المؤلفون: Tatum, NJ, Yufit, DS, Cobb, SL, Coxon, CR

المصدر: Journal of fluorine chemistry, 2015, Vol.173, pp.77-83 [Peer Reviewed Journal]

مصطلحات موضوعية: Inorganic Chemistry, Gauche effect, Nickel complex, Fluoro-proline, Organic Chemistry, X-ray crystallography, Environmental Chemistry, QD, Fluorinated ligands, Physical and Theoretical Chemistry, Biochemistry

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::226aadb88c0ea8e4cef86c9351c66abb

المؤلفون: Rowland RJ; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK., Korolchuk S; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.; Fujifilm, Belasis Ave, Stockton-on-Tees, Billingham, TS23 1LH, UK., Salamina M; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.; Evotec (UK) Ltd., Milton, Abingdon, OX14 4RZ, UK., Tatum NJ; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK., Ault JR; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds, LS2 9JT, UK., Hart S; York Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK., Turkenburg JP; York Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK., Blaza JN; York Structural Biology Laboratory and York Biomedical Research Institute, Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK., Noble MEM; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. martin.noble@ncl.ac.uk., Endicott JA; Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK. jane.endicott@ncl.ac.uk.

المصدر: Nature communications [Nat Commun] 2024 Aug 09; Vol. 15 (1), pp. 6807. Date of Electronic Publication: 2024 Aug 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: cdc25 Phosphatases*/metabolism , cdc25 Phosphatases*/chemistry , cdc25 Phosphatases*/ultrastructure , cdc25 Phosphatases*/genetics , Cyclin-Dependent Kinase 2*/metabolism , Cyclin-Dependent Kinase 2*/chemistry , Cyclin-Dependent Kinase 2*/ultrastructure , Cryoelectron Microscopy* , Cyclin A*/metabolism , Cyclin A*/chemistry, Humans ; Protein Binding ; Models, Molecular ; Amino Acid Sequence

المؤلفون: Martin MP; Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translation and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, United Kingdom., Endicott JA; Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translation and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, United Kingdom., Noble MEM; Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translation and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, United Kingdom., Tatum NJ; Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Translation and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne, United Kingdom. Electronic address: natalie.tatum@newcastle.ac.uk.

المصدر: Methods in enzymology [Methods Enzymol] 2023; Vol. 690, pp. 211-234. Date of Electronic Publication: 2023 Jul 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0212271 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-7988 (Electronic) Linking ISSN: 00766879 NLM ISO Abbreviation: Methods Enzymol Subsets: MEDLINE

مواضيع طبية MeSH: Early Detection of Cancer* , Neoplasms*, Crystallography, X-Ray ; Drug Discovery/methods ; Proteins ; Drug Evaluation, Preclinical/methods

المؤلفون: Alblihy A; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK.; Medical Center, King Fahad Security College (KFSC), Riyadh, 11461, Saudi Arabia., Ali R; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK., Algethami M; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK., Shoqafi A; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK., Toss MS; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK.; Department of Pathology, Nottingham University Hospitals, City Hospital Campus, Nottingham, NG5 1PB, UK., Brownlie J; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK., Tatum NJ; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Hickson I; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Moran PO; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK., Grabowska A; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK., Jeyapalan JN; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK., Mongan NP; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK.; Department of Pharmacology, Weill Cornell Medicine, New York, 10065, NY, USA., Rakha EA; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK.; Department of Pathology, Nottingham University Hospitals, City Hospital Campus, Nottingham, NG5 1PB, UK., Madhusudan S; Nottingham Biodiscovery Institute, School of Medicine, University of Nottingham, University Park, Nottingham, NG7 3RD, UK. srinivasan.madhusudan@nottingham.ac.uk.; Department of Oncology, Nottingham University Hospitals, Nottingham, NG51PB, UK. srinivasan.madhusudan@nottingham.ac.uk.

المصدر: NPJ precision oncology [NPJ Precis Oncol] 2022 Jul 19; Vol. 6 (1), pp. 51. Date of Electronic Publication: 2022 Jul 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Nature Country of Publication: England NLM ID: 101708166 Publication Model: Electronic Cited Medium: Print ISSN: 2397-768X (Print) Linking ISSN: 2397768X NLM ISO Abbreviation: NPJ Precis Oncol Subsets: PubMed not MEDLINE

المؤلفون: Bieniek MK; School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU UK., Cree B; School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU UK., Pirie R; School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU UK., Horton JT; School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU UK., Tatum NJ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE2 4HH UK., Cole DJ; School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne, NE1 7RU UK.

المصدر: Communications chemistry [Commun Chem] 2022; Vol. 5 (1), pp. 136. Date of Electronic Publication: 2022 Oct 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Nature Country of Publication: England NLM ID: 101725670 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2399-3669 (Electronic) Linking ISSN: 23993669 NLM ISO Abbreviation: Commun Chem Subsets: PubMed not MEDLINE

المؤلفون: Mesquita KA; Translational Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK., Ali R; Translational Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK., Doherty R; Translational Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK., Toss MS; Department of Pathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK., Miligy I; Department of Pathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK., Alblihy A; Translational Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.; Medical Center, King Fahad Security College (KFSC), Riyadh 11461, Saudi Arabia., Dorjsuren D; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA., Simeonov A; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA., Jadhav A; NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA., Wilson DM 3rd; Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium., Hickson I; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Tatum NJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Rakha EA; Department of Pathology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK., Madhusudan S; Translational Oncology, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham Biodiscovery Institute, Nottingham NG7 2RD, UK.; Department of Oncology, Nottingham University Hospitals, City Hospital Campus, Nottingham NG5 1PB, UK.

المصدر: Cancers [Cancers (Basel)] 2021 Apr 14; Vol. 13 (8). Date of Electronic Publication: 2021 Apr 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101526829 Publication Model: Electronic Cited Medium: Print ISSN: 2072-6694 (Print) Linking ISSN: 20726694 NLM ISO Abbreviation: Cancers (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Salamina M; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Montefiore BC; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Liu M; Department of Biochemistry and Molecular Pharmacology, Perlmutter NYU Cancer Center, New York University Grossman School of Medicine, and Howard Hughes Medical Institute, The Alexandria Center of Life Science, East Tower, 450 E, 29th Street, New York, NY 10016, USA., Wood DJ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Heath R; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Ault JR; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Wang LZ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Korolchuk S; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Baslé A; Biosciences Institute, Newcastle University, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Pastok MW; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Reeks J; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Tatum NJ; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Sobott F; Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, University of Leeds, Leeds LS2 9JT, UK., Arold ST; Division of Biological and Environmental Sciences and Engineering (BESE), Computational Bioscience Research Center (CBRC), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia; Centre de Biochimie Structurale, CNRS, INSERM, Université de Montpellier, 34090 Montpellier, France., Pagano M; Department of Biochemistry and Molecular Pharmacology, Perlmutter NYU Cancer Center, New York University Grossman School of Medicine, and Howard Hughes Medical Institute, The Alexandria Center of Life Science, East Tower, 450 E, 29th Street, New York, NY 10016, USA., Noble MEM; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK., Endicott JA; Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Framlington Place, Newcastle upon Tyne NE2 4HH, UK. Electronic address: jane.endicott@ncl.ac.uk.

المصدر: Journal of molecular biology [J Mol Biol] 2021 Mar 05; Vol. 433 (5), pp. 166795. Date of Electronic Publication: 2021 Jan 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: G1 Phase Cell Cycle Checkpoints*, Cyclin A/*chemistry , Cyclin-Dependent Kinase 2/*chemistry , Cyclin-Dependent Kinase Inhibitor p27/*chemistry , S-Phase Kinase-Associated Proteins/*chemistry, Binding Sites ; CDC2-CDC28 Kinases/chemistry ; CDC2-CDC28 Kinases/genetics ; CDC2-CDC28 Kinases/metabolism ; Cyclin A/genetics ; Cyclin A/metabolism ; Cyclin E/chemistry ; Cyclin E/genetics ; Cyclin E/metabolism ; Cyclin-Dependent Kinase 2/genetics ; Cyclin-Dependent Kinase 2/metabolism ; Cyclin-Dependent Kinase Inhibitor p27/genetics ; Cyclin-Dependent Kinase Inhibitor p27/metabolism ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Proteolysis ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; S-Phase Kinase-Associated Proteins/genetics ; S-Phase Kinase-Associated Proteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Signal Transduction

المؤلفون: Tatum NJ; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom., Endicott JA; Cancer Research UK Newcastle Drug Discovery Unit, Newcastle Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom. Electronic address: jane.endicott@newcastle.ac.uk.

المصدر: Seminars in cell & developmental biology [Semin Cell Dev Biol] 2020 Nov; Vol. 107, pp. 4-20. Date of Electronic Publication: 2020 May 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Academic Press Country of Publication: England NLM ID: 9607332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-3634 (Electronic) Linking ISSN: 10849521 NLM ISO Abbreviation: Semin Cell Dev Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cyclins/*chemistry , Cyclins/*metabolism, Animals ; Humans ; Models, Molecular ; Protein Domains ; Proteolysis ; Structure-Activity Relationship ; Substrate Specificity

المؤلفون: Lochhead PA; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. pamela.lochhead@babraham.ac.uk., Tucker JA; York Biomedical Research Institute and Department of Biology, University of York, York, YO10 5DD, UK., Tatum NJ; CRUK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Newcastle University, Newcastle, NE2 4HH, UK., Wang J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA., Oxley D; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Kidger AM; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Johnson VP; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK.; Institute of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London, SW3 6JB, UK., Cassidy MA; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, 02215, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, 02115, USA., Noble MEM; CRUK Newcastle Drug Discovery Unit, Newcastle University Centre for Cancer, Newcastle University, Newcastle, NE2 4HH, UK., Cook SJ; Signalling Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, CB22 3AT, UK. simon.cook@babraham.ac.uk.

المصدر: Nature communications [Nat Commun] 2020 Mar 13; Vol. 11 (1), pp. 1383. Date of Electronic Publication: 2020 Mar 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Mitogen-Activated Protein Kinase 7/*metabolism , Protein Kinase Inhibitors/*metabolism , Transcription Factors/*metabolism, Gene Expression Regulation ; HEK293 Cells ; HeLa Cells ; Humans ; Inflammation/metabolism ; Mitogen-Activated Protein Kinase 7/genetics ; Models, Molecular ; Mutation ; Protein Conformation ; Protein Domains ; Protein Kinase Inhibitors/pharmacology ; Transcription, Genetic

المؤلفون: Lightfoot HL; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland., Hagen T; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland., Tatum NJ; Newcastle Cancer Centre, Northern Institute for Cancer Research, Medical School, Newcastle University, Newcastle upon Tyne, UK., Hall J; Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, Switzerland.

المصدر: FEBS letters [FEBS Lett] 2019 Aug; Vol. 593 (16), pp. 2083-2102. Date of Electronic Publication: 2019 Jul 30.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

مواضيع طبية MeSH: DNA/*chemistry , RNA/*chemistry, Animals ; G-Quadruplexes ; Humans ; Models, Molecular