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1دورية أكاديمية
المؤلفون: Dong Dong, Koichi Hosomi, Nobuhiko Mori, Yoshi-ichiro Kamijo, Yohei Furotani, Daisuke Yamagami, Yu-ichiro Ohnishi, Yoshiyuki Watanabe, Takeshi Nakamura, Fumihiro Tajima, Haruhiko Kishima, Youichi Saitoh
المصدر: Frontiers in Neurology, Vol 14 (2023)
مصطلحات موضوعية: neuropathic pain, spinal cord injury, diffusion tensor imaging, white matter microstructural alterations, corpus callosum, Neurology. Diseases of the nervous system, RC346-429
الوصف: BackgroundThrough contrastive analysis, we aimed to identify the white matter brain regions that show microstructural changes in patients with neuropathic pain (NP) after spinal cord injury (SCI).MethodsWe categorized patients with SCI into NP (n = 30) and non-NP (n = 15) groups. We extracted diffusion tensor maps of fractional anisotropy (FA) and mean (MD), axial (AD), and radial (RD) diffusivity. A randomization-based method in tract-based spatial statistics was used to perform voxel-wise group comparisons among the FA, MD, AD, and RD for nonparametric permutation tests.ResultsAtlas-based analysis located significantly different regions (p
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Masumi Nakahama-Matsushima, Yoshi-ichiro Kamijyo, Yasunori Umemoto, Takamasa Hashizaki, Yukihide Nishimura, Kazunari Furusawa, Yohei Furotani, Fumihiro Tajima, Ken Kouda
المصدر: Journal of Clinical Medicine, Vol 12, Iss 22, p 7098 (2023)
مصطلحات موضوعية: exercise, myokine, interleukin-6, neutrophil, parasports, Medicine
الوصف: Exercise increases the serum level of interleukin-6 (IL-6), which in turn stimulates the production of various inflammatory cytokine antagonists, such as interleukin-1 receptor antagonist (IL-1ra). Individuals with cervical spinal cord injury (CSCI) are at high risk of inflammatory conditions. This study compared the effects of wheelchair half marathon on the immune system of male athletes with CSCI and those with thoracic/lumber spinal cord injury (SCI). Neutrophil count, IL-1ra, IL-6, and various endocrine parameters were measured before, immediately and 1 h after the race in five CSCI and six SCI who completed the wheelchair marathon race. The percentage of neutrophils was significantly higher in CSCI immediately and 1 h after the race, compared with the baseline, and significantly higher in SCI at 1 h after the race. IL-6 was significantly higher immediately and 1 h after the race in SCI, whereas no such changes were noted in IL-6 in CSCI. IL-1ra was significantly higher at 1 h after the race in both SCI and CSCI. The race was associated with an increase in IL-1ra in both CSCI and SCI. These findings suggest wheelchair half marathon race increases IL-1ra even under stable IL-6 status in male CSCI individuals, and that such post-race increase in IL-1ra is probably mediated through circulatory neutrophils.
وصف الملف: electronic resource
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المؤلفون: Shinnnosuke, Hori, Masakazu, Minetama, Hiroyuki, Suzuki, Akio, Otaka, Tadashi, Sumiya, Yohei, Furotani, Tokio, Kinoshita, Yumi, Koike, Hiroyasu, Uenishi, Tatsuya, Yoshikawa, Yoshi-ichiro, Kamijo, Fumihiro, Tajima
المصدر: Dokkyo Medical Journal. 1(3):197-206
مصطلحات موضوعية: SARS-CoV-2, therapists, infection control, regional facilities, physiatrist
الوصف: Background: A new role of a regional core hospital for educating medical personnel through a regional therapy association has been previously reported in the COVID-19 crisis. In the present study, physical (PT), occupational (OT), and speech language hearing therapist (ST) and physiatrists, who have been providing COVID-19 rehabilitation in a regional core hospital, were instructed how to control infection via a webinar. The purpose of this report was to investigate the effects of webinars on therapists working in local facilities. Methods: The webinar was sponsored by the Wakayama Physical Therapy Association. A PT, OT, ST, and physiatrist from Wakayama Medical University Kihoku Hospital, who had been providing rehabilitation for mildly and/or moderately infected COVID-19 patients. All participants answered the 18-item online questionnaire after the webinar to assess the educational effects. Results: There were 41 participants in this region and 30 participants from 19 facilities responded the questionnaire (valid responses ratio was 73%) and 30% of the respondents had experienced COVID-19 rehabilitation. Most responders (83%) felt that difficulty level of the contents was appropriate and 80% of the respondents replied that rehabilitation was necessary for the patients. 70% of the respondents replied that got confidence after this webinar, even 7 of the 13 respondents (43%), who attended the webinar about infection control of COVID-19 for the first time, were involved. Conclusion: A webinar from therapists and physiatrists in a regional core hospital, who had experiences to provide COVID-19 rehabilitation, were satisfactory and effective for the education of regional therapists.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=jairo_______::517283c5b71e85143638236d99043a6f
http://id.nii.ac.jp/1199/00005204/ -
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المؤلفون: Masumi Nakahama, Christof A. Leicht, Yasunori Umemoto, Victoria L. Goosey-Tolfrey, Sven P. Hoekstra, Yohei Furotani, Fumihiro Tajima, Takayoshi Matsushita, Kazunari Nishiyama, Yasunori Nagano, Yoshi-ichiro Kamijo
المصدر: Spinal Cord. 59:274-281
مصطلحات موضوعية: 030506 rehabilitation, medicine.medical_specialty, medicine.medical_treatment, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dopamine, Internal medicine, medicine, Triglyceride, business.industry, Interleukin, Lipid metabolism, General Medicine, Endocrinology, Cytokine, Acetoacetic acid, Neurology, chemistry, Ketone bodies, Catecholamine, Neurology (clinical), 0305 other medical science, business, 030217 neurology & neurosurgery, medicine.drug
الوصف: Study design Acute experimental study. Objectives To investigate the acute response of markers of lipid metabolism and interleukin (IL)-6 to dopamine infusion in people with a cervical spinal cord injury (CSCI). Setting Laboratory of Wakayama Medical University, Japan. Methods Ten participants, four with CSCI and six AB individuals, underwent 50 min of dopamine infusion. Blood samples were collected prior to, immediately after and 1 h following cessation of dopamine infusion for the determination of circulating catecholamine, lipid, ketone body and IL-6 concentrations. Results The adrenaline concentration following dopamine infusion was increased by 59 ± 7% in CSCI (p = 0.038, Cohen's d effect size (ES): 1.47), while this was not changed in AB (p = 0.223). Triglycerides and acetoacetic acid concentration were increased in both groups, immediately after and 1 h post-infusion (triglycerides p ≤ 0.042, ES CSCI: 1.00, ES AB: 1.12; acetoacetic acid p ≤ 0.030; ES CSCI: 1.72, ES AB: 1.31). 3-Hydroxybutyric acid concentration was increased in CSCI only (48 ± 15%, p = 0.039, ES: 1.44; AB p = 0.115). Dopamine infusion did not affect plasma IL-6 concentration in either group (p ≥ 0.368). Conclusions Dopamine infusion induced a sustained increase in triglyceride and ketone body concentrations in persons with CSCI. In contrast, cytokine concentrations were not affected by dopamine infusion. These findings suggest that circulating catecholamines can stimulate metabolism in people with CSCI despite the presence of autonomic dysfunction.
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المؤلفون: Sven P, Hoekstra, Yoshi-Ichiro, Kamijo, Takayoshi, Matsushita, Christof A, Leicht, Kazunari, Nishiyama, Victoria L, Goosey-Tolfrey, Yasunori, Nagano, Yasunori, Umemoto, Masumi, Nakahama, Yohei, Furotani, Fumihiro, Tajima
المصدر: Spinal cord. 59(3)
مصطلحات موضوعية: Dopamine, Cervical Cord, Cytokines, Humans, Pilot Projects, Lipids, Spinal Cord Injuries
الوصف: Acute experimental study.To investigate the acute response of markers of lipid metabolism and interleukin (IL)-6 to dopamine infusion in people with a cervical spinal cord injury (CSCI).Laboratory of Wakayama Medical University, Japan.Ten participants, four with CSCI and six AB individuals, underwent 50 min of dopamine infusion. Blood samples were collected prior to, immediately after and 1 h following cessation of dopamine infusion for the determination of circulating catecholamine, lipid, ketone body and IL-6 concentrations.The adrenaline concentration following dopamine infusion was increased by 59 ± 7% in CSCI (p = 0.038, Cohen's d effect size (ES): 1.47), while this was not changed in AB (p = 0.223). Triglycerides and acetoacetic acid concentration were increased in both groups, immediately after and 1 h post-infusion (triglycerides p ≤ 0.042, ES CSCI: 1.00, ES AB: 1.12; acetoacetic acid p ≤ 0.030; ES CSCI: 1.72, ES AB: 1.31). 3-Hydroxybutyric acid concentration was increased in CSCI only (48 ± 15%, p = 0.039, ES: 1.44; AB p = 0.115). Dopamine infusion did not affect plasma IL-6 concentration in either group (p ≥ 0.368).Dopamine infusion induced a sustained increase in triglyceride and ketone body concentrations in persons with CSCI. In contrast, cytokine concentrations were not affected by dopamine infusion. These findings suggest that circulating catecholamines can stimulate metabolism in people with CSCI despite the presence of autonomic dysfunction.
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