المؤلفون: Po Hu, Hongzheng Wang, Xiaoxuan Yu, Wenzhuo Sun, Hui Hui, Hui Li, Mengyuan Zhu, Zhanyu Wang, Jingyan Xu, Qinglong Guo, Yingjie Qing

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 3178-3192 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: NPC, Niemann-Pick type disease C, Cathepsin D, ATG, autophagy related, NH4Cl, ammonium chloride, Lysosomal damage, Calcium in biology, Hematological malignancies, 0302 clinical medicine, RAB7A, RAS-related protein RAB-7a, K48, lysine 48, LC3, microtubule-associated protein 1 light chain 3, TFEB, transcription factor EB, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, RT-qPCR, real time quantitative PCR, Chemistry, LCD, lysosome-dependent cell death, CaN, calcineurin, P62/SQSTM1, sequestosome 1, Cell biology, TRPML1, transient receptor potential mucolipin 1, medicine.anatomical_structure, Cholesterol, 030220 oncology & carcinogenesis, shRNA, short hairpin RNA, Original Article, CsA, cyclosporine A, DAPI, 4′,6-diamidino-2-phenylindole dihydrochloride, Programmed cell death, AO, acridine orange, CTSD, cathepsin D, LW-218, PBS, phosphate-buffered saline, CTSB, cathepsin B, LMP, lysosome membrane permeabilization, EGTA, ethylene glycol-bis(2-aminoethyl ether)-N,N,N′,N′-tetraacetic acid, RM1-950, Lysosome-dependent cell death, 03 medical and health sciences, Dex, dexamethasone, ROS, reactive oxygen species, FBS, fetal bovine serum, Lysosome, NPC1, NPC intracellular cholesterol transporter 1, medicine, BAF A1, bafilomycin A1, 030304 developmental biology, Cathepsin, PBMCs, peripheral blood mononuclear cells, Lysosomal membrane permeabilization, K63, lysine 63, Cell growth, DCFH-DA, 2,7-dichlorodi-hydrofluorescein diacetate, Autophagy, BID, BH3-interacting domain death agonist, Lysophagy, OD, optical density, TFEB, CCK8, Cell Counting Kit, Therapeutics. Pharmacology, LAMPs, lysosomal-associated membrane proteins

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2bc1bb062d92dcf545995a174a1320
http://www.sciencedirect.com/science/article/pii/S2211383521000411

المؤلفون: James E. Goldman, Alice Tang, Michelle L. Olsen, Natasha L. Pacheco, Jiangtao Li, Daniel Flint, Brett S. Phinney, Anthony W. Herren, Fatima Khan, Michael R. Heaven

المصدر: Molecular & cellular proteomics : MCP, vol 21, iss 1
Molecular & Cellular Proteomics : MCP

مصطلحات موضوعية: Proteomics, Cnp, 2′,3′-cyclic-nucleotide 3′-phosphodiesterase, Nadk2, NAD kinase 2, mitochondrial, Pck2, phosphoenolpyruvate carboxykinase [GTP], mitochondrial, Slc16a1, monocarboxylate transporter 1, PPAR, peroxisome proliferator-activated receptor, Mog, myelin-oligodendrocyte glycoprotein, Nfe2l2, nuclear factor erythroid 2-related factor 2, Mlc1, membrane protein MLC1, Biochemistry, C1qc, complement C1q subcomponent subunit C, Transgenic, Analytical Chemistry, Acadl, Long-chain specific acyl-CoA dehydrogenase, mitochondrial, Myelin, Mice, Gsr, glutathione reductase, mitochondrial, Cryl1, lambda-crystallin homolog, Sqstm1, sequestosome-1, BCA, bicinchoninic acid assay, LC3, microtubule-associated protein 1A/1B-light chain 3, Gliosis, SRM, selected reaction monitoring, Aetiology, Gclm, glutamate--cysteine ligase regulatory subunit, μDIA, micro-data-independent acquisition, Acsl3, long-chain-fatty-acid--CoA ligase 3, Cat, catalase, Acot2, Acyl-coenzyme A thioesterase 2, Glial fibrillary acidic protein, Rps27a, ubiquitin-40S ribosomal protein S27a, Acsl6, long-chain-fatty-acid--CoA ligase 6, Aldh1l1, Cytosolic 10-formyltetrahydrofolate dehydrogenase, Slc25a18, mitochondrial glutamate carrier 2, Bsn, protein bassoon, Fabp7, fatty acid binding protein, brain, Plp1, myelin proteolipid protein, Gsta3, glutathione S-transferase A3, Prdx6, peroxiredoxin-6, Alexander Disease, Slc6a11, sodium- and chloride-dependent GABA transporter 3, Ccnd2, G1/S-specific cyclin-D2, Stxbp5l, syntaxin-binding protein 5-like, GAPDH, glyceraldehyde 3 phosphate dehydrogenase, Slc6a17, sodium-dependent neutral amino acid transporter SLC6A17, Biochemistry & Molecular Biology, Ilk, integrin-linked protein kinase, Kcnj10, ATP-sensitive inward rectifier potassium channel 10, Ugt8, Gan, gigaxonin, Ttyh1, protein tweety homolog 1, Hsp27, heat shock protein beta-1, TBI, traumatic brain injury, reactive gliosis, Hmgcs2, hydroxymethylglutaryl-CoA synthase, mitochondrial, Idh2, isocitrate dehydrogenase [NADP], mitochondrial, KEGG, Kyoto encyclopedia of genes and genomes, Genetics, Humans, Gpr37l1, prosaposin receptor GPR37L1, Molecular Biology, Txnrd1, thioredoxin reductase 1, cytoplasmic, Slc38a3, sodium-coupled neutral amino acid transporter 3, Animal, DAVID, database for annotation, visualization and integrated discovery, GFAP, glial fibrillary acidic protein, astrocytes, Rack1, receptor of activated protein C kinase 1, Ugt8, 2-hydroxyacylsphingosine 1-beta-galactosyltransferase, Apoa1, apolipoprotein A-I, medicine.disease, Oligodendrocyte, GABA, gamma aminobutyric acid, Slc27a1, long-chain fatty acid transport protein 1, nervous system, Fabp7, Mutation, Mag, myelin-associated glycoprotein, Gclc, glutamate--cysteine ligase catalytic subunit, Gsto1, glutathione S-transferase omega-1, Ephx1, epoxide hydrolase 1, Gpx1, glutathione peroxidase 1, C1qa, complement C1q subcomponent subunit A, MDD, major depressive disorder, Cd44, Cd44 antigen, Slc4a4, electrogenic sodium bicarbonate cotransporter 1, Neurodegenerative, Dlg4, disks large homolog 4, TIC, total ion current, Gstm1, glutathione S-transferase Mu 1, Alexander disease, 2.1 Biological and endogenous factors, Functional ability, Ndrg2, protein NDRG2, Sfxn5, sideroflexin-5, Ca2, carbonic anhydrase 2, S1pr1, sphingosine 1-phosphate receptor 1, Gpx3, glutathione peroxidase 3, Snap25, synaptosomal-associated protein 25, Sparcl1, SPARC-like protein 1, medicine.diagnostic_test, Prdx1, peroxiredoxin-1, medicine.anatomical_structure, Neurological, Pgd, 6-phosphogluconate dehydrogenase, decarboxylating, Mbp, myelin basic protein, LPA, lysophosphatidic acid, Astrocyte, Gss, glutathione synthetase, Stat3, signal transducer and activator of transcription 3, Biotechnology, Sorbs1, Sorbin and SH3 domain-containing protein 1, RFs, Rosenthal fibers, Pygb, glycogen phosphorylase, brain form, Ctsd, cathepsin D, Ddx3x, ATP-dependent RNA helicase DDX3X, Fasn, fatty acid synthase, Slc1a2, excitatory amino acid transporter 2, PPP, pentose phosphate pathway, Mice, Transgenic, Plpp3, phospholipid phosphatase 3, Biology, C1qb, complement C1q subcomponent subunit B, CNS, central nervous system, Gja1, gap junction alpha-1 protein, PRM-MS, parallel reaction monitoring-mass spectrometry, TFA, trifluoro acetic acid, Vim, vimentin, Rare Diseases, Western blot, Downregulation and upregulation, Acox1, peroxisomal acyl-coenzyme A oxidase 1, Mobp, myelin-associated oligodendrocyte basic protein, medicine, Atp1b2, sodium/potassium-transporting ATPase subunit beta-2, Animals, Cryab, alpha-crystallin B chain, MS2, MS/MS or tandem mass spectrometry, Research, Neurosciences, Molecular biology, Ntrk2, BDNF/NT-3 growth factors receptor, Brain Disorders, AxD, Alexander disease, Disease Models, Animal, Acox3, Peroxisomal acyl-coenzyme A oxidase 3, Disease Models, biology.protein, Ugp2, UTP--glucose-1-phosphate uridylyl transferase, Acot1, Acyl-coenzyme A thioesterase 1

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27db73f1a1ae5cb5705d0a860adbda89
https://hdl.handle.net/10919/111277

المؤلفون: David Hood, Jonathan Memme, Ashley Oliveira

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: p53, muscle atrophy, mitochondrial biogenesis, ATF4, activating transcription factor 4, log2FC, log2 fold change, Biochemistry, mKO, muscle-specific KO, Mice, transcriptomics, 0302 clinical medicine, GSEA, gene set enrichment analysis, PINK1, phosphatase and tensin homolog–induced kinase 1, ClpP, caseinolytic mitochondrial matrix peptidase proteolytic subunit, SirT3, sirtuin 3, TFEB, transcription factor EB, UPRmt, mitochondrial unfolded protein response, PGC-1α, peroxisome proliferator–activated receptor gamma coactivator 1 alpha, 0303 health sciences, mitochondrial quality control, EDL, extensor digitorum longus, Mitophagy, unfolded protein response, LC3, microtubule-associated proteins 1a/1b light chain 3, CtsD, cathepsin D, Denervation, MQC, mitochondrial quality control, mitochondria, Muscular Atrophy, LonP, lon protease homolog, mitochondrial, CON, control, COX, cytochrome c oxidase, SDH, succinate dehydrogenase, lysosome, HSP, heat shock protein, Research Article, DEN, denervated, REVIGO, reduce and visualize Gene Ontology, CHOP, C/EBP homologous protein, 03 medical and health sciences, cDNA, complementary DNA, ROS, reactive oxygen species, GO, Gene Ontology, Animals, skeletal muscle, Muscle, Skeletal, Molecular Biology, 030304 developmental biology, Atg, autophagy-related protein, TA, tibialis anterior, ATF5, activating transcription factor 5, Prkn, Parkin, TFE3, transcription factor E3, Cell Biology, p62, sequestosome-1, Mitochondria, Muscle, mtDNA, mitochondrial DNA, Tumor Suppressor Protein p53, qPCR, quantitative PCR, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb3a97e49a86a03392f94c39be1c648
https://pubmed.ncbi.nlm.nih.gov/34958797

المؤلفون: Elisabeth Sehn, Christian Behl, Christof Hiebel, Franz H. Grus, Vanessa Felzen, Uwe Wolfrum, Caroline Manicam, Natarajan Perumal, Debapriya Chakraborty, Elisabeth Stürner

المصدر: Redox Biology
Redox Biology, Vol 24, Iss, Pp-(2019)

مصطلحات موضوعية: 0301 basic medicine, Clinical Biochemistry, LFQ, Label-free quantification, LETM, Leucine zipper and EF-hand containing transmembrane protein, medicine.disease_cause, Biochemistry, CHX, Cycloheximide, 0302 clinical medicine, BNIP3, Bcl-2 interacting protein 3, RAPA, Rapamycin, PIK3C3, Class III PI3‐kinase, Phosphorylation, lcsh:QH301-705.5, Neurons, lcsh:R5-920, PolyUB, Polyubiquitin, Chemistry, BAG3, OPA1, Optic atrophy 1, TOR Serine-Threonine Kinases, WIPI1, WD repeat domain phosphoinositide-interacting protein 1, ATG, Autophagy related, TFEB, Transcription factor EB, Cell biology, Mitochondria, siRNA, Small interfering RNA, DLP1, Dynamin-like protein 1, LAMP1, Lysosomal‐associated membrane protein 1, PURO, Puromycin, lcsh:Medicine (General), Protein homeostasis, Research Paper, BafA1, Bafilomycin A1, LAMP2, Lysosomal‐associated membrane protein 2, Proteasome Endopeptidase Complex, RAB18, Member RAS oncogene, TUB, Tubulin, LC3, Light chain 3 protein, Oxidative phosphorylation, CTSD, Cathepsin D, Models, Biological, Cell Line, 03 medical and health sciences, Downregulation and upregulation, Macroautophagy, medicine, Autophagy, Humans, Adaptation, BAG1, Bcl-2-associated athanogene 1, BECN1, Beclin1, PI3K/AKT/mTOR pathway, Adaptor Proteins, Signal Transducing, TEM, Transmission electron microscopy, Hsp70, Heat shock protein 70, Organic Chemistry, Autophagosomes, mTOR, Mammalian target of rapamycin, Hsp70, Oxidative Stress, 030104 developmental biology, Proteostasis, lcsh:Biology (General), CV, Canavanine, BAG3, Bcl-2-associated athanogene 3, MTT, (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide), Apoptosis Regulatory Proteins, Lysosomes, 030217 neurology & neurosurgery, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cc330b09215555a3158f06dbb32cb3
http://europepmc.org/articles/PMC6454062

المؤلفون: Stephanie Aungst, Alan I. Faden, Marta M. Lipinski, Zaorui Zhao, Boris Sabirzhanov, Chinmoy Sarkar

المصدر: Autophagy

مصطلحات موضوعية: CAPS12, caspase 12, Hippocampus, Cathepsin D, Phagosomes, Sequestosome-1 Protein, LAMP1, lysosomal-associated membrane protein 1, SQSTM1, sequestosome 1, Heat-Shock Proteins, GFP, green fluorescent protein, Neurons, education.field_of_study, Cell Death, traumatic brain injury, Brain, APC, adenomatous polyposis coli, CCI, controlled cortical impact, Cell biology, ATG5, autophagy-related 5, medicine.anatomical_structure, autophagy flux, β, AIF1/IBA1, allograft inflammatory factor 1, lysosome, AIFM1, apoptosis-inducing factor, mitochondrion-associated, 1, CASP3, caspase 3, Genetically modified mouse, autophagy, Programmed cell death, Basic Research Papers, CTSD, cathepsin D, Traumatic brain injury, ATG12, autophagy-related 12, SPTAN1, spectrin, α, non-erythrocytic 1, Biology, TBI, traumatic brain injury, Sequestosome 1, Lysosome, CSPG4, chondroitin sulfate proteoglycan 4, medicine, Animals, LAMP2, lysosomal-associated membrane protein 2, education, Molecular Biology, Adaptor Proteins, Signal Transducing, neuronal cell death, Autophagy, Cell Biology, LC3, microtubule associated protein 1 light chain 3, medicine.disease, ULK1, unc-51 like autophagy activating kinase 1, Mice, Inbred C57BL, Disease Models, Animal, Brain Injuries, RBFOX3, RNA binding protein, fox-1 homolog (C. elegans) 3, CD68, CD68 molecule, Apoptosis Regulatory Proteins, ATG7, autophagy-related 7, ACTB, actin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b62d13590f8f039fbc50cad65856712
https://doi.org/10.4161/15548627.2014.981787

المؤلفون: Pierre Dourlen, Yves Lemoine, Amandine Flaig, Frédéric Checler, Anne Marie Ayral, Jean-Charles Lambert, Kris Gevaert, Mathias Laga, Fanny Eysert, Tiago Mendes, David M. A. Mann, Linda Chami, Anne Sophie Hérard, Thierry Delzescaux, Franck Lafont, Florie Demiautte, Franck Hansmannel, Benoit Deprez, Charlotte Delay, David Hot, Florence Leroux, Bart Dermaut, Philippe Amouyel, Ludovic Huot, Yoann Sottejeau, Florence Pasquier, Nicolas Souedet, Florent Letronne, Charlotte Bauer, Marc Dhenain, Marie Lesaffre, Geoffroy Laumet, Nicolas Malmanche, David Tulasne, Claudine Berr, Rebecca Deprez, Julie Dumont, Elisabeth Werkmeister, Michel E. Vandenberghe, Jean Jacques Hauw, Julien Chapuis

المساهمون: Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé, Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 (RID-AGE), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Vlaams Instituut voor Biotechnologie [Ghent, Belgique] (VIB), Universiteit Gent = Ghent University (UGENT), Laboratoire des Maladies Neurodégénératives - UMR 9199 (LMN), Service MIRCEN (MIRCEN), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Médicaments et molécules pour agir sur les Systèmes Vivants - U 1177 (M2SV), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Mécanismes de la Tumorigénèse et Thérapies Ciblées - UMR 8161 (M3T), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Réseau International des Instituts Pasteur (RIIP), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Hépato-gastro-entérologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CEA [Fontenay-aux-Roses] (UGRA / SETA), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Troubles cognitifs dégénératifs et vasculaires - U 1171 - EA 1046 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Neuropsychiatrie : recherche épidémiologique et clinique (PSNREC), Université Montpellier 1 (UM1)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Laboratoire de Neuropathologie Raymond Escourolle [CHU Pitié-Salpétriêre], Université Pierre et Marie Curie - Paris 6 (UPMC)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institute of Brain, Behaviour and Mental Health, University of Manchester [Manchester], Hérard, Anne-Sophie, Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Institut de Biologie François JACOB (JACOB), Troubles cognitifs dégénératifs et vasculaires - U 1171 (TCDV), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut de Biologie François JACOB (JACOB), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), CDithem Platform, IGM, CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 (RNMCD), Institut Fédératif de Recherche 142, Institut Fédératif de Recherche, Center for Medical Genetics [Ghent], Ghent University Hospital, Département de neurologie, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Neuropathologie Raymond Escourolle, Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Division of Neuroscience and Experimental Psychology [Salford, UK], University of Manchester [Manchester]-Salford Royal NHS Foundation Trust [Salford, UK], Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Dept Med Prot Res, Flanders Institute for Biotechnology, Département Imagerie et Simulation pour le Contrôle (DISC), Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Laboratoire des Maladies Neurodégénératives - UMR 9199 [LMN], Institut de pharmacologie moléculaire et cellulaire [IPMC], Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc], Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL], Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011 [RNMCD], Facteurs de Risque et Déterminants Moléculaires des Maladies liées au Vieillissement - U 1167 [RID-AGE], Nutrition-Génétique et Exposition aux Risques Environnementaux [NGERE], CEA [Fontenay-aux-Roses] [UGRA / SETA], Institut de biologie de Lille - IBL [IBLI]

المصدر: EBioMedicine
EBioMedicine, 2016, 9, pp.278-292. ⟨10.1016/j.ebiom.2016.06.002⟩
Letronne, F, Laumet, G, Ayral, A-M, Chapuis, J, Demiautte, F, Laga, M, Vandenberghe, M, Malmanche, N, Leroux, F, Eysert, F, Sottejeau, Y, Chami, L, Flaig, A, Bauer, C, Dourlen, P, Lesaffre, M, Delay, C, Huot, L, Dumont, J, Werkmeister, E, Lafont, F, Mendes, T, Hansmannel, F, Dermaut, B, Deprez, B, Hérard, A-S, Dhenain, M, Souedet, N, Pasquier, F, Tulasne, D, Berr, C, Hauw, J-J, Lemoine, Y, Amouyel, P, Mann, D, Déprez, R, Checler, F, Hot, D, Delzescaux, T, Gevaert, K & Lambert, J-C 2016, ' ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease ', EBioMedicine . https://doi.org/10.1016/j.ebiom.2016.06.002
EBioMedicine, Elsevier, 2016, 9, pp.278-292. ⟨10.1016/j.ebiom.2016.06.002⟩
EBioMedicine, Vol 9, Iss C, Pp 278-292 (2016)
EBIOMEDICINE

مصطلحات موضوعية: 0301 basic medicine, Patch-Clamp Techniques, ADAM, A Disintegrin and Metalloproteinase Domain, lcsh:Medicine, Cathepsin D, COFRADIC, combined fractional diagonal chromatography, ALPHA-SECRETASE, Mice, 0302 clinical medicine, Pepstatins, Amyloid precursor protein, BRAIN, RNA, Small Interfering, Tissues and Organs (q-bio.TO), GENE-EXPRESSION, lcsh:R5-920, ROLES, IRS4, insulin receptor substrate 4, P3 peptide, Brain, Long-term potentiation, General Medicine, AMYLOID PRECURSOR PROTEIN, Alpha secretase, BACE, Beta-site APP cleaving enzyme 1, Neurons and Cognition (q-bio.NC), [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], RNA Interference, Macrolides, LTP, lcsh:Medicine (General), GKAP1, G kinase-anchoring protein 1, Research Paper, Genetically modified mouse, Amyloid, CTSD, cathepsin D, Down-Regulation, Mice, Transgenic, Biology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, TD2, Type 2 diabetes, Alzheimer Disease, APP, amyloid precursor protein, Cell Line, Tumor, Animals, Humans, Secretion, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Amino Acid Sequence, TRANSGENIC MOUSE MODEL, Amyloid beta-Peptides, PLA, proximity ligation assay, lcsh:R, LTP, long term potentiation, Biology and Life Sciences, Quantitative Biology - Tissues and Organs, ADAM30, DEGRADATION, CamKIIα, Ca2 +/calmodulin-dependent protein kinase II alpha, Molecular biology, Mice, Inbred C57BL, MICE, ADAM Proteins, 030104 developmental biology, HEK293 Cells, Metabolism, Microscopy, Fluorescence, Quantitative Biology - Neurons and Cognition, FOS: Biological sciences, COGNITIVE DECLINE, biology.protein, Alzheimer, BSA, bovine serum albumin, MMP, metalloproteinase, INHIBITORS, Lysosomes, APP, MRI, magnetic resonance imaging, 030217 neurology & neurosurgery

وصف الملف: application/pdf; application/octet-stream

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9bf8d295c4426a333c53668484f520
https://pubmed.ncbi.nlm.nih.gov/27333034

المؤلفون: Maria Dominguez, Issidora S. Papassideri, Aimilia D. Sklirou, Marianna Ralli, Ioannis P. Trougakos, Alexios-Leandros Skaltsounis

المصدر: Redox Biology
Redox Biology, Vol 5, Iss, Pp 205-215 (2015)

مصطلحات موضوعية: Antioxidant responses, Sqstm1, sequestosome 1, Clinical Biochemistry, Cell, PDR, proteome damage responses, Chaperone, hdac6, histone deacetylase 6, Biochemistry, Antioxidants, Cell Movement, hsf1, heat shock transcription factor-1, lcsh:QH301-705.5, Cellular Senescence, lcsh:R5-920, BECN1, Keap1, Kelch-like ECH-associated protein 1, medicine.anatomical_structure, ctsd, cathepsin-D, HDFs, human diploid fibroblasts, Matrix Metalloproteinase 9, Nqo1, NAD(P)H dehydrogenase, quinone 1, Matrix Metalloproteinase 2, lcsh:Medicine (General), Oligopeptides, Nrf2, NF-E2-related factor 2, Research Paper, ALS, autophagy lysosome system, Senescence, Proteasome Endopeptidase Complex, Cell Survival, NF-E2-Related Factor 2, Human fibroblasts, Biology, Hexapeptide-11, Cell Line, ER, endoplasmic reticulum, ROS, reactive oxygen species, UPS, ubiquitin proteasome system, Extracellular, medicine, Autophagy, CLU, apolipoprotein J/Clusterin, Humans, Viability assay, ctsl, cathepsin-L, Txnrd1, thioredoxin reductase 1, hsp, heat shock protein, Proteasome, Organic Chemistry, PN, proteostasis network, Fibroblasts, KEAP1, Diploidy, Oxidative Stress, Proteostasis, lcsh:Biology (General), becn1, beclin-1, Molecular Chaperones

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d21d891c4db690600e8c356f78ea8f22
https://pubmed.ncbi.nlm.nih.gov/25974626

المؤلفون: Jean Paul Briand, Nicolas Page, Sylviane Muller, Christophe Macri, Nicolas Schall, Ana Maria Cuervo, Inmaculada Tasset, Fengjuan Wang

المساهمون: Biotechnologie et signalisation cellulaire (BSC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Institut de recherche de l'Ecole de biotechnologie de Strasbourg (IREBS), Immunopathologie et chimie thérapeutique (ICT), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Autophagy
Autophagy, Taylor & Francis, 2015, 11 (3), pp.472-486. ⟨10.1080/15548627.2015.1017179⟩

مصطلحات موضوعية: Phosphopeptides, Mice, Inbred MRL lpr, LC-MS, liquid chromatography-mass spectrometry, NBD, nucleotide binding domain, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, T-Lymphocytes, Autoimmunity, CPZ: chlorpromazine, SLE, systemic lupus erythematosus, chemistry.chemical_compound, Mice, Chaperone-mediated autophagy, paraquat, 1, 1′-dimethyl-4, 4′-bipyridyldinium dichloride, qRT-PCR, quantitative reverse transcriptase-polymerase chain reaction, immune system diseases, Serine, Lupus Erythematosus, Systemic, antigen-presenting cells, ALF, artificial lysosomal fluid, RPL5, ribosomal protein L5, Phosphorylation, skin and connective tissue diseases, chaperone-mediated autophagy, HSPA8/HSC70, education.field_of_study, B-Lymphocytes, SBD, substrate binding domain, Sciences du Vivant [q-bio]/Biotechnologies, ELISA, enzyme-linked immunosorbent assay, MHCII, major histocompatibility complex class II, class II MHC molecules, Endocytosis, Basic Research Paper, CMA, chaperone-mediated autophagy, Cell biology, Lysosomal lumen, GAPDH, glyceraldehyde-3-phosphate dehydrogenase, bodipy: BODIPY FL C5 Lactosylceramide/bovine serum albumin, LAMP2A, lysosomal-associated membrane protein 2A, RP-HPLC, reversed-phase high-performance liquid chromatography, autophagy, CTSD, cathepsin D, PBS, phosphate-buffered saline, Endosomes, Biology, SEM, standard error of the mean, Ribosomal protein L5, Ribonucleoprotein, U1 Small Nuclear, lysosomal chaperones, TFA, trifluoroacetic acid, Sequestosome 1, lysosomes, CoIP, coimmunoprecipitation, Downregulation and upregulation, Animals, Humans, education, Antigen-presenting cell, Molecular Biology, SQSTM1/p62, sequestosome 1, iv, intravenous, SNRNP70/U170K: small nuclear ribonucleoprotein 70kDa, Autophagy, HSC70 Heat-Shock Proteins, Histocompatibility Antigens Class II, Cell Biology, lupus, HCQ, hydroxychloroquine, LC3-II, MAP1LC3-II, Molecular biology, Peptide Fragments, TF, transferrin, chemistry, APC, antigen-presenting cell, Phosphoserine, heat shock proteins, NIH 3T3 Cells, FCS, fetal calf serum, SD, standard deviation, DAPI, 4′, 6-diamidino-2-phenylindole, Molecular Chaperones, B lymphocytes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3852162ef8e4c9b772246960eadd1b
https://hal.archives-ouvertes.fr/hal-02988901

المؤلفون: Matthew E. Gegg, Shi Yu Yang, Anthony H.V. Schapira, David Chau

المصدر: Neurobiology of Disease
Neurobiology of Disease, Vol 134, Iss, Pp-(2020)

مصطلحات موضوعية: 0301 basic medicine, Glucocerebrosidase, CTSD, cathepsin D, Parkinson's disease, GCase, Glucocerebrosidase enzyme, Mutant, Cathepsin D, NCSC, Neural crest stem cell, Gene mutation, PD, Parkinson's disease, ABX, ambroxol, Article, lcsh:RC321-571, CTSB, Cathepsin B, 03 medical and health sciences, 0302 clinical medicine, Neural Stem Cells, Cerezyme, LAMP1, Lysosomal-associated membrane protein 1, Humans, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Cells, Cultured, chemistry.chemical_classification, biology, Dopaminergic Neurons, Dopaminergic, Parkinson Disease, Cell biology, nervous system diseases, Monomeric α-Synuclein, Ambroxol, GBA, Glucocerebrosidase gene, 030104 developmental biology, Enzyme, Neurology, chemistry, nervous system, Neural Crest, Chaperone (protein), Mutation, alpha-Synuclein, biology.protein, Glucosylceramidase, Stem cell, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad60dd74c70214a3dbd2729a2d8fc5a

المؤلفون: Hu P; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China., Li H; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China., Sun W; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China., Wang H; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China., Yu X; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China.; Department of Pharmacology, School of Medicine & Holostic Integrative Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, China., Qing Y; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China., Wang Z; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China., Zhu M; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China., Xu J; Department of Hematology, the Affiliated DrumTower Hospital of Nanjing University Medical School, Nanjing 210008, China., Guo Q; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China., Hui H; State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China.

المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Oct; Vol. 11 (10), pp. 3178-3192. Date of Electronic Publication: 2021 Feb 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE