المؤلفون: Asowata EO; Bioscience Renal, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom; Department of Surgery, University of Cambridge and NIHR Biomedical Research Centre, Cambridge, United Kingdom., Romoli S; Bioscience Renal, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Sargeant R; Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Tan JY; Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Hoffmann S; Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Huang MM; Department of Surgery, University of Cambridge and NIHR Biomedical Research Centre, Cambridge, United Kingdom., Mahbubani KT; Department of Surgery, University of Cambridge and NIHR Biomedical Research Centre, Cambridge, United Kingdom., Krause FN; Bioscience Renal, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom., Jachimowicz D; Discovery Biology, Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Agren R; Translational Science and Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Koulman A; NIHR BRC Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Cambridge, United Kingdom., Jenkins B; NIHR BRC Core Metabolomics and Lipidomics Laboratory, University of Cambridge, Cambridge, United Kingdom., Musial B; Bioscience Renal, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Griffin JL; Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom., Soderberg M; Department of Pathology, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Ling S; Imaging and Data Analytics, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Hansen PBL; Bioscience Renal, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Biomedical Research Centre, Cambridge, United Kingdom. Electronic address: ks10014@cam.ac.uk., Woollard KJ; Bioscience Renal, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom. Electronic address: kevin.woollard@astrazeneca.com.

المصدر: Kidney international [Kidney Int] 2024 Jul; Vol. 106 (1), pp. 85-97. Date of Electronic Publication: 2024 Feb 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0323470 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-1755 (Electronic) Linking ISSN: 00852538 NLM ISO Abbreviation: Kidney Int Subsets: MEDLINE

مواضيع طبية MeSH: Phenotype* , Acute Kidney Injury*/metabolism , Acute Kidney Injury*/pathology , Acute Kidney Injury*/etiology, Humans ; Male ; Middle Aged ; Metabolomics/methods ; Female ; Kidney Transplantation/adverse effects ; Adult ; Image Cytometry/methods ; Kidney/pathology ; Kidney/metabolism ; Phospholipases A2/metabolism ; Arachidonic Acid/metabolism ; Kidney Tubules, Proximal/metabolism ; Kidney Tubules, Proximal/pathology ; Transcriptome ; Dinoprostone/metabolism ; Dinoprostone/analysis ; Fibroblasts/metabolism ; Gene Expression Profiling ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Biopsy ; Multiomics

المؤلفون: Han K; Laboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Room 5-3342, Bld 10-CRC, 10 Center Drive, Bethesda, MD 20817, United States., Meadows AM; Laboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Room 5-3342, Bld 10-CRC, 10 Center Drive, Bethesda, MD 20817, United States.; Department of Biochemistry, University of Cambridge, Sanger Bld, 80 Tennis Ct Rd, Cambridge CB2 1GA, United Kingdom., Rodman MJ; Laboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Room 5-3342, Bld 10-CRC, 10 Center Drive, Bethesda, MD 20817, United States., Russo AC; Laboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Room 5-3342, Bld 10-CRC, 10 Center Drive, Bethesda, MD 20817, United States., Sharma R; Laboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Room 5-3342, Bld 10-CRC, 10 Center Drive, Bethesda, MD 20817, United States., Singh K; Laboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Room 5-3342, Bld 10-CRC, 10 Center Drive, Bethesda, MD 20817, United States., Hassanzadeh S; Laboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Room 5-3342, Bld 10-CRC, 10 Center Drive, Bethesda, MD 20817, United States., Dagur PK; Flow Cytometry Core Facility, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, United States., Huffstutler RD; Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, United States., Krause FN; Department of Biochemistry, University of Cambridge, Sanger Bld, 80 Tennis Ct Rd, Cambridge CB2 1GA, United Kingdom., Griffin JL; Department of Biochemistry, University of Cambridge, Sanger Bld, 80 Tennis Ct Rd, Cambridge CB2 1GA, United Kingdom.; Rowett Institute, School of Medicine, Medical Sciences and Nutrition, Foresterhill Campus, University of Aberdeen, Ashgrove Rd W, Aberdeen AB25 2ZD, United Kingdom., Baumer Y; Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, United States., Powell-Wiley TM; Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, United States., Sack MN; Laboratory of Mitochondrial Biology and Metabolism, National Heart, Lung, and Blood Institute, National Institutes of Health, Room 5-3342, Bld 10-CRC, 10 Center Drive, Bethesda, MD 20817, United States.; Cardiovascular Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, United States.

المصدر: Journal of leukocyte biology [J Leukoc Biol] 2024 Mar 29; Vol. 115 (4), pp. 738-749.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE

مواضيع طبية MeSH: Propionates*/pharmacology , Fatty Acids, Nonesterified*, Humans ; Leukocytes, Mononuclear ; Receptors, G-Protein-Coupled/genetics ; Obesity

المؤلفون: O'Brien KA; Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK. ko337@cam.ac.uk., McNally BD; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Sanger Building Tennis Court Road, Cambridge, CB2 1GA, UK., Sowton AP; Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK., Murgia A; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Sanger Building Tennis Court Road, Cambridge, CB2 1GA, UK., Armitage J; Global Investigative Safety, GlaxoSmithKline R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK., Thomas LW; Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ, UK., Krause FN; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Sanger Building Tennis Court Road, Cambridge, CB2 1GA, UK., Maddalena LA; Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ, UK., Francis I; Ultrastructure and Cellular Bioimaging, GlaxoSmithKline R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK., Kavanagh S; Oncology Safety Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, CB2 OAA, Cambridge, UK., Williams DP; Functional and Mechanistic Safety, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, CB2 OAA, Cambridge, UK., Ashcroft M; Department of Medicine, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge, CB2 0QQ, UK., Griffin JL; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Sanger Building Tennis Court Road, Cambridge, CB2 1GA, UK.; Section of Biomolecular Medicine, Department of Digestion, Metabolism and Reproduction, Imperial College London, South Kensington Campus, London, SW7 2AZ, UK., Lyon JJ; Global Investigative Safety, GlaxoSmithKline R&D, Park Road, Ware, Hertfordshire, SG12 0DP, UK., Murray AJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, UK. ajm267@cam.ac.uk.

المصدر: BMC biology [BMC Biol] 2021 Dec 15; Vol. 19 (1), pp. 265. Date of Electronic Publication: 2021 Dec 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101190720 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7007 (Electronic) Linking ISSN: 17417007 NLM ISO Abbreviation: BMC Biol Subsets: MEDLINE

مواضيع طبية MeSH: Lipid Metabolism* , Liver*/metabolism, Homeostasis ; Humans ; Hypoxia/metabolism ; Lipogenesis

المؤلفون: Whitehead A; School of Medicine, University of Leeds, Leeds, UK., Krause FN; Department of Biochemistry, University of Cambridge, Cambridge, UK., Moran A; School of Medicine, University of Leeds, Leeds, UK., MacCannell ADV; School of Medicine, University of Leeds, Leeds, UK., Scragg JL; School of Medicine, University of Leeds, Leeds, UK., McNally BD; Department of Biochemistry, University of Cambridge, Cambridge, UK., Boateng E; School of Medicine, University of Leeds, Leeds, UK., Murfitt SA; Department of Biochemistry, University of Cambridge, Cambridge, UK., Virtue S; Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wright J; School of Medicine, University of Leeds, Leeds, UK., Garnham J; School of Medicine, University of Leeds, Leeds, UK., Davies GR; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Dodgson J; Phenotypic Screening and High Content Imaging, Antibody Discovery & Protein Engineering, R&D, AstraZeneca, Cambridge, UK., Schneider JE; School of Medicine, University of Leeds, Leeds, UK., Murray AJ; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Church C; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Vidal-Puig A; Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Witte KK; School of Medicine, University of Leeds, Leeds, UK., Griffin JL; Department of Biochemistry, University of Cambridge, Cambridge, UK., Roberts LD; School of Medicine, University of Leeds, Leeds, UK. L.D.Roberts@leeds.ac.uk.

المصدر: Nature communications [Nat Commun] 2021 Mar 26; Vol. 12 (1), pp. 1905. Date of Electronic Publication: 2021 Mar 26.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Adipose Tissue, Beige/*metabolism , Adipose Tissue, Brown/*metabolism , Energy Metabolism/*genetics , Homeostasis/*genetics , Signal Transduction/*genetics, Adipocytes, Brown/metabolism ; Adipocytes, White/metabolism ; Adipose Tissue, Beige/cytology ; Adipose Tissue, Brown/cytology ; Animals ; Cell Line ; Cells, Cultured ; Chromatography, Liquid ; Gas Chromatography-Mass Spectrometry ; Gene Expression Profiling/methods ; Humans ; Male ; Mass Spectrometry ; Metabolomics/methods ; Mice, Inbred C57BL ; Mice

المؤلفون: McMurran CE; Wellcome-MRC Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, United Kingdom., Guzman de la Fuente A; Wellcome-MRC Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, United Kingdom.; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, BT9 7BL Belfast, United Kingdom., Penalva R; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, BT9 7BL Belfast, United Kingdom., Ben Menachem-Zidon O; Wellcome-MRC Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, United Kingdom.; Hadassah Human Embryonic Stem Cell Research Center, Goldyne Savad Institute of Gene Therapy, Hadassah-Hebrew University Hospital, 91240 Jerusalem, Israel., Dombrowski Y; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, BT9 7BL Belfast, United Kingdom., Falconer J; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, BT9 7BL Belfast, United Kingdom., Gonzalez GA; Wellcome-MRC Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, United Kingdom., Zhao C; Wellcome-MRC Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, United Kingdom., Krause FN; Department of Biochemistry, University of Cambridge, CB2 1GA Cambridge, United Kingdom., Young AMH; Wellcome-MRC Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, United Kingdom., Griffin JL; Department of Biochemistry, University of Cambridge, CB2 1GA Cambridge, United Kingdom., Jones CA; Respiratory, Inflammation and Autoimmunity Research, MedImmune Ltd., CB21 6GH Cambridge, United Kingdom., Hollins C; Respiratory, Inflammation and Autoimmunity Research, MedImmune Ltd., CB21 6GH Cambridge, United Kingdom., Heimesaat MM; Institute for Microbiology, Infectious Diseases and Immunology, Charité-University Medicine Berlin, 14195 Berlin, Germany., Fitzgerald DC; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, BT9 7BL Belfast, United Kingdom; d.fitzgerald@qub.ac.uk rjf1000@cam.ac.uk., Franklin RJM; Wellcome-MRC Stem Cell Institute, University of Cambridge, CB2 0AW Cambridge, United Kingdom; d.fitzgerald@qub.ac.uk rjf1000@cam.ac.uk.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Dec 10; Vol. 116 (50), pp. 25311-25321. Date of Electronic Publication: 2019 Nov 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Gastrointestinal Microbiome*/drug effects, Central Nervous System/*physiopathology , Multiple Sclerosis/*immunology , Multiple Sclerosis/*microbiology, Animals ; Anti-Bacterial Agents/administration & dosage ; Anti-Bacterial Agents/adverse effects ; Cell Differentiation/drug effects ; Central Nervous System/drug effects ; Central Nervous System/immunology ; Female ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/physiopathology ; Oligodendroglia/cytology ; Oligodendroglia/drug effects ; Probiotics/administration & dosage ; Remyelination/drug effects ; Stem Cells/cytology ; Stem Cells/drug effects