المؤلفون: Willems S; Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany., Busch R; Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany., Nawa F; Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany., Ballarotto M; Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.; Department of Pharmaceutical Sciences, Università degli Studi di Perugia, 06123 Perugia, Italy., Lillich FF; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt, Germany., Kasch T; Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany., López-García Ú; Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany., Marschner JA; Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany., Rüger LA; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany., Renelt B; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany., Ohrndorf J; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany., Arifi S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany., Zaienne D; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany., Proschak E; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 60596 Frankfurt, Germany., Pabel J; Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany., Merk D; Department of Pharmacy, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, 60438 Frankfurt, Germany.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Aug 08; Vol. 67 (15), pp. 13324-13348. Date of Electronic Publication: 2024 Jul 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Nuclear Receptor Subfamily 4, Group A, Member 2*/agonists , Nuclear Receptor Subfamily 4, Group A, Member 2*/metabolism , Nuclear Receptor Subfamily 4, Group A, Member 2*/chemistry, Structure-Activity Relationship ; Humans ; Animals ; Molecular Structure ; Drug Inverse Agonism

المؤلفون: Brunst S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany., Schönfeld J; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany., Breunig P; Buchmann Institute for Molecular Life Sciences and Institute for Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Strasse 15, 60438 Frankfurt, Germany., Burgers LD; Institute of Pharmaceutical Biology, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany., DeMeglio M; Buchmann Institute for Molecular Life Sciences and Institute for Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Strasse 15, 60438 Frankfurt, Germany., Ehrler JHM; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany., Lillich FF; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany., Weizel L; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany., Hefendehl JK; Buchmann Institute for Molecular Life Sciences and Institute for Cell Biology and Neuroscience, Goethe University Frankfurt, Max-von-Laue-Strasse 15, 60438 Frankfurt, Germany., Fürst R; Institute of Pharmaceutical Biology, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany., Proschak E; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany., Hiesinger K; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Strasse 9, 60438 Frankfurt, Germany.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Jun 14; Vol. 13 (7), pp. 1062-1067. Date of Electronic Publication: 2022 Jun 14 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Seredinski S; Institute for Cardiovascular Physiology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.; German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany., Boos F; Institute for Cardiovascular Physiology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.; German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany., Günther S; Max Planck Institute for Heart and Lung Research, 61231 Bad Nauheim, Germany., Oo JA; Institute for Cardiovascular Physiology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.; German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany., Warwick T; Institute for Cardiovascular Physiology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.; German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany., Izquierdo Ponce J; Institute for Cardiovascular Physiology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany., Lillich FF; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt, Germany., Proschak E; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University, 60438 Frankfurt, Germany., Gilsbach R; Institute for Cardiovascular Physiology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.; German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany., Pflüger-Müller B; Institute for Cardiovascular Physiology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.; German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany., Brandes RP; Institute for Cardiovascular Physiology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.; German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany., Leisegang MS; Institute for Cardiovascular Physiology, Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany.; German Center of Cardiovascular Research (DZHK), Partner Site RheinMain, Frankfurt, Germany.

المصدر: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2022 Jan 25; Vol. 27, pp. 1023-1035. Date of Electronic Publication: 2022 Jan 25 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: eCollection Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE

المؤلفون: Lillich FF; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Willems S; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Ni X; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe-University, Max-von-Laue-Str. 15, D-60438 Frankfurt, Germany., Kilu W; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Borkowsky C; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Brodsky M; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Kramer JS; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Brunst S; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Hernandez-Olmos V; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, D-60596 Frankfurt, Germany., Heering J; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, D-60596 Frankfurt, Germany., Schierle S; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Kestner RI; Department of Neurology, University Hospital Frankfurt, Goethe University, D-60590 Frankfurt am Main, Germany., Mayser FM; Department of Neurology, University Hospital Frankfurt, Goethe University, D-60590 Frankfurt am Main, Germany., Helmstädter M; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Göbel T; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Weizel L; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Namgaladze D; Institute of Biochemistry I, University Hospital Frankfurt, Goethe University, D-60590 Frankfurt am Main, Germany., Kaiser A; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Pfeilschifter W; Department of Neurology, University Hospital Frankfurt, Goethe University, D-60590 Frankfurt am Main, Germany., Kahnt AS; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Proschak A; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Chaikuad A; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe-University, Max-von-Laue-Str. 15, D-60438 Frankfurt, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe-University, Max-von-Laue-Str. 15, D-60438 Frankfurt, Germany., Merk D; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany., Proschak E; Institute of Pharmaceutical Chemistry, Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, D-60596 Frankfurt, Germany.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Dec 09; Vol. 64 (23), pp. 17259-17276. Date of Electronic Publication: 2021 Nov 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Enzyme Inhibitors/*chemistry , Enzyme Inhibitors/*pharmacology , Epoxide Hydrolases/*antagonists & inhibitors , PPAR gamma/*agonists, Animals ; Crystallography, X-Ray ; HEK293 Cells ; Humans ; Mice ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Polypharmacy ; Rats ; Structure-Activity Relationship

المؤلفون: Schierle S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany., Chaikuad A; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany.; Structural Genomics Consortium, BMLS, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt, Germany., Lillich FF; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany., Ni X; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany.; Structural Genomics Consortium, BMLS, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt, Germany., Woltersdorf S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany., Schallmayer E; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany., Renelt B; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany., Ronchetti R; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany., Knapp S; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany.; Structural Genomics Consortium, BMLS, Goethe University Frankfurt, Max-von-Laue-Str. 15, 60438 Frankfurt, Germany., Proschak E; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany., Merk D; Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, D-60438 Frankfurt, Germany.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Apr 22; Vol. 64 (8), pp. 5123-5136. Date of Electronic Publication: 2021 Apr 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Oxaprozin/*analogs & derivatives , Retinoid X Receptors/*agonists, Animals ; Binding Sites ; Cell Survival/drug effects ; Crystallography, X-Ray ; Half-Life ; Humans ; Ligands ; Mice ; Microsomes/metabolism ; Molecular Dynamics Simulation ; Oxaprozin/metabolism ; Oxaprozin/pharmacology ; Protein Isoforms/agonists ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; Pyrazoles/chemistry ; Pyrazoles/metabolism ; Pyrazoles/pharmacology ; Rats ; Retinoid X Receptors/genetics ; Retinoid X Receptors/metabolism ; Structure-Activity Relationship

المؤلفون: Lillich FF; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Frankfurt, Germany., Imig JD; Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI, United States., Proschak E; Institute of Pharmaceutical Chemistry, Goethe-University of Frankfurt, Frankfurt, Germany.

المصدر: Frontiers in pharmacology [Front Pharmacol] 2021 Mar 12; Vol. 11, pp. 554961. Date of Electronic Publication: 2021 Mar 12 (Print Publication: 2020).

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

المؤلفون: Kramer JS; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany., Woltersdorf S; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany., Duflot T; Laboratory of Pharmacokinetics, Toxicology and Pharmacogenetics , Rouen University Hospital , 76000 Rouen , France.; Normandie Université, UNIROUEN, INSERM U1096 , 1 rue de Germont , 76000 Rouen , France., Hiesinger K; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany., Lillich FF; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany., Knöll F; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany., Wittmann SK; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany., Klingler FM; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany., Brunst S; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany., Chaikuad A; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany.; Structural Genomics Consortium, Buchmann Institute for Life Sciences , Goethe-University Frankfurt , Max-von-Laue-Strasse 15 , 60438 Frankfurt am Main , Germany., Morisseau C; Department of Entomology and Nematology and UC Davis Comprehensive Cancer Center , University of California Davis , Davis , California 95616 , United States., Hammock BD; Department of Entomology and Nematology and UC Davis Comprehensive Cancer Center , University of California Davis , Davis , California 95616 , United States., Buccellati C; Department of Pharmacological and Biomolecular Sciences , University of Milan , Via Balzaretti 9 , 20133 Milan , Italy., Sala A; Department of Pharmacological and Biomolecular Sciences , University of Milan , Via Balzaretti 9 , 20133 Milan , Italy., Rovati GE; Department of Pharmacological and Biomolecular Sciences , University of Milan , Via Balzaretti 9 , 20133 Milan , Italy., Leuillier M; Normandie Université, UNIROUEN, INSERM U1096 , 1 rue de Germont , 76000 Rouen , France., Fraineau S; Normandie Université, UNIROUEN, INSERM U1096 , 1 rue de Germont , 76000 Rouen , France., Rondeaux J; Normandie Université, UNIROUEN, INSERM U1096 , 1 rue de Germont , 76000 Rouen , France., Hernandez-Olmos V; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany.; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology TMP , Theodor-Stern-Kai 7 , 60596 Frankfurt am Main , Germany., Heering J; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany.; Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Branch for Translational Medicine and Pharmacology TMP , Theodor-Stern-Kai 7 , 60596 Frankfurt am Main , Germany., Merk D; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany., Pogoryelov D; Institute of Biochemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany., Steinhilber D; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany., Knapp S; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany.; Laboratory of Pharmacokinetics, Toxicology and Pharmacogenetics , Rouen University Hospital , 76000 Rouen , France., Bellien J; Normandie Université, UNIROUEN, INSERM U1096 , 1 rue de Germont , 76000 Rouen , France.; Department of Clinical Pharmacology , Rouen University Hospital , 76000 Rouen , France., Proschak E; Institute of Pharmaceutical Chemistry , Goethe-University Frankfurt , Max-von-Laue-Strasse 9 , 60438 Frankfurt am Main , Germany.

المصدر: Journal of medicinal chemistry [J Med Chem] 2019 Sep 26; Vol. 62 (18), pp. 8443-8460. Date of Electronic Publication: 2019 Sep 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*chemistry , Epoxide Hydrolases/*antagonists & inhibitors , Epoxide Hydrolases/*chemistry, Animals ; Binding Sites ; Catalytic Domain ; Drug Design ; Humans ; Ligands ; Male ; Oxazoles/chemistry ; Phosphoric Monoester Hydrolases/chemistry ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Temperature

المؤلفون: Kretschmer SB; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Woltersdorf S; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Vogt D; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Lillich FF; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Rühl M; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Karas M; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Maucher IV; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Roos J; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Häfner AK; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Kaiser A; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Wurglics M; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Schubert-Zsilavecz M; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Angioni C; Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, Goethe-University Frankfurt, Theodor Stern Kai 7, D-60590 Frankfurt/Main, Germany., Geisslinger G; Institute of Clinical Pharmacology, Pharmazentrum Frankfurt, Goethe-University Frankfurt, Theodor Stern Kai 7, D-60590 Frankfurt/Main, Germany., Stark H; Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf, Germany., Steinhilber D; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany., Hofmann B; Institute of Pharmaceutical Chemistry, Goethe-University Frankfurt, Max-von-Laue-Strasse 9, D-60438 Frankfurt, Germany. Electronic address: hofmann@pharmchem.uni-frankfurt.de.

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2017 Jan 01; Vol. 123, pp. 52-62. Date of Electronic Publication: 2016 Sep 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Lipoxygenase Inhibitors/*pharmacology , Thiazoles/*pharmacology, Cells, Cultured ; Humans ; Lipoxygenase Inhibitors/pharmacokinetics ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Thiazoles/pharmacokinetics