المؤلفون: Cao, Jin-Xia, Liu, Li, Sun, Yun-Tao, Zeng, Qing-Hong, Wang, Yan, Chen, Jie-Chun

المصدر: Brazilian Journal of Medical and Biological Research. January 2020 53(11)

مصطلحات موضوعية: Acute cerebral infarction, Escitalopram, Prognosis, Copeptin, Stroke

الوصف: This study aimed to investigate whether the routine administration of escitalopram for three months would improve the prognosis of patients with ischemic stroke and decrease the plasma copeptin level. A total of 97 patients with acute cerebral infarction were randomly allocated to receive escitalopram (5-10 mg once per day, orally; n=49) or not to receive escitalopram (control group; n=48) for 12 weeks starting at 2-7 days after the onset of stroke. Both groups received conventional treatments, including physiotherapy and secondary prevention of stroke. The National Institutes of Health Stroke Scale (NIHSS) score was used to evaluate the disability of patients at the initial evaluation and at the monthly follow-up visits for three months. Impairment in the daily activities was assessed using the Barthel Index (BI), while cognitive impairment was assessed using Mini-Mental State Examination (MMSE) score. The psychiatric assessment included the administration of the Present State Examination modified to identify Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) symptoms of depression. The severity of depression was measured using the 17-item Hamilton Rating Scale for Depression (HAMD). During the 3-month follow-up period, 95 patients were included in the analysis (two patients withdrew from the escitalopram group). NIHSS and BI improvement at the 90th day were significantly greater in the escitalopram group (P<0.05), while HAMD and plasma copeptin levels significantly decreased, compared to the control group (P<0.01). In patients with acute ischemic stroke, the earlier administration of escitalopram for three months may improve neurological functional prognosis and decrease copeptin level.

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المؤلفون: Sun, Yan, Zeng, Qing-Hong, Lu, Hui-Qiang, Meng, Fan-Cheng, Shen, Yong, Zeng, Wei-You, Chi, Hao, Zhou, Yu-Qiang, Chen, Min

المصدر: Natural Product Research; Jul2022, Vol. 36 Issue 13, p3331-3336, 6p

مصطلحات موضوعية: LIGNANS, ZANTHOXYLUM, NORMAL-phase chromatography, CHEMICAL peel

مستخلص: Zanthoxylum armatum, its peels possessed better special flavour, as well as various bioactivities, such as anti-inflammatory, anti-microbial and anti-tumour. In our chemical investigation on the peels of Z. armatum, two new lignans (1 and 2) and three known lignans (3–5) were isolated by silica gel column chromatography, ODS column and preparative HPLC and their structures were established as zanthlignans A and B (1–2), (-)-asarinin (3), phylligenin (4) and planispine A (5) through various spectroscopic techniques including UV, IR, HR-ESI-MS, NMR and CD methods. [ABSTRACT FROM AUTHOR]

: Copyright of Natural Product Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Dong, Zhao-Yue, Zeng, Qing-Hong, Wei, Lin, Guo, Xin, Sun, Yan, Meng, Fan-Cheng, Wang, Guo-Wei, Lan, Xiao-Zhong, Liao, Zhi-Hua, Chen, Min

المصدر: Natural Product Research; Apr2022, Vol. 36 Issue 8, p1996-2001, 6p

مصطلحات موضوعية: BENZOIC acid, ACID derivatives, BENZOATES, BARBERRIES, GLYCOSIDE derivatives

مستخلص: Three undescribed prenylated benzoic acid derivatives berberisides A-C (1-3) and a new clerodane glycoside berberiside D (4) were isolated from Berberis tsarica Aherndt. Their structures were elucidated on the basis of extensive NMR and HR-ESI-MS analysis. The in vitro cytotoxic activities of all isolates were studied against lung carcinoma A549, hepatocellular carcinoma HepG2 and breast carcinoma MDA-MB-231 cell lines. Among them, compounds 1 and 4 exhibited anti-proliferative effects against three tumor cell lines with IC50 ranging from 28.97 ± 2.18 to 35.83 ± 0.72 μM. [ABSTRACT FROM AUTHOR]

: Copyright of Natural Product Research is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

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المؤلفون: Zeng, Qing-Hong^Aff3

المساهمون: Bullinger, H.-J., editor^Aff1, Warnecke, H. J., editor^Aff2

المصدر: Toward the Factory of the Future : Proceedings of the 8th International Conference on Production Research and 5th Working Conference of the Fraunhofer-Institute for Industrial Engineering (FHG-IAO) at University of Stuttgart, August 20 – 22, 1985. :108-113