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1دورية أكاديمية
المؤلفون: Kang Yuan, Yanjun Huang, Shuo Yang, Zewei Zhou, Yulei Wang, Dongpu Cao, Hong Chen
المصدر: Engineering, Vol 33, Iss , Pp 108-120 (2024)
مصطلحات موضوعية: Autonomous driving, Decision-making, Motion planning, Deep reinforcement learning, Model predictive control, Engineering (General). Civil engineering (General), TA1-2040
الوصف: Decision-making and motion planning are extremely important in autonomous driving to ensure safe driving in a real-world environment. This study proposes an online evolutionary decision-making and motion planning framework for autonomous driving based on a hybrid data- and model-driven method. First, a data-driven decision-making module based on deep reinforcement learning (DRL) is developed to pursue a rational driving performance as much as possible. Then, model predictive control (MPC) is employed to execute both longitudinal and lateral motion planning tasks. Multiple constraints are defined according to the vehicle’s physical limit to meet the driving task requirements. Finally, two principles of safety and rationality for the self-evolution of autonomous driving are proposed. A motion envelope is established and embedded into a rational exploration and exploitation scheme, which filters out unreasonable experiences by masking unsafe actions so as to collect high-quality training data for the DRL agent. Experiments with a high-fidelity vehicle model and MATLAB/Simulink co-simulation environment are conducted, and the results show that the proposed online-evolution framework is able to generate safer, more rational, and more efficient driving action in a real-world environment.
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Xiaomin Pang, Miao Jia, Ying Zhang, Meihui Chen, Pengyao Miao, Weiting Cheng, Zewei Zhou, Qi Zhang, Jianghua Ye, Jiayu Li, Haibin Wang, Xiaoli Jia
المصدر: Frontiers in Microbiomes, Vol 3 (2024)
مصطلحات موضوعية: pear, planting year, quality, soil enzymes, rhizosphere soil, microbial diversity, Microbial ecology, QR100-130
الوصف: Few studies have been reported on the effect of planting years on fruit quality and soil of pear trees. In this study, four planting years (T5, T20, T30, and T40) of Cuiguan pears were used to analyze fruit quality, rhizosphere soil enzymes, and microbial diversity of pear trees, and their correlations. The results showed that the content of sucrose, reducing sugar and ascorbic acid in Cuiguan Pear showed a tendency of increasing and then decreasing with the increase of planting years, in which the highest content was found in 20- and 30-year-old fruits, and the highest content of total acid was found in 5-year-old fruits. Rhizosphere soil enzyme activities varied with planting year, with the highest protease activity in 20-year-old soil, phosphatase and urease in 30-year-old soil, polyphenol oxidase in 5-year-old soil, and sucrase in 40-year-old soil. The microbial diversity index and the number of OTUs showed an increasing and decreasing trend with the increase of planting years. Among the top 11 bacteria in pear rhizosphere soil average relative abundance, with Bradyrhizobium decreasing in relative abundance at the peak pear fruiting stages (T20 and T30), while Acidothermus showed an increasing trend in relative abundance with increasing planting years. RDA analysis showed that there were differences in the microbial community structure of pear trees at different planting years, and that both sucrose and reducing sugar contents in pears were positively correlated with T20 and T30, ascorbic acid content was positively correlated with T40, whereas the total acid content was positively correlated with T5, and that T20 was positively correlated with soil protease and phosphate mono esterase activities, and that T30 was positively correlated with polyphenol oxidase and urease activities, whereas T40 was positively correlated with sucrase activity. In summary, with the increase of planting years, changes in soil microbial community structure and soil enzyme activity have a significant impact on pear quality formation, and the results of the study provide a theoretical basis for scientific management of pear orchards.
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Yangjie Ji, Zewei Zhou, Ziru Yang, Yanjun Huang, Yuanjian Zhang, Wanting Zhang, Lu Xiong, Zhuoping Yu
المصدر: iScience, Vol 27, Iss 5, Pp 109751- (2024)
مصطلحات موضوعية: Internet of things, Artificial intelligence, Transportation engineering, Science
الوصف: Summary: Cooperative vehicle-infrastructure system (CVIS) is an important part of the intelligent transport system (ITS). Autonomous vehicles have the potential to improve safety, efficiency, and energy saving through CVIS. Although a few CVIS studies have been conducted in the transportation field recently, a comprehensive analysis of CVIS is necessary, especially about how CVIS is applied in autonomous vehicles. In this paper, we overview the relevant architectures and components of CVIS. After that, state-of-the-art research and applications of CVIS in autonomous vehicles are reviewed from the perspective of improving vehicle safety, efficiency, and energy saving, including scenarios such as straight road segments, intersections, ramps, etc. In addition, the datasets and simulators used in CVIS-related studies are summarized. Finally, challenges and future directions are discussed to promote the development of CVIS and provide inspiration and reference for researchers in the field of ITS.
وصف الملف: electronic resource
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4دورية أكاديمية
المؤلفون: Xiaomin Pang, Meihui Chen, Pengyao Miao, Weiting Cheng, Zewei Zhou, Ying Zhang, Qi Zhang, Jianghua Ye, Xiaoli Jia, Haibin Wang
المصدر: Agriculture, Vol 14, Iss 2, p 226 (2024)
مصطلحات موضوعية: pear tree, planting years, Biolog EcoPlates, rhizosphere soil, fruit quality, Agriculture (General), S1-972
الوصف: This study explores the interaction between pear fruit quality and the soil environment over four different planting years (5, 20, 30, and 40 years), focusing on the fruit’s chemical properties, rhizosphere soil properties, microbial communities, and both microbiomass and functional diversity. The results found that reducing sugar, sucrose, and vitamin C contents in pears initially increased with planting years before declining, while total acidity showed an inverse trend. Analysis of the soil physicochemical index revealed that rhizosphere soil physicochemical indexes were significantly different between different planting years, but there was no obvious regularity. Correlation analysis found that total phosphorus, total potassium, organic matter, and available nitrogen were significantly and positively correlated with pear quality indexes. Soil microbiomass carbon decreased before increasing with increasing planting year, while soil microbial nitrogen was irregular. Results of functional diversity of rhizosphere soil bacterial communities showed that the relationship of carbon source utilization among the six groups was 20 years > 5 years > 30 years > 40 years. Interestingly, the 20-year group had the most core differences in microbial communities. The study suggests that as pear trees age, adequate plant nutrition during peak fruiting periods can improve soil fertility, microbial functional diversity, and ultimately enhance fruit quality.
وصف الملف: electronic resource
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5دورية أكاديمية
المؤلفون: Zewei Zhou, Ziru Yang, Yuanjian Zhang, Yanjun Huang, Hong Chen, Zhuoping Yu
المصدر: iScience, Vol 25, Iss 3, Pp 103909- (2022)
مصطلحات موضوعية: Algorithms, Engineering, Transportation engineering, Science
الوصف: Summary: In the intelligent transportation system (ITS), speed prediction plays a significant role in supporting vehicle routing and traffic guidance. Recently, a considerable amount of research has been devoted to a single-level (e.g., traffic or vehicle) prediction. However, a systematic review of speed prediction in and between different levels is still missing. In this article, existing research is comprehensively analyzed and divided into three levels, i.e. macro traffic, micro vehicles, and meso lane. In addition, this article summarizes the influencing factors and reviews the prediction methods based on how those methods utilize the available information to meet the challenges of the prediction at different levels. This is followed by a summary of evaluation metrics, public datasets, and open-source codes. Finally, future directions in this field are discussed to inspire and guide readers. This article aims to draw a complete picture of speed prediction and promote the development of ITS.
وصف الملف: electronic resource
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6دورية أكاديمية
المؤلفون: Jie Sun, Dongju Feng, Huiyu Xi, Jiajing Luo, Zewei Zhou, Qinghuai Liu, Yun Chen, Qing Shao
المصدر: Molecular Oncology, Vol 14, Iss 8, Pp 1740-1759 (2020)
مصطلحات موضوعية: autophagy, CD24, lipid raft, retinoblastoma, vincristine, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. The clinical efficacy of vincristine (VCR) in the treatment of RB is severely limited by drug resistance. Here, we found that CD24, a GPI‐anchored protein, was overexpressed in human RB tissues and RB cell lines, and was associated with the sensitivity of RB cells in response to VCR therapy. We demonstrated that CD24 plays a critical role in impairing RB sensitivity to VCR via regulating autophagy. Mechanistically, CD24 recruits PTEN to the lipid raft domain and regulates the PTEN/AKT/mTORC1 pathway to activate autophagy. Lipid raft localization was essential for CD24 recruitment function. Collectively, our findings revealed a novel role of CD24 in regulating RB sensitivity to VCR and showed that CD24 is a potential target for improving chemotherapeutic sensitivity and RB patient outcomes.
وصف الملف: electronic resource
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7دورية أكاديمية
المؤلفون: Yun Chen, Rui Peng, Dongju Feng, Changxian Li, Yu Jin, Boyuan Liu, Zewei Zhou, Jinying Lu, Hua Sun, Xiaoxin Mu
المصدر: Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
وصف الملف: electronic resource
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8دورية أكاديمية
المؤلفون: Jie Chao, Xingang Wang, Yuxia Zhang, Tiebing Zhu, Wei Zhang, Zewei Zhou, Jian Yang, Bing Han, Yusi Cheng, Xiaojie Tu, Honghong Yao
المصدر: Cellular Physiology and Biochemistry, Vol 40, Iss 1-2, Pp 309-325 (2016)
مصطلحات موضوعية: Endothelial-mesenchymal transition, MCPIP1, Silicosis, Fibrosis, Autophagy, Physiology, QP1-981, Biochemistry, QD415-436
الوصف: Background: Silicosis is characterized by the accumulation of fibroblasts and the excessive deposition of extracellular matrix. Fibroblast generation via endothelial-mesenchymal transition (EndMT) is one process responsible for this accumulation of fibroblasts. However, the mechanisms underlying EndMT remain unknown. Methods: Human umbilical vein endothelial cells (HUVECs) were exposed to SiO2 (50 µg/cm2). Specific endothelial and mesenchymal markers were evaluated using immunofluorescence and western blot analysis. Functional changes were evaluated by analyzing cell migration and proliferation. LC3-adenovirus transfections were performed, and changes in autophagy were measured using a marker of autophagy. Results: SiO2 induced decreases in the endothelial cell-specific markers in HUVECs while dramatically increasing mesenchymal cell product levels and mesenchymal functions. Although MCPIP1 expression increased in parallel with the increase in specific mesenchymal cell products, the MCPIP1 expression level was not consistent with the observed decrease in specific endothelial marker expression. Autophagy mediated the effects of MCPIP1, as rapamycin and 3-MA enhanced and attenuated the effect of SiO2 on HUVECs, respectively. MAPKs and the PI3K/Akt pathway were involved in the regulation of MCPIP1 by SiO2, and Pyk2 and MLC-2 mediated cell migration. Conclusion: Our findings reveal a new potential function of MCPIP1, suggesting a possible mechanism of fibrosis in pulmonary silicosis.
وصف الملف: electronic resource
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9دورية أكاديمية
المؤلفون: Deguan Li, Zhenyuan Tian, Weisheng Tang, Junling Zhang, Lu Lu, Zhaojin Sun, Zewei Zhou, Feiyue Fan
المصدر: International Journal of Molecular Sciences, Vol 17, Iss 6, p 935 (2016)
مصطلحات موضوعية: ionizing radiation, hematopoietic cells, radiation protection, reactive oxygen species (ROS), radioprotectors, 5-methoxytryptamine-α-lipoic acid, Biology (General), QH301-705.5, Chemistry, QD1-999
الوصف: Antioxidants are prospective radioprotectors because of their ability to scavenge radiation-induced reactive oxygen species (ROS). The hematopoietic system is widely studied in radiation research because of its high radiosensitivity. In the present study, we describe the beneficial effects of 5-methoxytryptamine-α-lipoic acid (MLA), which was synthesized from melatonin and α-lipoic acid, against radiation-induced hematopoietic injury. MLA administration significantly enhanced the survival rate of mice after 7.2 Gy total body irradiation. The results showed that MLA not only markedly increased the numbers and clonogenic potential of hematopoietic cells but also decreased DNA damage, as determined by flow cytometric analysis of histone H2AX phosphorylation. In addition, MLA decreased the levels of ROS in hematopoietic cells by inhibiting NOX4 expression. These data demonstrate that MLA prevents radiation-induced hematopoietic syndrome by increasing the number and function of and by inhibiting DNA damage and ROS production in hematopoietic cells. These data suggest MLA is beneficial for the protection of radiation injuries.
وصف الملف: electronic resource
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10دورية أكاديمية
المؤلفون: Shuo Sun, author1, Dongyan Shi, author1, Jian Liu, author1, JinYing Lu, author1, Pingnan Dou, author1, Zewei Zhou, author1, Yun Chen, author1, 2
المصدر: Journal of Visualized Experiments. (192)
الإتاحة: http://www.jove.com/video/65026
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