المؤلفون: Sankhala K; Cedars-Sinai Medical Center, Beverly Hills, CA, USA., Takimoto CH; Institute for Drug Development, Cancer Therapy & Research Center, San Antonio, TX, USA., Mita AC; Cedars-Sinai Medical Center, Los Angeles, CA, USA., Xiong H; The Center for Cancer and Blood Disorders/SCRI, Fort Worth, TX, USA., Rodón J; Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mehrvarz Sarshekeh A; Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA., Burns K; Institute for Drug Development, Cancer Therapy & Research Center, San Antonio, TX, USA., Iizuka K; Delta-Fly Pharma Inc., Tokushima, Japan., Kopetz S; Department of Gastrointestinal Medical Oncology, Unit 426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA. skopetz@mdanderson.org.

المصدر: Investigational new drugs [Invest New Drugs] 2019 Feb; Vol. 37 (1), pp. 76-86. Date of Electronic Publication: 2018 Apr 18.

نوع المنشور: Clinical Trial, Phase I; Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Country of Publication: United States NLM ID: 8309330 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0646 (Electronic) Linking ISSN: 01676997 NLM ISO Abbreviation: Invest New Drugs Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacokinetics , Antineoplastic Agents/*pharmacology , Deoxycytidine/*analogs & derivatives , Isoflurophate/*chemistry , Neoplasms/*drug therapy, Adult ; Aged ; Antineoplastic Agents/administration & dosage ; Deoxycytidine/administration & dosage ; Deoxycytidine/pharmacokinetics ; Deoxycytidine/pharmacology ; Drug Administration Schedule ; Female ; Follow-Up Studies ; Humans ; Infusions, Intravenous ; Male ; Maximum Tolerated Dose ; Middle Aged ; Neoplasms/pathology ; Prognosis ; Tissue Distribution

المؤلفون: Grem JL; National Cancer Institute-Navy Medical Oncology, National Naval Medical Center, Bethesda, MD 20889, USA. gremj@mail.nih.gov, Quinn MG, Keith B, Monahan BP, Hamilton JM, Xu Y, Harold N, Nguyen D, Takimoto CH, Rowedder A, Pang J, Morrison G, Chen A

المصدر: Cancer chemotherapy and pharmacology [Cancer Chemother Pharmacol] 2003 Dec; Vol. 52 (6), pp. 487-96. Date of Electronic Publication: 2003 Aug 29.

نوع المنشور: Clinical Trial; Clinical Trial, Phase I; Journal Article

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7806519 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0344-5704 (Print) Linking ISSN: 03445704 NLM ISO Abbreviation: Cancer Chemother Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols/*pharmacology , Deoxycytidine/*analogs & derivatives , Neoplasms/*drug therapy, Administration, Oral ; Adult ; Aged ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics ; Deoxycytidine/administration & dosage ; Drug Administration Schedule ; Female ; Floxuridine/administration & dosage ; Humans ; Infusions, Intravenous ; Leucovorin/administration & dosage ; Male ; Maximum Tolerated Dose ; Middle Aged ; Neoplasms/enzymology ; Neutropenia/chemically induced ; Ribonucleotide Reductases/antagonists & inhibitors ; Thrombocytopenia/chemically induced ; Gemcitabine

المؤلفون: Patnaik A; Institute for Drug Development, Cancer Therapy and Research Center, San Antonio, Texas 78229, USA. apatniak@idd.org, Eckhardt SG, Izbicka E, Tolcher AA, Hammond LA, Takimoto CH, Schwartz G, McCreery H, Goetz A, Mori M, Terada K, Gentner L, Rybak ME, Richards H, Zhang S, Rowinsky EK

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2003 Oct 15; Vol. 9 (13), pp. 4761-71.

نوع المنشور: Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Print ISSN: 1078-0432 (Print) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Alkyl and Aryl Transferases/*antagonists & inhibitors , Deoxycytidine/*administration & dosage , Deoxycytidine/*analogs & derivatives , Enzyme Inhibitors/*pharmacokinetics , Neoplasms/*drug therapy , Quinolones/*administration & dosage, Adult ; Aged ; Aged, 80 and over ; Antimetabolites, Antineoplastic/pharmacokinetics ; Area Under Curve ; Dose-Response Relationship, Drug ; Drug Interactions ; Farnesyltranstransferase ; Female ; Humans ; Leukocytes, Mononuclear/drug effects ; Male ; Middle Aged ; Models, Chemical ; Protein Prenylation ; Time Factors ; Treatment Outcome ; ras Proteins/metabolism ; Gemcitabine