-
1دورية أكاديمية
المؤلفون: Jeannette Bassimbié Kakou Danho, Yao Nicaise Atiméré, Daouda Koné, Donafologo Daouda Yéo, Line Couitchéré
المصدر: Advances in Hematology, Vol 2021 (2021)
مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5
الوصف: Sickle cell disease is a hereditary disease that predominantly affects black people. It is very widespread in sub-Saharan Africa, particularly at the Lehmann “sickle belt” level, where the prevalence of the hemoglobin S involves at least 10% of the population in West Africa and can reach 40% in Central Africa. In Côte d’Ivoire, the prevalence of the hemoglobin S is about 12–14% in the general population and about 11.71% in the child population in Abidjan. On the other hand, its coexistence with other hemoglobin phenotypes such as AC (6.2%) and β-thalassemia (2.7%) traits may also cause composite heterogeneous sickle cell disease, e.g., SC or S/β-thalassemia in this study. Since 2009, sickle cell disease has been recognized as a public health problem; however, much still remains to be performed despite the progress achieved. The objective of this study is thus to promote a rapid screening for the struggling against sickle cell disease in Côte d’Ivoire. This study was carried out over 6 months (April–September 2019) and has included 336 children, of which 236 all-comers, recruited in the municipality of Treichville in Abidjan and 100 other children with already known hemoglobin phenotype followed up in the Hematology Department of the University Hospital of Treichville. Two tests were used: the HemoTypeSC™ for rapid screening and the hemoglobin electrophoresis which is the reference method used for confirming the diagnosis in the laboratory. The findings confirmed the reliability of the HemoTypeSC™ with a sensitivity and specificity at 100% for the detection of hemoglobin A, S, and C. On the other hand, this sensitivity and specificity drop to 98.2% and 99.7%, respectively, when we analyze all the 336 children together, including the cases with HbF detected by hemoglobin electrophoresis. Hence, the importance of performing certainty tests following the HemoTypeSC™ screening test in order to determine the accurate phenotypes and proportions of the types of hemoglobin. The prevalence of hemoglobin S in subgroup 1 of 236 children of all-comers was 15%. The HemoTypeSC™ is therefore reliable, inexpensive, and disposable for rapid screening and early detection of sickle cell disease in Côte d’Ivoire. The HemoTypeSC™ provides rapid detection of hemoglobin phenotypes HbAA, HbSS, HbSC, HbCC, HbAS, and HbAC.
وصف الملف: electronic resource
-
2دورية أكاديمية
المؤلفون: Gabrielle C. Bouda, Fousseyni Traoré, Line Couitchere, Marie-Anne Raquin, Koffi M. Guedenon, Angele Pondy, Claude Moreira, Mbola Rakotomahefa, Mhamed Harif, Catherine Patte
المصدر: Journal of Global Oncology, Vol 5, Pp 1-9 (2019)
مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: PURPOSE: To evaluate the results of an intensive polychemotherapy regimen for Burkitt lymphoma (BL) in sub-Saharan African pediatric centers. PATIENTS AND METHODS: Children with advanced-stage BL (stages II bulky, III, and IV) treated with the GFAOP–Lymphomes Malins B (GFALMB) 2009 protocol in 7 centers between April 2009 and September 2015 were prospectively registered. Treatment regimen contained a prephase with cyclophosphamide followed by 2 induction courses (cyclophosphamide, vincristine, prednisone, high-dose methotrexate [HDMTX]), 2 consolidation courses (cytarabine, HDMTX), and a maintenance phase only for stage IV. HDMTX was given at the dose of 3 g/m2. RESULTS: Four hundred patients were analyzed: 7% had stage II bulky, 76% stage III, and 17% stage IV disease. Median age was 7.3 years, and sex ratio was 1.9:1 (male:female). A total of 221 patients received the whole protocol treatment and 195 achieved complete remission (CR), 11 of them after a second-line treatment. Treatment abandonment rate was 22%. One hundred twenty-five patients died, of whom 49 deaths were related to treatment toxicity. A total of 275 patients are alive, including 25 despite treatment abandonment, but only 110 are known to be in CR with a follow-up > 1 year, indicating a high rate of loss to follow-up. Twelve-month overall survival (OS) was 60% (95% CI, 54% to 66%) and 63%, 60%, and 31%, respectively, for stage II bulky, III, and IV. Patients with stage III disease who started second induction course within 34 days had OS of 76%, versus 57% (P = .0062) beyond 34 days. CONCLUSION: The GFA-LMB2009 protocol improved patients’ survival. Early dose intensity of treatment is a strong prognostic factor. Improving supportive care and decreasing loss to follow-up are crucial.
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2378-9506
-
3
المؤلفون: Biying Liu, Natasha Abraham, Inam Chitsike, line couitchere, Joyce Balagadde-Kambugu, Nsimba Makouanzi Alda Stévy, ANGELE PONDY, Lorna Renner, Donald Maxwell Parkin
الوصف: Background/Purpose Stage at diagnosis is an important metric in treatment and prognosis of cancer, and also in planning and evaluation of cancer control. In sub-Saharan Africa (SSA), for the latter, the only data source is the population-based cancer registry (PBCR). For childhood cancers, the “Toronto Staging Guidelines” have been developed to facilitate abstraction of stage by cancer registry personnel. Although the feasibility of staging using this system has been shown, there is limited information on the accuracy of staging. Methods A panel of case records of 6 common childhood cancers was established. 51 cancer registrars from 20 SSA countries staged these records, using Tier 1 of the Toronto guidelines. The stage that they assigned was compared with that decided by two expert clinicians. Results The registrars assigned the correct stage for 53-83% of cases (71% overall), with the lowest values for acute lymphocytic leukaemia (ALL), retinoblastoma and non Hodgkin lymphoma (NHL), and the highest for osteosarcoma (81%) and Wilms tumour (83%). For ALL and NHL, many unstageable cases were mis-staged, probably due to confusion over the rules for dealing with missing data; for the cases with adequate information, accuracy was 72-73%. Some confusion was observed over the precise definition of three stage levels of retinoblastomas. Conclusions A single training in staging resulted in an accuracy, for solid tumours, that was not much inferior to what has been observed in high income settings. Nevertheless, some lessons were learned on how to improve both the guidelines, and the training course.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::56f5a9a4d74006417be50b31cbf1fd75
https://doi.org/10.22541/au.167844911.10698670/v1 -
4
المؤلفون: Carole Coze, Charles Akoun, Line Couitchere, Lacina Cissé, Yao Nicaise Atiméré, Joseph Ouattara, Max N’doumy, Guy Constant Yao
المصدر: Bulletin du Cancer. 108:242-249
مصطلحات موضوعية: 0301 basic medicine, Gynecology, Cancer Research, medicine.medical_specialty, business.industry, Cote d ivoire, Hematology, General Medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, medicine, Radiology, Nuclear Medicine and imaging, business
الوصف: Resume Introduction Pour favoriser la precocite du diagnostic des cancers pediatriques, nous avons initie un programme visant a former les medecins de proximite aux signes d’appel et a sensibiliser la population. Ce travail avait pour objectif de comparer les delais, les stades et la survie des malades avant et trois ans apres l’initiation du dit programme. Methodes Cette etude retrospective concernait les enfants de 0 a 17 ans admis de janvier a decembre 2014 et de mai 2018 a avril 2019. Le test non parametrique de Mann-Whitney et le test exact de Fisher ont ete utilises pour comparer les delais, les stades, la survie. Resultats Cent cinquante-neuf medecins etaient formes et 1020 personnes sensibilisees. L’âge median des 216 enfants inclus etait de sept ans, le sex-ratio de 1,4. Sur les deux periodes, les delais medians de consultation etaient de 75 et 30 jours (p = 0,003) et les delais diagnostiques medians de 120 et 105 jours (p = 0,033). Les lymphomes classes a haut risque representaient 60,5 % et 58,5 % (p = 0,99) respectivement et les cas de nephroblastome 46,1 % et 56,2 % (p = 0,51). La survie globale etait de 31 % et 30,2 % (p = 0,92). Discussion le programme diagnostic precoce n’a pas eu d’impact. Les delais diagnostiques et la proportion de cancer classes a haut risque sont comparables aux donnees rapportees en Afrique subsaharienne qui varient respectivement de 7 a 15,8 semaines et de 60 a 71 %. Ce programme doit etre intensifie, etendu a tous les agents de sante et integrer l’amelioration de l’acces aux soins.
-
5
المؤلفون: Brenda Mallon, Rolande Kaboré, Line Couitchere, Fatou Binetou Akonde, Robert Lukamba, Tankélé Arsène Dackono, Mbolanirina Lala Rakotomahefa Narison, Mohammed Khattab, Angèle Pondy, Faten Fedhila Ben Ayed, Aléine Budiongo, Koffi Guedenon, Odile Oberlin, Catherine Patte
المصدر: Pediatric Blood & Cancer. 69
مصطلحات موضوعية: Male, Oncology, Neoplasms, Pediatrics, Perinatology and Child Health, Humans, Female, Hematology, Cancer Care Facilities, Child, Medical Oncology, Wilms Tumor, Hospitals, Kidney Neoplasms
الوصف: The establishment of an international hospital-based register (HBR) for the French African Pediatric Oncology Group (GFAOP) was a necessary step in the group's clinical research program. With help from the Sanofi Espoir Foundation's "My Child Matters" program, the GFAOP resolved to develop an international HBR network to collect quality data on children attending the Pediatric Oncology Units (POUs).All children entering POUs from January 2016 to December 2018 were registered using an online questionnaire. Data collection included information on diagnosis, disease stage, demographics, socioeconomic status, and outcome. An intensive training program was developed to improve both data quality and quantity.Among the 3348 children registered, 3230 had a suspected cancer, 681 were not confirmed. A diagnosis was confirmed on radiological, clinical, or histological examination for 2549 children including Burkitt lymphoma (516: 20%)-the most frequent diagnosis, Wilms' tumor (459: 18%), retinoblastoma (357: 14%), and acute lymphoblastic leukemia (345: 13%). Of these, 2187 children were treated. Early deaths, abandonment, economic difficulties, and lack of equipment were some of the reasons offered to explain the numbers of undiagnosed and untreated children. Vital status is known for 1994 children: 1187 died and 807 were alive, 551 of these with a follow-up 12 months.This work has provided reliable data on children attending the POUs, especially clarifying reasons and occasions for care rupture. The data will help to identify material, human resources, and staff training needs, to evaluate progress, and to encourage consideration of pediatric cancer in national cancer plans.
-
6دورية أكاديمية
لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل. -
7
المؤلفون: Fousseyni Traoré, Laila Hessissen, Jean Michon, Line Couitchere
المصدر: Pediatric Blood & Cancer
مصطلحات موضوعية: medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, MEDLINE, French, Hematology, language.human_language, Patient management, Oncology, Family medicine, Pediatrics, Perinatology and Child Health, Pandemic, language, Pediatric oncology, Medicine, Pediatrics, Perinatology, and Child Health, business
-
8
المؤلفون: Donafologo Daouda Yéo, Yao Nicaise Atiméré, Line Couitchere, Jeannette Bassimbié Kakou Danho, Daouda Koné
المصدر: Advances in Hematology
Advances in Hematology, Vol 2021 (2021)مصطلحات موضوعية: education.field_of_study, medicine.medical_specialty, Pediatrics, Hemoglobin electrophoresis, Article Subject, business.industry, Public health, Population, Cote d ivoire, Hematology, Disease, University hospital, 03 medical and health sciences, 0302 clinical medicine, Hemoglobin A, 030220 oncology & carcinogenesis, Medicine, Diseases of the blood and blood-forming organs, Hemoglobin, RC633-647.5, education, business, 030215 immunology, Research Article
الوصف: Sickle cell disease is a hereditary disease that predominantly affects black people. It is very widespread in sub-Saharan Africa, particularly at the Lehmann “sickle belt” level, where the prevalence of the hemoglobin S involves at least 10% of the population in West Africa and can reach 40% in Central Africa. In Côte d’Ivoire, the prevalence of the hemoglobin S is about 12–14% in the general population and about 11.71% in the child population in Abidjan. On the other hand, its coexistence with other hemoglobin phenotypes such as AC (6.2%) and β-thalassemia (2.7%) traits may also cause composite heterogeneous sickle cell disease, e.g., SC or S/β-thalassemia in this study. Since 2009, sickle cell disease has been recognized as a public health problem; however, much still remains to be performed despite the progress achieved. The objective of this study is thus to promote a rapid screening for the struggling against sickle cell disease in Côte d’Ivoire. This study was carried out over 6 months (April–September 2019) and has included 336 children, of which 236 all-comers, recruited in the municipality of Treichville in Abidjan and 100 other children with already known hemoglobin phenotype followed up in the Hematology Department of the University Hospital of Treichville. Two tests were used: the HemoTypeSC™ for rapid screening and the hemoglobin electrophoresis which is the reference method used for confirming the diagnosis in the laboratory. The findings confirmed the reliability of the HemoTypeSC™ with a sensitivity and specificity at 100% for the detection of hemoglobin A, S, and C. On the other hand, this sensitivity and specificity drop to 98.2% and 99.7%, respectively, when we analyze all the 336 children together, including the cases with HbF detected by hemoglobin electrophoresis. Hence, the importance of performing certainty tests following the HemoTypeSC™ screening test in order to determine the accurate phenotypes and proportions of the types of hemoglobin. The prevalence of hemoglobin S in subgroup 1 of 236 children of all-comers was 15%. The HemoTypeSC™ is therefore reliable, inexpensive, and disposable for rapid screening and early detection of sickle cell disease in Côte d’Ivoire. The HemoTypeSC™ provides rapid detection of hemoglobin phenotypes HbAA, HbSS, HbSC, HbCC, HbAS, and HbAC.
وصف الملف: text/xhtml
-
9
المؤلفون: Jacob Slanziahuelie Enoh, Line Couitchere, Jean Jacques Atteby Yao, Lassina Cisse, Vincent Kouadio Asse, Baumaney Sylvanus Koui Beossin, Richard Azagoh Kouadio
المصدر: International Journal of Medical Reviews and Case Reports, Vol 4, Iss 1 (2020)
مصطلحات موضوعية: medicine.medical_specialty, child, medicine.diagnostic_test, treatment, Adjuvant chemotherapy, Bone cancer, business.industry, diagnosis, Osteomyelitis, General surgery, lcsh:R, Cancer, lcsh:Medicine, medicine.disease, Primary tumor, osteosarcoma, Biopsy, medicine, Etiology, Osteosarcoma, business
الوصف: Background: In pediatric, it is sometimes difficult to differentiate the relapse of primary tumor from other diagnoses such as osteomyelitis, without performing an organ biopsy. In addition, primitive bone cancer represents 6% of children cancer. Etiologies are predominated by the osteosarcoma that represents around 30 - 80% of the original sarcomas of the skeleton. Case presentation: The authors report a case of 8 years old african boy with osteosarcoma. He suffered of a painful tumefaction of the left leg. That was declared since 6 months with the alteration of his general shape. In the beginning of his symptomatology, he was taken in charge by a small town near Abidjan where the osteomyelitis diagnosis was made. He was not only given an antibiotherapy but also his leg was put in plaster. Conclusion: The biopsy osseous performed on a piece representing the histological exam remains the very key of the diagnosis. The association of both the conservative surgery of the limb and the adjuvant chemotherapy allows today to have a reproduction rate of 7%.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6922a29d2ad4bb584c3eb5aff0f6b67e
http://www.mdpub.net/index.php?fulltxt=76996&fulltxtj=172&fulltxtp=172-1575719190.pdf -
10
المؤلفون: Delphine Lagou, Daouda Koné, Yao Nicaise Atiméré, Line Couitchere
المصدر: Open Journal of Blood Diseases. :10-16
مصطلحات موضوعية: medicine.medical_specialty, business.industry, Induction chemotherapy, Wilms' tumor, medicine.disease, Gastroenterology, Lymphoma, Transplantation, Maintenance therapy, hemic and lymphatic diseases, Internal medicine, medicine, Rhabdomyosarcoma, Complication, business, Burkitt's lymphoma
الوصف: The Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease (VOD), is a well-known complication of haematopoietic stem cell transplantation, of the treatment of Wilms tumor and rhabdomyosarcoma and maintenance therapy of acute lymphoblastic leukemias. Its occurrence is rare in other cancers of the child. We report the observation of a 7-year-old girl with Burkitt’s lymphoma who developed a severe HSOS during her second induction treatment with dexamethasone, cisplatin, cytosine arabinoside. The evolution was fatal. This observation shows that the diagnosis of HSOS should not be excluded in the absence of the risk factors usually described.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6d8e113ec419eb4234ac8166bfd1d5a9
https://doi.org/10.4236/ojbd.2018.81002
Full Text Finder