المؤلفون: Amy R. Howell, Kevin Shannon, Anthony D. Long, Predovic M, Bihua Huang, Remsberg, Inguva A, Micah J. Niphakis, Nhi Ngo, Radu M. Suciu, Stewart K. Richardson, Kenneth M. Lum, Hanigan Tw, Firestone Aj, Cassandra L. Henry, Benjamin F. Cravatt, Zambetti Na

مصطلحات موضوعية: chemistry.chemical_classification, Membrane, Enzyme, chemistry, Palmitoylation, Proteome, Lipase inhibitors, medicine, Myeloid leukemia, Cancer, Oncogenicity, medicine.disease, Cell biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ee779cfd11259dabc59a9be1a2d0354a
https://doi.org/10.1101/2020.05.21.108316

المؤلفون: Lazear MR; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Remsberg JR; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA. Electronic address: remsberg@scripps.edu., Jaeger MG; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Rothamel K; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Her HL; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., DeMeester KE; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Njomen E; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Hogg SJ; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Rahman J; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Whitby LR; Vividion Therapeutics, 5820 Nancy Ridge Drive, San Diego, CA 92121, USA., Won SJ; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Schafroth MA; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Ogasawara D; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Yokoyama M; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Lindsey GL; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Li H; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Germain J; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Barbas S; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Vaughan J; Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, CA, USA., Hanigan TW; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Vartabedian VF; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA., Reinhardt CJ; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Dix MM; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA., Koo SJ; Molecular and Cellular Pharmacology, Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Heo I; Molecular and Cellular Pharmacology, Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Teijaro JR; Department of Immunology and Microbiology, Scripps Research, La Jolla, CA 92037, USA., Simon GM; Vividion Therapeutics, 5820 Nancy Ridge Drive, San Diego, CA 92121, USA., Ghosh B; Discovery Chemistry, Janssen Research & Development, Spring House, PA 19477, USA., Abdel-Wahab O; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA., Ahn K; Molecular and Cellular Pharmacology, Discovery Technologies and Molecular Pharmacology, Janssen Research and Development, Spring House, PA 19477, USA., Saghatelian A; Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, La Jolla, CA, USA., Melillo B; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA., Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02142, USA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA., Yeo GW; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA., Cravatt BF; Department of Chemistry, Scripps Research, La Jolla, CA 92037, USA. Electronic address: cravatt@scripps.edu.

المصدر: Molecular cell [Mol Cell] 2023 May 18; Vol. 83 (10), pp. 1725-1742.e12. Date of Electronic Publication: 2023 Apr 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Proteomics*/methods , Transcription Factors*, Humans ; Cysteine/metabolism ; Ligands

المؤلفون: Remsberg JR; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Suciu RM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Zambetti NA; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Hanigan TW; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Firestone AJ; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Inguva A; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Long A; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Ngo N; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Lum KM; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Henry CL; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA., Richardson SK; Department of Chemistry, University of Connecticut, Storrs, CT, USA., Predovic M; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA., Huang B; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA., Dix MM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA., Howell AR; Department of Chemistry, University of Connecticut, Storrs, CT, USA., Niphakis MJ; Lundbeck La Jolla Research Center, Inc., San Diego, CA, USA. MIIP@lundbeck.com., Shannon K; Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA. Kevin.Shannon@ucsf.edu.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA, USA. Kevin.Shannon@ucsf.edu., Cravatt BF; Department of Chemistry, The Scripps Research Institute, La Jolla, CA, USA. cravatt@scripps.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2021 Aug; Vol. 17 (8), pp. 856-864. Date of Electronic Publication: 2021 Apr 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Membrane/*metabolism , Hydrolases/*metabolism , Leukemia, Myeloid, Acute/*metabolism , Leukemia, Promyelocytic, Acute/*metabolism , ras Proteins/*metabolism, Cell Proliferation ; Cells, Cultured ; Humans ; Leukemia, Myeloid, Acute/pathology ; Leukemia, Promyelocytic, Acute/pathology ; Lipoylation ; Microsomes, Liver/chemistry ; Microsomes, Liver/metabolism ; Molecular Structure

المؤلفون: Taha TY, Aboukhatwa SM, Knopp RC, Ikegaki N, Abdelkarim H, Neerasa J, Lu Y, Neelarapu R, Hanigan TW, Thatcher GRJ, Petukhov PA

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Aug 02; Vol. 10 (9), pp. 1358. Date of Electronic Publication: 2019 Aug 02 (Print Publication: 2019).

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Aboukhatwa SM; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612, USA.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt., Hanigan TW; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612, USA., Taha TY; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612, USA., Neerasa J; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612, USA., Ranjan R; Section of Hematology/Oncology, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA., El-Bastawissy EE; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt., Elkersh MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University, Alexandria, 21311, Egypt., El-Moselhy TF; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, 31527, Egypt., Frasor J; Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA., Mahmud N; Section of Hematology/Oncology, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA., McLachlan A; Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL, 60612, USA., Petukhov PA; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612, USA.

المصدر: ChemMedChem [ChemMedChem] 2019 Jun 05; Vol. 14 (11), pp. 1096-1107. Date of Electronic Publication: 2019 Apr 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design* , Optical Imaging*, Fluorescent Dyes/*pharmacology , Histone Deacetylase Inhibitors/*pharmacology , Histone Deacetylases/*metabolism , Photoaffinity Labels/*pharmacology, Animals ; Cells, Cultured ; Fluorescent Dyes/chemical synthesis ; Fluorescent Dyes/chemistry ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Liver/diagnostic imaging ; Mice ; Mice, 129 Strain ; Photoaffinity Labels/chemical synthesis ; Photoaffinity Labels/chemistry

المؤلفون: Hanigan TW; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, 833 South Wood Street, Chicago, IL 60612, USA., Danes JM; Department of Physiology and Biophysics, College of Medicine, University of Illinois, 835 S. Wolcott Street, Chicago, IL 60612, USA., Taha TY; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, 833 South Wood Street, Chicago, IL 60612, USA., Frasor J; Department of Physiology and Biophysics, College of Medicine, University of Illinois, 835 S. Wolcott Street, Chicago, IL 60612, USA., Petukhov PA; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois, 833 South Wood Street, Chicago, IL 60612, USA.

المصدر: Journal of biological methods [J Biol Methods] 2018; Vol. 5 (1).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: [POL Scientific, LLC] Country of Publication: United States NLM ID: 101639022 Publication Model: Print Cited Medium: Print ISSN: 2326-9901 (Print) Linking ISSN: 23269901 NLM ISO Abbreviation: J Biol Methods Subsets: PubMed not MEDLINE

المؤلفون: Hanigan TW; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA., Aboukhatwa SM; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt 31527., Taha TY; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA., Frasor J; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, IL 60612, USA., Petukhov PA; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, USA. Electronic address: pap4@uic.edu.

المصدر: Cell chemical biology [Cell Chem Biol] 2017 Nov 16; Vol. 24 (11), pp. 1356-1367.e8. Date of Electronic Publication: 2017 Sep 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Histone Deacetylases/*metabolism , JNK Mitogen-Activated Protein Kinases/*metabolism, Cell Line, Tumor ; Female ; Histone Deacetylase Inhibitors/chemistry ; Histone Deacetylase Inhibitors/metabolism ; Histone Deacetylases/chemistry ; Histone Deacetylases/genetics ; Humans ; Hydroxamic Acids/chemistry ; Hydroxamic Acids/metabolism ; Isoenzymes/chemistry ; Isoenzymes/genetics ; Isoenzymes/metabolism ; MCF-7 Cells ; Phosphorylation ; Protein Binding ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology

المؤلفون: Hanigan TW; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America., Taha TY; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America., Aboukhatwa SM; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt., Frasor J; Department of Physiology and Biophysics, University of Illinois at Chicago, Chicago, Illinois, United States of America., Petukhov PA; Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, Illinois, United States of America.

المصدر: PloS one [PLoS One] 2017 Oct 18; Vol. 12 (10), pp. e0186620. Date of Electronic Publication: 2017 Oct 18 (Print Publication: 2017).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Histone Deacetylase Inhibitors/*pharmacology , Histone Deacetylases/*metabolism , Protein Processing, Post-Translational/*drug effects, Acetylation/drug effects ; Cytosol/drug effects ; Cytosol/enzymology ; Histone Deacetylase Inhibitors/chemistry ; Histones/metabolism ; Humans ; MCF-7 Cells ; Microscopy, Confocal ; Mitogens/pharmacology ; Models, Biological ; Phosphorylation/drug effects ; Protein Transport/drug effects ; Subcellular Fractions/drug effects ; Subcellular Fractions/enzymology

المؤلفون: Taha TY; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Aboukhatwa SM; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt., Knopp RC; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Ikegaki N; Department of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Abdelkarim H; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Neerasa J; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Lu Y; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Neelarapu R; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Hanigan TW; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Thatcher GRJ; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States., Petukhov PA; Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2017 Aug 01; Vol. 8 (8), pp. 824-829. Date of Electronic Publication: 2017 Aug 01 (Print Publication: 2017).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE