المؤلفون: Kuo J; Department of Infectious Diseases and Host-Microbe Interactions, Genentech Inc., South San Francisco, CA, USA., Uzunovic J; Department of Bioinformatics, Genentech Inc., South San Francisco, CA, USA., Jacobson A; Department of Immunology Discovery, Genentech Inc., South San Francisco, CA, USA., Dourado M; Department of Neuroscience, Genentech Inc., South San Francisco, CA, USA., Gierke S; Department of Pathology, Genentech Inc., South San Francisco, CA, USA., Rajendram M; Department of Infectious Diseases and Host-Microbe Interactions, Genentech Inc., South San Francisco, CA, USA., Keilberg D; Department of Infectious Diseases and Host-Microbe Interactions, Genentech Inc., South San Francisco, CA, USA., Mar J; Department of Human Pathobiology and OMNI Reverse Translation, Genentech Inc., South San Francisco, CA, USA., Stekol E; Department of Pediatrics, University of California San Francisco Benioff Children's Hospital, San Francisco, CA, 94158, USA., Curry J; Department of Pediatrics, University of California San Francisco Benioff Children's Hospital, San Francisco, CA, 94158, USA., Verstraete S; Department of Pediatrics, University of California San Francisco Benioff Children's Hospital, San Francisco, CA, 94158, USA., Lund J; Department of Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., Liang Y; Department of Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., Tamburini FB; Department of Human Pathobiology and OMNI Reverse Translation, Genentech Inc., South San Francisco, CA, USA., Omattage NS; Department of Infectious Diseases and Host-Microbe Interactions, Genentech Inc., South San Francisco, CA, USA., Masureel M; Department of Structural Biology, Genentech Inc., South San Francisco, CA, USA., Rutherford ST; Department of Infectious Diseases and Host-Microbe Interactions, Genentech Inc., South San Francisco, CA, USA., Hackos DH; Department of Neuroscience, Genentech Inc., South San Francisco, CA, USA., Tan MW; Department of Infectious Diseases and Host-Microbe Interactions, Genentech Inc., South San Francisco, CA, USA., Byrd AL; Department of Cancer Immunology, Genentech Inc., South San Francisco, CA, USA., Keir ME; Department of Human Pathobiology and OMNI Reverse Translation, Genentech Inc., South San Francisco, CA, USA., Skippington E; Department of Infectious Diseases and Host-Microbe Interactions, Genentech Inc., South San Francisco, CA, USA.; Department of Bioinformatics, Genentech Inc., South San Francisco, CA, USA., Storek KM; Department of Infectious Diseases and Host-Microbe Interactions, Genentech Inc., South San Francisco, CA, USA.

المصدر: Journal of Crohn's & colitis [J Crohns Colitis] 2024 Aug 06; Vol. 18 (7), pp. 985-1001.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101318676 Publication Model: Print Cited Medium: Internet ISSN: 1876-4479 (Electronic) Linking ISSN: 18739946 NLM ISO Abbreviation: J Crohns Colitis Subsets: MEDLINE

مواضيع طبية MeSH: Clostridium perfringens*/isolation & purification , Clostridium perfringens*/genetics , Clostridium perfringens*/pathogenicity , Intestinal Mucosa*/microbiology , Intestinal Mucosa*/pathology , Inflammatory Bowel Diseases*/microbiology , Bacterial Toxins*/genetics , Feces*/microbiology, Humans ; Child ; Female ; Male ; Adolescent ; Biopsy ; Clostridium Infections/microbiology ; Hemolysin Proteins

المؤلفون: Storek KM; Department of Infectious Diseases, Genentech Inc., South San Francisco, CA, USA., Sun D; Department of Structural Biology, Genentech Inc., South San Francisco, CA, USA., Rutherford ST; Department of Infectious Diseases, Genentech Inc., South San Francisco, CA, USA. Electronic address: rutherford.steven@gene.com.

المصدر: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2024 Jan; Vol. 1871 (1), pp. 119609. Date of Electronic Publication: 2023 Oct 16.

نوع المنشور: Review; Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2596 (Electronic) Linking ISSN: 01674889 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Res Subsets: MEDLINE

مواضيع طبية MeSH: Escherichia coli Proteins*/metabolism, Humans ; Escherichia coli/metabolism ; Protein Folding ; Bacterial Outer Membrane Proteins/chemistry ; Bacterial Outer Membrane Proteins/metabolism ; Gram-Negative Bacteria/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Bacterial Agents/metabolism

المؤلفون: Mahoney AR; Department of Chemistry, Emory Univers ity, and Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia 30322, United States., Storek KM; Department of Infectious Diseases, Genentech, Inc. South San Francisco, California 94080, United States., Wuest WM; Department of Chemistry, Emory Univers ity, and Emory Antibiotic Resistance Center, Emory University School of Medicine, Atlanta, Georgia 30322, United States.

المصدر: ACS omega [ACS Omega] 2023 Mar 22; Vol. 8 (13), pp. 12558-12564. Date of Electronic Publication: 2023 Mar 22 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE

المؤلفون: White P; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.; GlaxoSmithKline R&D, Stevenage, UK., Haysom SF; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Iadanza MG; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.; Scientific Computing Department, Science and Technology Facilities Council, Didcot, UK., Higgins AJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Machin JM; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Whitehouse JM; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Horne JE; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.; Department of Biochemistry, University of Oxford, Oxford, UK., Schiffrin B; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Carpenter-Platt C; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Calabrese AN; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Storek KM; Department of Infectious Diseases, Genentech Inc., South San Francisco, CA, USA., Rutherford ST; Department of Infectious Diseases, Genentech Inc., South San Francisco, CA, USA., Brockwell DJ; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK., Ranson NA; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK. n.a.ranson@leeds.ac.uk., Radford SE; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK. s.e.radford@leeds.ac.uk.

المصدر: Nature communications [Nat Commun] 2021 Jul 07; Vol. 12 (1), pp. 4174. Date of Electronic Publication: 2021 Jul 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Protein Folding*, Bacterial Outer Membrane Proteins/*metabolism , Escherichia coli Proteins/*metabolism , Hydrolases/*metabolism , Liposomes/*metabolism, Bacterial Outer Membrane Proteins/genetics ; Bacterial Outer Membrane Proteins/isolation & purification ; Bacterial Outer Membrane Proteins/ultrastructure ; Cryoelectron Microscopy ; Dynamic Light Scattering ; Escherichia coli Proteins/genetics ; Escherichia coli Proteins/isolation & purification ; Escherichia coli Proteins/ultrastructure ; Hydrolases/genetics ; Hydrolases/isolation & purification ; Hydrolases/ultrastructure ; Lipid Metabolism ; Liposomes/ultrastructure ; Molecular Dynamics Simulation ; Protein Conformation, beta-Strand ; Proteolipids/metabolism ; Proteolipids/ultrastructure ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Recombinant Proteins/ultrastructure

المؤلفون: Kajihara KK; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Pantua H; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Hernandez-Barry H; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, USA., Hazen M; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Deshmukh K; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, USA., Chiang N; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Ohri R; Department of Protein Chemistry, Genentech, Inc., South San Francisco, California, USA., Castellanos ER; Department of Structural Biology, Genentech, Inc., South San Francisco, California, USA., Martin L; Department of BioMolecular Resources, Genentech, Inc., South San Francisco, California, USA., Matsumoto ML; Department of Structural Biology, Genentech, Inc., South San Francisco, California, USA., Payandeh J; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA.; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA.; Department of Structural Biology, Genentech, Inc., South San Francisco, California, USA., Storek KM; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Schneider K; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Smith PA; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Koehler MFT; Department of Medicinal Chemistry; Genentech, Inc., South San Francisco, California, USA., Tsai SP; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, USA., Vandlen R; Department of Protein Chemistry, Genentech, Inc., South San Francisco, California, USA., Loyet KM; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, California, USA., Nakamura G; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Pillow T; Department of Medicinal Chemistry; Genentech, Inc., South San Francisco, California, USA., Seshasayee D; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Kapadia SB; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Hazenbos WLW; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA.

المصدر: MBio [mBio] 2021 Jun 29; Vol. 12 (3), pp. e0020221. Date of Electronic Publication: 2021 Jun 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Antibodies, Monoclonal/*pharmacology , Macrophages/*drug effects , Macrophages/*immunology , Pseudomonas aeruginosa/*drug effects , Pseudomonas aeruginosa/*immunology, Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/immunology ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/immunology ; Antibodies, Monoclonal/metabolism ; Drug Delivery Systems/methods ; Humans ; Macrophages/microbiology ; Mice ; Microbial Viability/drug effects ; Phagocytosis/drug effects ; Proof of Concept Study ; Pseudomonas Infections/drug therapy ; Pseudomonas Infections/immunology ; Pseudomonas aeruginosa/metabolism ; RAW 264.7 Cells ; Rats

المؤلفون: Diao J; Department of Infectious Diseases, Genentech, South San Francisco, California, USA., Komura R; Peptidream Inc., Kawasaki, Kanagawa, Japan., Sano T; Peptidream Inc., Kawasaki, Kanagawa, Japan., Pantua H; Department of Infectious Diseases, Genentech, South San Francisco, California, USA., Storek KM; Department of Infectious Diseases, Genentech, South San Francisco, California, USA., Inaba H; Peptidream Inc., Kawasaki, Kanagawa, Japan., Ogawa H; Peptidream Inc., Kawasaki, Kanagawa, Japan., Noland CL; Department of Structural Biology, Genentech, South San Francisco, California, USA., Peng Y; Department of Infectious Diseases, Genentech, South San Francisco, California, USA., Gloor SL; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California, USA., Yan D; Department of Translational Immunology, Genentech, South San Francisco, California, USA., Kang J; Department of Translational Immunology, Genentech, South San Francisco, California, USA., Katakam AK; Department of Pathology, Genentech, South San Francisco, California, USA., Volny M; Department of Protein Chemistry, Genentech, South San Francisco, California, USA., Liu P; Department of Protein Chemistry, Genentech, South San Francisco, California, USA., Nickerson NN; Department of Infectious Diseases, Genentech, South San Francisco, California, USA., Sandoval W; Department of Protein Chemistry, Genentech, South San Francisco, California, USA., Austin CD; Department of Pathology, Genentech, South San Francisco, California, USA., Murray J; Department of Structural Biology, Genentech, South San Francisco, California, USA., Rutherford ST; Department of Infectious Diseases, Genentech, South San Francisco, California, USA., Reichelt M; Department of Pathology, Genentech, South San Francisco, California, USA., Xu Y; Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California, USA., Xu M; Department of Translational Immunology, Genentech, South San Francisco, California, USA., Yanagida H; Peptidream Inc., Kawasaki, Kanagawa, Japan., Nishikawa J; Peptidream Inc., Kawasaki, Kanagawa, Japan., Reid PC; Peptidream Inc., Kawasaki, Kanagawa, Japan., Cunningham CN; Department of Early Discovery Biochemistry, Genentech, South San Francisco, California, USA., Kapadia SB; Department of Infectious Diseases, Genentech, South San Francisco, California, USA.

المصدر: Journal of bacteriology [J Bacteriol] 2021 Jun 08; Vol. 203 (13), pp. e0014921. Date of Electronic Publication: 2021 Jun 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 2985120R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5530 (Electronic) Linking ISSN: 00219193 NLM ISO Abbreviation: J Bacteriol Subsets: MEDLINE

مواضيع طبية MeSH: Escherichia coli/*metabolism , Lipoproteins/*metabolism , Transferases/*metabolism, Animals ; Anti-Bacterial Agents/pharmacology ; Aspartic Acid Endopeptidases ; Bacterial Proteins ; Escherichia coli/genetics ; Female ; Gene Deletion ; Gene Expression Regulation, Bacterial/drug effects ; Mice ; Peptidoglycan/metabolism ; Transferases/chemistry ; Transferases/genetics ; Uropathogenic Escherichia coli/genetics ; Uropathogenic Escherichia coli/metabolism

المؤلفون: Jennings LK; Department of Microbiology, University of Washington, Seattle, WA 98195, USA., Dreifus JE; Department of Microbiology, University of Washington, Seattle, WA 98195, USA., Reichhardt C; Department of Microbiology, University of Washington, Seattle, WA 98195, USA., Storek KM; Department of Microbiology, University of Washington, Seattle, WA 98195, USA., Secor PR; Department of Microbiology, University of Washington, Seattle, WA 98195, USA., Wozniak DJ; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA; Department of Microbiology, The Ohio State University, Columbus, OH 43210, USA; Infectious Disease Institute, The Ohio State University, Columbus, OH 43210, USA., Hisert KB; Department of Medicine, University of Washington, Seattle, WA 98195, USA., Parsek MR; Department of Microbiology, University of Washington, Seattle, WA 98195, USA. Electronic address: parsem@u.washington.edu.

المصدر: Cell reports [Cell Rep] 2021 Feb 23; Vol. 34 (8), pp. 108782.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Cystic Fibrosis/*microbiology , Lung/*microbiology , Polysaccharides, Bacterial/*metabolism , Pseudomonas Infections/*microbiology , Pseudomonas aeruginosa/*metabolism , Respiratory Tract Infections/*microbiology, Anti-Bacterial Agents/therapeutic use ; Biofilms/growth & development ; Cystic Fibrosis/drug therapy ; DNA, Bacterial/genetics ; DNA, Bacterial/metabolism ; Drug Resistance, Bacterial ; Expectorants/therapeutic use ; Humans ; Pseudomonas Infections/drug therapy ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/genetics ; Pseudomonas aeruginosa/growth & development ; Respiratory Tract Infections/drug therapy ; Sputum/microbiology

المؤلفون: Clairfeuille T; Structural Biology, Genentech Inc., South San Francisco, CA, USA., Buchholz KR; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA., Li Q; Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., Verschueren E; Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., Liu P; Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., Sangaraju D; Drug Metabolism & Pharmacokinetics, Genentech Inc., South San Francisco, CA, USA., Park S; Translational Immunology, Genentech Inc., South San Francisco, CA, USA., Noland CL; Structural Biology, Genentech Inc., South San Francisco, CA, USA., Storek KM; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA., Nickerson NN; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA., Martin L; BioMolecular Resources, Genentech Inc., South San Francisco, CA, USA., Dela Vega T; BioMolecular Resources, Genentech Inc., South San Francisco, CA, USA., Miu A; Biochemical & Cellular Pharmacology, Genentech Inc., South San Francisco, CA, USA., Reeder J; Bioinformatics & Computational Biology, Genentech Inc., South San Francisco, CA, USA., Ruiz-Gonzalez M; Discovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA., Swem D; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA., Han G; Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., DePonte DP; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Hunter MS; Linac Coherent Light Source, SLAC National Accelerator Laboratory, Menlo Park, CA, USA., Gati C; Bioscience Division, SLAC National Accelerator Laboratory, Menlo Park, CA, USA.; Stanford University, Department of Structural Biology, Stanford, CA, USA., Shahidi-Latham S; Drug Metabolism & Pharmacokinetics, Genentech Inc., South San Francisco, CA, USA., Xu M; Translational Immunology, Genentech Inc., South San Francisco, CA, USA., Skelton N; Discovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA., Sellers BD; Discovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA., Skippington E; Bioinformatics & Computational Biology, Genentech Inc., South San Francisco, CA, USA., Sandoval W; Microchemistry, Proteomics & Lipidomics, Genentech Inc., South San Francisco, CA, USA., Hanan EJ; Discovery Chemistry Departments, Genentech Inc., South San Francisco, CA, USA. hanan.emily@gene.com., Payandeh J; Structural Biology, Genentech Inc., South San Francisco, CA, USA. payandeh.jian@gene.com.; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA. payandeh.jian@gene.com., Rutherford ST; Infectious Diseases, Genentech Inc., South San Francisco, CA, USA. rutherford.steven@gene.com.

المصدر: Nature [Nature] 2020 Aug; Vol. 584 (7821), pp. 479-483. Date of Electronic Publication: 2020 Aug 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Membrane/*chemistry , Escherichia coli/*chemistry , Escherichia coli/*pathogenicity , Escherichia coli Proteins/*chemistry , Escherichia coli Proteins/*metabolism , Lipopolysaccharides/*chemistry , Lipopolysaccharides/*metabolism, Amidohydrolases/chemistry ; Amidohydrolases/metabolism ; Amino Acid Motifs ; Bacterial Outer Membrane/chemistry ; Bacterial Outer Membrane/metabolism ; Binding Sites ; Cell Membrane/metabolism ; Enzyme Stability ; Escherichia coli/cytology ; Escherichia coli/drug effects ; Genes, Essential ; Hydrolases/chemistry ; Hydrolases/metabolism ; Lipid A/chemistry ; Lipid A/metabolism ; Lipopolysaccharides/biosynthesis ; Microbial Sensitivity Tests ; Microbial Viability/drug effects ; Models, Molecular ; Peptide Fragments/chemistry ; Peptide Fragments/metabolism ; Peptide Fragments/pharmacology ; Periplasm/chemistry ; Periplasm/metabolism ; Protein Binding ; Virulence

المؤلفون: Storek KM; Department of Infectious Diseases, Genentech, Inc, South San Francisco, United States., Chan J; Department of Biochemical and Cellular Pharmacology, Genentech, Inc, South San Francisco, United States., Vij R; Department of Antibody Engineering, Genentech, Inc, South San Francisco, United States., Chiang N; Department of Antibody Engineering, Genentech, Inc, South San Francisco, United States., Lin Z; Department of Antibody Engineering, Genentech, Inc, South San Francisco, United States., Bevers J 3rd; Department of Antibody Engineering, Genentech, Inc, South San Francisco, United States., Koth CM; Department of Structural Biology, Genentech, Inc, South San Francisco, United States., Vernes JM; Department of Biochemical and Cellular Pharmacology, Genentech, Inc, South San Francisco, United States., Meng YG; Department of Biochemical and Cellular Pharmacology, Genentech, Inc, South San Francisco, United States., Yin J; Department of Structural Biology, Genentech, Inc, South San Francisco, United States., Wallweber H; Department of Structural Biology, Genentech, Inc, South San Francisco, United States., Dalmas O; Department of Structural Biology, Genentech, Inc, South San Francisco, United States., Shriver S; Department of Biomolecular Resources, Genentech, Inc, South San Francisco, United States., Tam C; Department of Biomolecular Resources, Genentech, Inc, South San Francisco, United States., Schneider K; Department of Antibody Engineering, Genentech, Inc, South San Francisco, United States., Seshasayee D; Department of Antibody Engineering, Genentech, Inc, South San Francisco, United States., Nakamura G; Department of Antibody Engineering, Genentech, Inc, South San Francisco, United States., Smith PA; Department of Infectious Diseases, Genentech, Inc, South San Francisco, United States., Payandeh J; Department of Structural Biology, Genentech, Inc, South San Francisco, United States., Koerber JT; Department of Antibody Engineering, Genentech, Inc, South San Francisco, United States., Comps-Agrar L; Department of Biochemical and Cellular Pharmacology, Genentech, Inc, South San Francisco, United States., Rutherford ST; Department of Infectious Diseases, Genentech, Inc, South San Francisco, United States.

المصدر: ELife [Elife] 2019 Jun 25; Vol. 8. Date of Electronic Publication: 2019 Jun 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*metabolism , Bacterial Outer Membrane Proteins/*chemistry , Bacterial Outer Membrane Proteins/*metabolism , Escherichia coli Proteins/*chemistry , Escherichia coli Proteins/*metabolism, Animals ; Anti-Bacterial Agents/pharmacology ; Binding Sites ; Epitope Mapping ; Epitopes/metabolism ; Escherichia coli/growth & development ; Escherichia coli/metabolism ; Mice, Inbred BALB C ; Protein Structure, Secondary ; Rats, Sprague-Dawley ; Structure-Activity Relationship

المؤلفون: Storek KM; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Vij R; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Sun D; Department of Structural Biology, Genentech, Inc., South San Francisco, California, USA., Smith PA; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA., Koerber JT; Department of Antibody Engineering, Genentech, Inc., South San Francisco, California, USA., Rutherford ST; Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA rutherford.steven@gene.com.

المصدر: Journal of bacteriology [J Bacteriol] 2018 Dec 07; Vol. 201 (1). Date of Electronic Publication: 2018 Dec 07 (Print Publication: 2019).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 2985120R Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5530 (Electronic) Linking ISSN: 00219193 NLM ISO Abbreviation: J Bacteriol Subsets: MEDLINE

مواضيع طبية MeSH: Membrane Fluidity* , Protein Folding* , Protein Multimerization*, Bacterial Outer Membrane Proteins/*metabolism , Escherichia coli/*enzymology , Escherichia coli Proteins/*metabolism , Lipoproteins/*metabolism, Amino Acid Substitution ; Bacterial Outer Membrane Proteins/genetics ; DNA Mutational Analysis ; Escherichia coli/genetics ; Escherichia coli Proteins/genetics