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المؤلفون: Wendy Cao, Johnathan C. Maza, Natalia Chernyak, John A. Flygare, Shane W. Krska, F. Dean Toste, Matthew B. Francis
المصدر: Bioconjugate Chemistry. 34:510-517
مصطلحات موضوعية: Pharmacology, Organic Chemistry, Biomedical Engineering, Pharmaceutical Science, Bioengineering, Biotechnology
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المؤلفون: Jagath R. Junutula, John A. Flygare, Andrew G. Polson, Paul Polakis, Susan Spencer, Katherine K. Kozak, Janet Gunzner-Toste, Jinhua Chen, Fan Fang, Philip W. Howard, Stephen J. Gregson, Luke Masterson, Donglu Zhang, Amrita V. Kamath, Douglas D. Leipold, Keyang Xu, Carl Ng, Luna Liu, Jintang He, Sharon Yee, Jeffrey Lau, Mary Ann T. Go, Geoffrey Del Rosario, Fiona Zhong, Willy Solis, Kirsten Achilles Poon, Jack Sadowsky, Rachana Ohri, Shang-Fan Yu, Melissa Schutten, Thomas H. Pillow
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bd04853a3b7478b1a76289e951f293
https://doi.org/10.1158/1535-7163.22503312.v1 -
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المؤلفون: Ryan L. Gonciarz, Honglin Jiang, Cedric L. Hugelshofer, Oscar Ekpenyong, Ian Knemeyer, John A. Flygare, Eric A. Collisson, Adam R. Renslo
المصدر: SSRN Electronic Journal.
مصطلحات موضوعية: History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::efdc0ef96d2b30b5c1a77a27046f83a1
https://doi.org/10.2139/ssrn.4279906 -
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المؤلفون: Paul Nimmer, Erwin R. Boghaert, Robin R. Frey, Phuong N Le, Andrew J. Souers, Peter Kovar, Wenqing Gao, Deepak Sampath, Dolores Diaz, Haichao Zhang, T. Matthew Hansen, Michael J. Mitten, Stephen K. Tahir, Russell A. Judge, Edna F. Choo, Yu Xiao, Shashank Shekhar, Xiaohong Song, George Doherty, Zhi-Fu Tao, Andrew S. Judd, Wayne J. Fairbrother, Michael D. Wendt, Steven W. Elmore, Kunzer Aaron R, Le Wang, Xilu Wang, Darren C. Phillips, Morey L. Smith, John A. Flygare, John Xue, Joel D. Leverson, Milan Bruncko, Chang H. Park, Nathaniel D. Catron
المصدر: ACS Medicinal Chemistry Letters
مصطلحات موضوعية: Drug, media_common.quotation_subject, A-1331852, Design elements and principles, BCL-2, Bcl-xL, Pharmacology, 01 natural sciences, Biochemistry, BCL-XL, Drug Discovery, media_common, biology, 010405 organic chemistry, Drug discovery, Chemistry, Organic Chemistry, apoptosis, A-1155463, Featured Letter, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, Orally active, structure-based drug design (SBDD), Apoptosis, biology.protein, Pharmacophore
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المؤلفون: Gilberto E. Fernandez, Paroma Chakravarty, David H. Russell, Harvey Wong, Wayne J. Fairbrother, Danny Shih, Hank La, Ajit S. Narang, Ronald Steigerwalt, Minli Xie, Priscilla Mantik, Geoffrey Ganem, John A. Flygare, Uday Devanaboyina
المصدر: Journal of Pharmaceutical Sciences. 108:1934-1943
مصطلحات موضوعية: Male, Maximum Tolerated Dose, Injections, Subcutaneous, Drug Evaluation, Preclinical, Pharmaceutical Science, 02 engineering and technology, Pharmacology, Hemolysis, 030226 pharmacology & pharmacy, Micelle, Excipients, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Cyclohexanes, Toxicity Tests, Acute, medicine, Animals, Drug Interactions, Pyrroles, Solubility, Dose-Response Relationship, Drug, 021001 nanoscience & nanotechnology, medicine.disease, 2-Hydroxypropyl-beta-cyclodextrin, Rats, chemistry, Tolerability, Succinic acid, Critical micelle concentration, Injections, Intravenous, Models, Animal, Toxicity, 0210 nano-technology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36676e006855d921476d5a2533c0db0
https://doi.org/10.1016/j.xphs.2019.01.004 -
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المؤلفون: Katherine R. Kozak, Siao Ping Tsai, Doug Leipold, Luke Masterson, Hui Yao, Stefan Steinbacher, Jim Nonomiya, Keyang Xu, Helga Raab, Vishal Verma, Binqing Wei, Jeff Lau, Tao Wang, Janet Gunzner-Toste, Shang-Fan Yu, John A. Flygare, Thomas H. Pillow, Leanna Staben, John S. Wai, Zijin Xu, Brian Safina, Gail Dianne Phillips, Philip Howard, Jing Wang, Dian Su, Josefa Chuh, Jinhua Chen, Guiling Zhao, Guangmin Li, Rachana Ohri, Yichin Liu, Amrita V. Kamath, Charles Eigenbrot
المصدر: Journal of Medicinal Chemistry. 61:989-1000
مصطلحات موضوعية: 0301 basic medicine, Proteases, Antibody-drug conjugate, Immunoconjugates, Peptidomimetic, medicine.medical_treatment, Intracellular Space, Cathepsin B, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, medicine, Humans, Dipeptide, Protease, Drug discovery, body regions, 030104 developmental biology, Biochemistry, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine, Peptidomimetics, Linker
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المؤلفون: Binqing Wei, Janet Gunzner-Toste, Guangmin Li, Helga Raab, Susan D. Spencer, Gail Lewis Phillips, Shang-Fan Yu, Katherine R. Kozak, Rachana Ohri, Jeffrey Lau, Philip Howard, Andrew Polson, Brian Safina, Luke Masterson, John A. Flygare, Thomas H. Pillow, Martine Darwish, Stephen J. Gregson, Gyoung-Dong Kang, Josefa dela Cruz-Chuh
المصدر: Journal of Medicinal Chemistry. 60:9490-9507
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Immunoconjugates, Cell Survival, Receptor, ErbB-2, Stereochemistry, Sialic Acid Binding Ig-like Lectin 2, Triazole, Pyrrolobenzodiazepine, Antineoplastic Agents, Breast Neoplasms, Benzodiazepines, Mice, 03 medical and health sciences, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Pyrroles, Maleimide, Piperazine, 030104 developmental biology, chemistry, Molecular Medicine, Female, Dimerization, Linker, Conjugate, Cysteine
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المؤلفون: John A. Flygare, Ingrid E. Wertz, David S. Hewings, Matthew Bogyo
المصدر: The Febs Journal
مصطلحات موضوعية: 0301 basic medicine, Proteasome Endopeptidase Complex, Proteases, Ubiquitin-Specific Proteases, activity‐based protein profiling, Special Issue: Proteases, Review Article, Protein degradation, Biochemistry, Deubiquitinating enzyme, E1, 03 medical and health sciences, E3, Ubiquitin, Animals, Humans, Review Articles, Molecular Biology, Deubiquitinating Enzymes, biology, Chemistry, Activity-based proteomics, protease, Cell Biology, chemoproteomics, activity‐based probe, Ubiquitin ligase, ubiquitin–proteasome system, deubiquitinase, 030104 developmental biology, Proteasome, biology.protein, Protein Processing, Post-Translational, Peptide Hydrolases
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المؤلفون: Leanna Staben, Klaus Koefoed, Helga Raab, Cecile Chalouni, Yana Khalfin, Laura DePalatis, Kelly M. Loyet, Thomas H. Pillow, Min Xu, Byoung-Chul Lee, Peter S. Andersen, Emile Plise, Janice Kim, Elizabeth Luis, Martine Darwish, Rina Fong, Man-Wah Tan, Eric J. Brown, Patrick J. Lupardus, J. Hiroshi Morisaki, Summer Park, Sophie M. Lehar, Donghong Yan, Richard Vandlen, Joseph P. Lyssikatos, Magnus Strandh, Wouter L. W. Hazenbos, John A. Flygare, Sanjeev Mariathasan, Kimberly Kajihara, Hilda Hernandez, Jonathan Cheong
المصدر: Nature. 527:323-328
مصطلحات موضوعية: Methicillin-Resistant Staphylococcus aureus, Staphylococcus aureus, Immunoconjugates, medicine.drug_class, Antibiotics, Intracellular Space, Bacteremia, Microbial Sensitivity Tests, Biology, medicine.disease_cause, Staphylococcal infections, Phagolysosome, Microbiology, Mice, Vancomycin, Phagosomes, medicine, Animals, Pathogen, Multidisciplinary, Staphylococcal Infections, medicine.disease, Methicillin-resistant Staphylococcus aureus, Anti-Bacterial Agents, Drug Design, Carrier State, Female, Intracellular, medicine.drug
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المؤلفون: Wei-Ching Liang, Cecilia Chiu, Steven R. Leong, Angela Hendricks, Vanessa Clark, Andrew Polson, Yan Wu, Rajesh Vij, Jack Sadowsky, Wayne Chu, Thomas H. Pillow, John A. Flygare, Genee Y. Lee, Geoffrey Del Rosario, Melissa Schutten, Shang-Fan Yu, Kirsten Achilles Poon, Cecile Chalouni, Bing Zheng
المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research. 25(4)
مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Antibody-drug conjugate, Myeloid, Immunoconjugates, CD33, Sialic Acid Binding Ig-like Lectin 3, 03 medical and health sciences, Mice, 0302 clinical medicine, hemic and lymphatic diseases, medicine, Animals, Humans, Lectins, C-Type, business.industry, Myeloid leukemia, medicine.disease, Flow Cytometry, Xenograft Model Antitumor Assays, Antibodies, Anti-Idiotypic, body regions, Gene Expression Regulation, Neoplastic, Leukemia, Haematopoiesis, Leukemia, Myeloid, Acute, 030104 developmental biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Receptors, Mitogen, Cytarabine, Cancer research, Stem cell, business, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8889d91a81d4543f26032b1ad4f51a1b
https://pubmed.ncbi.nlm.nih.gov/29959143