المؤلفون: Fan L; Department of Pharmacy, China-Japan Union Hospital of Jilin University, Changchun 130033, China., Tong W; Department of Otolaryngology Head and Neck Surgery, The Second Hospital of Jilin University, Changchun 130021, China., Wei A; Jilin University School of Pharmaceutical Sciences, Changchun 130021, China., Mu X; Scientific Research Center, China-Japan Union Hospital of Jilin University, Changchun 130033, China. Electronic address: muxupeng@jlu.edu.cn.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 Aug; Vol. 275 (Pt 1), pp. 133680. Date of Electronic Publication: 2024 Jul 04.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Drug Delivery Systems*/methods , Neoplasms*/drug therapy , Proteolysis*/drug effects , Proteolysis Targeting Chimera*/chemistry , Proteolysis Targeting Chimera*/pharmacology, Animals ; Humans

المؤلفون: Zhang Y; Department of Urology, Qilu Hospital of Shandong University, Ji'nan, China; Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, China., Ming A; Department of Urology, Qilu Hospital of Shandong University, Ji'nan, China; Shandong Provincial Hospital Affiliated to Shandong First Medical University, Ji'nan, China., Wang J; Department of Urology, Qilu Hospital of Shandong University, Ji'nan, China., Chen W; Gan & Lee Pharmaceuticals, Beijing, China. Electronic address: wenmin.chen@ganlee.com., Fang Z; Department of Urology, Qilu Hospital of Shandong University, Ji'nan, China. Electronic address: doctor_fangzq@sdu.edu.cn.

المصدر: Pharmacological research [Pharmacol Res] 2024 Jul; Vol. 205, pp. 107234. Date of Electronic Publication: 2024 May 28.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8907422 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1186 (Electronic) Linking ISSN: 10436618 NLM ISO Abbreviation: Pharmacol Res Subsets: MEDLINE

مواضيع طبية MeSH: Prostatic Neoplasms, Castration-Resistant*/drug therapy , Prostatic Neoplasms, Castration-Resistant*/metabolism , Prostatic Neoplasms, Castration-Resistant*/pathology , Proteolysis Targeting Chimera* , Receptors, Androgen*/metabolism , Signal Transduction*/drug effects, Animals ; Humans ; Male ; Androgen Receptor Antagonists/therapeutic use ; Androgen Receptor Antagonists/pharmacology ; Antineoplastic Agents/therapeutic use ; Antineoplastic Agents/pharmacology

المؤلفون: Wu M; Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China. Electronic address: wmfayd@163.com., Wang W; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences; Zhejiang University, Cancer Center; Zhejiang University School of Medicine Children'sHospital, Division of Hematology-Oncology, Hangzhou, 310058, PR China., Mao X; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences; Zhejiang University, Cancer Center; Zhejiang University School of Medicine Children'sHospital, Division of Hematology-Oncology, Hangzhou, 310058, PR China., Wu Y; Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China., Jin Y; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, 310058, PR China., Liu T; Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China., Lu Y; Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China., Dai H; Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China., Zeng S; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, 310058, PR China., Huang W; Key Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Hangzhou Medical College, Hangzhou, 310058, PR China., Wang Y; College of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, PR China., Yao X; Centre for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau, 999078, PR China., Che J; Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China. Electronic address: chejx@zju.edu.cn., Ying M; Institute of Pharmacology and Toxicology, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, College of Pharmaceutical Sciences; Zhejiang University, Cancer Center; Zhejiang University School of Medicine Children'sHospital, Division of Hematology-Oncology, Hangzhou, 310058, PR China. Electronic address: mying@zju.edu.cn., Dong X; Hangzhou Institute of Innovative Medicine, Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, PR China; Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, PR China. Electronic address: dongxw@zju.edu.cn.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2024 Sep 05; Vol. 275, pp. 116539. Date of Electronic Publication: 2024 May 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Cyclin-Dependent Kinases*/antagonists & inhibitors , Cyclin-Dependent Kinases*/metabolism , Drug Discovery* , fms-Like Tyrosine Kinase 3*/antagonists & inhibitors , fms-Like Tyrosine Kinase 3*/metabolism , Leukemia, Myeloid, Acute*/drug therapy , Protein Kinase Inhibitors*/pharmacology , Protein Kinase Inhibitors*/chemistry , Protein Kinase Inhibitors*/chemical synthesis , Proteolysis Targeting Chimera*/chemistry , Proteolysis Targeting Chimera*/pharmacology , Proteolysis Targeting Chimera*/therapeutic use , Proteolysis*, Humans ; Cell Differentiation/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Molecular Structure ; Structure-Activity Relationship

المؤلفون: Wang C; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, Shandong, China., Zhang Y; The Affiliated Cardiovascular Hospital of Qingdao University, Qingdao University, Qingdao, 266071, Shandong, China. yujingzhang666@163.com., Chen W; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, Shandong, China., Wu Y; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, Shandong, China. wuyudong@qdu.edu.cn., Xing D; Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, 266071, Shandong, China. xdm_tsinghua@163.com.; School of Life Sciences, Tsinghua University, Beijing, 100084, China. xdm_tsinghua@163.com.

المصدر: Molecular cancer [Mol Cancer] 2024 May 21; Vol. 23 (1), pp. 110. Date of Electronic Publication: 2024 May 21.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101147698 Publication Model: Electronic Cited Medium: Internet ISSN: 1476-4598 (Electronic) Linking ISSN: 14764598 NLM ISO Abbreviation: Mol Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Neoplasms*/drug therapy , Proteolysis Targeting Chimera*/pharmacology, Animals ; Humans ; Molecular Targeted Therapy ; Proteasome Endopeptidase Complex/metabolism ; Ubiquitin-Protein Ligases/metabolism

المؤلفون: Zhang R; Shandong Provincial Key Laboratory of Animal Resistance Biology, Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China., Xie S; Shandong Provincial Key Laboratory of Animal Resistance Biology, Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China., Ran J; Shandong Provincial Key Laboratory of Animal Resistance Biology, Center for Cell Structure and Function, College of Life Sciences, Shandong Normal University, Jinan, China., Li T; Haihe Laboratory of Cell Ecosystem, State Key Laboratory of Medicinal Chemical Biology, Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin, China.

المصدر: Journal of cellular physiology [J Cell Physiol] 2024 May; Vol. 239 (5), pp. e31255. Date of Electronic Publication: 2024 Mar 19.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0050222 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4652 (Electronic) Linking ISSN: 00219541 NLM ISO Abbreviation: J Cell Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Proteasome Endopeptidase Complex*/metabolism , Proteolysis*/drug effects , Proteolysis Targeting Chimera*, Animals ; Humans ; Peptides/metabolism ; Ubiquitin/metabolism

المؤلفون: Price E; Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Weinheimer M; Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Rivkin A; Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Jenkins G; Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Nijsen M; Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., Cox PB; Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States., DeGoey D; Research and Development, AbbVie Inc., 1 North Waukegan Road, North Chicago, Illinois 60064, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Apr 11; Vol. 67 (7), pp. 5683-5698. Date of Electronic Publication: 2024 Mar 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Proteolysis Targeting Chimera* , Drug Discovery*/methods, Humans ; Drug Design ; Intestinal Absorption ; Proteolysis

المؤلفون: Apprato G; Department of Molecular Biotechnology and Health Sciences, University of Torino, Piazza Nizza 44bis, 10126 Torino, Italy., Poongavanam V; Department of Chemistry - BMC, Uppsala University, SE-75123 Uppsala, Sweden., Garcia Jimenez D; Department of Molecular Biotechnology and Health Sciences, University of Torino, Piazza Nizza 44bis, 10126 Torino, Italy., Atilaw Y; Department of Chemistry - BMC, Uppsala University, SE-75123 Uppsala, Sweden., Erdelyi M; Department of Chemistry - BMC, Uppsala University, SE-75123 Uppsala, Sweden., Ermondi G; Department of Molecular Biotechnology and Health Sciences, University of Torino, Piazza Nizza 44bis, 10126 Torino, Italy., Caron G; Department of Molecular Biotechnology and Health Sciences, University of Torino, Piazza Nizza 44bis, 10126 Torino, Italy. Electronic address: giulia.caron@unito.it., Kihlberg J; Department of Chemistry - BMC, Uppsala University, SE-75123 Uppsala, Sweden. Electronic address: jan.kihlberg@kemi.uu.se.

المصدر: Drug discovery today [Drug Discov Today] 2024 Apr; Vol. 29 (4), pp. 103917. Date of Electronic Publication: 2024 Feb 14.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Science Ltd. Country of Publication: England NLM ID: 9604391 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5832 (Electronic) Linking ISSN: 13596446 NLM ISO Abbreviation: Drug Discov Today Subsets: MEDLINE

مواضيع طبية MeSH: Proteolysis Targeting Chimera* , Drug Discovery*, Proteolysis ; Drug Design ; Biological Availability

المؤلفون: Li H; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China., Chai M; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China; Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China., Chen Y; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China., Zhou F; International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery of Chinese Ministry of Education (MOE), Guangzhou City Key Laboratory of Precision Chemical Drug Development, College of Pharmacy, Jinan University, Guangzhou 511400, China., Ren X; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China., Xu J; Livzon Research Institute, Livzon Pharmaceutical Group Inc., Zhuhai 519000, China., Wang J; Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China. Electronic address: wang_jian989@163.com., Wang Z; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China; Ningbo Zhongke Creation Center of New Materials, Ningbo 315000, China. Electronic address: wangz@sioc.ac.cn., Huang W; State Key Laboratory of Chemical Biology, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China; Ningbo Zhongke Creation Center of New Materials, Ningbo 315000, China. Electronic address: wxhuang@sioc.ac.cn.

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2024 Apr 01; Vol. 103, pp. 117661. Date of Electronic Publication: 2024 Mar 02.

نوع المنشور: Clinical Trial, Phase I; Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Proteolysis Targeting Chimera* , Proto-Oncogene Proteins p21(ras)*/genetics, Cell Line, Tumor ; Proteolysis ; Signal Transduction

المؤلفون: Hu Z; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.; Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China., Chen PH; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.; Department of Biochemistry and Molecular Biology, College of Medicine, National Cheng Kung University, Tainan City, 701, Taiwan.; Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City, 701, Taiwan., Li W; Yale Cancer Biology Institute, Yale University, West Haven, CT 06516, USA., Krone M; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA., Zheng S; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA., Saarbach J; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA., Velasco IU; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA., Hines J; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA., Liu Y; Yale Cancer Biology Institute, Yale University, West Haven, CT 06516, USA., Crews CM; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA.; Department of Chemistry, Yale University, New Haven, CT 06511, USA.; Department of Pharmacology, Yale University, New Haven, CT 06511, USA.; Yale University School of Medicine, New Haven, CT 06511, USA.

المصدر: Science advances [Sci Adv] 2024 Mar 29; Vol. 10 (13), pp. eadj7251. Date of Electronic Publication: 2024 Mar 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: ErbB Receptors* , Tyrosine Kinase Inhibitors*/pharmacology , Proteolysis Targeting Chimera*/metabolism, Apoptosis ; Cell Line, Tumor ; Phosphorylation ; Signal Transduction ; Tyrosine/metabolism ; Humans

المؤلفون: Desantis J; Department of Chemistry, Biology, and Biotechnology, University of Perugia, Italy., Bazzacco A; Department of Molecular Medicine, University of Padua, Padua, Italy., Eleuteri M; Department of Chemistry, Biology, and Biotechnology, University of Perugia, Italy., Tuci S; Department of Molecular Medicine, University of Padua, Padua, Italy., Bianconi E; Department of Pharmaceutical Science, University of Perugia, Italy., Macchiarulo A; Department of Pharmaceutical Science, University of Perugia, Italy., Mercorelli B; Department of Molecular Medicine, University of Padua, Padua, Italy. Electronic address: beatrice.mercorelli@unipd.it., Loregian A; Department of Molecular Medicine, University of Padua, Padua, Italy. Electronic address: arianna.loregian@unipd.it., Goracci L; Department of Chemistry, Biology, and Biotechnology, University of Perugia, Italy. Electronic address: laura.goracci@unipg.it.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2024 Mar 15; Vol. 268, pp. 116202. Date of Electronic Publication: 2024 Feb 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Proteolysis Targeting Chimera* , COVID-19* , Coronavirus 3C Proteases*, Humans ; Proteolysis ; SARS-CoV-2/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Antiviral Agents/pharmacology