المؤلفون: Docken SS; Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia., McCormick K; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Pampena MB; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Center for AIDS Research and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Samer S; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Lindemuth E; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Pinkevych M; Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia., Viox EG; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Wu Y; Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia., Schlub TE; Sydney School of Public Health, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia., Cromer D; Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia., Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Paiardini M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, School of Medicine, Emory University, Atlanta, Georgia, United States of America., Betts MR; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Center for AIDS Research and Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Bar KJ; Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Davenport MP; Infection Analytics Program, Kirby Institute, UNSW Sydney, Sydney, New South Wales, Australia.

المصدر: PLoS pathogens [PLoS Pathog] 2023 Nov 30; Vol. 19 (11), pp. e1011755. Date of Electronic Publication: 2023 Nov 30 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

مواضيع طبية MeSH: Simian Acquired Immunodeficiency Syndrome* , Simian Immunodeficiency Virus* , HIV Infections*, Animals ; Macaca mulatta ; Virus Replication/physiology ; CD8-Positive T-Lymphocytes ; Epitopes ; Viral Load ; Anti-Retroviral Agents/therapeutic use ; Anti-Retroviral Agents/pharmacology

المؤلفون: Pinkevych M; Infection Analytics Program, Kirby Institute for Infection and Immunity, UNSW Australia, Sydney, New South Wales, Australia., Docken SS; Infection Analytics Program, Kirby Institute for Infection and Immunity, UNSW Australia, Sydney, New South Wales, Australia., Okoye AA; Vaccine & Gene Therapy Institute, and Oregon National Primate Research Center, Beaverton, Oregon, United States of America., Fennessey CM; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Del Prete GQ; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Pino M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Harper JL; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America., Betts MR; Department of Microbiology and Center for AIDS Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Paiardini M; Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America.; Department of Pathology and Laboratory Medicine, School of Medicine; Emory University, Atlanta, Georgia, United States of America., Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Davenport MP; Infection Analytics Program, Kirby Institute for Infection and Immunity, UNSW Australia, Sydney, New South Wales, Australia.

المصدر: PLoS pathogens [PLoS Pathog] 2023 Oct 06; Vol. 19 (10), pp. e1011660. Date of Electronic Publication: 2023 Oct 06 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

مواضيع طبية MeSH: HIV Infections*/drug therapy, Animals ; CD8-Positive T-Lymphocytes ; RNA, Viral ; Viral Load ; Anti-Retroviral Agents/pharmacology ; Anti-Retroviral Agents/therapeutic use

المؤلفون: Docken SS; Department of Mathematics, University of California Davis, Davis, CA, USA; Department of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA. Electronic address: sdocken@kirby.unsw.edu.au., Clancy CE; Department of Physiology and Membrane Biology, University of California Davis, Davis, CA, USA., Lewis TJ; Department of Mathematics, University of California Davis, Davis, CA, USA.

المصدر: Journal of theoretical biology [J Theor Biol] 2023 Sep 21; Vol. 573, pp. 111595. Date of Electronic Publication: 2023 Aug 09.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 0376342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-8541 (Electronic) Linking ISSN: 00225193 NLM ISO Abbreviation: J Theor Biol Subsets: MEDLINE

مواضيع طبية MeSH: Sodium Channel Blockers*/pharmacology , Sodium Channels*/metabolism, Humans ; Arrhythmias, Cardiac ; Heart ; Ion Channels

المؤلفون: Bauer A; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Lindemuth E; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Marino FE; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Krause R; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Joy J; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Docken SS; Kirby Institute, University of New South Wales, Sydney, Australia., Mallick S; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., McCormick K; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Holt C; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America., Georgiev I; Department of Pathology, Microbiology, and Immunology, Vanderbilt University, Nashville, Tennessee, United States of America., Felber B; Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Maryland, United States of America., Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, United States of America., Veazey R; Department of Pathology and Laboratory Medicine, Tulane School of Medicine, New Orleans, Louisiana, United States of America., Davenport MP; Kirby Institute, University of New South Wales, Sydney, Australia., Li H; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Departments of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Shaw GM; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.; Departments of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America., Bar KJ; Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

المصدر: PLoS pathogens [PLoS Pathog] 2023 Jul 03; Vol. 19 (7), pp. e1011059. Date of Electronic Publication: 2023 Jul 03 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

مواضيع طبية MeSH: Simian Acquired Immunodeficiency Syndrome* , Simian Immunodeficiency Virus* , HIV Infections* , HIV-1* , HIV Seropositivity*, Animals ; Humans ; Macaca mulatta/metabolism ; env Gene Products, Human Immunodeficiency Virus ; Virus Replication/physiology

المؤلفون: Khoury DS; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia., Docken SS; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia., Subbarao K; WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia., Kent SJ; Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.; Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia., Davenport MP; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia., Cromer D; Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia. d.cromer@unsw.edu.au.

المصدر: Nature medicine [Nat Med] 2023 Mar; Vol. 29 (3), pp. 574-578. Date of Electronic Publication: 2023 Mar 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19 Vaccines* , COVID-19*/prevention & control, Humans ; SARS-CoV-2 ; Antibodies, Viral

SCR Protocol: COVID-19 vaccine booster shot

SCR Organism: SARS-CoV-2 variants

المؤلفون: Statzu M; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Jin W; Kirby Institute, University of New South Wales, Sydney, Australia., Fray EJ; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Wong AKH; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Kumar MR; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Ferrer E; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Docken SS; Kirby Institute, University of New South Wales, Sydney, Australia., Pinkevych M; Kirby Institute, University of New South Wales, Sydney, Australia., McBrien JB; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Fennessey CM; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Keele BF; AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Liang S; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Harper JL; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Mutascio S; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Franchitti L; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Wang H; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Cicetti D; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Bosinger SE; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Carnathan DG; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Vanderford TH; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Margolis DM; Division of Infectious Diseases, Center for AIDS Research, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, USA., Garcia-Martinez JV; Division of Infectious Diseases, Center for AIDS Research, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC, USA., Chahroudi A; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA.; Department of Pediatrics, Emory University, Atlanta, GA, USA., Paiardini M; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Siliciano J; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Davenport MP; Kirby Institute, University of New South Wales, Sydney, Australia., Kulpa DA; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA., Siliciano RS; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Silvestri G; Emory National Primate Research Center, Department of Pathology and Laboratory Medicine, and Emory Vaccine Center, Emory University, Atlanta, GA, USA. gsilves@emory.edu.

المصدر: Nature microbiology [Nat Microbiol] 2023 Feb; Vol. 8 (2), pp. 299-308. Date of Electronic Publication: 2023 Jan 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101674869 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2058-5276 (Electronic) Linking ISSN: 20585276 NLM ISO Abbreviation: Nat Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Simian Immunodeficiency Virus*/genetics , Simian Acquired Immunodeficiency Syndrome*/drug therapy , HIV Infections*/drug therapy, Animals ; Humans ; CD8-Positive T-Lymphocytes ; Anti-Retroviral Agents/therapeutic use ; Macaca mulatta

المؤلفون: Eustaquio PC; Love Yourself, Inc., Mandaluyong, Metro Manila, Philippines., Docken SS; Kirby Institute, 2786University of New South Wales, Sydney, Australia., Leyritana KT; Sustained Health Initiatives of the Philippines, Inc., Metro Manila, Philippines., Wulandari LPL; Kirby Institute, 2786University of New South Wales, Sydney, Australia.; Department of Faculty of Public Health and Preventive Medicine, Faculty of Medicine, Udayana University, Denpasar, Indonesia.

المصدر: International journal of STD & AIDS [Int J STD AIDS] 2021 Jul; Vol. 32 (8), pp. 718-728. Date of Electronic Publication: 2021 Feb 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Sage Country of Publication: England NLM ID: 9007917 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1758-1052 (Electronic) Linking ISSN: 09564624 NLM ISO Abbreviation: Int J STD AIDS Subsets: MEDLINE

مواضيع طبية MeSH: HIV Infections*/diagnosis , HIV Infections*/drug therapy , HIV Infections*/epidemiology , Sexual and Gender Minorities*, Cross-Sectional Studies ; Homosexuality, Male ; Humans ; Male ; Philippines/epidemiology ; Retrospective Studies

المؤلفون: Docken SS; Department of Mathematics, University of California Davis, Davis, California, United States of America.; Department of Physiology and Membrane Biology, School of Medicine, University of California Davis, Davis, California, United States of America., Clancy CE; Department of Physiology and Membrane Biology, School of Medicine, University of California Davis, Davis, California, United States of America., Lewis TJ; Department of Mathematics, University of California Davis, Davis, California, United States of America.

المصدر: PLoS computational biology [PLoS Comput Biol] 2021 Jun 29; Vol. 17 (6), pp. e1009145. Date of Electronic Publication: 2021 Jun 29 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238922 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7358 (Electronic) Linking ISSN: 1553734X NLM ISO Abbreviation: PLoS Comput Biol Subsets: MEDLINE

مواضيع طبية MeSH: Models, Cardiovascular*, Heart/*drug effects , Lidocaine/*pharmacokinetics , Lidocaine/*pharmacology , Myocardium/*metabolism , Voltage-Gated Sodium Channels/*metabolism, Action Potentials/drug effects ; Animals ; Anti-Arrhythmia Agents/pharmacokinetics ; Anti-Arrhythmia Agents/pharmacology ; Arrhythmias, Cardiac/drug therapy ; Arrhythmias, Cardiac/metabolism ; Computational Biology ; Computer Simulation ; Heart Rate/physiology ; Humans ; Kinetics ; Markov Chains ; Patch-Clamp Techniques ; Voltage-Gated Sodium Channel Blockers/pharmacokinetics ; Voltage-Gated Sodium Channel Blockers/pharmacology

المؤلفون: Corder RM; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., de Lima ACP; Department of Statistics, Institute of Mathematics and Statistics, University of São Paulo, São Paulo, Brazil., Khoury DS; Kirby Institute for Infection and Immunity, University of New South Wales, Sidney, Australia., Docken SS; Kirby Institute for Infection and Immunity, University of New South Wales, Sidney, Australia., Davenport MP; Kirby Institute for Infection and Immunity, University of New South Wales, Sidney, Australia., Ferreira MU; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

المصدر: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2020 Jul 31; Vol. 14 (7), pp. e0008526. Date of Electronic Publication: 2020 Jul 31 (Print Publication: 2020).

نوع المنشور: Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE

مواضيع طبية MeSH: Plasmodium vivax*, Antimalarials/*therapeutic use , Malaria, Vivax/*prevention & control , Pregnancy Complications, Parasitic/*prevention & control , Primaquine/*administration & dosage, Adolescent ; Adult ; Brazil ; Case-Control Studies ; Child ; Chloroquine/administration & dosage ; Chloroquine/therapeutic use ; Female ; Humans ; Malaria, Vivax/drug therapy ; Models, Biological ; Pregnancy ; Primaquine/therapeutic use ; Recurrence ; Young Adult

المؤلفون: DeMarino C; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA., Cowen M; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA., Pleet ML; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA., Pinto DO; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA., Khatkar P; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA., Erickson J; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA., Docken SS; Department of Mathematics, University of California Davis, Davis, CA, USA., Russell N; Department of Mathematical Sciences, University of Delaware, Newark, DE, USA., Reichmuth B; Department of Mathematical Sciences, George Mason University, Fairfax, VA, USA., Phan T; School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ, USA., Kuang Y; School of Mathematical and Statistical Sciences, Arizona State University, Tempe, AZ, USA., Anderson DM; Department of Mathematical Sciences, George Mason University, Fairfax, VA, USA. danders1@gmu.edu., Emelianenko M; Department of Mathematical Sciences, George Mason University, Fairfax, VA, USA. memelian@gmu.edu., Kashanchi F; Laboratory of Molecular Virology, School of Systems Biology, George Mason University, Manassas, VA, USA. fkashanc@gmu.edu.

المصدر: Scientific reports [Sci Rep] 2020 Feb 10; Vol. 10 (1), pp. 2227. Date of Electronic Publication: 2020 Feb 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Anti-HIV Agents/*pharmacology , Gene Expression Regulation, Viral/*immunology , HIV Infections/*drug therapy , HIV-1/*genetics , Macrophages/*immunology , T-Lymphocytes/*immunology, Anti-HIV Agents/therapeutic use ; Cell Line ; Drug Resistance, Viral/drug effects ; Drug Resistance, Viral/genetics ; Drug Resistance, Viral/immunology ; HIV Infections/blood ; HIV Infections/immunology ; HIV Long Terminal Repeat/genetics ; HIV-1/drug effects ; HIV-1/immunology ; Humans ; Macrophages/virology ; Models, Genetic ; Models, Immunological ; Primary Cell Culture ; RNA, Viral/genetics ; RNA, Viral/metabolism ; T-Lymphocytes/virology ; Transcription, Genetic/drug effects ; Transcription, Genetic/immunology ; Virus Replication/drug effects ; Virus Replication/genetics ; Virus Replication/immunology