المؤلفون: Yang, Fan, Wong, Richard J., Zakeri, Kaveh, Singh, Annu, Estilo, Cherry L., Lee, Nancy Y.

المصدر: In Practical Radiation Oncology July-August 2024 14(4):e264-e275

المؤلفون: Mell, Loren K., Pugh, Stephanie L., Jones, Christopher U., Nelson, Tyler J., Zakeri, Kaveh, Rose, Brent S., Zeitzer, Kenneth L., Gore, Elizabeth M., Bahary, Jean-Paul, Souhami, Luis, Michalski, Jeff M., Hartford, Alan C., Mishra, Mark V., Roach, Mack, III, Parliament, Matthew B., Choi, Kwang N., Pisansky, Thomas M., Husain, Siraj M., Malone, Shawn C., Horwitz, Eric M., Feng, Felix

المصدر: In European Urology April 2024 85(4):373-381

المؤلفون: Raab, Gabriel, Yu, Yao, Sherman, Eric, Wong, Richard, Mell, Loren K., Lee, Nancy Y., Zakeri, Kaveh

المصدر: In Clinical and Translational Radiation Oncology March 2024 45

المؤلفون: Aristophanous, Michalis ^*, Aliotta, Eric ^*, Lichtenwalner, Phillip ^*, Abraham, Shira ^*, Nehmeh, Mohammad, Caringi, Amanda ^*, Zhang, Peng ^*, Hu, Yu-Chi ^*, Zhang, Pengpeng ^*, Cervino, Laura ^*, Gelblum, Daphna, McBride, Sean, Riaz, Nadeem, Chen, Linda, Yu, Yao, Zakeri, Kaveh, Lee, Nancy

المصدر: In International Journal of Radiation Oncology, Biology, Physics February 2024

المؤلفون: Raab, Gabriel T., Restifo, Daniel, Tin, Amy L., Vickers, Andrew J., McBride, Sean M., Wong, Richard J., Lee, Nancy Y., Zakeri, Kaveh, Shahrokni, Armin

المصدر: In Journal of Geriatric Oncology November 2023 14(8)

المؤلفون: Yu, Yao, Schöder, Heiko, Zakeri, Kaveh, Chen, Linda, Kang, Jung Julie, McBride, Sean Matthew, Tsai, C. Jillian, Gelblum, Daphna Y., Boyle, Jay O., Cracchiolo, Jennifer R., Cohen, Marc A., Singh, Bhuvanesh, Ganly, Ian, Patel, Snehal G., Michel, Loren S., Dunn, Lara, Sherman, Eric J., Pfister, David G., Wong, Richard J., Riaz, Nadeem, Lee, Nancy Y.

المصدر: In Oral Oncology June 2023 141

المؤلفون: Vitzthum, Lucas K, Park, Helen, Zakeri, Kaveh, Heide, Elena S, Nalawade, Vinit, Mundt, Arno J, Vaida, Florin, Murphy, James D, Mell, Loren K

المصدر: International Journal of Radiation Oncology • Biology • Physics. 106(3)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Cancer, Aging, Urologic Diseases, Age Factors, Aged, Brachytherapy, Cohort Studies, Confidence Intervals, Female, Fractures, Bone, Gastrointestinal Neoplasms, Genital Neoplasms, Female, Humans, Incidence, Male, Pelvic Bones, Pelvic Neoplasms, Prostatic Neoplasms, Radiotherapy, Conformal, Radiotherapy, Intensity-Modulated, Regression Analysis, Risk, Sex Factors, White People, Other Physical Sciences, Oncology & Carcinogenesis, Oncology and carcinogenesis, Theoretical and computational chemistry, Medical and biological physics

الوصف: PurposeOlder patients undergoing radiation therapy (RT) for pelvic malignancies are at increased risk for pelvic fracture, which is associated with significant morbidity and mortality. RT techniques such as brachytherapy or intensity modulated RT (IMRT) allow for more conformal dose distributions, but it is not known whether the risk for pelvic fracture varies by RT modality.Methods and materialsThis observational cohort study involved 28,354 patients ≥65 years old, treated with RT for pelvic malignancies. We evaluated the relative risk of pelvic fracture by type of RT when accounting for baseline factors. To test for nonspecific effects, we also evaluated risk of nonpelvic fractures in the same population.ResultsThe 5-year incidence of pelvic fractures was 12.7% (95% confidence interval [CI], 11.6%-13.8%), 11.8% (10.8%-12.8%), and 3.7% (3.4%-4.0%) for patients with gastrointestinal, gynecologic, and prostate cancer, respectively. On multivariable analysis, being treated with IMRT (hazard ratio, 0.85; 95% CI, 0.73-0.99) or brachytherapy therapy alone (hazard ratio, 0.43; 95% CI, 0.34-0.54) was associated with a reduced hazard for pelvic fractures compared with 3D conformal radiation therapy in female patients. In contrast, there was no association with RT modality and the hazard for nonpelvic fractures among females. There was no significant association between pelvic fractures and IMRT or brachytherapy for male patients. White race, advanced age, and higher comorbidity were associated with an increased hazard for pelvic fracture.ConclusionsIMRT and brachytherapy were associated with a reduced risk of pelvic fractures in older women undergoing RT for pelvic malignancies. Pelvic insufficiency fracture risk should be considered when treating with pelvic RT.

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8m10f5pd

المؤلفون: Zakeri, Kaveh^Aff6, Rao, Shyam S. D.^Aff7, Riaz, Nadeem^Aff6, Lee, Nancy Y.^Aff6, Foote, Robert L.^Aff8

المساهمون: Lee, Nancy Y., Series Editor^{Aff1, Aff3}, Lu, Jiade J., Series Editor^{Aff2, Aff4}, Yu, Yao, editor^Aff5

المصدر: Target Volume Delineation and Field Setup : A Practical Guide for Conformal and Intensity-Modulated Radiation Therapy. :109-120

المؤلفون: Strohl, Madeleine P.^Aff3, Ha, Patrick K.^Aff4, Zakeri, Kaveh^Aff5, Lee, Nancy^Aff5

المساهمون: Chandra, Ravi A., editor^Aff1, Li, Ryan J., editor^Aff2

المصدر: Multidisciplinary Management of Head and Neck Cancer : Contemporary Applications and Techniques. :1-12

المؤلفون: Mell, Loren K, Shen, Hanjie, Nguyen-Tân, Phuc Felix, Rosenthal, David I, Zakeri, Kaveh, Vitzthum, Lucas K, Frank, Steven J, Schiff, Peter B, Trotti, Andy M, Bonner, James A, Jones, Christopher U, Yom, Sue S, Thorstad, Wade L, Wong, Stuart J, Shenouda, George, Ridge, John A, Zhang, Qiang E, Le, Quynh-Thu

المصدر: Clinical Cancer Research. 25(23)

مصطلحات موضوعية: Cancer, Rare Diseases, Clinical Research, Dental/Oral and Craniofacial Disease, Adult, Aged, Aged, 80 and over, Case-Control Studies, Chemoradiotherapy, Female, Follow-Up Studies, Head and Neck Neoplasms, Humans, Male, Middle Aged, Neoplasm Recurrence, Local, Nomograms, Prognosis, Survival Rate, Oncology and Carcinogenesis, Oncology & Carcinogenesis

الوصف: PurposePrevious studies indicate that the benefit of therapy depends on patients' risk for cancer recurrence relative to noncancer mortality (ω ratio). We sought to test the hypothesis that patients with head and neck cancer (HNC) with a higher ω ratio selectively benefit from intensive therapy.Experimental designWe analyzed 2,688 patients with stage III-IVB HNC undergoing primary radiotherapy (RT) with or without systemic therapy on three phase III trials (RTOG 9003, RTOG 0129, and RTOG 0522). We used generalized competing event regression to stratify patients according to ω ratio and compared the effectiveness of intensive therapy as a function of predicted ω ratio (i.e., ω score). Intensive therapy was defined as treatment on an experimental arm with altered fractionation and/or multiagent concurrent systemic therapy. A nomogram was developed to predict patients' ω score on the basis of tumor, demographic, and health factors. Analysis was by intention to treat.ResultsDecreasing age, improved performance status, higher body mass index, node-positive status, P16-negative status, and oral cavity primary predicted a higher ω ratio. Patients with ω score ≥0.80 were more likely to benefit from intensive treatment [5-year overall survival (OS), 70.0% vs. 56.6%; HR of 0.73, 95% confidence interval (CI): 0.57-0.94; P = 0.016] than those with ω score

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/9b4469zc