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المؤلفون: Hobson AD, McPherson MJ, Waegell W, Goess CA, Stoffel RH, Li X, Zhou J, Wang Z, Yu Y, Hernandez A Jr, Bryant SH, Mathieu SL, Bischoff AK, Fitzgibbons J, Pawlikowska M, Puthenveetil S, Santora LC, Wang L, Wang L, Marvin CC, Hayes ME, Shrestha A, Sarris KA, Li B

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Apr 27; Vol. 66 (8), pp. 6011. Date of Electronic Publication: 2023 Apr 14.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Gesmundo NJ; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Tu NP; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Sarris KA; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Wang Y; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Mar 16; Vol. 14 (4), pp. 521-529. Date of Electronic Publication: 2023 Mar 16 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Hobson AD; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., McPherson MJ; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Waegell W; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Goess CA; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Stoffel RH; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Li X; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China., Zhou J; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China., Wang Z; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China., Yu Y; WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China., Hernandez A Jr; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Bryant SH; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Mathieu SL; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Bischoff AK; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Fitzgibbons J; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Pawlikowska M; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Puthenveetil S; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Santora LC; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Wang L; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Wang L; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Marvin CC; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Hayes ME; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States., Shrestha A; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Sarris KA; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Li B; AbbVie Bioresearch Center, 381 Plantation Street, Worcester, Massachusetts 01605, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Mar 24; Vol. 65 (6), pp. 4500-4533. Date of Electronic Publication: 2022 Feb 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents* , Immunoconjugates*/pharmacology , Immunoconjugates*/therapeutic use, Animals ; Antibodies ; Mice ; Receptors, Glucocorticoid

المؤلفون: Dombrowski AW; Advanced Chemistry Technologies Group, AbbVie, Inc., North Chicago, Illinois 60064, United States., Aguirre AL; Advanced Chemistry Technologies Group, AbbVie, Inc., North Chicago, Illinois 60064, United States., Shrestha A; Advanced Chemistry Technologies Group, AbbVie, Inc., North Chicago, Illinois 60064, United States., Sarris KA; Advanced Chemistry Technologies Group, AbbVie, Inc., North Chicago, Illinois 60064, United States., Wang Y; Advanced Chemistry Technologies Group, AbbVie, Inc., North Chicago, Illinois 60064, United States.

المصدر: The Journal of organic chemistry [J Org Chem] 2022 Feb 18; Vol. 87 (4), pp. 1880-1897. Date of Electronic Publication: 2021 Nov 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*

المؤلفون: Dombrowski AW; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Gesmundo NJ; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Aguirre AL; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Sarris KA; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Young JM; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Bogdan AR; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Martin MC; Northwestern University Center for Molecular Innovation and Drug Discovery, 2145 Sheridan Road, Evanston, Illinois 60208, United States., Gedeon S; Florida A&M University College of Pharmacy and Pharmaceutical Sciences, 1415 South Martin Luther King, Jr. Boulevard, Tallahassee, Florida 32307, United States., Wang Y; AbbVie, Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Mar 23; Vol. 11 (4), pp. 597-604. Date of Electronic Publication: 2020 Mar 23 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Curtin ML; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States. Electronic address: mike.curtin@abbvie.com., Heyman HR; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Clark RF; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sorensen BK; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Doherty GA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Hansen TM; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Frey RR; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sarris KA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Aguirre AL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Shrestha A; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Tu N; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Woller K; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Pliushchev MA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sweis RF; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Cheng M; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Wilsbacher JL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Kovar PJ; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Guo J; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Cheng D; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Longenecker KL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Raich D; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Korepanova AV; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Soni NB; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Algire MA; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Richardson PL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Marin VL; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Badagnani I; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Vasudevan A; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Buchanan FG; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Maag D; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Chiang GG; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Tse C; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States., Michaelides MR; AbbVie Inc, 1 North Waukegan Rd., North Chicago, IL 60064, United States.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Aug 01; Vol. 27 (15), pp. 3317-3325. Date of Electronic Publication: 2017 Jun 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemistry , Antineoplastic Agents/*pharmacology , Cytokines/*antagonists & inhibitors , Enzyme Inhibitors/*chemistry , Enzyme Inhibitors/*pharmacology , Nicotinamide Phosphoribosyltransferase/*antagonists & inhibitors , Urea/*analogs & derivatives , Urea/*pharmacology, Animals ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Crystallography, X-Ray ; Cytokines/chemistry ; Cytokines/metabolism ; Drug Discovery ; Enzyme Inhibitors/pharmacokinetics ; Enzyme Inhibitors/therapeutic use ; Humans ; Isoindoles/chemistry ; Isoindoles/pharmacokinetics ; Isoindoles/pharmacology ; Isoindoles/therapeutic use ; Mice ; Models, Molecular ; Neoplasms/drug therapy ; Neoplasms/metabolism ; Neoplasms/pathology ; Nicotinamide Phosphoribosyltransferase/chemistry ; Nicotinamide Phosphoribosyltransferase/metabolism ; Structure-Activity Relationship ; Urea/pharmacokinetics ; Urea/therapeutic use

المؤلفون: Curtin ML; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States. Electronic address: mike.curtin@abbvie.com., Pliushchev MA; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Li HQ; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Torrent M; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Dietrich JD; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Jakob CG; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Zhu H; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Zhao H; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Wang Y; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Ji Z; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Clark RF; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sarris KA; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Selvaraju S; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Shaw B; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Algire MA; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., He Y; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Richardson PL; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sweis RF; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Sun C; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Chiang GG; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States., Michaelides MR; AbbVie Inc., 1 North Waukegan Rd., North Chicago, IL 60064, United States.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Apr 01; Vol. 27 (7), pp. 1576-1583. Date of Electronic Publication: 2017 Feb 20.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Polycomb Repressive Complex 2/*antagonists & inhibitors , Polycomb Repressive Complex 2/*metabolism , Pyrrolidines/*pharmacology , Sulfonamides/*pharmacology, Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Humans ; Ligands ; Mice ; Microsomes, Liver/drug effects ; Microsomes, Liver/metabolism ; Polycomb Repressive Complex 2/chemistry ; Protein Binding ; Pyrrolidines/chemical synthesis ; Pyrrolidines/chemistry ; Stereoisomerism ; Structure-Activity Relationship ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry ; Xenograft Model Antitumor Assays

المؤلفون: Faghih R; Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064, USA. ramin.faghih@abbott.com, Gopalakrishnan SM, Gronlien JH, Malysz J, Briggs CA, Wetterstrand C, Ween H, Curtis MP, Sarris KA, Gfesser GA, El-Kouhen R, Robb HM, Radek RJ, Marsh KC, Bunnelle WH, Gopalakrishnan M

المصدر: Journal of medicinal chemistry [J Med Chem] 2009 May 28; Vol. 52 (10), pp. 3377-84.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Allosteric Regulation*, Pyrroles/*pharmacology , Receptors, Nicotinic/*drug effects , Sensory Gating/*drug effects , Sulfonamides/*pharmacology, Animals ; Brain/metabolism ; Cells, Cultured ; Drug Discovery ; Mice ; Microsomes ; Oocytes ; Patch-Clamp Techniques ; Pharmacokinetics ; Xenopus laevis ; alpha7 Nicotinic Acetylcholine Receptor ; Benzenesulfonamides

المؤلفون: Xin Z; Metabolic Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6098, USA. zhili.xin@abbott.com, Serby MD, Zhao H, Kosogof C, Szczepankiewicz BG, Liu M, Liu B, Hutchins CW, Sarris KA, Hoff ED, Falls HD, Lin CW, Ogiela CA, Collins CA, Brune ME, Bush EN, Droz BA, Fey TA, Knourek-Segel VE, Shapiro R, Jacobson PB, Beno DW, Turner TM, Sham HL, Liu G

المصدر: Journal of medicinal chemistry [J Med Chem] 2006 Jul 27; Vol. 49 (15), pp. 4459-69.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Aminopyridines/*chemical synthesis , Anti-Obesity Agents/*chemical synthesis , Receptors, G-Protein-Coupled/*antagonists & inhibitors, Administration, Oral ; Amides/chemical synthesis ; Amides/pharmacology ; Aminopyridines/pharmacology ; Animals ; Anti-Obesity Agents/pharmacology ; Appetite Depressants/chemical synthesis ; Appetite Depressants/pharmacology ; Biological Availability ; Body Weight/drug effects ; Cell Line ; Crystallography, X-Ray ; Eating/drug effects ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Obese ; Models, Molecular ; Molecular Structure ; Rats ; Rats, Sprague-Dawley ; Receptors, Ghrelin ; Structure-Activity Relationship ; Urea/analogs & derivatives ; Urea/chemical synthesis ; Urea/pharmacology