المؤلفون: Feldman HC; Department of Chemistry, Scripps Research, La Jolla, CA 92037., Merlini E; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0PY, United Kingdom., Guijas C; Lundbeck La Jolla Research Center Inc, San Diego, CA 92121., DeMeester KE; Department of Chemistry, Scripps Research, La Jolla, CA 92037., Njomen E; Department of Chemistry, Scripps Research, La Jolla, CA 92037., Kozina EM; Lundbeck La Jolla Research Center Inc, San Diego, CA 92121., Yokoyama M; Department of Chemistry, Scripps Research, La Jolla, CA 92037., Vinogradova E; Department of Chemistry, Scripps Research, La Jolla, CA 92037., Reardon HT; Lundbeck La Jolla Research Center Inc, San Diego, CA 92121., Melillo B; Department of Chemistry, Scripps Research, La Jolla, CA 92037.; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02138., Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA 02138.; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138., Loreto A; John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0PY, United Kingdom., Blankman JL; Lundbeck La Jolla Research Center Inc, San Diego, CA 92121., Cravatt BF; Department of Chemistry, Scripps Research, La Jolla, CA 92037.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Aug 30; Vol. 119 (35), pp. e2208457119. Date of Electronic Publication: 2022 Aug 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Armadillo Domain Proteins*/antagonists & inhibitors , Armadillo Domain Proteins*/chemistry , Armadillo Domain Proteins*/genetics , Cysteine* , Cytoskeletal Proteins*/antagonists & inhibitors , Cytoskeletal Proteins*/chemistry , Cytoskeletal Proteins*/genetics, Axons ; Homeostasis ; NAD+ Nucleosidase ; Proteomics

المؤلفون: Reardon HT; Abide Therapeutics, San Diego, CA, USA., Herbst RA; Abide Therapeutics, San Diego, CA, USA., Henry CL; Abide Therapeutics, San Diego, CA, USA., Herbst DM; Abide Therapeutics, San Diego, CA, USA., Ngo N; Abide Therapeutics, San Diego, CA, USA., Cisar JS; Abide Therapeutics, San Diego, CA, USA.; Janssen Research & Development, Spring House, PA., Weber OD; Abide Therapeutics, San Diego, CA, USA., Niphakis MJ; Abide Therapeutics, San Diego, CA, USA., O'Neill GP; Abide Therapeutics, San Diego, CA, USA.

المصدر: SLAS technology [SLAS Technol] 2019 Oct; Vol. 24 (5), pp. 489-498. Date of Electronic Publication: 2019 Jun 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697564 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-6311 (Electronic) Linking ISSN: 24726303 NLM ISO Abbreviation: SLAS Technol Subsets: MEDLINE

مواضيع طبية MeSH: Microfluidics/*methods , Proteomics/*methods, Algorithms ; Animals ; Biological Assay ; Mice ; Molecular Weight ; Reproducibility of Results

المؤلفون: Podvin S; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, 9500 Gilman Drive, MC0719, La Jolla, San Diego, CA, 92093-0719, USA., Reardon HT; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, 9500 Gilman Drive, MC0719, La Jolla, San Diego, CA, 92093-0719, USA., Yin K; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, 9500 Gilman Drive, MC0719, La Jolla, San Diego, CA, 92093-0719, USA., Mosier C; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, 9500 Gilman Drive, MC0719, La Jolla, San Diego, CA, 92093-0719, USA., Hook V; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, 9500 Gilman Drive, MC0719, La Jolla, San Diego, CA, 92093-0719, USA. vhook@ucsd.edu.; Department of Neurosciences, University of California, 9500 Gilman Drive, MC0719, La Jolla, San Diego, CA, 92093-0719, USA. vhook@ucsd.edu.; Department of Pharmacology, University of California, 9500 Gilman Drive, MC0719, La Jolla, San Diego, CA, 92093-0719, USA. vhook@ucsd.edu.

المصدر: Journal of neurology [J Neurol] 2019 Mar; Vol. 266 (3), pp. 551-564. Date of Electronic Publication: 2018 Jun 28.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0423161 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1459 (Electronic) Linking ISSN: 03405354 NLM ISO Abbreviation: J Neurol Subsets: MEDLINE

مواضيع طبية MeSH: Huntington Disease*/genetics , Huntington Disease*/metabolism , Huntington Disease*/pathology , Huntington Disease*/physiopathology, Huntingtin Protein/*genetics , Trinucleotide Repeats/*genetics, Humans

المؤلفون: Reardon HT; Division of Nutritional Sciences, Cornell University, Ithaca, New York, USA., Hsieh AT, Park WJ, Kothapalli KS, Anthony JC, Nathanielsz PW, Brenna JT

المصدر: Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2013 Jan; Vol. 88 (1), pp. 15-9. Date of Electronic Publication: 2012 Mar 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 8802730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2823 (Electronic) Linking ISSN: 09523278 NLM ISO Abbreviation: Prostaglandins Leukot Essent Fatty Acids Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Enzymologic*/drug effects, Arachidonic Acids/*metabolism , Dietary Fats/*administration & dosage , Docosahexaenoic Acids/*administration & dosage , Fatty Acid Desaturases/*biosynthesis , Liver/*metabolism, Alternative Splicing/drug effects ; Animals ; Animals, Newborn ; Arachidonic Acids/deficiency ; Delta-5 Fatty Acid Desaturase ; Dietary Fats/metabolism ; Docosahexaenoic Acids/metabolism ; Down-Regulation/drug effects ; Enzyme Induction/drug effects ; Fatty Acid Desaturases/genetics ; Fatty Acid Desaturases/metabolism ; Female ; Hep G2 Cells ; Humans ; Isoenzymes/biosynthesis ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Liver/drug effects ; Liver/growth & development ; Male ; PPAR gamma/antagonists & inhibitors ; PPAR gamma/metabolism ; Papio ; RNA, Messenger/metabolism ; Random Allocation

المؤلفون: Park WJ; Division of Nutritional Sciences, Cornell University, Ithaca, NY., Kothapalli KS, Reardon HT, Lawrence P, Qian SB, Brenna JT

المصدر: Journal of lipid research [J Lipid Res] 2012 Aug; Vol. 53 (8), pp. 1502-12. Date of Electronic Publication: 2012 May 22.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE

مواضيع طبية MeSH: Eicosanoids/*biosynthesis , Fatty Acid Desaturases/*genetics , Fatty Acid Desaturases/*metabolism, Alternative Splicing ; Animals ; Animals, Newborn ; Cell Differentiation ; Cell Line, Tumor ; Computational Biology ; Delta-5 Fatty Acid Desaturase ; Embryo, Mammalian/cytology ; Exons/genetics ; Gene Expression Regulation, Enzymologic ; Humans ; Intracellular Space/metabolism ; Isoenzymes/genetics ; Isoenzymes/metabolism ; Papio ; Poly A/genetics ; Poly A/metabolism ; Protein Transport ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcription, Genetic

المؤلفون: Reardon HT; Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA., Zhang J, Kothapalli KS, Kim AJ, Park WJ, Brenna JT

المصدر: Prostaglandins, leukotrienes, and essential fatty acids [Prostaglandins Leukot Essent Fatty Acids] 2012 Jul; Vol. 87 (1), pp. 25-33. Date of Electronic Publication: 2012 Jun 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 8802730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2823 (Electronic) Linking ISSN: 09523278 NLM ISO Abbreviation: Prostaglandins Leukot Essent Fatty Acids Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation* , INDEL Mutation*, Fatty Acid Desaturases/*genetics , Gene Expression/*drug effects , Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology , Simvastatin/*pharmacology, Base Sequence ; Benzoates/pharmacology ; Benzylamines/pharmacology ; Binding Sites ; Cells, Cultured ; Conserved Sequence ; Delta-5 Fatty Acid Desaturase ; Gene Frequency ; Haplotypes ; Heterozygote ; Humans ; Introns ; Linkage Disequilibrium ; Liver X Receptors ; Locus Control Region ; Multigene Family ; Oligonucleotide Array Sequence Analysis ; Orphan Nuclear Receptors/agonists ; Polymorphism, Single Nucleotide ; Quantitative Trait Loci ; Response Elements ; Rosiglitazone ; Sequence Analysis, DNA ; Sterol Regulatory Element Binding Protein 1/agonists ; Sterol Regulatory Element Binding Protein 1/metabolism ; Thiazolidinediones/pharmacology

المؤلفون: Reardon HT; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853., Park WJ; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853., Zhang J; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853., Lawrence P; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853., Kothapalli KSD; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853., Brenna JT; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853. Electronic address: jtb4@cornell.edu.

المصدر: Journal of lipid research [J Lipid Res] 2011 Dec; Vol. 52 (12), pp. 2279-2286. Date of Electronic Publication: 2011 Oct 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0376606 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1539-7262 (Electronic) Linking ISSN: 00222275 NLM ISO Abbreviation: J Lipid Res Subsets: MEDLINE

مواضيع طبية MeSH: Alternative Splicing/*genetics , Fatty Acid Desaturases/*genetics , Fatty Acids, Omega-3/*metabolism , Fatty Acids, Omega-6/*metabolism , Heterogeneous-Nuclear Ribonucleoproteins/*metabolism , Polypyrimidine Tract-Binding Protein/*metabolism, Animals ; Exons/genetics ; Fatty Acid Desaturases/deficiency ; Gene Knockdown Techniques ; Gene Silencing ; Hep G2 Cells ; Heterogeneous-Nuclear Ribonucleoproteins/deficiency ; Heterogeneous-Nuclear Ribonucleoproteins/genetics ; Humans ; Papio ; Polypyrimidine Tract-Binding Protein/deficiency ; Polypyrimidine Tract-Binding Protein/genetics ; Protein Binding ; RNA Splice Sites/genetics ; RNA, Small Interfering/genetics ; Up-Regulation

المؤلفون: Park WJ; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA., Reardon HT, Tyburczy C, Kothapalli KS, Brenna JT

المصدر: Molecular biology reports [Mol Biol Rep] 2010 Jun; Vol. 37 (5), pp. 2403-6. Date of Electronic Publication: 2009 Aug 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE

مواضيع طبية MeSH: Alternative Splicing/*genetics , Fatty Acid Desaturases/*genetics , Papio/*genetics, Animals ; Cell Line, Tumor ; Gene Expression Profiling ; Gene Expression Regulation, Enzymologic ; Humans ; Protein Transport ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Subcellular Fractions/enzymology

المؤلفون: Park WJ; Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA. wp48@cornell.edu, Kothapalli KS, Reardon HT, Kim LY, Brenna JT

المصدر: Gene [Gene] 2009 Oct 01; Vol. 446 (1), pp. 28-34. Date of Electronic Publication: 2009 Jun 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: Netherlands NLM ID: 7706761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0038 (Electronic) Linking ISSN: 03781119 NLM ISO Abbreviation: Gene Subsets: MEDLINE

مواضيع طبية MeSH: Alternative Splicing*, Fatty Acid Desaturases/*genetics , Papio/*genetics, Amino Acid Sequence ; Animals ; Animals, Newborn ; Cell Line ; Conserved Sequence ; Delta-5 Fatty Acid Desaturase ; Female ; Humans ; Isoenzymes/genetics ; Male ; Molecular Sequence Data ; Papio/metabolism ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Sequence Homology, Amino Acid ; Species Specificity ; Tissue Distribution