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1
المؤلفون: Mari Manuia, Wenshuo Lu, Laura J. Kingsley, Zhiwei Ma, Vicki Zhou, Darbi Witmer, Glen Spraggon, Mu-Yun Gao, Pierre-Yves Michellys, Min Lu, Yong Jia, Matthew McNeill, Sarah Greenblatt, Bender Steven Lee, Andreas Kreusch, Gerald Lelais, Xiaohui He, Victor Nikulin, Mei-Ting Vaillancourt, Christian C. Lee, Jacob R. Haling, John Nelson, Ajay A. Vashisht
المصدر: Journal of Medicinal Chemistry. 64:4857-4869
مصطلحات موضوعية: Drug, 0303 health sciences, Protease, Cancer cell proliferation, media_common.quotation_subject, medicine.medical_treatment, 01 natural sciences, 20s proteasome, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, chemistry, Biochemistry, Drug Discovery, medicine, Molecular Medicine, Structure based, Protein folding, Boronic acid, 030304 developmental biology, media_common
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2
المؤلفون: Shulin Han, Jeremy S. Caldwell, Xiaoqi Gao, Vicki Zhou, Achim Brinker, Xiang-ju Gu
المصدر: Analytical Biochemistry. 385:300-308
مصطلحات موضوعية: chemistry.chemical_classification, Conformational change, ABL, Protein Conformation, Kinase, Allosteric regulation, Mutation, Missense, Biophysics, Cell Biology, Biology, Biochemistry, Small molecule, Cell Line, Enzyme, chemistry, Animals, Humans, Luciferase, Enzyme Inhibitors, Luciferases, Oncogene Proteins v-abl, Molecular Biology, Intracellular
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3
المؤلفون: Ha-Soon, Choi, Zhicheng, Wang, Wendy, Richmond, Xiaohui, He, Kunyong, Yang, Tao, Jiang, Donald, Karanewsky, Xiang-ju, Gu, Vicki, Zhou, Yi, Liu, Jianwei, Che, Christian C, Lee, Jeremy, Caldwell, Takanori, Kanazawa, Ichiro, Umemura, Naoko, Matsuura, Osamu, Ohmori, Toshiyuki, Honda, Nathanael, Gray, Yun, He
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:2689-2692
مصطلحات موضوعية: Pyrimidines, Molecular Structure, Focal Adhesion Protein-Tyrosine Kinases, Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Enzyme Inhibitors, Molecular Biology, Biochemistry
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4
المؤلفون: Hayk Asatryan, Drew Gunderson, Frederick J. King, Sungjoon Kim, Jason T. Matzen, Daniel G. Sipes, Gang Xia, S. Frank Yan, Andrew I. Su, Jeremy S. Caldwell, Alham Saadat, Markus Warmuth, Peter G. Schultz, Tami Hood, Xiang-ju Gu, Ronak Beigi, Laura Jarnes, Jeff Janes, Michael Garcia, Jonathan S. Melnick, Richard A. Harig, Jim Yuchen Chang, Vicki Zhou, Christopher M. Shaw, Yingyao Zhou, Nathanael S. Gray, Robert T. Downs
المصدر: Proceedings of the National Academy of Sciences. 103:3153-3158
مصطلحات موضوعية: Time Factors, Multidisciplinary, ABL, Databases, Factual, Kinase, Phosphotransferases, Drug Evaluation, Preclinical, Reproducibility of Results, Robotics, Molecular Pharmacology, Computational biology, Biological Sciences, Biology, Small molecule, Molecular biology, Cell Line, Automation, Mice, Structure-Activity Relationship, Drug development, Growth factor receptor, Animals, Structure–activity relationship, Protein Kinase Inhibitors, Proto-oncogene tyrosine-protein kinase Src
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d85ea39d8267429bf0bd1743f5ae5680
https://doi.org/10.1073/pnas.0511292103 -
5
المؤلفون: Xiang-ju Gu, Vicki Zhou, Justin Haugen, Scott A. Lesley, Heath E. Klock, Yi Liu, Shifeng Pan, Nathanael S. Gray, Shulin Han, Michael Hornsby, Daniel McMullan, Jeremy S. Caldwell
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:5467-5473
مصطلحات موضوعية: Models, Molecular, Phosphopeptides, MAPK/ERK pathway, Protein Conformation, Stereochemistry, Clinical Biochemistry, Allosteric regulation, MAP Kinase Kinase 1, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Allosteric Regulation, Coumarins, Drug Discovery, Humans, Enzyme Inhibitors, Phosphorylation, Extracellular Signal-Regulated MAP Kinases, Protein kinase A, Molecular Biology, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, Coumarin, In vitro, Kinetics, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Signal transduction
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6
المؤلفون: Jeremy S. Caldwell, Heath E. Klock, Achim Brinker, Shulin Han, Xiang-ju Gu, Vicki Zhou
المصدر: Analytical Biochemistry. 331:349-357
مصطلحات موضوعية: Base Sequence, biology, Ligand binding assay, Biophysics, Biotin, Cell Biology, Surface Plasmon Resonance, Geldanamycin, Biochemistry, Hsp90, Radicicol, chemistry.chemical_compound, Scintillation proximity assay, Förster resonance energy transfer, chemistry, Heat shock protein, Fluorescence Resonance Energy Transfer, polycyclic compounds, biology.protein, HSP90 Heat-Shock Proteins, Surface plasmon resonance, Molecular Biology, DNA Primers
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7
المؤلفون: Osamu Ohmori, Zhicheng Wang, Ha-Soon Choi, Yi Liu, Toshiyuki Honda, Jeremy S. Caldwell, Xiang-ju Gu, Wendy Richmond, Vicki Zhou, Takanori Kanazawa, Nathanael S. Gray, Kunyong Yang, Ichiro Umemura, Naoko Matsuura, Yun He, Donald S. Karanewsky, Tao Jiang, Christian C. Lee, Jianwei Che, Xiaohui He
المصدر: Bioorganicmedicinal chemistry letters. 16(8)
مصطلحات موضوعية: Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Biochemistry, Chemical synthesis, Focal adhesion, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Humans, Pyrroles, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Kinase, Organic Chemistry, In vitro, Enzyme, Pyrimidines, chemistry, Enzyme inhibitor, Focal Adhesion Protein-Tyrosine Kinases, biology.protein, Molecular Medicine, Signal transduction, Drug Screening Assays, Antitumor
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8
المؤلفون: Achim Brinker, Yun He, Vicki Zhou, Jeremy S. Caldwell, Shulin Han, Andreas Kreusch, Scott A. Lesley, Xiang-ju Gu, Ha-Soon Choi
المصدر: Bioorganicmedicinal chemistry letters. 15(5)
مصطلحات موضوعية: Models, Molecular, Time Factors, Molecular model, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Crystal structure, Pyrazole, Crystallography, X-Ray, Biochemistry, Cell Line, chemistry.chemical_compound, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, Side chain, Molecule, Humans, HSP90 Heat-Shock Proteins, Molecular Biology, Adenine binding, Molecular Structure, Hydrogen bond, Chemistry, Organic Chemistry, Hydrogen Bonding, Protein Structure, Tertiary, Molecular Medicine, Pyrazoles, Binding domain