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1دورية أكاديمية
المؤلفون: Kathrin Tan, Christian Jäger, Stefanie Geissler, Dagmar Schlenzig, Mirko Buchholz, Daniel Ramsbeck
المصدر: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
مصطلحات موضوعية: Meprin, metalloprotease, hydroxamate, inhibitor, pyrazole, Therapeutics. Pharmacology, RM1-950
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Charles Bayly-Jones, Christopher J. Lupton, Claudia Fritz, Hariprasad Venugopal, Daniel Ramsbeck, Michael Wermann, Christian Jäger, Alex de Marco, Stephan Schilling, Dagmar Schlenzig, James C. Whisstock
المصدر: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
مصطلحات موضوعية: Science
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2041-1723
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3دورية أكاديمية
المؤلفون: Miriam Linnert, Claudia Fritz, Christian Jäger, Dagmar Schlenzig, Daniel Ramsbeck, Martin Kleinschmidt, Michael Wermann, Hans-Ulrich Demuth, Christoph Parthier, Stephan Schilling
المصدر: International Journal of Molecular Sciences, Vol 22, Iss 11, p 5651 (2021)
مصطلحات موضوعية: Meprin B, Meprin beta, metalloproteinase, astacin, hydroxamate, SAR (structure activity relationship), Biology (General), QH301-705.5, Chemistry, QD1-999
وصف الملف: electronic resource
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المؤلفون: Charles Bayly-Jones, Christopher J. Lupton, Claudia Fritz, Hariprasad Venugopal, Daniel Ramsbeck, Michael Wermann, Christian Jäger, Alex de Marco, Stephan Schilling, Dagmar Schlenzig, James C. Whisstock
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::cbbfde1089a3c0f2a89b17ff8ff31315
https://doi.org/10.1101/2022.03.13.484121 -
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المؤلفون: Daniel Ramsbeck, Christoph Parthier, Hans-Ulrich Demuth, Stephan Schilling, Miriam Linnert, Michael Wermann, Martin Kleinschmidt, Claudia Fritz, Dagmar Schlenzig, Christian Jäger
المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 5651, p 5651 (2021)
Volume 22
Issue 11مصطلحات موضوعية: 0301 basic medicine, Proteases, Arginine, QH301-705.5, medicine.medical_treatment, Drug design, Molecular Dynamics Simulation, hydroxamate, Hydroxamic Acids, 01 natural sciences, Isozyme, Catalysis, Article, MWT-S-270, Inorganic Chemistry, 03 medical and health sciences, Structure-Activity Relationship, 0103 physical sciences, medicine, Humans, Protease Inhibitors, Physical and Theoretical Chemistry, Biology (General), Molecular Biology, QD1-999, Meprin B, Spectroscopy, Metalloproteinase, Protease, 010304 chemical physics, biology, Chemistry, Organic Chemistry, SAR (structure activity relationship), Active site, Metalloendopeptidases, General Medicine, Meprin beta, Computer Science Applications, 030104 developmental biology, Biochemistry, biology.protein, metalloproteinase, Astacin, astacin
وصف الملف: application/pdf
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المؤلفون: Mirko Buchholz, Holger Cynis, Hans-Ulrich Demuth, Claudia Spahn, Ulrike Zeitschel, Daniel Ramsbeck, Michael Wermann, Maike Hartlage-Rübsamen, Steffen Roßner, Katja Menge, Dagmar Schlenzig, Anja Fothe, Stephan Schilling
المصدر: Journal of Alzheimer's Disease. 66:359-375
مصطلحات موضوعية: Male, 0301 basic medicine, Proteases, Dipeptidyl-peptidase activity, CHO Cells, Dipeptidyl peptidase, 03 medical and health sciences, Cricetulus, 0302 clinical medicine, Cricetinae, Animals, Humans, Amino Acid Sequence, Dipeptidyl-Peptidases and Tripeptidyl-Peptidases, Protein precursor, Peptide sequence, Aged, Aged, 80 and over, Exopeptidase activity, Amyloid beta-Peptides, biology, Chemistry, General Neuroscience, Brain, Metalloendopeptidases, General Medicine, Aminoacyltransferases, Peptide Fragments, Endopeptidase, Enzyme Activation, Psychiatry and Mental health, Clinical Psychology, HEK293 Cells, 030104 developmental biology, Biochemistry, biology.protein, Female, Geriatrics and Gerontology, Amyloid precursor protein secretase, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94ec447859ba4fdfdc0d846dcf89a41
https://doi.org/10.3233/jad-171183 -
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المؤلفون: Stephan Schilling, Michael Wermann, Miriam Linnert, Martin Kleinschmidt, Claudia Fritz, Hans-Ulrich Demuth, Christian Jäger, Daniel Ramsbeck, Dagmar Schlenzig
مصطلحات موضوعية: Metalloproteinase, Stereochemistry, Chemistry, Dynamics (mechanics), biochemistry, Astacin
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ec0001f5a64dcafc469baf1f2cb3c4
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8
المؤلفون: Mirko Buchholz, Christian Jäger, Stefanie Geissler, Daniel Ramsbeck, Kathrin Tan, Dagmar Schlenzig, Walter Stöcker, Hagen Körschgen
المصدر: Chemmedchem
مصطلحات موضوعية: Scaffold, Tertiary amine, Stereochemistry, Cell Survival, Antineoplastic Agents, scaffold hopping, Matrix metalloproteinase, Scaffold hopping, hydroxamate, 01 natural sciences, Biochemistry, Hydrocarbons, Aromatic, metalloproteinases, Structure-Activity Relationship, meprin, Very Important Paper, Drug Discovery, Tumor Cells, Cultured, Humans, Protease Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Amines, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, Full Paper, 010405 organic chemistry, Chemistry, Organic Chemistry, Metalloendopeptidases, Full Papers, ovastacin, Recombinant Proteins, heteroaromatics, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Metalloproteases, Molecular Medicine, Astacin, Drug Screening Assays, Antitumor, Selectivity
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المصدر: Bioorganic & Medicinal Chemistry Letters. 27:2428-2431
مصطلحات موضوعية: 0301 basic medicine, Proteases, Matrix metalloproteinase inhibitor, ADAM10, Clinical Biochemistry, Pharmaceutical Science, Matrix Metalloproteinase Inhibitors, Hydroxamic Acids, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Fibrosis, Drug Discovery, medicine, Structure–activity relationship, Protease Inhibitors, Molecular Biology, Sulfonamides, Metalloproteinase, Hydroxamic acid, Organic Chemistry, Metalloendopeptidases, medicine.disease, 030104 developmental biology, chemistry, Molecular Medicine, Astacin, 030217 neurology & neurosurgery
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10
المؤلفون: Liesa Heinrich, Angelika Schierhorn, Uwe Horn, Anka Thümmler, Marcus Fändrich, Hans-Ulrich Demuth, Jay Kant Yadav, Melanie Wulff, Jens-Ulrich Rahfeld, Monika Baumann, Dagmar Schlenzig, Jochen Balbach, Uwe Knüpfer
المصدر: Angewandte Chemie. 128:5165-5168
مصطلحات موضوعية: 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, General Medicine, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences