المؤلفون: Stefanie Kickinger, Maria E. K. Lie, Akihiro Suemasa, Anas Al-Khawaja, Koichi Fujiwara, Mizuki Watanabe, Kristine S. Wilhelmsen, Christina B. Falk-Petersen, Bente Frølund, Satoshi Shuto, Gerhard F. Ecker, Petrine Wellendorph

المصدر: Frontiers in Chemistry, Vol 9 (2021)

مصطلحات موضوعية: SLC6 neurotransmitter transporters, competitive inhibition, binding mode analysis, computational chemistry, bicyclo-GABA, BGT1, Chemistry, QD1-999

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fchem.2021.736457/full; https://doaj.org/toc/2296-2646

URL الوصول: https://doaj.org/article/eb62ced04b7242589c80acca580e939a

المؤلفون: Vojtech Dvorak, Tabea Wiedmer, Alvaro Ingles-Prieto, Patrick Altermatt, Helena Batoulis, Felix Bärenz, Eckhard Bender, Daniela Digles, Franz Dürrenberger, Laura H. Heitman, Adriaan P. IJzerman, Douglas B. Kell, Stefanie Kickinger, Daniel Körzö, Philipp Leippe, Thomas Licher, Vania Manolova, Riccardo Rizzetto, Francesca Sassone, Lia Scarabottolo, Avner Schlessinger, Vanessa Schneider, Hubert J. Sijben, Anna-Lena Steck, Hanna Sundström, Sara Tremolada, Maria Wilhelm, Marina Wright Muelas, Diana Zindel, Claire M. Steppan, Giulio Superti-Furga

المصدر: Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: solute carrier, cell-based assay, drug discovery, chemical screening, transporters, SLC, Therapeutics. Pharmacology, RM1-950

وصف الملف: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2021.722889/full; https://doaj.org/toc/1663-9812

URL الوصول: https://doaj.org/article/57add1b341ee425fb3b53addb4c3b962

المؤلفون: Mette H. Poulsen, Feng Xue, Svetlana R. Maurya, Stefanie Kickinger, Samuel Usher, Petrine Wellendorph, Alicia Lundby, Stephan A. Pless

المصدر: Biophysical Journal. 122:249a

مصطلحات موضوعية: Biophysics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5f1dc74ff43215ae2c17612f3f920a6c
https://doi.org/10.1016/j.bpj.2022.11.1448

المؤلفون: Stefanie Kickinger, Jennifer Hemmerich, Gerhard F. Ecker, Stefan Kubicek, Bettina Gürtl, Charles-Hugues Lardeau, Adrián César-Razquin, Giulio Superti-Furga, Richard Kumaran Kandasamy, Kristaps Klavins, Vitaly Sedlyarov, Alvaro Ingles-Prieto, Giuseppe Fiume, Sabrina Lindinger, Felix Kartnig, Konstantinos Papakostas, Anna Koren, Enrico Girardi, Justyna Konecka

المصدر: Nature chemical biology
Nature Chemical Biology

مصطلحات موضوعية: Cisplatin, 0303 health sciences, Chemistry, 030302 biochemistry & molecular biology, Transporter, Cell Biology, Chemical space, Transmembrane protein, Article, 3. Good health, 03 medical and health sciences, Biochemistry, medicine, Cytotoxic T cell, Artemisinin, Molecular Biology, Gene, 030304 developmental biology, Genetic screen, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5153483bde26a52b00f5d4a2cf2203ef
http://europepmc.org/articles/PMC7610918

المؤلفون: Alvaro Ingles-Prieto, Douglas B. Kell, Laura H. Heitman, Daniela Digles, Stefanie Kickinger, Patrick Altermatt, Diana Zindel, Adriaan P. IJzerman, Vanessa Schneider, Daniel Körzö, Maria Wilhelm, Tabea Wiedmer, Helena Batoulis, Sara Tremolada, Giulio Superti-Furga, Anna Lena Steck, Marina Wright Muelas, Thomas Licher, Eckhard Bender, Vojtech Dvorak, Hubert J. Sijben, Avner Schlessinger, Franz Dürrenberger, Francesca Sassone, Vania Manolova, Riccardo Rizzetto, Philipp Leippe, Lia Scarabottolo, Felix Bärenz, Hanna Sundström, Claire M. Steppan

المصدر: Frontiers in Pharmacology
Dvorak, V, Wiedmer, T, Ingles-Prieto, A, Altermatt, P, Batoulis, H, Bärenz, F, Bender, E, Digles, D, Dürrenberger, F, Heitman, L H, IJzerman, A P, Kell, D B, Kickinger, S, Körzö, D, Leippe, P, Licher, T, Manolova, V, Rizzetto, R, Sassone, F, Scarabottolo, L, Schlessinger, A, Schneider, V, Sijben, H J, Steck, A L, Sundström, H, Tremolada, S, Wilhelm, M, Wright Muelas, M, Zindel, D, Steppan, C M & Superti-Furga, G 2021, ' An Overview of Cell-Based Assay Platforms for the Solute Carrier Family of Transporters ', Frontiers in Pharmacology, vol. 12, 722889 . https://doi.org/10.3389/fphar.2021.722889
Frontiers in Pharmacology, 12, 722889
Frontiers in pharmacology
Frontiers in Pharmacology, Vol 12 (2021)

مصطلحات موضوعية: chemical screening, solute carrier, SLC, Druggability, cell-based assay, RM1-950, Computational biology, Review, transporters, Biology, drug discovery, 03 medical and health sciences, 0302 clinical medicine, Pharmacology (medical), 030304 developmental biology, Pharmacology, 0303 health sciences, Drug discovery, Chemical screening, Cellular Assay, Transporter, SUPERFAMILY, Solute carrier, 3. Good health, Solute carrier family, Transporters, Cell-based assay, Therapeutics. Pharmacology, 030217 neurology & neurosurgery, Cell based

وصف الملف: application/pdf; application/zip

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c538438b273fae113d94d4db91b031c
https://phaidra.univie.ac.at/o:1603733

المؤلفون: Arne Schousboe, Rasmus P. Clausen, Stefanie Kickinger, Jonas Skovgaard-Petersen, Maria E. K. Lie, Gerhard F. Ecker, Petrine Wellendorph, H. Steve White

المصدر: Lie, M E K, Kickinger, S, Skovgaard-Petersen, J, Ecker, G F, Clausen, R P, Schousboe, A, White, H S & Wellendorph, P 2020, ' Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects ', Neurochemical Research, vol. 45, pp. 1551–1565 . https://doi.org/10.1007/s11064-020-03017-y
Neurochemical Research

مصطلحات موضوعية: 0301 basic medicine, Male, GABA Plasma Membrane Transport Proteins, Tiagabine, Mice, Transgenic, GABA uptake, CHO Cells, Pharmacology, Biochemistry, Epilepsy, Reflex, Protein Structure, Secondary, GABA transporter 1, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Mice, 0302 clinical medicine, Betaine, Cricetulus, Seizures, medicine, GABA transporter, Animals, Humans, Q299L, Binding site, Original Paper, Epilepsy, biology, General Medicine, Cyclohexanecarboxylic acid, 030104 developmental biology, HEK293 Cells, Treatment Outcome, chemistry, Acoustic Stimulation, GAT1, Docking (molecular), Cell culture, biology.protein, Anticonvulsants, Homology modelling, 030217 neurology & neurosurgery, medicine.drug, Protein Binding

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be1e5b0f009359dee573c6df3162134
https://curis.ku.dk/portal/da/publications/pharmacological-characterization-of-a-betainegaba-transporter-1-bgt1-inhibitor-displaying-an-unusual-biphasic-inhibition-profile-and-antiseizure-effects(f58627b3-6c59-4d36-ad00-48d86bf6a034).html

المؤلفون: Anas Al-Khawaja, Stine B. Vogensen, Hans Bräuner-Osborne, Jonas Skovgaard-Petersen, Rasmus P. Clausen, Stefanie Kickinger, Petrine Wellendorph, Arne Schousboe, Rebekka Löffler, Karsten K. Madsen, Gerhard F. Ecker, Emil Rosenthal, Lars N. Jorgensen, Nrupa Borkar

المصدر: Journal of Medicinal Chemistry. 60:8834-8846

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, GABA Plasma Membrane Transport Proteins, Stereochemistry, Allosteric regulation, GABA transporter 1, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Betaine, Piperidines, Drug Discovery, Radioligand, Humans, Structure–activity relationship, Homology modeling, Binding site, Serotonin Plasma Membrane Transport Proteins, biology, Chimera, Chemistry, 030104 developmental biology, Biochemistry, Docking (molecular), Benzamides, biology.protein, Molecular Medicine, GABA Uptake Inhibitors, Carrier Proteins, Allosteric Site

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499720b95ef6ea9e98b0d0ca354ea4e8
https://doi.org/10.1021/acs.jmedchem.7b00924

المؤلفون: Charles-Hugues Lardeau, Stefanie Kickinger, Giulio Superti-Furga, Justyna Konecka, Giuseppe Fiume, Gerhard F. Ecker, Felix Kartnig, Anna Ringler, Sabrina Lindinger, Konstantinos Papakostas, Richard Kumaran Kandasamy, Enrico Girardi, Adrián César-Razquin, Alvaro Ingles-Prieto, Jennifer Hemmerich, Stefan Kubicek

مصطلحات موضوعية: Drug, 0303 health sciences, Cas9, media_common.quotation_subject, Cell, Transporter, Biology, Transmembrane protein, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Biochemistry, 030220 oncology & carcinogenesis, medicine, CRISPR, Cytotoxic T cell, 030304 developmental biology, media_common, Genetic screen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be34aa8b3f8d867e33780030c389a9d

المؤلفون: Stefanie Kickinger, Maria Damgaard, Anas Al-Khawaja, Rebekka Löffler, Gerhard F. Ecker, Maria E. K. Lie, Bente Frølund, Petrine Wellendorph, Anne S. Haugaard, Francesco Bavo

المصدر: Biophysical Journal. 118:130a

مصطلحات موضوعية: biology, Biochemistry, Chemistry, Biophysics, biology.protein, Subtype selectivity, GABA transporter

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::67c677d94d3244ada5e2856693b54ed7
https://doi.org/10.1016/j.bpj.2019.11.842

المؤلفون: Bente Frølund, Stefanie Kickinger, Petrine Wellendorph, Eva Hellsberg, Arne Schousboe, Gerhard F. Ecker

المصدر: Neuropharmacology. 161:107644

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Neurotransmitter transporter, GABA Plasma Membrane Transport Proteins, Synaptic cleft, Brain, Transporter, Biology, medicine.disease, Solute carrier family, GABA transporter 1, 03 medical and health sciences, Cellular and Molecular Neuroscience, Epilepsy, 030104 developmental biology, 0302 clinical medicine, medicine, biology.protein, Animals, Humans, GABAergic, GABA transporter, Neuroscience, 030217 neurology & neurosurgery

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a7be42389394f0046f5dac043f5d33
https://doi.org/10.1016/j.neuropharm.2019.05.021