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1دورية أكاديمية
المؤلفون: Xiaodi Yu, Rosalie E. Matico, Robyn Miller, Dhruv Chauhan, Bertrand Van Schoubroeck, Karolien Grauwen, Javier Suarez, Beth Pietrak, Nandan Haloi, Yanting Yin, Gary John Tresadern, Laura Perez-Benito, Erik Lindahl, Astrid Bottelbergs, Daniel Oehlrich, Nina Van Opdenbosch, Sujata Sharma
المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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2
المؤلفون: Shannon Dallas, Thomas Wilde, Avijit Ghosh, Jianyao Wang, Yawei Dong, Gaochao Tian, Daohong Liao, Xueliang Li, Lawrence Szewczuk, Peter King, David C. Evans, Yifan Shi, Kurtis E. Bachman, Javier Suarez, Beth Pietrak, James P. Edwards, Carlo Sensenhauser, Hao Chen, Vineet Pande, Peter J. Connolly, Karen DiLoreto, William G Bonnette, Shefali Patel, Zhuming Zhang
المصدر: Journal of Medicinal Chemistry. 64:11570-11596
مصطلحات موضوعية: Male, Adenoma, Cell Survival, Colorectal cancer, Antineoplastic Agents, Disease, Etoricoxib, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Cell Proliferation, Cyclooxygenase 2 Inhibitors, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, medicine.disease, Mice, Inbred C57BL, Celecoxib, Cyclooxygenase 2, biology.protein, Cancer research, Chemoprotective, Molecular Medicine, Cyclooxygenase, Drug Screening Assays, Antitumor, Colorectal Neoplasms, Ex vivo, medicine.drug
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3
المؤلفون: Guozhang Xu, Zhijie Liu, Xinkang Wang, Tianbao Lu, Renee L. DesJarlais, Tho Thieu, Jing Zhang, Zheng Huang Devine, Fuyong Du, Qiu Li, Cynthia M. Milligan, Paul Shaffer, Peder E. Cedervall, John C. Spurlino, Christopher F. Stratton, Beth Pietrak, Lawrence M. Szewczuk, Victoria Wong, Ruth A. Steele, Wouter Bruinzeel, Madhu Chintala, Jose Silva, Michael D. Gaul, Mark J. Macielag, Ravi Nargund
المصدر: Journal of medicinal chemistry. 65(15)
مصطلحات موضوعية: Dogs, Pyridines, Drug Design, Drug Discovery, Molecular Medicine, Animals, Anticoagulants, Rabbits, Factor XIa, Rats
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المؤلفون: Yong Jiang, Tia Lewis, Patricia M. McCormick, Michael Schaber, Beth Pietrak, Rachel D. Totoritis, Marc A. Holbert, Lawrence M. Szewczuk, Daniel Fornwald, William G. Bonnette, Geoffrey Quinque, Maggie Grimes, Rosalie E. Matico, Ed Dul, Randy K. Bledsoe, Derrick W. Meinhold, Stephanie Chen
المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reportsمصطلحات موضوعية: 0301 basic medicine, Models, Molecular, 030103 biophysics, Computer science, Protein Conformation, High-throughput screening, lcsh:Medicine, Computational biology, 010402 general chemistry, Ligands, 01 natural sciences, Protein expression, Article, 03 medical and health sciences, Mice, Protein structure, Drug Discovery, Animals, Humans, lcsh:Science, Multidisciplinary, business.industry, Drug discovery, lcsh:R, Proteins, Modular design, 0104 chemical sciences, Structural biology, Drug screening, Reagent, Feasibility Studies, lcsh:Q, business, Ligation
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المؤلفون: Frederik J. Rombouts, Lento William, Ingrid Velter, Ann Vos, Aldo Peschiulli, Reuillon Tristan, Maria Dominguez Blanco, Matthieu Jouffroy, Lisa McQueen, Helena Steyvers, Mariette Bekkers, Cristina Altrocchi, Beth Pietrak, Seong Joo Koo, Lawrence Szewczuk, David Walker, Kathryn Packman, Ruud Bueters, Petra Vinken, Amy Johnson, Ricardo Attar, Ulrike Philippar
المصدر: Cancer Research. 82:2133-2133
مصطلحات موضوعية: Cancer Research, Oncology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::d26c71d6d913e202af7c340f376b66d7
https://doi.org/10.1158/1538-7445.am2022-2133 -
6
المؤلفون: Helen F. Sneddon, Rodolfo Cadilla, Young Do, Jeffrey Guss, Gordon Saxty, Paresh I. Masuria, Caterina Musetti, J. Darren Stuart, Beth Pietrak, Daniela Ennulat, Andrew G. King, Barry G. Shearer, Nicholas J. Kramer, Peckham Gregory, Chuck Poole, Alan R. Rendina, Daniel J. Price, H. Fritz Kramer, Tiahshun Xu, Girish Sati, Stephen A. Thomson, Patricia A. Elkins, Jason A. Holt, Alan V. McDougal, Joseph W. Wilson, Susan B. Laffan, Michael R. Jeune, Jan Klapwijk, Dean N. Thomas, Mark Youngman, Paris Ward, Paul N. Mortenson, Lisa M. Shewchuk, Eugene L. Stewart, David N. Deaton
المصدر: Bioorganicmedicinal chemistry. 28(23)
مصطلحات موضوعية: Male, Cell Survival, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Polar surface area, chemistry.chemical_compound, Mice, Structure-Activity Relationship, Pharmacokinetics, Drug Stability, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Enzyme Inhibitors, Muscle, Skeletal, Molecular Biology, chemistry.chemical_classification, Aza Compounds, Binding Sites, 010405 organic chemistry, Drug discovery, Organic Chemistry, Quinoline, Brain, Cns toxicity, 0104 chemical sciences, Rats, Intramolecular Oxidoreductases, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Kinetics, Enzyme, Hematopoietic prostaglandin D synthase, chemistry, Quinolines, Molecular Medicine
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7
المؤلفون: Young Do, Lisa A. Orband-Miller, Anthony Shillings, Joelle Le, Caterina Musetti, Gordon Saxty, Beth Pietrak, Simon Teanby Hodgson, Petrov Kimberly, Daniel J. Price, Stephen A. Thomson, Eugene L. Stewart, Christie Schulte, Ashley Paul Hancock, Terrence L. Smalley, Michael R. Jeune, H. Fritz Kramer, Chuck Poole, Heather Hobbs, Kirsten M. Kahler, J. Darren Stuart, Paul N. Mortenson, Robert T. Nolte, Jason A. Holt, David N. Deaton, Don O. Somers, Elsie Diaz, Jeffrey Guss, Robert T. Gampe, Peckham Gregory
المصدر: Bioorganic & Medicinal Chemistry Letters. 47:128113
مصطلحات موضوعية: Imidazopyridine, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, 01 natural sciences, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Pyridine, Virtual screen, medicine, Humans, Enzyme Inhibitors, Molecular Biology, Class (computer programming), Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, 0104 chemical sciences, Intramolecular Oxidoreductases, 010404 medicinal & biomolecular chemistry, Orally active, chemistry, Molecular Medicine
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8دورية أكاديمية
المؤلفون: Lei Jiang, Alexander A. Shestov, Pamela Swain, Chendong Yang, Seth J. Parker, Qiong A. Wang, Lance S. Terada, Nicholas D. Adams, Michael T. McCabe, Beth Pietrak, Stan Schmidt, Christian M.
المصدر: Nature, Nature. 532(7598):255-258
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9دورية أكاديمية
المؤلفون: Han Dai, April W. Case, Thomas V. Riera, Thomas Considine, Jessica E. Lee, Yoshitomo Hamuro, Huizhen Zhao, Yong Jiang, Sharon M. Sweitzer, Beth Pietrak, Benjamin Schwartz, Charles A. Blum
المصدر: Nature, Nature Communications. 6(1):1-10
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المؤلفون: Hong Zhang, Benjamin Schwartz, Michael D. Schaber, Mark A. Seefeld, Jon-Paul Jaworski, Guanglei Cui, Shu-Yun Zhang, Kelly Federowicz, Aidan G. Gilmartin, Faitg Thomas H, Martin Brandt, Jingsong Yang, Mark Richter, Robert B. Kirkpatrick, Dean E. McNulty, Neysa Nevins, Arthur Groy, Elsie Diaz, Rakesh Kumar, Stan F. Martens, Amber D. Jones, Dirk A. Heerding, Peng Xin, Robert H. Sinnamon, Elisabeth A. Minthorn, Michael G. Darcy, Beth Pietrak
المصدر: Nature Chemical Biology. 10:181-187
مصطلحات موضوعية: Amino Acid Motifs, Phosphatase, Allosteric regulation, Administration, Oral, Aminopyridines, Antineoplastic Agents, Mice, SCID, Biology, Pyruvate dehydrogenase phosphatase, Models, Biological, Mice, chemistry.chemical_compound, Allosteric Regulation, Catalytic Domain, Cell Line, Tumor, Neoplasms, Phosphoprotein Phosphatases, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Kinase, Dipeptides, Cell Biology, Protein phosphatase 2, Enzyme Activation, Protein Phosphatase 2C, Disease Models, Animal, chemistry, Biochemistry, Cell culture, Cancer research, Heterografts, Phosphorylation, Female, Drug Screening Assays, Antitumor, Growth inhibition