المؤلفون: Lentzas A; Division of Pharmacology, The Netherlands Cancer Institute, Room H3.010, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands., de Gooijer MC; Division of Pharmacology, The Netherlands Cancer Institute, Room H3.010, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands.; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M1 3WE, UK.; The Christie NHS Foundation Trust, Manchester, M20 4BX, UK., Zuidema S; Division of Pharmacology, The Netherlands Cancer Institute, Room H3.010, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands., Meurs A; Division of Pharmacology, The Netherlands Cancer Institute, Room H3.010, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands., Çitirikkaya CH; Division of Pharmacology, The Netherlands Cancer Institute, Room H3.010, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands., Venekamp N; Division of Pharmacology, The Netherlands Cancer Institute, Room H3.010, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands.; Department of Pharmacy, The Netherlands Cancer Institute, Amsterdam, The Netherlands., Beijnen JH; Department of Pharmacy, The Netherlands Cancer Institute, Amsterdam, The Netherlands.; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, Utrecht, 3584 CG, The Netherlands., van Tellingen O; Division of Pharmacology, The Netherlands Cancer Institute, Room H3.010, Plesmanlaan 121, Amsterdam, 1066 CX, The Netherlands. o.v.tellingen@nki.nl.; Mouse Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, The Netherlands. o.v.tellingen@nki.nl.

المصدر: Fluids and barriers of the CNS [Fluids Barriers CNS] 2024 Aug 05; Vol. 21 (1), pp. 62. Date of Electronic Publication: 2024 Aug 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Biomed Central Country of Publication: England NLM ID: 101553157 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-8118 (Electronic) Linking ISSN: 20458118 NLM ISO Abbreviation: Fluids Barriers CNS Subsets: MEDLINE

مواضيع طبية MeSH: Mice, Knockout* , Tetrahydroisoquinolines*/pharmacology , Tetrahydroisoquinolines*/administration & dosage , ATP Binding Cassette Transporter, Subfamily G, Member 2*/metabolism , ATP Binding Cassette Transporter, Subfamily G, Member 2*/antagonists & inhibitors , Brain*/metabolism , Brain*/drug effects , Acridines*/pharmacology , Acridines*/administration & dosage , Blood-Brain Barrier*/metabolism , Blood-Brain Barrier*/drug effects, Animals ; Mice ; Quinolines/pharmacology ; Quinolines/pharmacokinetics ; Quinolines/administration & dosage ; Drug Delivery Systems/methods ; ATP Binding Cassette Transporter, Subfamily B/metabolism ; ATP Binding Cassette Transporter, Subfamily B/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B/genetics ; Male ; Mice, Inbred C57BL

المؤلفون: Uceda-Castro R; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands., Margarido AS; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands., Song JY; Division of Experimental Animal Pathology, The Netherlands Cancer Institute, Amsterdam, Netherlands., de Gooijer MC; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands.; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; The Christie NHS Foundation Trust, Manchester, UK., Messal HA; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands., Chambers CR; Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Nobis M; Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Çitirikkaya CH; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands., Hahn K; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands., Seinstra D; Department of Pathology, Amsterdam University Medical Centers/VUmc and Brain Tumor Center Amsterdam, Amsterdam, Netherlands., Herrmann D; Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Timpson P; Cancer Ecosystems Program, Garvan Institute of Medical Research, Sydney, NSW, Australia.; School of Clinical Medicine, Faculty of Medicine and Health, UNSW Sydney, Sydney, NSW, Australia., Wesseling P; Department of Pathology, Amsterdam University Medical Centers/VUmc and Brain Tumor Center Amsterdam, Amsterdam, Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, Netherlands., van Tellingen O; Division of Pharmacology, The Netherlands Cancer Institute, Amsterdam, Netherlands.; Mouse Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, Netherlands., Vennin C; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands., van Rheenen J; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, Netherlands.

المصدر: Science advances [Sci Adv] 2023 Oct 20; Vol. 9 (42), pp. eabp9530. Date of Electronic Publication: 2023 Oct 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/therapeutic use , Brain Neoplasms*/drug therapy , Breast Neoplasms*/drug therapy , Breast Neoplasms*/genetics , Breast Neoplasms*/metabolism, Animals ; Female ; Mice ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP-Binding Cassette Transporters/genetics ; ATP-Binding Cassette Transporters/metabolism ; Drug Resistance, Neoplasm/genetics ; Endothelial Cells/metabolism ; Neoplasm Proteins/metabolism

المؤلفون: Uceda-Castro R; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands., Margarido AS; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands., Cornet L; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands., Vegna S; Division of Tumor Biology and Immunology, Oncode Institute, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands., Hahn K; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands., Song JY; Division of Experimental Animal Pathology, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands., Putavet DA; Center for Molecular Medicine, Division LAB, University Medical Center Utrecht, 3584 Utrecht, North Holland, the Netherlands., van Geldorp M; Division of Pharmacology, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands., Çitirikkaya CH; Division of Pharmacology, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands., de Keizer PLJ; Center for Molecular Medicine, Division LAB, University Medical Center Utrecht, 3584 Utrecht, North Holland, the Netherlands., Ter Beek LC; Department of Medical Physics and Technology, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands., Borst GR; Department of Radiation Oncology, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands; Faculty of Biology, Medicine and Health, University of Manchester, Manchester M1 3WE, UK; The Christie NHS Foundation Trust, Manchester M20 4BX, UK., Akkari L; Division of Tumor Biology and Immunology, Oncode Institute, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands., van Tellingen O; Division of Pharmacology, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands; Mouse Cancer Clinic, the Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands., Broekman MLD; Department of Neurosurgery, Leiden University Medical Center, 2300 Leiden, South-Holland, the Netherlands; Department of Neurosurgery, Haaglanden Medical Center, Lijnbaan, 2597 The Hague, South-Holland, the Netherlands; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA., Vennin C; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands. Electronic address: c.vennin@nki.nl., van Rheenen J; Division of Molecular Pathology, Oncode Institute, The Netherlands Cancer Institute, 1066 Amsterdam, North Holland, the Netherlands. Electronic address: j.v.rheenen@nki.nl.

المصدر: Cell reports. Medicine [Cell Rep Med] 2022 Nov 15; Vol. 3 (11), pp. 100821.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms*/drug therapy , Brain Neoplasms*/drug therapy, Humans ; Female ; Doxorubicin/pharmacology ; Immunotherapy ; Tumor Microenvironment

المؤلفون: de Gooijer MC; Division of Pharmacology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Mouse Cancer Clinic, the Netherlands Cancer Institute, Amsterdam, the Netherlands., Kemper EM; Department of Hospital Pharmacy, Academic Medical Center, Amsterdam, the Netherlands., Buil LCM; Division of Pharmacology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Mouse Cancer Clinic, the Netherlands Cancer Institute, Amsterdam, the Netherlands., Çitirikkaya CH; Division of Pharmacology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Mouse Cancer Clinic, the Netherlands Cancer Institute, Amsterdam, the Netherlands., Buckle T; Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands., Beijnen JH; Division of Pharmacology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Department of Pharmacy and Pharmacology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands., van Tellingen O; Division of Pharmacology, the Netherlands Cancer Institute, Amsterdam, the Netherlands.; Mouse Cancer Clinic, the Netherlands Cancer Institute, Amsterdam, the Netherlands.

المصدر: Cell reports. Medicine [Cell Rep Med] 2021 Jan 19; Vol. 2 (1), pp. 100184. Date of Electronic Publication: 2021 Jan 19 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med

مواضيع طبية MeSH: ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics , Antineoplastic Agents/*pharmacokinetics , Blood-Brain Barrier/*metabolism , Brain Neoplasms/*drug therapy , Brain Neoplasms/*genetics , Docetaxel/*pharmacokinetics, ATP Binding Cassette Transporter, Subfamily B, Member 1/deficiency ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Autoradiography ; Biological Transport ; Blood-Brain Barrier/diagnostic imaging ; Brain/blood supply ; Brain/diagnostic imaging ; Brain/drug effects ; Brain Neoplasms/blood supply ; Brain Neoplasms/diagnostic imaging ; Cerebrovascular Circulation ; Docetaxel/pharmacology ; Endothelial Cells/cytology ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Female ; Fluorescent Dyes/metabolism ; Gene Expression ; Humans ; Magnetic Resonance Imaging ; Male ; Mice ; Mice, Knockout ; Protein Binding ; Xenograft Model Antitumor Assays

المؤلفون: de Gooijer MC, Buil LCM, Çitirikkaya CH, Hermans J, Beijnen JH; Department of Pharmacy and Pharmacology , The Netherlands Cancer Institute/MC Slotervaart Hospital , Louwesweg 6 , 1066 EC Amsterdam , The Netherlands.; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science , Utrecht University , Universiteitsweg 99 , 3584 CG Utrecht , The Netherlands., van Tellingen O

المصدر: Molecular pharmaceutics [Mol Pharm] 2018 Nov 05; Vol. 15 (11), pp. 5236-5243. Date of Electronic Publication: 2018 Oct 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE

مواضيع طبية MeSH: ATP Binding Cassette Transporter, Subfamily B, Member 1/*metabolism , Blood-Brain Barrier/*metabolism , Phthalazines/*pharmacokinetics , Piperidines/*pharmacokinetics , Poly(ADP-ribose) Polymerase Inhibitors/*pharmacokinetics, ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 2/metabolism ; Administration, Oral ; Animals ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Dogs ; Drug Screening Assays, Antitumor ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Madin Darby Canine Kidney Cells ; Mice ; Mice, Knockout ; Neoplasm Proteins/metabolism ; Permeability ; Phthalazines/administration & dosage ; Piperidines/administration & dosage ; Poly(ADP-ribose) Polymerase Inhibitors/administration & dosage

المؤلفون: de Gooijer MC; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Zhang P; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Department of Neurosurgery, Qilu Hospital, Shandong University, Wenhua Xi Road 107, 250012, Jinan, P.R. China., Buil LCM; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Çitirikkaya CH; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Thota N; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Beijnen JH; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.; Department of Pharmacy and Pharmacology, The Netherlands Cancer Institute / MC Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands.; Division of Pharmacoepidemiology and Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Universiteitsweg 99, 3584 CG, Utrecht, The Netherlands., van Tellingen O; Division of Pharmacology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. o.v.tellingen@nki.nl.; Mouse Cancer Clinic, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands. o.v.tellingen@nki.nl.

المصدر: Scientific reports [Sci Rep] 2018 Jul 17; Vol. 8 (1), pp. 10784. Date of Electronic Publication: 2018 Jul 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Phosphoinositide-3 Kinase Inhibitors*, Aminopyridines/*pharmacokinetics , Brain/*metabolism , Morpholines/*pharmacokinetics, Administration, Oral ; Aminopyridines/administration & dosage ; Animals ; Blood-Brain Barrier ; Female ; Male ; Mice ; Morpholines/administration & dosage