover, cereblon expression is positively correlated with LD regimen sensitivity: long-term lenalidomide exposure downregulates cereblon and induces multi-drug resistance against lenalidomide, dexamethasone, cytarabine, cisplatin, and methotrexate in vitro. Removal of lenalidomide resensitizes lenalidomide-resistant MCL cells to lenalidomide and dexamethasone. Our work suggests that rotating the LD regimen with other regimens would improve MCL maintenance therapy.

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396417302128; https://doaj.org/toc/2352-3964

URL الوصول: https://doaj.org/article/946827c880974ecdbc0a701a67291008

المؤلفون: Yanhui Xie, Jiancheng Shi, Yonghui Lei, Yunqing Li

المصدر: Remote Sensing, Vol 7, Iss 10, Pp 14099-14118 (2015)

مصطلحات موضوعية: microwave emissivity, short vegetation-covered surfaces, multilayered medium, two-stream radiative transfer approximation, Science

الوصف: Owing to the temporal and spatial variability of the emissivity spectra, problems remain in the interpretation and application of satellite passive microwave data over vegetation-covered surfaces. The commonly used microwave land emissivity model, developed by Weng et al. (2001) and implemented into the community radiative transfer model (CRTM), treats vegetation-covered surfaces as a three-layer medium. This simplification comes at the cost of accuracy. In this study, to reduce bias in the modeling of microwave emissions from short vegetation-covered surfaces, two modifications are made. First, vegetation was considered as a multilayered medium including leaves and stems to simulate volumetric absorption and scattering. The results suggest that the calculated brightness temperatures well agree with field experiments under different incidence angles for low soil moisture and sparse crop cover. On the other hand, large errors from the measurements are found for high soil moisture content and dense crop cover. Second, the advanced integral equation model (AIEM) was also used to improve the simulation of reflectivity from rough soil surfaces. Comparisons with field experimental data show that the determination coefficient between the calculated and measured brightness temperatures significantly increased and the root-mean-square errors remarkably decreased. The average improvement using the proposed approach is about 80% and 59% in accuracy for the vertical and horizontal polarization, respectively.

وصف الملف: electronic resource

Relation: http://www.mdpi.com/2072-4292/7/10/14099; https://doaj.org/toc/2072-4292

URL الوصول: https://doaj.org/article/892cd3c4ae36404f969f935b944fda23