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المؤلفون: Thibault Alle, Carmine Varricchio, Yuemang Yao, Bobby Lucero, Goodwell Nzou, Stefania Demuro, Megan Muench, Khoa D. Vuong, Killian Oukoloff, Anne-Sophie Cornec, Karol R. Francisco, Conor R. Caffrey, Virginia M.-Y. Lee, Amos B. Smith, Andrea Brancale, Kurt R. Brunden, Carlo Ballatore
المصدر: Journal of medicinal chemistry, vol 66, iss 1
مصطلحات موضوعية: Aging, Medicinal & Biomolecular Chemistry, Organic Chemistry, Neurosciences, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Neurodegenerative Diseases, Pharmacology and Pharmaceutical Sciences, Neurodegenerative, Alzheimer's Disease, Microtubules, Brain Disorders, Structure-Activity Relationship, Medicinal and Biomolecular Chemistry, Pyrimidines, Alzheimer Disease, Tubulin, Drug Discovery, Neurological, Acquired Cognitive Impairment, Molecular Medicine, Humans, Dementia
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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eec72b970204417d9dd0cef026d13404
https://escholarship.org/uc/item/7zv2q880 -
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المؤلفون: Romeo Romagnoli, Paola Oliva, Filippo Prencipe, Stefano Manfredini, Federica Budassi, Andrea Brancale, Salvatore Ferla, Ernest Hamel, Diana Corallo, Sanja Aveic, Lorenzo Manfreda, Elena Mariotto, Roberta Bortolozzi, Giampietro Viola
المصدر: Pharmaceuticals; Volume 15; Issue 8; Pages: 1031
Pharmaceuticalsمصطلحات موضوعية: 4]triazolo[1, Drug Discovery, [1,2,4]triazolo[1,5-a]pyrimidine, antitumor activity, apoptosis, colchicine binding site, microtubule-targeting agents, Pharmaceutical Science, Molecular Medicine, [1, 5-a]pyrimidine
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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c08dcd9c99600c2e0ad2a7d35ddf5c1
https://hdl.handle.net/11577/3474772 -
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المؤلفون: Andrea Brancale, Maria Rita Gulotta, Riccardo Brambilla, Ugo Perricone
المصدر: Pharmaceuticals
Volume 14
Issue 11
Pharmaceuticals, Vol 14, Iss 1099, p 1099 (2021)مصطلحات موضوعية: MAPK/ERK pathway, GTP', Pharmaceutical Science, Peptide, Article, Protein–protein interaction, Pharmacy and materia medica, Drug Discovery, Extracellular, intellectual disability (ID), MM-GBSA, chemistry.chemical_classification, Kinase, Chemistry, hydrogen-bond surrogate, Rational design, molecular dynamics, Cell biology, RS1-441, protein–protein interaction, Cell-penetrating peptide, autism spectrum disorder (ASD), Molecular Medicine, Medicine, computational residue scanning, ERK signalling, cocaine addiction, RasGRF1, Ras
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المؤلفون: Andrea Brancale, Charles Martin Heard, David Whitaker, Melissa Fallon, Matthew J. Burton, Carmine Varricchio, Hannah M. Boostrom, Philip N. Lewis, Siân R. Morgan, Peter W. J. Morrison, Andrew J. Quantock, Melissa G. Hewitt
المصدر: Molecular Pharmaceutics. 17:1428-1441
مصطلحات موضوعية: Drug, medicine.medical_specialty, Corneal Infection, Contact Lenses, Swine, media_common.quotation_subject, Pharmaceutical Science, 02 engineering and technology, 030226 pharmacology & pharmacy, Keratitis, Cornea, 03 medical and health sciences, Drug Delivery Systems, 0302 clinical medicine, Anti-Infective Agents, Ophthalmology, Drug Discovery, medicine, Animals, media_common, chemistry.chemical_classification, Cyclodextrin, Chemistry, Chlorhexidine, beta-Cyclodextrins, Hydrogels, 021001 nanoscience & nanotechnology, medicine.disease, eye diseases, In vitro, Contact lens, medicine.anatomical_structure, Tears, Molecular Medicine, sense organs, Ophthalmic Solutions, 0210 nano-technology, medicine.drug
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المؤلفون: Paola Oliva, Romeo Romagnoli, Elena Mariotto, Luisa Carlota Lopez-Cara, Salvatore Ferla, Maria Kimatrai Salvador, Elena Mattiuzzo, Andrea Brancale, Mariem Chayah, Filippo Prencipe, Ernest Hamel, Giampietro Viola, Roberto Ronca, Roberta Bortolozzi, Santiago Schiaffino Ortega, Stefania Baraldi, Pier Giovanni Baraldi
المصدر: Journal of Medicinal Chemistry. 62:1274-1290
مصطلحات موضوعية: Drug Evaluation, Preclinical, Apoptosis, Microtubules, 01 natural sciences, Polymerization, chemistry.chemical_compound, Pyrimidine analogue, derivates, Drug Discovery, Epidermal growth factor receptor, vascular disrupting agents, tyrosine kinase, EGFR inhibitors, colchicine site, lung cancer,tubulin, anticancer, thienopyrimidine, discovery, derivates, Membrane Potential, Mitochondrial, 0303 health sciences, biology, Kinase, Cell Cycle, tyrosine kinase, thienopyrimidine, ErbB Receptors, Biochemistry, vascular disrupting agents, Molecular Medicine, Poly(ADP-ribose) Polymerases, Tyrosine kinase, Pyrimidine, macromolecular substances, anticancer, NO, 03 medical and health sciences, Enzyme activator, Microtubule, Cell Line, Tumor, colchicine site, Humans, Cell Proliferation, 030304 developmental biology, EGFR inhibitors, Drug Discovery3003 Pharmaceutical Science, Vascular Endothelial Growth Factor Receptor-2, 0104 chemical sciences, Enzyme Activation, lung cancer, 010404 medicinal & biomolecular chemistry, Pyrimidines, Tubulin, tubulin, chemistry, Drug Design, biology.protein, Colchicine, Reactive Oxygen Species, discovery, HeLa Cells
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المؤلفون: Jane Kovalevich, Ludovica Monti, Goodwell Nzou, Amos B. Smith, Michael J. James, Bobby Lucero, Anne-Sophie Cornec, Yuemang Yao, Andrea Brancale, Carlo Ballatore, Kurt R. Brunden, Killian Oukoloff, Thibault Alle, Virginia M.-Y. Lee, Carmine Varricchio, John Q. Trojanowski
المصدر: J Med Chem
Journal of medicinal chemistry, vol 64, iss 2مصطلحات موضوعية: Models, Molecular, Aging, Neurodegenerative, Alzheimer's Disease, 01 natural sciences, Microtubules, Transgenic, Mice, Models, Drug Discovery, 2.1 Biological and endogenous factors, Aetiology, Cells, Cultured, Neurons, 0303 health sciences, Cultured, Chemistry, Brain, Neurodegenerative Diseases, Pharmacology and Pharmaceutical Sciences, Molecular Docking Simulation, Tauopathies, Neurological, Molecular Medicine, Genetically modified mouse, Cells, Medicinal & Biomolecular Chemistry, Transgene, Mice, Transgenic, Computational biology, Article, Cell Line, Medicinal and Biomolecular Chemistry, 03 medical and health sciences, Structure-Activity Relationship, Microtubule, Acquired Cognitive Impairment, Structure–activity relationship, Animals, Humans, Computer Simulation, 030304 developmental biology, Extramural, Organic Chemistry, Neurosciences, Molecular, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Triazoles, Brain Disorders, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Pyrimidines, Cell culture, Dementia
وصف الملف: application/pdf
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المؤلفون: Charles Martin Heard, Andrea Brancale, Carmine Varricchio, Pascale Aeschlimann, Kathy Beirne, Marcela Votruba, Malgorzata Barbara Rozanowska
المصدر: Journal of medicinal chemistry. 63(22)
مصطلحات موضوعية: Drug, Cell Survival, media_common.quotation_subject, Mitochondrial disease, Optic Atrophy, Hereditary, Leber, Pharmacology, 01 natural sciences, Optic neuropathy, 03 medical and health sciences, Mice, Drug Discovery, medicine, NAD(P)H Dehydrogenase (Quinone), Idebenone, Potency, Animals, Humans, Mode of action, 030304 developmental biology, media_common, 0303 health sciences, Dose-Response Relationship, Drug, Chemistry, Leber's hereditary optic neuropathy, Hep G2 Cells, medicine.disease, 0104 chemical sciences, Mice, Inbred C57BL, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Treatment Outcome, Pharmaceutical Preparations, Molecular Medicine, Female, NAD+ kinase, medicine.drug, Naphthoquinones
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المؤلفون: Baptiste Martin, Barbara Selisko, Bruno Canard, Arissa Falat, Joy E. Thames, Wahiba Aouadi, Etienne Decroly, Bruno Coutard, Marcella Bassetto, Charles D. Waters, Katherine L. Seley-Radtke, Coralie Valle, Andrea Brancale
المساهمون: University of Maryland School of Medicine, University of Maryland System, Architecture et fonction des macromolécules biologiques (AFMB), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Swansea University, Unité des Virus Emergents (UVE), Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM), Cardiff University, University of Maryland School of Dentistry [Baltimore] (UMSOD), United States Department of Health & Human Services National Institutes of Health (NIH) - USA NIGMS T32 GM066706United States Department of Health & Human Services National Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) R21AI135252-01, Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)
المصدر: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2020, 28 (22), pp.115713. ⟨10.1016/j.bmc.2020.115713⟩
Bioorganic and Medicinal Chemistry Letters, 2020, 28 (22), pp.115713. ⟨10.1016/j.bmc.2020.115713⟩
Bioorganic & Medicinal Chemistryمصطلحات موضوعية: Models, Molecular, Methyltransferase, viruses, [SDV]Life Sciences [q-bio], Clinical Biochemistry, Pharmaceutical Science, Acyclovir, Virus Replication, 01 natural sciences, Biochemistry, Dengue fever, Dengue, chemistry.chemical_compound, RNA polymerase, Drug Discovery, Nucleoside, Fleximers, biology, Molecular Structure, Chemistry, virus diseases, Flavivirus, Nucleosides, 3. Good health, Molecular Medicine, Microbial Sensitivity Tests, Antiviral Agents, Virus, Article, Structure-Activity Relationship, Zika, Yellow Fever, medicine, Molecular Biology, ComputingMethodologies_COMPUTERGRAPHICS, Dose-Response Relationship, Drug, 010405 organic chemistry, Organic Chemistry, RNA, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, medicine.disease, Virology, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry
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المؤلفون: Daniela Friese, Joachim Jakob Bugert, Martina Salerno, Andrea Brancale, Cecilia Maria Cima, Marcella Bassetto, Frank Schwarze, Mattia Basso
المصدر: Molecules, Vol 25, Iss 4813, p 4813 (2020)
Molecules
Volume 25
Issue 20مصطلحات موضوعية: Microcephaly, Adenosine, viruses, Pharmaceutical Science, Virus Replication, Article, Tubercidin, Analytical Chemistry, Zika virus, Small Molecule Libraries, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, lcsh:Organic chemistry, Drug Discovery, antiviral agents, Autophagy, Cell Adhesion, medicine, aryloxyphosphoramidate prodrugs, Humans, 030212 general & internal medicine, Physical and Theoretical Chemistry, Polymerase, 030304 developmental biology, Cytopathic effect, 0303 health sciences, biology, Nucleoside analogue, Zika Virus Infection, business.industry, Organic Chemistry, Nucleosides, in vitro screening, biology.organism_classification, medicine.disease, Virology, Flavivirus, chemistry, Chemistry (miscellaneous), Host-Pathogen Interactions, biology.protein, Molecular Medicine, Vaccinia, business, Nucleoside, medicine.drug
وصف الملف: application/pdf
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المؤلفون: Ernest Hamel, Salvatore Ferla, Filippo Prencipe, Paola Oliva, Matteo Zurlo, Alessia Finotti, Andrea Brancale, Romeo Romagnoli, Roberto Gambari, Sandra Liekens, Barbara Cacciari, Jan Balzarini, Stefano Manfredini
المصدر: Molecules
Volume 25
Issue 7
Molecules, Vol 25, Iss 1690, p 1690 (2020)مصطلحات موضوعية: antiproliferative activity, Programmed cell death, structure–activity relationship, Stereochemistry, Pharmaceutical Science, Peripheral blood mononuclear cell, Analytical Chemistry, lcsh:QD241-441, microtubules, 03 medical and health sciences, 0302 clinical medicine, lcsh:Organic chemistry, Microtubule, Drug Discovery, Structure–activity relationship, Physical and Theoretical Chemistry, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Organic Chemistry, Cell cycle, Tubulin, tubulin, Chemistry (miscellaneous), Apoptosis, 030220 oncology & carcinogenesis, Cancer cell, biology.protein, Molecular Medicine, tetrahydrothieno[2,3-c]pyridine
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