المؤلفون: Thakore PI; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Schnell A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Whitehead Institute for Biomedical Research, Cambridge, MA, USA., Huang L; The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA., Zhao M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hou Y; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Christian E; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zaghouani S; The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Wang C; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Department of Immunology, University of Toronto and Biological Sciences Platform, Sunnybrook Research Institute, Toronto, Ontario, Canada., Singh V; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Singaraju A; The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Krishnan RK; The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Kozoriz D; The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Ma S; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Sankar V; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Notarbartolo S; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.; Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Infectious Diseases Unit, Milan, Italy., Buenrostro JD; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.; Gene Regulation Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sallusto F; Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera Italiana, Bellinzona, Switzerland.; Institute of Microbiology, ETH Zurich, Zurich, Switzerland., Patsopoulos NA; Systems Biology and Computer Science Program, Ann Romney Center for Neurological Diseases, Department of Neurology, Brigham & Women's Hospital, Boston, MA, USA.; Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA.; Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Kuchroo VK; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. vkuchroo@bwh.harvard.edu.; The Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. vkuchroo@bwh.harvard.edu., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com.

المصدر: Nature immunology [Nat Immunol] 2024 Jul 15. Date of Electronic Publication: 2024 Jul 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE

المؤلفون: Simmons SK; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lithwick-Yanai G; Ultima Genomics, Newark, CA, USA., Adiconis X; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Oberstrass F; Ultima Genomics, Newark, CA, USA., Iremadze N; Ultima Genomics, Newark, CA, USA., Geiger-Schuller K; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Thakore PI; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Frangieh CJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, USA., Barad O; Ultima Genomics, Newark, CA, USA., Almogy G; Ultima Genomics, Newark, CA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Biology, MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Lipson D; Ultima Genomics, Newark, CA, USA., Levin JZ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. jlevin@broadinstitute.org.; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. jlevin@broadinstitute.org.

المصدر: Nature biotechnology [Nat Biotechnol] 2023 Feb; Vol. 41 (2), pp. 204-211. Date of Electronic Publication: 2022 Sep 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Profiling*/methods , Leukocytes, Mononuclear*, Humans ; Sequence Analysis, RNA/methods ; Single-Cell Gene Expression Analysis ; Single-Cell Analysis/methods ; Nucleotides

المؤلفون: Geiger-Schuller K, Eraslan B, Kuksenko O, Dey KK, Jagadeesh KA, Thakore PI, Karayel O, Yung AR, Rajagopalan A, Meireles AM, Yang KD, Amir-Zilberstein L, Delorey T, Phillips D, Raychowdhury R, Moussion C, Price AL, Hacohen N, Doench JG, Uhler C, Rozenblatt-Rosen O, Regev A

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 24. Date of Electronic Publication: 2023 Jan 24.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Ursu O; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Neal JT; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Shea E; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Thakore PI; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Jerby-Arnon L; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Nguyen L; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Dionne D; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Diaz C; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA., Bauman J; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Mosaad MM; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Fagre C; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lo A; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., McSharry M; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Giacomelli AO; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Princess Margaret Cancer Centre, Toronto, ON, Canada., Ly SH; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Duke-NUS Medical School, Singapore, Singapore., Rozenblatt-Rosen O; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Hahn WC; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Aguirre AJ; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Berger AH; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Regev A; Broad Institute of Harvard and MIT, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. aviv.regev.sc@gmail.com.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com., Boehm JS; Broad Institute of Harvard and MIT, Cambridge, MA, USA. boehm@broadinstitute.org.

المصدر: Nature biotechnology [Nat Biotechnol] 2022 Nov; Vol. 40 (11), pp. 1691.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Ursu O; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Neal JT; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Shea E; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Cancer Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA., Thakore PI; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Jerby-Arnon L; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Nguyen L; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Dionne D; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Diaz C; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA., Bauman J; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA., Mosaad MM; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Fagre C; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lo A; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., McSharry M; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Giacomelli AO; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Princess Margaret Cancer Centre, Toronto, ON, Canada., Ly SH; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Duke-NUS Medical School, Singapore, Singapore., Rozenblatt-Rosen O; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Hahn WC; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Aguirre AJ; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Berger AH; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Regev A; Broad Institute of Harvard and MIT, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. aviv.regev.sc@gmail.com.; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com., Boehm JS; Broad Institute of Harvard and MIT, Cambridge, MA, USA. boehm@broadinstitute.org.

المصدر: Nature biotechnology [Nat Biotechnol] 2022 Jun; Vol. 40 (6), pp. 896-905. Date of Electronic Publication: 2022 Jan 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Lung Neoplasms*/genetics , Proto-Oncogene Proteins p21(ras)*/genetics, Chromosome Mapping ; Humans ; Phenotype

المؤلفون: Schnell A; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Huang L; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Singer M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Singaraju A; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA., Barilla RM; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA., Regan BML; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA., Bollhagen A; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; German Cancer Research Center, DKFZ, Heidelberg 69120, Germany., Thakore PI; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Dionne D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Delorey TM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pawlak M; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Meyer Zu Horste G; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Irizarry RA; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: aviv.regev.sc@gmail.com., Kuchroo VK; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: vkuchroo@evergrande.hms.harvard.edu.

المصدر: Cell [Cell] 2021 Dec 22; Vol. 184 (26), pp. 6281-6298.e23. Date of Electronic Publication: 2021 Dec 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Autoimmunity*, Intestines/*immunology , Stem Cells/*metabolism , Th17 Cells/*immunology, Animals ; Cell Movement ; Clone Cells ; Encephalomyelitis, Autoimmune, Experimental/immunology ; Granulocyte-Macrophage Colony-Stimulating Factor/metabolism ; Homeostasis ; Humans ; Interferon-gamma/metabolism ; Interleukin-17/metabolism ; Mice, Inbred C57BL ; Organ Specificity ; RNA/metabolism ; RNA-Seq ; Receptors, Antigen, T-Cell/metabolism ; Receptors, CXCR6/metabolism ; Receptors, Interleukin/metabolism ; Reproducibility of Results ; Signaling Lymphocytic Activation Molecule Family/metabolism ; Single-Cell Analysis ; Spleen/metabolism ; Mice

المؤلفون: Mimitou EP; Technology Innovation Lab, New York Genome Center, New York, NY, USA., Lareau CA; Department of Pathology, Stanford University, Stanford, CA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology / Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Chen KY; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan., Zorzetto-Fernandes AL; BioLegend, Inc., San Diego, CA, USA., Hao Y; Center for Genomics and Systems Biology, New York University, New York, NY, USA.; New York Genome Center, New York, NY, USA., Takeshima Y; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan., Luo W; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology / Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Huang TS; BioLegend, Inc., San Diego, CA, USA., Yeung BZ; BioLegend, Inc., San Diego, CA, USA., Papalexi E; Center for Genomics and Systems Biology, New York University, New York, NY, USA.; New York Genome Center, New York, NY, USA., Thakore PI; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kibayashi T; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan., Wing JB; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.; Laboratory of Human Immunology (Single Cell Immunology), Immunology Frontier Research Center, Osaka University, Osaka, Japan., Hata M; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan., Satija R; Center for Genomics and Systems Biology, New York University, New York, NY, USA.; New York Genome Center, New York, NY, USA., Nazor KL; BioLegend, Inc., San Diego, CA, USA., Sakaguchi S; Department of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Osaka, Japan.; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan., Ludwig LS; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology / Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Berlin Institute for Medical Systems Biology, Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany., Sankaran VG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Division of Hematology / Oncology, Boston Children's Hospital and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; New York Genome Center, New York, NY, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA.; Department of Biology and Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Smibert P; Technology Innovation Lab, New York Genome Center, New York, NY, USA. smibertp@gmail.com.

المصدر: Nature biotechnology [Nat Biotechnol] 2021 Oct; Vol. 39 (10), pp. 1246-1258. Date of Electronic Publication: 2021 Jun 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

مواضيع طبية MeSH: RNA-Seq/*methods , Single-Cell Analysis/*methods, Cell Differentiation ; Cell Lineage ; Chromatin/genetics ; Chromatin/metabolism ; DNA, Mitochondrial/genetics ; Epigenomics ; Gene Expression Profiling ; Gene Expression Regulation ; Hematopoiesis ; Humans ; Leukocytes, Mononuclear/cytology ; Leukocytes, Mononuclear/metabolism ; Proteins/genetics ; Proteins/metabolism ; T-Lymphocytes/cytology ; T-Lymphocytes/metabolism

المؤلفون: Oren Y; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Tsabar M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Cuoco MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Amir-Zilberstein L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cabanos HF; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Departments of Medicine, Harvard Medical School, Boston, MA, USA., Hütter JC; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hu B; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Thakore PI; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Tabaka M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA., Colgan W; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cuevas BM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hurvitz SA; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA., Slamon DJ; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA., Deik A; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Pierce KA; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Clish C; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Hata AN; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Departments of Medicine, Harvard Medical School, Boston, MA, USA., Zaganjor E; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Lahav G; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Politi K; Section of Medical Oncology, Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Yale Cancer Center, New Haven, CT, USA., Brugge JS; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. joan_brugge@hms.harvard.edu.; Ludwig Center at Harvard, Boston, MA, USA. joan_brugge@hms.harvard.edu., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com.

المصدر: Nature [Nature] 2021 Aug; Vol. 596 (7873), pp. 576-582. Date of Electronic Publication: 2021 Aug 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Cycle*/drug effects , Cell Lineage*/drug effects, Neoplasm Recurrence, Local/*drug therapy , Neoplasm Recurrence, Local/*pathology , Neoplasms/*drug therapy , Neoplasms/*pathology, Antioxidants/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Clone Cells/drug effects ; Clone Cells/metabolism ; Clone Cells/pathology ; DNA Barcoding, Taxonomic ; Fatty Acids/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Lentivirus/genetics ; Neoplasm Recurrence, Local/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; Oncogene Proteins/antagonists & inhibitors ; Oxidation-Reduction ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Transcription, Genetic/drug effects

المؤلفون: Kiner E; Department of Immunology, Harvard Medical School, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA.; Immunai, New York, NY, USA., Willie E; Bioinformatics Program, University of British Columbia, Vancouver, British Columbia, Canada., Vijaykumar B; Department of Immunology, Harvard Medical School, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA., Chowdhary K; Department of Immunology, Harvard Medical School, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA., Schmutz H; Department of Immunology, Harvard Medical School, Boston, MA, USA.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA., Chandler J; Malaghan Institute of Medical Research, Wellington, New Zealand., Schnell A; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA., Thakore PI; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., LeGros G; Malaghan Institute of Medical Research, Wellington, New Zealand., Mostafavi S; Departments of Statistics and Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada.; Canadian Institute for Advanced Research, Toronto, Ontario, Canada.; Vector Institute, Toronto, Ontario, Canada., Mathis D; Department of Immunology, Harvard Medical School, Boston, MA, USA. cbdm@hms.harvard.edu.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. cbdm@hms.harvard.edu., Benoist C; Department of Immunology, Harvard Medical School, Boston, MA, USA. cbdm@hms.harvard.edu.; Evergrande Center for Immunologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. cbdm@hms.harvard.edu.

مؤلفون مشاركون: Immunological Genome Project Consortium

المصدر: Nature immunology [Nat Immunol] 2021 May; Vol. 22 (5), pp. 666-668.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Frangieh CJ; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Melms JC; Columbia Center for Translational Immunology, New York, NY, USA.; Department of Medicine, Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA., Thakore PI; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Geiger-Schuller KR; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Ho P; Columbia Center for Translational Immunology, New York, NY, USA.; Department of Medicine, Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA., Luoma AM; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Cleary B; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Jerby-Arnon L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.; Chan Zuckerberg Biohub, San Francisco, CA, USA., Malu S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Immunitas Therapeutics, Waltham, MA, USA., Cuoco MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhao M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ager CR; Columbia Center for Translational Immunology, New York, NY, USA., Rogava M; Columbia Center for Translational Immunology, New York, NY, USA.; Department of Medicine, Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA., Hovey L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rotem A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA.; AstraZeneca, Waltham, MA, USA., Bernatchez C; Department of Melanoma Medical Oncology, MD Anderson Cancer Center, Houston, TX, USA., Wucherpfennig KW; Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA., Johnson BE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA, USA., Rozenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Schadendorf D; Department of Dermatology, University Hospital Essen and German Cancer Consortium, Partner Site, Essen, Germany., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aregev@broadinstitute.org.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aregev@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. aregev@broadinstitute.org.; Genentech, South San Francisco, CA, USA. aregev@broadinstitute.org., Izar B; Columbia Center for Translational Immunology, New York, NY, USA. bi2175@cumc.columbia.edu.; Department of Medicine, Division of Hematology and Oncology, Columbia University Medical Center, New York, NY, USA. bi2175@cumc.columbia.edu.; Program for Mathematical Genomics, Columbia University, New York, NY, USA. bi2175@cumc.columbia.edu.

المصدر: Nature genetics [Nat Genet] 2021 Mar; Vol. 53 (3), pp. 332-341. Date of Electronic Publication: 2021 Mar 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Tumor Escape*/genetics, CD58 Antigens/*immunology , Drug Resistance, Neoplasm/*immunology , Melanoma/*pathology , Single-Cell Analysis/*methods, CD58 Antigens/genetics ; CD58 Antigens/metabolism ; CRISPR-Cas Systems ; Coculture Techniques ; Computational Biology/methods ; Drug Resistance, Neoplasm/drug effects ; Drug Resistance, Neoplasm/genetics ; Epitopes/genetics ; Gene Knockout Techniques ; Humans ; Immune Checkpoint Inhibitors/pharmacology ; Interferon-gamma/immunology ; Interferon-gamma/metabolism ; Lymphocytes, Tumor-Infiltrating/pathology ; Melanoma/drug therapy ; Melanoma/immunology ; Sequence Analysis, RNA